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  1. Article: Exemestane-Everolimus-Induced Angioedema in a Woman With Metastatic Breast Cancer: A Case Report and Review.

    Grabie, Yisroel Y / Ahmed, Adham / Acharya, Sudeep / Flamenbaum, Matthew H

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48628

    Abstract: Dual exemestane-everolimus therapy has been shown to confer a progression-free survival benefit in women with refractory advanced hormone-receptor-positive breast cancer. Patients with breast cancer may experience several other comorbidities, including ... ...

    Abstract Dual exemestane-everolimus therapy has been shown to confer a progression-free survival benefit in women with refractory advanced hormone-receptor-positive breast cancer. Patients with breast cancer may experience several other comorbidities, including hypertension, for which angiotensin-converting enzyme inhibitors (ACE-I) are a first-line therapy for hypertension of cardiovascular and/or renal etiology. One rare but feared side effect of ACE-I is severe angioedema due to decreased bradykinin degradation, which can lead to respiratory collapse. Several single-center case series have previously suggested that the use of everolimus in conjunction with ACE-I may lower the threshold for angioedema development. We report our experiences managing a 71-year-old with metastatic breast carcinoma and hypertension who presented with severe angioedema after the combined use of exemestane-everolimus with lisinopril.
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Endemic and Emerging Coronavirus Pulmonary Infections.

    Flamenbaum, Matthew / Roman, Jesse

    The American journal of the medical sciences

    2020  Volume 360, Issue 6, Page(s) 728–732

    Abstract: Coronaviruses are a well-known cause of upper and lower respiratory disease, and since 2002 have been a recognized source of potential pandemic spread. Over the past two decades, since the Severe Acute Respiratory Syndrome (SARS) outbreak, a large body ... ...

    Abstract Coronaviruses are a well-known cause of upper and lower respiratory disease, and since 2002 have been a recognized source of potential pandemic spread. Over the past two decades, since the Severe Acute Respiratory Syndrome (SARS) outbreak, a large body of research has accumulated on the virology, clinical symptoms and signs, and experimental treatments of Coronaviruses. In 2020, a new form of Coronaviruses (SARS-CoV-2) emerged and spread rapidly throughout the globe. Given the wide-ranging clinical presentations of those infected with SARS-CoV-2, other viruses might be overlooked when evaluating at-risk patients. Furthermore, due to suboptimal testing capabilities, an early clinical diagnosis is not always possible. Here, we present a case of a patient with pneumonia thought to be caused by SARS-CoV-2 only to be found to have another Coronavirus. This emphasizes the need to be vigilant when evaluating patients with viral-like respiratory infections.
    MeSH term(s) Aged ; Communicable Diseases, Emerging/diagnosis ; Communicable Diseases, Emerging/pathology ; Communicable Diseases, Emerging/therapy ; Communicable Diseases, Emerging/virology ; Coronavirus/classification ; Coronavirus/isolation & purification ; Coronavirus Infections/diagnosis ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Endemic Diseases ; Fatal Outcome ; Female ; Humans ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/pathology ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2020.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.2/10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Endemic and emerging coronavirus pulmonary infections

    Flamenbaum, Matthew / Roman, Jesse

    Am. j. med. sci

    Abstract: Coronaviruses are a well-known cause of upper and lower respiratory disease, and since 2002 have been a recognized source of potential pandemic spread. Over the past two decades, since the Severe Acute Respiratory Syndrome (SARS) outbreak, a large body ... ...

    Abstract Coronaviruses are a well-known cause of upper and lower respiratory disease, and since 2002 have been a recognized source of potential pandemic spread. Over the past two decades, since the Severe Acute Respiratory Syndrome (SARS) outbreak, a large body of research has accumulated on the virology, clinical symptoms and signs, and experimental treatments of Coronaviruses. In 2020, a new form of Coronaviruses (SARS-CoV-2) emerged and spread rapidly throughout the globe. Given the wide-ranging clinical presentations of those infected with SARS-CoV-2, other viruses might be overlooked when evaluating at-risk patients. Furthermore, due to suboptimal testing capabilities, an early clinical diagnosis is not always possible. Here, we present a case of a patient with pneumonia thought to be caused by SARS-CoV-2 only to be found to have another Coronavirus. This emphasizes the need to be vigilant when evaluating patients with viral-like respiratory infections.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #597582
    Database COVID19

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  4. Article: Rare diseases and space health: optimizing synergies from scientific questions to care.

    Puscas, Maria / Martineau, Gabrielle / Bhella, Gurjot / Bonnen, Penelope E / Carr, Phil / Lim, Robyn / Mitchell, John / Osmond, Matthew / Urquieta, Emmanuel / Flamenbaum, Jaime / Iaria, Giuseppe / Joly, Yann / Richer, Étienne / Saary, Joan / Saint-Jacques, David / Buckley, Nicole / Low-Decarie, Etienne

    NPJ microgravity

    2022  Volume 8, Issue 1, Page(s) 58

    Abstract: Knowledge transfer among research disciplines can lead to substantial research progress. At first glance, astronaut health and rare diseases may be seen as having little common ground for such an exchange. However, deleterious health conditions linked to ...

    Abstract Knowledge transfer among research disciplines can lead to substantial research progress. At first glance, astronaut health and rare diseases may be seen as having little common ground for such an exchange. However, deleterious health conditions linked to human space exploration may well be considered as a narrow sub-category of rare diseases. Here, we compare and contrast research and healthcare in the contexts of rare diseases and space health and identify common barriers and avenues of improvement. The prevalent genetic basis of most rare disorders contrasts sharply with the occupational considerations required to sustain human health in space. Nevertheless small sample sizes and large knowledge gaps in natural history are examples of the parallel challenges for research and clinical care in the context of both rare diseases and space health. The two areas also face the simultaneous challenges of evidence scarcity and the pressure to deliver therapeutic solutions, mandating expeditious translation of research knowledge into clinical care. Sharing best practices between these fields, including increasing participant involvement in all stages of research and ethical sharing of standardized data, has the potential to contribute to humankind's efforts to explore ever further into space while caring for people on Earth in a more inclusive fashion.
    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2823626-9
    ISSN 2373-8065
    ISSN 2373-8065
    DOI 10.1038/s41526-022-00224-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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