LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 31

Search options

  1. Article: Nutritional Counseling of Stroke Patients by Neurology Residents, a Call to Action.

    Benameur, Karima / Gandrakota, Nikhila / Ali, Mohammed K

    Frontiers in neurology

    2022  Volume 13, Page(s) 940931

    Abstract: Background: Poor diet quality has been found to be an independent risk factor for mortality in stroke. However, it is unknown to what extent Neurologists are trained and are comfortable enough to provide dietary counseling to stroke patients.: ... ...

    Abstract Background: Poor diet quality has been found to be an independent risk factor for mortality in stroke. However, it is unknown to what extent Neurologists are trained and are comfortable enough to provide dietary counseling to stroke patients.
    Objective: To assess the knowledge, attitudes, and practices of neurology residents relating to dietary counseling of stroke patients.
    Methods: An online anonymous survey was administered to neurology residents throughout the country between August and November 2019 among a total of 109 (68%) US neurology programs. Self-reported practices and knowledge regarding stroke prevention through nutritional counseling were queried using validated questionnaires.
    Results: 453 responses out of a potential 672 were received. A minority of residents (12.3%) consistently offered nutritional counseling to stroke patients. 47.7% considered that it was not the neurologist's role to provide nutritional counseling to stroke patients. 83.4% of residents felt that it was the responsibility of the dietician to provide nutritional counseling, yet only 21.4% of residents consistently referred stroke patients to a dietician. 77.9% of respondents felt nutritional counseling is important for stroke patients, yet 65.6% felt they were not adequately trained to provide nutritional counseling.
    Conclusion: Neurologists in training believe diet to be an important part of stroke prevention, but practical knowledge and training in nutrition are suboptimal. This study suggests the need to include nutrition as an integral part of neurology training, to ensure neurologists feel empowered to be an important part of the team providing nutritional counseling to stroke patients.
    Language English
    Publishing date 2022-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.940931
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Immune Reconstitution Syndrome After Nivolumab for Progressive Multifocal Leukoencephalopathy.

    Haroche, Julien / Cohen Aubart, Fleur / Mokhtari, Karima / Seilhean, Danielle / Benameur, Neila / Peyre, Matthieu / Idbaih, Ahmed / Amoura, Zahir

    Neurology. Clinical practice

    2021  Volume 11, Issue 3, Page(s) e376–e378

    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000811
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Catastrophic Neurological Complications in 2 Patients With Sickle Cell Disease and COVID-19.

    Clarke, Karen / Benameur, Karima / Wiley, Zanthia / Shin, Yoo Mee / Moussa, Mohamad / El Rassi, Fuad / McLemore, Morgan

    Journal of investigative medicine high impact case reports

    2022  Volume 10, Page(s) 23247096221111778

    Abstract: Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is commonly associated with neurological complications. Patients with sickle cell disease are at increased risk of developing neurologic complications throughout their lifetimes and ... ...

    Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is commonly associated with neurological complications. Patients with sickle cell disease are at increased risk of developing neurologic complications throughout their lifetimes and often have underlying cardiopulmonary comorbidities that may predispose them to poor outcomes during serious infections. In this case series, we describe 2 patients with sickle cell disease who developed devastating neurologic complications following SARS-CoV-2 infection, which ultimately led to brain edema and death. We highlight the unusual manifestations of coronavirus disease 2019 in patients with sickle cell disease and address the risk of these patients to develop catastrophic neurologic injury due to COVID-19, if not recognized promptly.
    MeSH term(s) Anemia, Sickle Cell/complications ; COVID-19/complications ; Comorbidity ; Humans ; Nervous System Diseases/epidemiology ; Nervous System Diseases/etiology ; SARS-CoV-2
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article ; Case Reports
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/23247096221111778
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Trends in Diet Counseling Among Stroke Versus Non-Stroke Patients: Evidence from the NAMCS, 2011-2016.

