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  1. Article: Employing drug delivery strategies to create safe and effective pharmaceuticals for COVID-19.

    McHugh, Kevin J

    Bioengineering & translational medicine

    2020  Volume 5, Issue 2, Page(s) e10163

    Keywords covid19
    Language English
    Publishing date 2020-05-13
    Publishing country United States
    Document type Editorial
    ISSN 2380-6761
    ISSN 2380-6761
    DOI 10.1002/btm2.10163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Injectable controlled-release systems for the prevention and treatment of infectious diseases.

    Kunkel, Alyssa A / McHugh, Kevin J

    Journal of biomedical materials research. Part A

    2023  

    Abstract: Pharmaceutical drugs, including vaccines, pre- and post-exposure prophylactics, and chronic drug therapies, are crucial tools in the prevention and treatment of infectious diseases. These drugs have the ability to increase survival and improve patient ... ...

    Abstract Pharmaceutical drugs, including vaccines, pre- and post-exposure prophylactics, and chronic drug therapies, are crucial tools in the prevention and treatment of infectious diseases. These drugs have the ability to increase survival and improve patient quality of life; however, infectious diseases still accounted for more than 10.2 million deaths in 2019 before the COVID-19 pandemic. High mortality can be, in part, attributed to challenges in the availability of adequate drugs and vaccines, limited accessibility, poor drug bioavailability, the high cost of some treatments, and low patient adherence. A majority of these factors are logistical rather than technical challenges, providing an opportunity for existing drugs and vaccines to be improved through formulation. Injectable controlled-release drug delivery systems are one class of formulations that have the potential to overcome many of these limitations by releasing their contents in a sustained manner to reduce the need for frequent re-administration and improve clinical outcomes. This review provides an overview of injectable controlled drug delivery platforms, including microparticles, nanoparticles, and injectable gels, detailing recent developments using these systems for single-injection vaccination, long-acting prophylaxis, and sustained-release treatments for infectious disease.
    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6195: Show issues Location:
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  3. Article ; Online: Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems.

    Shi, Miusi / McHugh, Kevin J

    Advanced drug delivery reviews

    2023  Volume 199, Page(s) 114904

    Abstract: The global pharmaceutical market has recently shifted its focus from small molecule drugs to peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling pharmaceutical products on the market. Although these biologics often ... ...

    Abstract The global pharmaceutical market has recently shifted its focus from small molecule drugs to peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling pharmaceutical products on the market. Although these biologics often offer improved drug specificity, new mechanisms of action, and/or enhanced efficacy, they also present new challenges, including an increased potential for degradation and a need for frequent administration via more invasive administration routes, which can limit patient access, patient adherence, and ultimately the clinical impact of these drugs. Controlled-release systems have the potential to mitigate these challenges by offering superior control over in vivo drug levels, localizing these drugs to tissues of interest (e.g., tumors), and reducing administration frequency. Unfortunately, adapting controlled-release devices to release biologics has proven difficult due to the poor stability of biologics. In this review, we summarize the current state of controlled-release peptides and proteins, discuss existing techniques used to stabilize these drugs through encapsulation, storage, and in vivo release, and provide perspective on the most promising opportunities for the clinical translation of controlled-release peptides and proteins.
    MeSH term(s) Humans ; Delayed-Action Preparations ; Drug Delivery Systems ; Proteins/chemistry ; Peptides/chemistry ; Biological Products
    Chemical Substances Delayed-Action Preparations ; Proteins ; Peptides ; Biological Products
    Language English
    Publishing date 2023-05-30
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2023.114904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2241: Show issues Location:
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  4. Article ; Online: Employing drug delivery strategies to create safe and effective pharmaceuticals for COVID ‐19

    McHugh, Kevin J.

    Bioengineering & Translational Medicine

    2020  Volume 5, Issue 2

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ISSN 2380-6761
    DOI 10.1002/btm2.10163
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Employing drug delivery strategies to create safe and effective pharmaceuticals for COVID ‐19

    McHugh, Kevin J.

    2020  

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Employing drug delivery strategies to create safe and effective pharmaceuticals for COVID‐19

    Kevin J. McHugh

    Bioengineering & Translational Medicine, Vol 5, Iss 2, Pp n/a-n/a (2020)

    2020  

    Keywords Chemical engineering ; TP155-156 ; Biotechnology ; TP248.13-248.65 ; Therapeutics. Pharmacology ; RM1-950 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems.

    Baryakova, Tsvetelina H / Pogostin, Brett H / Langer, Robert / McHugh, Kevin J

    Nature reviews. Drug discovery

    2023  Volume 22, Issue 5, Page(s) 387–409

    Abstract: Poor medication adherence is a pervasive issue with considerable health and socioeconomic consequences. Although the underlying reasons are generally understood, traditional intervention strategies rooted in patient-centric education and empowerment have ...

    Abstract Poor medication adherence is a pervasive issue with considerable health and socioeconomic consequences. Although the underlying reasons are generally understood, traditional intervention strategies rooted in patient-centric education and empowerment have proved to be prohibitively complex and/or ineffective. Formulating a pharmaceutical in a drug delivery system (DDS) is a promising alternative that can directly mitigate many common impediments to adherence, including frequent dosing, adverse effects and a delayed onset of action. Existing DDSs have already positively influenced patient acceptability and improved rates of adherence across various disease and intervention types. The next generation of systems have the potential to instate an even more radical paradigm shift by, for example, permitting oral delivery of biomacromolecules, allowing for autonomous dose regulation and enabling several doses to be mimicked with a single administration. Their success, however, is contingent on their ability to address the problems that have made DDSs unsuccessful in the past.
    MeSH term(s) Humans ; Drug Delivery Systems ; Medication Adherence
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-023-00670-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5564: Show issues Location:
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    Zs.MO 334: Show issues
    Zs.MG 63: Show issues

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  8. Article: Methacrylated poly(glycerol sebacate) as a photocurable, biocompatible, and biodegradable polymer with tunable degradation and drug release kinetics.

