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Book ; Online ; E-Book: Endocrine disruptors, brain, and behavior

Patisaul, Heather B. / Belcher, Scott M.

(Oxford series in behavioral neuroendocrinology)

2017

Author's details	Heather B. Patisaul and Scott M. Belcher
Series title	Oxford series in behavioral neuroendocrinology
Keywords	Endocrine disrupting chemicals/Health aspects ; Endocrine glands/Diseases
Subject code	616.4071
Language	English
Size	1 Online-Ressource (xi, 258 Seiten), Illustrationen
Publisher	Oxford University Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019383009
ISBN	978-0-19-993574-1 ; 9780199935734 ; 0-19-993574-2 ; 0199935734
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: REPRODUCTIVE TOXICOLOGY: Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways.

Patisaul, Heather B

Reproduction (Cambridge, England)

2021 Volume 162, Issue 5, Page(s) F111–F130

Abstract: We are all living with hundreds of anthropogenic chemicals in our bodies every day, a situation that threatens the reproductive health of present and future generations. This review focuses on endocrine-disrupting compounds (EDCs), both naturally ... ...

Abstract	We are all living with hundreds of anthropogenic chemicals in our bodies every day, a situation that threatens the reproductive health of present and future generations. This review focuses on endocrine-disrupting compounds (EDCs), both naturally occurring and man-made, and summarizes how they interfere with the neuroendocrine system to adversely impact pregnancy outcomes, semen quality, age at puberty, and other aspects of human reproductive health. While obvious malformations of the genitals and other reproductive organs are a clear sign of adverse reproductive health outcomes and injury to brain sexual differentiation, the hypothalamic-pituitary-gonadal (HPG) axis can be much more difficult to discern, particularly in humans. It is well-established that, over the course of development, gonadal hormones shape the vertebrate brain such that sex-specific reproductive physiology and behaviors emerge. Decades of work in neuroendocrinology have elucidated many of the discrete and often very short developmental windows across pre- and postnatal development in which this occurs. This has allowed toxicologists to probe how EDC exposures in these critical windows can permanently alter the structure and function of the HPG axis. This review includes a discussion of key EDC principles including how latency between exposure and the emergence of consequential health effects can be long, along with a summary of the most common and less well-understood EDC modes of action. Extensive examples of how EDCs are impacting human reproductive health, and evidence that they have the potential for multi-generational physiological and behavioral effects are also provided.
MeSH term(s)	Endocrine Disruptors/toxicity ; Female ; Humans ; Male ; Neurosecretory Systems ; Pregnancy ; Puberty ; Reproduction ; Semen Analysis
Chemical Substances	Endocrine Disruptors
Language	English
Publishing date	2021-10-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2034501-X
ISSN	1741-7899 ; 1470-1626 ; 1476-3990
ISSN (online)	1741-7899
ISSN	1470-1626 ; 1476-3990
DOI	10.1530/REP-20-0596
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Article ; Online: Endocrine disrupting chemicals (EDCs) and the neuroendocrine system: Beyond estrogen, androgen, and thyroid.

Patisaul, Heather B

Advances in pharmacology (San Diego, Calif.)

2021 Volume 92, Page(s) 101–150

Abstract: Hundreds of anthropogenic chemicals occupy our bodies, a situation that threatens the health of present and future generations. This chapter focuses on endocrine disrupting compounds (EDCs), both naturally occurring and man-made, that affect the ... ...