    Gandrakota, Nikhila / Patel, Vishal B / Moore, Miranda / Benameur, Karima / Shah, Megha K

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2021  Volume 31, Issue 2, Page(s) 106223

    Abstract: Introduction: Dietary modifications in post-stroke patients facilitated by diet counseling improves post-stroke recovery and stroke recurrence. The extent to which clinicians provide dietary counseling for these patients is unknown.: Methods: 2011 to ...

    Abstract Introduction: Dietary modifications in post-stroke patients facilitated by diet counseling improves post-stroke recovery and stroke recurrence. The extent to which clinicians provide dietary counseling for these patients is unknown.
    Methods: 2011 to 2016 National Ambulatory Medical Care Surveys (NAMCS) data were used to assess trends in post-stroke diet consultations by age. Multivariate logistic regression models assessed the likelihood of dietary counseling provision among patients with and without stroke.
    Results: The proportion of patients with stroke aged 60-79 who received diet counseling decreased from 18.2% in 2011 to 5.3%, 11.9%, 8.7%, 13.4%, and 15.2% in 2012-2016, respectively. Among patients without stroke aged 60-79, diet counseling rate decreased from 12.9% in 2011 to 7%, 9.5%, 10.5%, 13.5%, and 12% in 2012-2016, respectively. Similar trends were observed among patients with and without stroke aged over 80.
    Conclusions: The proportion of patients with and without stroke receiving dietary counseling has remained low over the past half-decade. It is likely multifactorial- related to clinician knowledge, patients' receptiveness, and system-level factors of time and reimbursement. Future interventions should explore methods to address barriers to nutrition recommendations for post-stroke patients and patient activation to adopt dietary changes.
    MeSH term(s) Aged ; Counseling/trends ; Diet ; Health Care Surveys ; Humans ; Middle Aged ; Stroke/epidemiology
    Language English
    Publishing date 2021-11-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2021.106223
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: sPDGFRβ and neuroinflammation are associated with AD biomarkers and differ by race: The ASCEND Study.

    Butts, Brittany / Huang, Hanfeng / Hu, William T / Kehoe, Patrick Gavin / Miners, James Scott / Verble, Danielle D / Zetterberg, Henrik / Zhao, Liping / Trotti, Lynn Marie / Benameur, Karima / Scorr, Laura M / Wharton, Whitney

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2023  Volume 20, Issue 2, Page(s) 1175–1189

    Abstract: Introduction: There remains an urgent need to identify preclinical pathophysiological mechanisms of Alzheimer's disease (AD) development in high-risk, racially diverse populations. We explored the relationship between cerebrospinal fluid (CSF) markers ... ...

    Abstract Introduction: There remains an urgent need to identify preclinical pathophysiological mechanisms of Alzheimer's disease (AD) development in high-risk, racially diverse populations. We explored the relationship between cerebrospinal fluid (CSF) markers of vascular injury and neuroinflammation with AD biomarkers in middle-aged Black/African American (B/AA) and non-Hispanic White (NHW) participants.
    Methods: Adults (45-65 years) with a parental history of AD were enrolled (n = 82). CSF and blood biomarkers were collected at baseline and year 2.
    Results: CSF total tau (t-tau), phosphorylated tau (p-tau), and amyloid beta (Aβ)40 were elevated at year 2 compared to baseline. CSF soluble platelet-derived growth factor receptor β (sPDGFRβ) levels, a marker of pericyte injury, correlated positively with t-tau, p-tau, Aβ40 markers of vascular injury, and cytokines at baseline and year 2. CSF sPDGFRβ and tau were significantly lower in B/AA than NHW.
    Discussion: Vascular dysfunction and neuroinflammation may precede cognitive decline and disease pathology in the very early preclinical stages of AD, and there are race-related differences in these relationships.
    Highlights: Cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers changed over 2 years in high-risk middle-aged adults. Markers of vascular dysfunction were associated with the CSF biomarkers amyloid beta and tau. AD biomarkers were lower in Black compared to non-Hispanic White individuals. Markers of vascular dysfunction were lower among Black individuals.
    MeSH term(s) Middle Aged ; Humans ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/cerebrospinal fluid ; Neuroinflammatory Diseases ; Vascular System Injuries ; tau Proteins/cerebrospinal fluid ; Cognitive Dysfunction/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Peptide Fragments/cerebrospinal fluid
    Chemical Substances Amyloid beta-Peptides ; tau Proteins ; Biomarkers ; Peptide Fragments
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13457
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Myoclonus in Patients With Coronavirus Disease 2019: A Multicenter Case Series.

