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  1. Article ; Online: Selection tools and student diversity in health professions education: a multi-site study.

    Fikrat-Wevers, S / Stegers-Jager, K M / Afonso, P M / Koster, A S / Van Gestel, R A / Groenier, M / Ravesloot, J H / Wouters, A / Van Den Broek, W W / Woltman, A M

    Advances in health sciences education : theory and practice

    2023  Volume 28, Issue 4, Page(s) 1027–1052

    Abstract: Student diversity in health professions education (HPE) can be affected by selection procedures. Little is known about how different selection tools impact student diversity across programs using different combinations of traditional and broadened ... ...

    Abstract Student diversity in health professions education (HPE) can be affected by selection procedures. Little is known about how different selection tools impact student diversity across programs using different combinations of traditional and broadened selection criteria. The present multi-site study examined the chances in selection of subgroups of applicants to HPE undergraduate programs with distinctive selection procedures, and their performance on corresponding selection tools. Probability of selection of subgroups (based on gender, migration background, prior education, parental education) of applicants (N = 1935) to five selection procedures of corresponding Dutch HPE undergraduate programs was estimated using multilevel logistic regression. Multilevel linear regression was used to analyze performance on four tools: prior-education grade point average (pe-GPA), biomedical knowledge test, curriculum-sampling test, and curriculum vitae (CV). First-generation Western immigrants and applicants with a foreign education background were significantly less likely to be selected than applicants without a migration background and with pre-university education. These effects did not vary across programs. More variability in effects was found between different selection tools. Compared to women, men performed significantly poorer on CVs, while they had higher scores on biomedical knowledge tests. Applicants with a non-Western migration background scored lower on curriculum-sampling tests. First-generation Western immigrants had lower CV-scores. First-generation university applicants had significantly lower pe-GPAs. There was a variety in effects for applicants with different alternative forms of prior education. For curriculum-sampling tests and CVs, effects varied across programs. Our findings highlight the need for continuous evaluation, identifying best practices within existing tools, and applying alternative tools.
    MeSH term(s) Male ; Humans ; Female ; School Admission Criteria ; Students ; Educational Measurement ; Educational Status ; Health Occupations
    Language English
    Publishing date 2023-01-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1352832-4
    ISSN 1573-1677 ; 1382-4996
    ISSN (online) 1573-1677
    ISSN 1382-4996
    DOI 10.1007/s10459-022-10204-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: External validation of NTCP-models for radiation pneumonitis in lung cancer patients treated with chemoradiotherapy.

    Niezink, Anne G H / van der Schaaf, Arjen / Wijsman, Robin / Chouvalova, Olga / van der Wekken, Anthonie J / Rutgers, Steven R / Pieterman, Remge M / van Putten, John W G / de Hosson, Sander M / van der Leest, Annija H D / Ubbels, Jan F / Woltman-van Iersel, Marleen / Widder, Joachim / Langendijk, Johannes A / Muijs, Christina T

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2023  Volume 186, Page(s) 109735

    Abstract: Purpose: Normal tissue complication probability (NTCP) models can be used to estimate the risk of radiation pneumonitis (RP). The aim of this study was to externally validate the most frequently used prediction models for RP, i.e., the QUANTEC and ... ...

    Abstract Purpose: Normal tissue complication probability (NTCP) models can be used to estimate the risk of radiation pneumonitis (RP). The aim of this study was to externally validate the most frequently used prediction models for RP, i.e., the QUANTEC and APPELT models, in a large cohort of lung cancer patients treated with IMRT or VMAT. [1-2] METHODS AND MATERIALS: This prospective cohort study, included lung cancer patients treated between 2013 and 2018. A closed testing procedure was performed to test the need for model updating. To improve model performance, modification or removal of variables was considered. Performance measures included tests for goodness of fit, discrimination, and calibration.
    Results: In this cohort of 612 patients, the incidence of RP ≥ grade 2 was 14.5%. For the QUANTEC-model, recalibration was recommended which resulted in a revised intercept and adjusted regression coefficient (from 0.126 to 0.224) of the mean lung dose (MLD),. The APPELT-model needed revision including model updating with modification and elimination of variables. After revision, the New RP-model included the following predictors (and regression coefficients): MLD (B = 0.250), age (B = 0.049, and smoking status (B = 0.902). The discrimination of the updated APPELT-model was higher compared to the recalibrated QUANTEC-model (AUC: 0.79 vs. 0.73).
    Conclusions: This study demonstrated that both the QUANTEC- and APPELT-model needed revision. Next to changes of the intercept and regression coefficients, the APPELT model improved further by model updating and performed better than the recalibrated QUANTEC model. This New RP-model is widely applicable containing non-tumour site specific variables, which can easily be collected.
    MeSH term(s) Humans ; Radiation Pneumonitis/diagnosis ; Radiation Pneumonitis/epidemiology ; Radiation Pneumonitis/etiology ; Prospective Studies ; Lung Neoplasms/radiotherapy ; Probability ; Chemoradiotherapy/adverse effects ; Radiotherapy Dosage
    Language English
    Publishing date 2023-06-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2023.109735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Gliomas of the cerebellopontine angle.