Abstract	Hundreds of anthropogenic chemicals occupy our bodies, a situation that threatens the health of present and future generations. This chapter focuses on endocrine disrupting compounds (EDCs), both naturally occurring and man-made, that affect the neuroendocrine system to adversely impact health, with an emphasis on reproductive and metabolic pathways. The neuroendocrine system is highly sexually dimorphic and essential for maintaining homeostasis and appropriately responding to the environment. Comprising both neural and endocrine components, the neuroendocrine system is hormone sensitive throughout life and touches every organ system in the body. The integrative nature of the neuroendocrine system means that EDCs can have multi-system effects. Additionally, because gonadal hormones are essential for the sex-specific organization of numerous neuroendocrine pathways, endocrine disruption of this programming can lead to permanent deficits. Included in this review is a brief history of the neuroendocrine disruption field and a thorough discussion of the most common and less well understood neuroendocrine disruption modes of action. Also provided are extensive examples of how EDCs are likely contributing to neuroendocrine disorders such as obesity, and evidence that they have the potential for multi-generational effects.
MeSH term(s)	Androgens/pharmacology ; Endocrine Disruptors/toxicity ; Estrogens ; Female ; Humans ; Male ; Neurosecretory Systems ; Thyroid Gland
Chemical Substances	Androgens ; Endocrine Disruptors ; Estrogens
Language	English
Publishing date	2021-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ISSN	1557-8925
ISSN (online)	1557-8925
DOI	10.1016/bs.apha.2021.03.007
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Article ; Online: Developmental organophosphate flame retardant exposure disrupts adult hippocampal neurogenesis in Wistar rats.

Newell, Andrew J / Patisaul, Heather B

Neurotoxicology

2023 Volume 99, Page(s) 104–114

Abstract: Organophosphate flame retardant (OPFR) contamination is ubiquitous and bio-monitoring studies have shown that human exposure is widespread and may be unavoidable. OPFRs bear structural similarities to known neurotoxicants such as organophosphate ... ...

Abstract	Organophosphate flame retardant (OPFR) contamination is ubiquitous and bio-monitoring studies have shown that human exposure is widespread and may be unavoidable. OPFRs bear structural similarities to known neurotoxicants such as organophosphate insecticides and have been shown to have both endocrine disrupting and developmental neurotoxic effects. The perinatal period in rodents represents a critical period in the organization of the developing nervous system and insults during this time can impart profound changes on the trajectory of neural development and function, lasting into adulthood. Adult hippocampal neurogenesis (AHN) facilitates dentate gyrus function and broader hippocampal circuit activity in adults; however, the neurogenic potential of this process in adulthood is vulnerable to disruption by exogenous factors during early life. We sought to assess the impact of OPFRs on AHN in offspring of dams exposed during gestation and lactation. Results indicate that developmental OPFR exposure has significant, sex specific impacts on multiple markers of AHN in the dentate gyrus of rats. In males, OPFR exposure significantly reduced the number of neural progenitors the number of new/immature neurons and reduced dentate gyrus volume. In females, exposure increased the number of neural progenitors, decreased the number of new/immature neurons, but had no significant effect on dentate gyrus volume. These results further elucidate the developmental neurotoxic properties of OPFRs, emphasize the long-term impact of early life OPFR exposure on neural processes, and highlight the importance of including sex as a biological variable in neurotoxicology research.
MeSH term(s)	Pregnancy ; Female ; Male ; Humans ; Rats ; Animals ; Organophosphates/toxicity ; Rats, Wistar ; Flame Retardants/toxicity ; Hippocampus ; Neurogenesis
Chemical Substances	Organophosphates ; Flame Retardants
Language	English
Publishing date	2023-09-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800820-6
ISSN	1872-9711 ; 0161-813X
ISSN (online)	1872-9711
ISSN	0161-813X
DOI	10.1016/j.neuro.2023.09.009
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Article ; Online: Virtual Issue: Neurotoxicology.

Sombers, Leslie A / Patisaul, Heather B

ACS chemical neuroscience

2022 Volume 13, Issue 15, Page(s) 2238–2239

Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Editorial
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.2c00375
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Article ; Online: Achieving CLARITY on bisphenol A, brain and behaviour.