    Bice, Mei-Li L / Ortega, Valentina L / Yu, Marina H / McHugh, Kevin J

    Research square

    2023  

    Abstract: Poly(glycerol sebacate) (PGS) is a biodegradable, elastomeric polymer that has been explored for applications ranging from tissue engineering to drug delivery and wound repair. Despite its promise, its biomedical utility is limited by its rapid, and ... ...

    Abstract Poly(glycerol sebacate) (PGS) is a biodegradable, elastomeric polymer that has been explored for applications ranging from tissue engineering to drug delivery and wound repair. Despite its promise, its biomedical utility is limited by its rapid, and largely fixed, degradation rate. Additionally, its preparation requires high temperatures for long periods of time, rendering it incompatible with heat-sensitive molecules, complex device geometries, and high-throughput production. In this study, we synthesized methacrylated PGS (PGS-M), imparting the ability to rapidly photocross-link the polymer. Increasing the degree of methacrylation was found to slow PGS-M degradation; PGS-M (5.5 kDa) disks with 21% methacrylation lost 43% of their mass over 11 weeks in vivo whereas 47% methacrylated disks lost just 14% of their mass over the same period. Increasing the methacrylation also extended the release of encapsulated daunorubicin by up to two orders of magnitude in vitro, releasing drug over months instead of one week. Like PGS, PGS-M exhibited good biocompatibility, eliciting limited inflammation and fibrous encapsulation when implanted subcutaneously. These studies are the first to perform long-term studies demonstrating the ability to tune PGS-M degradation rate, use PGS-M to release drug, demonstrate sustained release of drug from PGS-M, and evaluate PGS-M behavior in vivo. Taken together, these studies show that PGS-M offers several key advantages over PGS for drug delivery and tissue engineering, including rapid curing, facile loading of drugs without exposure to heat, tunable degradation rates, and tunable release kinetics, all while retaining the favorable biocompatibility of PGS.
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3384762/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Employing Drug Delivery Strategies to Create Safe and Effective Pharmaceuticals for COVID-19

    McHugh, Kevin J.

    Bioeng. Trans. Med.

    Abstract: The outbreak of the novel SARS-CoV-2 pathogen and corresponding coronavirus disease 2019 (COVID-19) have had an enormous impact on both global health and the daily lives of billions of people worldwide. With a proven vaccine at least a year from being ... ...

    Abstract The outbreak of the novel SARS-CoV-2 pathogen and corresponding coronavirus disease 2019 (COVID-19) have had an enormous impact on both global health and the daily lives of billions of people worldwide. With a proven vaccine at least a year from being fully tested for safety and efficacy, there may be an opportunity to rapidly repurpose existing drugs in order to prevent SARS-CoV-2 infections and improve outcomes for patients already infected with COVID-19. At present, more than 40 different drugs are being explored for efficacy against COVID-19, including antivirals and immune modulating compounds. Unfortunately, many of these drugs are associated with side effects that limit their use to the most severe cases and thereby prevent their use as prophylactics. This commentary describes drug formulation strategies that can be used to maintain the efficacy of these drugs through controlled release, targeted delivery, and non-viral nucleic acid delivery. If successful, these approaches could enable the expanded use of drugs to reduce the mortality of this devastating disease and equip healthcare providers with the tools to accelerate our recovery from this pandemic and improve our response to the next outbreak of a novel pathogenic virus. The author has no conflicts of interest to declare. This article is protected by copyright. All rights reserved.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #141658
    Database COVID19

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  10. Article: Novel Vaccine Adjuvants as Key Tools for Improving Pandemic Preparedness.

    Pogostin, Brett H / McHugh, Kevin J

    Bioengineering (Basel, Switzerland)

    2021  Volume 8, Issue 11

    Abstract: Future infectious disease outbreaks are inevitable; therefore, it is critical that we maximize our readiness for these events by preparing effective public health policies and healthcare innovations. Although we do not know the nature of future pathogens, ...

    Abstract Future infectious disease outbreaks are inevitable; therefore, it is critical that we maximize our readiness for these events by preparing effective public health policies and healthcare innovations. Although we do not know the nature of future pathogens, antigen-agnostic platforms have the potential to be broadly useful in the rapid response to an emerging infection-particularly in the case of vaccines. During the current COVID-19 pandemic, recent advances in mRNA engineering have proven paramount in the rapid design and production of effective vaccines. Comparatively, however, the development of new adjuvants capable of enhancing vaccine efficacy has been lagging. Despite massive improvements in our understanding of immunology, fewer than ten adjuvants have been approved for human use in the century since the discovery of the first adjuvant. Modern adjuvants can improve vaccines against future pathogens by reducing cost, improving antigen immunogenicity, and increasing antigen stability. In this perspective, we survey the current state of adjuvant use, highlight potentially impactful preclinical adjuvants, and propose new measures to accelerate adjuvant safety testing and technology sharing to enable the use of "off-the-shelf" adjuvant platforms for rapid vaccine testing and deployment in the face of future pandemics.
    Language English
    Publishing date 2021-10-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering8110155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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