    KERNOHAN, J W / WOLTMAN, H W / ADSON, A W

    Journal of neuropathology and experimental neurology

    2008  Volume 7, Issue 4, Page(s) 349–367

    MeSH term(s) Cerebellar Neoplasms ; Cerebellopontine Angle ; Cerebellum ; Glioma ; Humans ; Neoplasms
    Language English
    Publishing date 2008-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1097/00005072-194810000-00001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Some where's and why's of neuritis; a consideration of structures and causes.

    WOLTMAN, H W / GOLDSTEIN, N P

    Neurology

    2003  Volume 8, Issue 3, Page(s) 187–192

    MeSH term(s) Neuritis
    Language English
    Publishing date 2003-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/wnl.8.3.187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Vitamin B12 and coordination exercises for combined degeneration of the spinal cord in pernicious anemia.

    HALL, B E / KRUSEN, F H / WOLTMAN, H W

    Journal of the American Medical Association

    2006  Volume 141, Issue 4, Page(s) 257–260

    MeSH term(s) Anemia ; Anemia, Pernicious ; Corrinoids ; Exercise ; Exercise Therapy ; Humans ; Spinal Cord/pathology ; Therapeutics ; Vitamin B 12
    Chemical Substances Corrinoids ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2006-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0002-9955 ; 0254-9077 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0002-9955 ; 0254-9077 ; 0098-7484
    DOI 10.1001/jama.1949.02910040019004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Tumors of the spinal cord associated with choking of the optic disks.

    LOVE, J G / WAGENER, H P / WOLTMAN, H W

    A.M.A. archives of neurology and psychiatry

    2004  Volume 66, Issue 2, Page(s) 171–177

    MeSH term(s) Airway Obstruction ; Humans ; Neoplasms ; Optic Disk ; Optic Nerve ; Spinal Cord
    Language English
    Publishing date 2004-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 211579-7
    ISSN 0096-6886
    ISSN 0096-6886
    DOI 10.1001/archneurpsyc.1951.02320080055005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Assessment of Bone Lesions with

    van Es, Suzanne C / Velleman, Ton / Elias, Sjoerd G / Bensch, Frederike / Brouwers, Adrienne H / Glaudemans, Andor W J M / Kwee, Thomas C / Iersel, Marleen Woltman-van / Maduro, John H / Oosting, Sjoukje F / de Vries, Elisabeth G E / Schröder, Carolina P

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2020  Volume 62, Issue 2, Page(s) 177–183

    Abstract: It is unknown whether assessment of potential bone lesions in metastatic breast cancer (MBC) ... ...

    Abstract It is unknown whether assessment of potential bone lesions in metastatic breast cancer (MBC) by
    MeSH term(s) Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/secondary ; Bone and Bones/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Middle Aged ; Neoplasm Metastasis ; Positron-Emission Tomography/methods ; Retrospective Studies ; Technetium
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Technetium (7440-26-8)
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.244640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Intramedullary tumors of spinal cord and gliomas of intradural portion of filum terminale; fate of patients who have these tumors.