Patisaul, Heather B

Journal of neuroendocrinology

2019 Volume 32, Issue 1, Page(s) e12730

Abstract: There is perhaps no endocrine disrupting chemical more controversial than bisphenol A (BPA). Comprising a high-volume production chemical used in a variety of applications, BPA has been linked to a litany of adverse health-related outcomes, including ... ...

Abstract	There is perhaps no endocrine disrupting chemical more controversial than bisphenol A (BPA). Comprising a high-volume production chemical used in a variety of applications, BPA has been linked to a litany of adverse health-related outcomes, including effects on brain sexual differentiation and behaviour. Risk assessors preferentially rely on classical guideline-compliant toxicity studies over studies published by academic scientists, and have generally downplayed concerns about the potential risks that BPA poses to human health. It has been argued, however, that, because traditional toxicity studies rarely contain neural endpoints, and only a paucity of endocrine-sensitive endpoints, they are incapable of fully evaluating harm. To address current controversies on the safety of BPA, the United States National Institute of Environmental Health Sciences, the National Toxicology Program (NTP), and the US Food and Drug Administration established the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA). CLARITY-BPA performed a classical regulatory-style toxicology study (Core study) in conjunction with multiple behavioural, molecular and cellular studies conducted by academic laboratories (grantee studies) using a collaboratively devised experimental framework and the same animals and tissues. This review summarises the results from the grantee studies that focused on brain and behaviour. Evidence of altered neuroendocrine development, including age- and sex-specific expression of oestrogen receptor (ER)α and ERβ, and the abrogation of brain and behavioural sexual dimorphisms, supports the conclusion that developmental BPA exposure, even at doses below what regulatory agencies regard as "safe" for humans, contribute to brain and behavioural change. The consistency and the reproducibility of the effects across CLARITY-BPA and prior studies using the same animal strain and almost identical experimental conditions are compelling. Combined analysis of all of the data from the CLARITY-BPA project is underway at the NTP and a final report expected in late 2019.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Benzhydryl Compounds/toxicity ; Brain/drug effects ; Endocrine Disruptors/toxicity ; Female ; Humans ; Male ; Neurons/drug effects ; Phenols/toxicity ; Pregnancy ; Sex Differentiation/drug effects ; United States ; United States Food and Drug Administration
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2019-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/jne.12730
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Article ; Online: Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development.

Marinello, William P / Patisaul, Heather B

Advances in pharmacology (San Diego, Calif.)

2021 Volume 92, Page(s) 347–400

Abstract: Pregnancy is a critical time of vulnerability for the development of the fetal brain. Exposure to environmental pollutants at any point in pregnancy can negatively impact many aspects of fetal development, especially the organization and differentiation ... ...

Abstract	Pregnancy is a critical time of vulnerability for the development of the fetal brain. Exposure to environmental pollutants at any point in pregnancy can negatively impact many aspects of fetal development, especially the organization and differentiation of the brain. The placenta performs a variety of functions that can help protect the fetus and sustain brain development. However, disruption of any of these functions can have negative impacts on both the pregnancy outcome and fetal neurodevelopment. This review presents current understanding of how environmental exposures, specifically to endocrine disrupting chemicals (EDCs), interfere with placental function and, in turn, neurodevelopment. Some of the key differences in placental development between animal models are presented, as well as how placental functions such as serving as a xenobiotic barrier and exchange organ, immune interface, regulator of growth and fetal oxygenation, and a neuroendocrine organ, could be vulnerable to environmental exposure. This review illustrates the importance of the placenta as a modulator of fetal brain development and suggests critical unexplored areas and possible vulnerabilities to environmental exposure.
MeSH term(s)	Animals ; Brain ; Endocrine Disruptors/toxicity ; Female ; Fetal Development ; Fetus ; Humans ; Placenta ; Pregnancy
Chemical Substances	Endocrine Disruptors
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ISSN	1557-8925
ISSN (online)	1557-8925
DOI	10.1016/bs.apha.2021.04.003
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Article ; Online: Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure.

