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  1. Article: Reply: COVID-19, A and Hypersensitivity Pneumonitis.

    Shin, Hyoung Shik

    Infection & chemotherapy

    2020  Volume 52, Issue 2, Page(s) 217–218

    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country Korea (South)
    Document type Letter
    ZDB-ID 2573798-3
    ISSN 2093-2340
    ISSN 2093-2340
    DOI 10.3947/ic.2020.52.2.217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6842: Show issues Location:
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  2. Article: Empirical Treatment and Prevention of COVID-19.

    Shin, Hyoung Shik

    Infection & chemotherapy

    2020  Volume 52, Issue 2, Page(s) 142–153

    Abstract: The rapid spread of severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2) in the population and throughout the cells within our body has been developing. Another major cycle of coronavirus disease 2019 (COVID-19), which is expected in the coming ... ...

    Abstract The rapid spread of severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2) in the population and throughout the cells within our body has been developing. Another major cycle of coronavirus disease 2019 (COVID-19), which is expected in the coming fall, could be even more severe than the current one. Therefore, effective countermeasures should be developed based on the already obtained clinical and research information about SARS-CoV-2. The aim of this review was to summarize the data on the empirical treatment of COVID-19 acquired during this SARS-CoV-2 infection cycle; this would aid the establishment of an appropriate healthcare policy to meet the challenges in the future. The infectious disease caused by SARS-CoV-2 is characterized by common cold along with hypersensitivity reaction. Thus, in addition to treating common cold, it is essential to minimize the exposure of cells to the virus and to mitigate the uncontrolled immune response. A proper combination of antiviral agents, immune modulators such as prednisolone, and anticoagulants such as heparin and anti-C5a antagonists could be employed to minimize lung damage and prevent systemic involvements. Finally, strategies to achieve population immunity against SARS-CoV-2 should be developed through understanding of the interaction between the immune system and the virus.
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2573798-3
    ISSN 2093-2340
    ISSN 2093-2340
    DOI 10.3947/ic.2020.52.2.142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6842: Show issues Location:
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  4. Article: COVID-19, A Clinical Syndrome Manifesting as Hypersensitivity Pneumonitis.

    Song, Young Goo / Shin, Hyoung Shik

    Infection & chemotherapy

    2020  Volume 52, Issue 1, Page(s) 110–112

    Keywords covid19
    Language English
    Publishing date 2020-03-10
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 2573798-3
    ISSN 2093-2340
    ISSN 2093-2340
    DOI 10.3947/ic.2020.52.1.110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Association of KIR Genes with Middle East Respiratory Syndrome Coronavirus Infection in South Koreans.

    Baek, In-Cheol / Choi, Eun-Jeong / Kim, Hyoung-Jae / Choi, Haeyoun / Shin, Hyoung-Shik / Lim, Dong-Gyun / Kim, Tai-Gyu

    Journal of clinical medicine

    2024  Volume 13, Issue 1

    Abstract: Background: Middle East respiratory syndrome (MERS) is a lower respiratory tract disease caused by a beta coronavirus (CoV) called MERS-CoV, characterized by a high mortality rate. We aimed to evaluate the association between genetic variation in killer ...

    Abstract Background: Middle East respiratory syndrome (MERS) is a lower respiratory tract disease caused by a beta coronavirus (CoV) called MERS-CoV, characterized by a high mortality rate. We aimed to evaluate the association between genetic variation in killer cell immunoglobulin-like receptors (KIRs) and the risk of MERS in South Koreans.
    Methods: KIR genes were genotyped by multiplex polymerase chain reaction with sequence-specific primers (PCR-SSP). A case-control study was performed to identify the odds ratios (OR) of KIR genes for MERS and the association of KIR genes and their ligands, human leukocyte antigens (HLA) genes.
    Results: KIR2DS4D and KIR3DP1F showed higher frequencies in the group of all patients infected with MERS-CoV than in the control group (
    Conclusion: Further investigations are needed to prove the various immune responses of MERS-CoV-infected cells according to variations in the KIR gene and ligand gene. A treatment strategy based on current research on the KIR gene and MERS-CoV will suggest potential treatment targets.
    Language English
    Publishing date 2024-01-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of KIR Genes with Middle East Respiratory Syndrome Coronavirus Infection in South Koreans

    In-Cheol Baek / Eun-Jeong Choi / Hyoung-Jae Kim / Haeyoun Choi / Hyoung-Shik Shin / Dong-Gyun Lim / Tai-Gyu Kim

    Journal of Clinical Medicine, Vol 13, Iss 1, p

    2024  Volume 258

    Abstract: Background: Middle East respiratory syndrome (MERS) is a lower respiratory tract disease caused by a beta coronavirus (CoV) called MERS-CoV, characterized by a high mortality rate. We aimed to evaluate the association between genetic variation in killer ... ...