    Anand, Pria / Zakaria, Asma / Benameur, Karima / Ong, Charlene / Putman, Maryann / O'Shea, Sarah / Greer, David / Cervantes-Arslanian, Anna M

    Critical care medicine

    2020  Volume 48, Issue 11, Page(s) 1664–1669

    Abstract: Objectives: To describe the risk factors for and outcomes after myoclonus in a cohort of patients with coronavirus disease 2019.: Design: Multicenter case series.: Setting: Three tertiary care hospitals in Massachusetts, Georgia, and Virginia.: ... ...

    Abstract Objectives: To describe the risk factors for and outcomes after myoclonus in a cohort of patients with coronavirus disease 2019.
    Design: Multicenter case series.
    Setting: Three tertiary care hospitals in Massachusetts, Georgia, and Virginia.
    Patients: Eight patients with clinical myoclonus in the setting of coronavirus disease 2019.
    Interventions & measurements and main results: Outcomes in patients with myoclonus were variable, with one patient who died during the study period and five who were successfully extubated cognitively intact and without focal neurologic deficits. In five cases, the myoclonus completely resolved within 2 days of onset, while in three cases, it persisted for 10 days or longer. Seven patients experienced significant metabolic derangements, hypoxemia, or exposure to sedating medications that may have contributed to the development of myoclonus. One patient presented with encephalopathy and developed prolonged myoclonus in the absence of clear systemic provoking factors.
    Conclusions: Our findings suggest that myoclonus may be observed in severe acute respiratory syndrome coronavirus 2 infected patients, even in the absence of hypoxia. This association warrants further evaluation in larger cohorts to determine whether the presence of myoclonus may aid in the assessment of disease severity, neurologic involvement, or prognostication.
    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Female ; Follow-Up Studies ; Georgia ; Humans ; Hypoxia ; Male ; Massachusetts ; Middle Aged ; Myoclonus/diagnosis ; Myoclonus/etiology ; Myoclonus/therapy ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Virginia
    Keywords covid19
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004570
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Ischemic stroke in COVID-19: An urgent need for early identification and management.

    Jillella, Dinesh V / Janocko, Nicholas J / Nahab, Fadi / Benameur, Karima / Greene, James G / Wright, Wendy L / Obideen, Mahmoud / Rangaraju, Srikant

    PloS one

    2020  Volume 15, Issue 9, Page(s) e0239443

    Abstract: Objective: In the setting of the Coronavirus Disease 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association of this disease with stroke has been suggested. We aimed to describe the characteristics of patients who were admitted ... ...