Newell, Andrew J / Jima, Dereje / Reading, Benjamin / Patisaul, Heather B

Toxicological sciences : an official journal of the Society of Toxicology

2023 Volume 195, Issue 1, Page(s) 103–122

Abstract: Toxicogenomics is a critical area of inquiry for hazard identification and to identify both mechanisms of action and potential markers of exposure to toxic compounds. However, data generated by these experiments are highly dimensional and present ... ...

Abstract	Toxicogenomics is a critical area of inquiry for hazard identification and to identify both mechanisms of action and potential markers of exposure to toxic compounds. However, data generated by these experiments are highly dimensional and present challenges to standard statistical approaches, requiring strict correction for multiple comparisons. This stringency often fails to detect meaningful changes to low expression genes and/or eliminate genes with small but consistent changes particularly in tissues where slight changes in expression can have important functional differences, such as brain. Machine learning offers an alternative analytical approach for "omics" data that effectively sidesteps the challenges of analyzing highly dimensional data. Using 3 rat RNA transcriptome sets, we utilized an ensemble machine learning approach to predict developmental exposure to a mixture of organophosphate esters (OPEs) in brain (newborn cortex and day 10 hippocampus) and late gestation placenta of male and female rats, and identified genes that informed predictor performance. OPE exposure had sex specific effects on hippocampal transcriptome, and significantly impacted genes associated with mitochondrial transcriptional regulation and cation transport in females, including voltage-gated potassium and calcium channels and subunits. To establish if this holds for other tissues, RNAseq data from cortex and placenta, both previously published and analyzed via a more traditional pipeline, were reanalyzed with the ensemble machine learning methodology. Significant enrichment for pathways of oxidative phosphorylation and electron transport chain was found, suggesting a transcriptomic signature of OPE exposure impacting mitochondrial metabolism across tissue types and developmental epoch. Here we show how machine learning can complement more traditional analytical approaches to identify vulnerable "signature" pathways disrupted by chemical exposures and biomarkers of exposure.
MeSH term(s)	Male ; Pregnancy ; Female ; Animals ; Rats ; Transcriptome ; Flame Retardants/toxicity ; Plasticizers ; Placenta/metabolism ; Organophosphates/toxicity ; Brain/metabolism ; Esters
Chemical Substances	Flame Retardants ; Plasticizers ; Organophosphates ; Esters
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1420885-4
ISSN	1096-0929 ; 1096-6080
ISSN (online)	1096-0929
ISSN	1096-6080
DOI	10.1093/toxsci/kfad062
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Article ; Online: Skeletal effects following developmental flame-retardant exposure are specific to sex and chemical class in the adult Wistar rat.

Schkoda, Stacy / Horman, Brian / Witchey, Shannah K / Jansson, Anton / Macari, Soraia / Patisaul, Heather B

Frontiers in toxicology

2023 Volume 5, Page(s) 1216388

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-3080
ISSN (online)	2673-3080
DOI	10.3389/ftox.2023.1216388
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Article: Endocrine Disruption of Vasopressin Systems and Related Behaviors.

Patisaul, Heather B

Frontiers in endocrinology

2017 Volume 8, Page(s) 134

Abstract: Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a ...

Abstract	Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a myriad of species reveals that the nonapeptide hormones vasopressin (AVP) and oxytocin (OT) may also be EDC targets. EDCs shown to alter pathways and behaviors coordinated by AVP and/or OT include the plastics component bisphenol A (BPA), the soy phytoestrogen genistein (GEN), and various flame retardants. Many effects are sex specific and likely involve action at nuclear estrogen receptors. Effects include the elimination or reversal of well-characterized sexually dimorphic aspects of the AVP system, including innervation of the lateral septum and other brain regions critical for social and other non-reproductive behaviors. Disruption of magnocellular AVP function has also been reported in rats, suggesting possible effects on hemodynamics and cardiovascular function.
Language	English
Publishing date	2017-06-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2017.00134
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