    Abstract Background: Middle East respiratory syndrome (MERS) is a lower respiratory tract disease caused by a beta coronavirus (CoV) called MERS-CoV, characterized by a high mortality rate. We aimed to evaluate the association between genetic variation in killer cell immunoglobulin-like receptors (KIRs) and the risk of MERS in South Koreans. Methods: KIR genes were genotyped by multiplex polymerase chain reaction with sequence-specific primers (PCR-SSP). A case-control study was performed to identify the odds ratios (OR) of KIR genes for MERS and the association of KIR genes and their ligands, human leukocyte antigens (HLA) genes. Results: KIR2DS4D and KIR3DP1F showed higher frequencies in the group of all patients infected with MERS-CoV than in the control group ( p = 0.023, OR = 2.4; p = 0.039, OR = 2.7). KIR2DL1, KIR2DP1, and KIR3DP1D were significantly associated with moderate/mild (Mo/Mi) cases. KIR2DL2, KIR2DS1, and KIR3DP1F were affected in severe cases. When we investigated the association between KIR genes and their ligands in MERS patient and control groups, KIR3DL1+/Bw4(80I)+, KIR3DL1+/Bw6+, KIR3DL1+/Bw6−, KIR2DS1+/C2+, and KIR3DS+/Bw4(80I)+ were associated with MERS. KIR3DL1+/Bw6− was found in Mo/Mi cases. KIR2DS1+/C2+ and KIR2DS2+/C1+ were found in severe cases. Conclusion: Further investigations are needed to prove the various immune responses of MERS-CoV-infected cells according to variations in the KIR gene and ligand gene. A treatment strategy based on current research on the KIR gene and MERS-CoV will suggest potential treatment targets.
    Keywords KIR ; HLA ; polymorphism ; MERS ; immunogenetics ; Koreans ; Medicine ; R
    Subject code 572 ; 616
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Emergent Strategies for the Next Phase of COVID-19.

    Huh, Kyungmin / Shin, Hyoung Shik / Peck, Kyong Ran

    Infection & chemotherapy

    2020  Volume 52, Issue 1, Page(s) 105–109

    Keywords covid19
    Language English
    Publishing date 2020-02-25
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 2573798-3
    ISSN 2093-2340
    ISSN 2093-2340
    DOI 10.3947/ic.2020.52.1.105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6842: Show issues Location:
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  8. Article: Empirical Treatment and Prevention of COVID-19

    Shin, Hyoung Shik

    Infection & chemotherapy

    Abstract: The rapid spread of severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2) in the population and throughout the cells within our body has been developing Another major cycle of coronavirus disease 2019 (COVID-19), which is expected in the coming ... ...

    Abstract The rapid spread of severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2) in the population and throughout the cells within our body has been developing Another major cycle of coronavirus disease 2019 (COVID-19), which is expected in the coming fall, could be even more severe than the current one Therefore, effective countermeasures should be developed based on the already obtained clinical and research information about SARS-CoV-2 The aim of this review was to summarize the data on the empirical treatment of COVID-19 acquired during this SARS-CoV-2 infection cycle;this would aid the establishment of an appropriate healthcare policy to meet the challenges in the future The infectious disease caused by SARS-CoV-2 is characterized by common cold along with hypersensitivity reaction Thus, in addition to treating common cold, it is essential to minimize the exposure of cells to the virus and to mitigate the uncontrolled immune response A proper combination of antiviral agents, immune modulators such as prednisolone, and anticoagulants such as heparin and anti-C5a antagonists could be employed to minimize lung damage and prevent systemic involvements Finally, strategies to achieve population immunity against SARS-CoV-2 should be developed through understanding of the interaction between the immune system and the virus
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #457094
    Database COVID19

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  10. Article: Psychiatric adverse events associated with the COVID-19 vaccines approved in the Republic of Korea: a systematic review.

    Ryoo, Seungeun / Choi, Miyoung / Choi, Nam-Kyong / Shin, Hyoung-Shik / Woo, Jun Hee / Park, Byung-Joo / Oh, Sanghoon

    Osong public health and research perspectives

    2024  

    Abstract: This systematic review evaluated psychiatric adverse events (AEs) following vaccination against coronavirus disease 2019 (COVID-19). We included studies that reported or investigated psychiatric AEs in individuals who had received an approved COVID-19 ... ...

    Abstract This systematic review evaluated psychiatric adverse events (AEs) following vaccination against coronavirus disease 2019 (COVID-19). We included studies that reported or investigated psychiatric AEs in individuals who had received an approved COVID-19 vaccine in the Republic of Korea. Systematic electronic searches of Ovid-Medline, Embase, CENTRAL, and KoreaMed databases were conducted on March 22, 2023. Risk of bias was assessed using the Risk of Bias Assessment Tool for Non-randomized Studies 2.0. The study protocol was registered in the International Prospective Register of Systematic Reviews (CRD42023449422). Of the 301 articles initially selected, 7 were included in the final analysis. All studies reported on sleep disturbances, and 2 highlighted anxiety-related AEs. Sleep disorders like insomnia and narcolepsy were the most prevalent AEs, while depression was not reported. Our review suggests that these AEs may have been influenced by biological mechanisms as well as the broader psychosocial context of the COVID-19 pandemic. Although this study had limitations, such as a primary focus on the BNT162b2 vaccine and an observational study design, it offered a systematic, multi-vaccine analysis that fills a critical gap in the existing literature. This review underscores the need for continued surveillance of psychiatric AEs and guides future research to investigate underlying mechanisms, identify risk factors, and inform clinical management.
    Language English
    Publishing date 2024-03-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2656431-2
    ISSN 2233-6052 ; 2210-9099
    ISSN (online) 2233-6052
    ISSN 2210-9099
    DOI 10.24171/j.phrp.2023.0325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6955: Show issues Location:
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