    Abstract Objective: In the setting of the Coronavirus Disease 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association of this disease with stroke has been suggested. We aimed to describe the characteristics of patients who were admitted with COVID-19 and had an acute ischemic stroke (AIS).
    Methods: This is a case series of PCR-confirmed COVID-19 patients with ischemic stroke admitted to an academic health system in metropolitan Atlanta, Georgia (USA) between March 24th, 2020 and July 17th, 2020. Demographic, clinical, and radiographic characteristics were described.
    Results: Of 396 ischemic stroke patients admitted during this study period, 13 (2.5%) were also diagnosed with COVID-19. The mean age of patients was 61.6 ± 10.8 years, 10 (76.9%) male, 8 (61.5%) were Black Americans, mean time from last normal was 4.97 ± 5.1 days, and only one received acute reperfusion therapy. All 13 patients had at least one stroke-associated co-morbidity. The predominant pattern of ischemic stroke was embolic with 4 explained by atrial fibrillation. COVID-19 patients had a significantly higher rate of cryptogenic stroke than non-COVID-19 patients during the study period (69% vs 17%, p = 0.0001).
    Conclusions: In our case series, ischemic stroke affected COVID-19 patients with traditional stroke risk factors at an age typically seen in non-COVID populations, and mainly affecting males and Black Americans. We observed a predominantly embolic pattern of stroke with a higher than expected rate of cryptogenic strokes, a prolonged median time to presentation and symptom recognition limiting the use of acute reperfusion treatments. These results highlight the need for increased community awareness, early identification, and management of AIS in COVID-19 patients.
    MeSH term(s) Black or African American ; Aged ; Atrial Fibrillation/complications ; Betacoronavirus ; Brain Ischemia/ethnology ; Brain Ischemia/etiology ; Brain Ischemia/virology ; COVID-19 ; Comorbidity ; Coronavirus Infections/complications ; Coronavirus Infections/ethnology ; Disease Management ; Early Diagnosis ; Embolism/complications ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/ethnology ; SARS-CoV-2 ; Stroke/ethnology ; Stroke/etiology ; Stroke/virology
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0239443
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Initial experiences of US neurologists in practice during the COVID-19 pandemic via survey.

    Sharma, Akanksha / Maxwell, Christina R / Farmer, Jill / Greene-Chandos, Diana / LaFaver, Kathrin / Benameur, Karima

    Neurology

    2020  Volume 95, Issue 5, Page(s) 215–220

    Abstract: Objective: To test the hypothesis that US neurologists were experiencing significant challenges with lack of personal protective equipment (PPE), rapid changes in practice, and varying institutional protocols, we conducted this survey study. The current ...

    Abstract Objective: To test the hypothesis that US neurologists were experiencing significant challenges with lack of personal protective equipment (PPE), rapid changes in practice, and varying institutional protocols, we conducted this survey study. The current coronavirus disease of 2019 (COVID-19) pandemic has caused widespread disease and death. Rapid increases in patient volumes have exposed weaknesses in health care systems and challenged our ability to provide optimal patient care and adequate safety measures to health care workers (HCWs).
    Methods: A 36-item survey was distributed to neurologists around the United States through various media platforms.
    Results: Over a 1-week period, 567 responses were received. Of these, 56% practiced in academia. A total of 87% had access to PPE, with 45% being asked to reuse PPE due to shortages. The pandemic caused rapid changes in practice, most notably a shift toward providing care by teleneurology, although a third experienced challenges in transitioning to this model. Wide variations were noted both in testing and in the guidance provided for the exposed, sick, or vulnerable HCWs. Notably, 59% of respondents felt that their practices were doing what they could, although 56% did not feel safe taking care of patients.
    Conclusions: Results from our survey demonstrate significant variability in preparedness and responsiveness to the COVID-19 pandemic in neurology, affected by region, health care setting, and practice model. Practice guidelines from professional societies and other national entities are needed to improve protection for physicians and their patients, promote recommended practice changes during a pandemic, and optimize future preparedness for public health emergencies.
    MeSH term(s) Academic Medical Centers ; Adult ; Ambulatory Care ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Notification ; Female ; Hospitals ; Humans ; Male ; Middle Aged ; Neurologists ; Organizational Policy ; Pandemics/prevention & control ; Personal Protective Equipment/supply & distribution ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Practice Guidelines as Topic ; SARS-CoV-2 ; Surveys and Questionnaires ; Telemedicine ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000009844
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Postacute Sequelae of SARS-CoV-2 Infection and Impact on Quality of Life 1-6 Months After Illness and Association With Initial Symptom Severity.