    WOLTMAN, H W / KERNOHAN, J W / ADSON, A W / CRAIG, W M

    A.M.A. archives of neurology and psychiatry

    2004  Volume 65, Issue 3, Page(s) 378–395

    MeSH term(s) Cauda Equina ; Dura Mater ; Glioma ; Humans ; Spinal Cord
    Language English
    Publishing date 2004-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 211579-7
    ISSN 0096-6886
    ISSN 0096-6886
    DOI 10.1001/archneurpsyc.1951.02320030115010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Inheritance of resistance to angular leaf spot (Pseudomonas syringae pv. lachrymans) in cucumber and identification of molecular markers linked to resistance

    Olczak-Woltman, H / Bartoszewski, G / Mądry, W / Niemirowicz-Szczytt, K

    Plant pathology. 2009 Feb., v. 58, no. 1

    2009  

    Abstract: Angular leaf spot is a common disease of cucumber (Cucumis sativus) caused by Pseudomonas syringae pv. lachrymans. Genetics of resistance to this disease was investigated using two sets of parameters: (i) disease severity, i.e. the number and size of ... ...

    Abstract Angular leaf spot is a common disease of cucumber (Cucumis sativus) caused by Pseudomonas syringae pv. lachrymans. Genetics of resistance to this disease was investigated using two sets of parameters: (i) disease severity, i.e. the number and size of necrotic and chlorotic lesions on the infected leaves, and (ii) presence or absence of a chlorotic halo around the necrotic spots on the infected leaves. Disease severity appears to be controlled by multiple genes and the heritability of the resistance was estimated to be 53%. The presence or absence of the chlorotic halo was determined to be governed by a single gene, with the presence of the halo (the susceptible phenotype) being a dominant character. A RAPD marker linked to the gene conferring the chlorotic halo was identified. Genetic distance between this marker, OP-AO07, a polymorphic 420 bp amplicon in the DNA of the susceptible plants, and the locus encoding the chlorotic halo was estimated to be 13 cM.
    Keywords Cucumis sativus ; disease resistance ; marker-assisted selection
    Language English
    Dates of publication 2009-02
    Size p. 145-151.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 415941-x
    ISSN 1365-3059 ; 0032-0862
    ISSN (online) 1365-3059
    ISSN 0032-0862
    DOI 10.1111/j.1365-3059.2008.01911.x
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Similar frequencies, phenotype and activation status of intrahepatic NK cells in chronic HBV patients after long-term treatment with tenofovir disoproxil fumarate (TDF).

    Tjwa, Eric T T L / Zoutendijk, Roeland / van Oord, Gertine W / Boeijen, Lauke L / Reijnders, Jurrien G P / van Campenhout, Margo J H / de Knegt, Robert J / Janssen, Harry L A / Woltman, Andrea M / Boonstra, Andre

    Antiviral research

    2016  Volume 132, Page(s) 70–75

    Abstract: Background: Currently, much effort is directed at further improving treatment for chronic hepatitis B patients by assessing the effect of immunomodulatory agents during therapy with nucleotide analogues (NUC). Although there are some reports on the ... ...

    Abstract Background: Currently, much effort is directed at further improving treatment for chronic hepatitis B patients by assessing the effect of immunomodulatory agents during therapy with nucleotide analogues (NUC). Although there are some reports on the effect of NUC therapy on peripheral natural killer (NK) cells, no studies investigated the long-term effects of NUC treatment on intrahepatic NK cells of chronic HBV patients. We aimed to prospectively investigate cell frequencies, phenotype, and activation status of intrahepatic NK cells of CHB patients on prolonged treatment with TDF.
    Methods: Fine needle aspiration biopsies were collected from 11 chronic HBV patients at baseline, and at 12, 24, and 48 weeks of treatment with a daily 245 mg dose of TDF. Four patients underwent an additional aspiration biopsy after appoximately 6 years of treatment.
    Results: Longitudinal evaluation of these patients during tenofovir therapy showed that all patients achieved a viral load reduction with undetectable DNA load after 48 weeks of therapy. Repeated sampling of the liver during therapy showed that the frequency of distinct lymphocyte populations in the liver remained unchanged despite viral load reduction. During the course of therapy, no modulation of the expression levels and frequencies of CD69, HLA-DR, NKG2A and NKG2D on liver NK cells were detected. However, evaluation of intrahepatic NK cell activation after continuous TDF therapy for 6 years demonstrated a mild increase in 3 out of 4 patients.
    Conclusions: Our findings provide a unique insight in the intrahepatic NK cell compartment in chronic HBV patients during prolonged treatment. We observed that long-term NUC-induced viral suppression, accompanied by gradual decrease of HBsAg levels, had no or only a limited effect on the frequencies, phenotype, and activation status of intrahepatic NK cells.
    Language English
    Publishing date 2016-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2016.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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