    O'Keefe, James B / Minton, H Caroline / Morrow, Mary / Johnson, Colin / Moore, Miranda A / O'Keefe, Ghazala A D / Benameur, Karima / Higdon, Jason / Fairley, Jessica K

    Open forum infectious diseases

    2021  Volume 8, Issue 8, Page(s) ofab352

    Abstract: Background: Individuals with coronavirus disease 2019 (COVID-19) may have persistent symptoms following their acute illness. The prevalence and predictors of these symptoms, termed postacute sequelae of severe acute respiratory syndrome coronavirus 2 ( ... ...

    Abstract Background: Individuals with coronavirus disease 2019 (COVID-19) may have persistent symptoms following their acute illness. The prevalence and predictors of these symptoms, termed postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; PASC), have not been fully described.
    Methods: Participants discharged from an outpatient telemedicine program for COVID-19 were emailed a survey (1-6 months after discharge) about ongoing symptoms, acute illness severity, and quality of life. Standardized telemedicine notes from acute illness were used for covariates (comorbidities and provider-assessed symptom severity). Bivariate and multivariable analyses were performed to assess predictors of persistent symptoms.
    Results: Two hundred ninety patients completed the survey, of whom 115 (39.7%) reported persistent symptoms including fatigue (n = 59, 20.3%), dyspnea on exertion (n = 41, 14.1%), and mental fog (n = 39, 13.5%), among others. The proportion of persistent symptoms did not differ based on duration since illness (<90 days: n = 32, 37.2%; vs >90 days: n = 80, 40.4%;
    Conclusions: Symptoms following acute COVID-19 are common and may be predicted by factors during the acute phase of illness. Fatigue and neuropsychiatric symptoms figured prominently. Select symptoms seem to be particularly associated with perceptions of physical health following COVID-19 and warrant specific attention on future studies of PASC.
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab352
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Ischemic stroke in COVID-19

    Dinesh V Jillella / Nicholas J Janocko / Fadi Nahab / Karima Benameur / James G Greene / Wendy L Wright / Mahmoud Obideen / Srikant Rangaraju

    PLoS ONE, Vol 15, Iss 9, p e

    An urgent need for early identification and management.

    2020  Volume 0239443

    Abstract: Objective In the setting of the Coronavirus Disease 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association of this disease with stroke has been suggested. We aimed to describe the characteristics of patients who were admitted with ... ...

    Abstract Objective In the setting of the Coronavirus Disease 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association of this disease with stroke has been suggested. We aimed to describe the characteristics of patients who were admitted with COVID-19 and had an acute ischemic stroke (AIS). Methods This is a case series of PCR-confirmed COVID-19 patients with ischemic stroke admitted to an academic health system in metropolitan Atlanta, Georgia (USA) between March 24th, 2020 and July 17th, 2020. Demographic, clinical, and radiographic characteristics were described. Results Of 396 ischemic stroke patients admitted during this study period, 13 (2.5%) were also diagnosed with COVID-19. The mean age of patients was 61.6 ± 10.8 years, 10 (76.9%) male, 8 (61.5%) were Black Americans, mean time from last normal was 4.97 ± 5.1 days, and only one received acute reperfusion therapy. All 13 patients had at least one stroke-associated co-morbidity. The predominant pattern of ischemic stroke was embolic with 4 explained by atrial fibrillation. COVID-19 patients had a significantly higher rate of cryptogenic stroke than non-COVID-19 patients during the study period (69% vs 17%, p = 0.0001). Conclusions In our case series, ischemic stroke affected COVID-19 patients with traditional stroke risk factors at an age typically seen in non-COVID populations, and mainly affecting males and Black Americans. We observed a predominantly embolic pattern of stroke with a higher than expected rate of cryptogenic strokes, a prolonged median time to presentation and symptom recognition limiting the use of acute reperfusion treatments. These results highlight the need for increased community awareness, early identification, and management of AIS in COVID-19 patients.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top