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  1. Book: Endocrinology of aging

    Veldhuis, Johannes D.

    (Endocrinology and metabolism clinics of North America ; 34,4)

    2005  

    Author's details guest ed. Johannes D. Veldhuis
    Series title Endocrinology and metabolism clinics of North America ; 34,4
    Collection
    Language English
    Size XVIII S., S. 833 - 1113 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014624757
    ISBN 1-4160-2689-4 ; 978-1-4160-2689-1
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Conference proceedings: Sex steroid interactions with growth hormone

    Veldhuis, Johannes D.

    [proceedings of the International Symposium on Sex-Steroid Interactions with Growth Hormone, ... held Oct. 22 to 25, 1998, in Naples, Fla.]

    (Proceedings in the Serono Symposia USA series)

    1999  

    Title variant Sex-steroid
    Institution Serono Symposia
    Event/congress International Symposium on Sex Steroid Interactions with Growth Hormone (1998, NaplesFla.)
    Author's details Serono Symposia USA. Johannes D. Veldhuis ... ed
    Series title Proceedings in the Serono Symposia USA series
    Keywords Sex Hormones / physiology / congresses ; Growth Substances / physiology / congresses ; Sexualhormon ; Somatotropin ; Wechselwirkung
    Subject Wechselwirkungen ; Interaktion ; Somatropin ; Genotropin ; CAS 12629-01-5 ; HGH ; Somatotropes Hormon ; STH ; Wachstumshormon ; Menschliches Wachstumshormon ; Growth Hormone ; GH ; Geschlechtshormon
    Language English
    Size XXI, 354 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York, NY u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT011128994
    ISBN 0-387-98810-6 ; 978-0-387-98810-8
    Database Catalogue ZB MED Medicine, Health

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    1999 A 6742 order for loan Magazin

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  3. Article ; Online: HormoneBayes: A novel Bayesian framework for the analysis of pulsatile hormone dynamics.

    Voliotis, Margaritis / Abbara, Ali / Prague, Julia K / Veldhuis, Johannes D / Dhillo, Waljit S / Tsaneva-Atanasova, Krasimira

    PLoS computational biology

    2024  Volume 20, Issue 2, Page(s) e1011928

    Abstract: The hypothalamus is the central regulator of reproductive hormone secretion. Pulsatile secretion of gonadotropin releasing hormone (GnRH) is fundamental to physiological stimulation of the pituitary gland to release luteinizing hormone (LH) and follicle ... ...

    Abstract The hypothalamus is the central regulator of reproductive hormone secretion. Pulsatile secretion of gonadotropin releasing hormone (GnRH) is fundamental to physiological stimulation of the pituitary gland to release luteinizing hormone (LH) and follicle stimulating hormone (FSH). Furthermore, GnRH pulsatility is altered in common reproductive disorders such as polycystic ovary syndrome (PCOS) and hypothalamic amenorrhea (HA). LH is measured routinely in clinical practice using an automated chemiluminescent immunoassay method and is the gold standard surrogate marker of GnRH. LH can be measured at frequent intervals (e.g., 10 minutely) to assess GnRH/LH pulsatility. However, this is rarely done in clinical practice because it is resource intensive, and there is no open-access, graphical interface software for computational analysis of the LH data available to clinicians. Here we present hormoneBayes, a novel open-access Bayesian framework that can be easily applied to reliably analyze serial LH measurements to assess LH pulsatility. The framework utilizes parsimonious models to simulate hypothalamic signals that drive LH dynamics, together with state-of-the-art (sequential) Monte-Carlo methods to infer key parameters and latent hypothalamic dynamics. We show that this method provides estimates for key pulse parameters including inter-pulse interval, secretion and clearance rates and identifies LH pulses in line with the widely used deconvolution method. We show that these parameters can distinguish LH pulsatility in different clinical contexts including in reproductive health and disease in men and women (e.g., healthy men, healthy women before and after menopause, women with HA or PCOS). A further advantage of hormoneBayes is that our mathematical approach provides a quantified estimation of uncertainty. Our framework will complement methods enabling real-time in-vivo hormone monitoring and therefore has the potential to assist translation of personalized, data-driven, clinical care of patients presenting with conditions of reproductive hormone dysfunction.
    MeSH term(s) Male ; Female ; Humans ; Bayes Theorem ; Luteinizing Hormone ; Gonadotropin-Releasing Hormone/metabolism ; Follicle Stimulating Hormone ; Hypothalamus/metabolism
    Chemical Substances Luteinizing Hormone (9002-67-9) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011928
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  4. Book: Neuroendocrinology / 2

    Veldhuis, Johannes D.

    (... ; 22,1)

    1993  

    Author's details Johannes D. Veldhuis, guest ed
    Series title ... ; 22,1
    Endocrinology and metabolism clinics of North America
    Neuroendocrinology
    Collection Endocrinology and metabolism clinics of North America
    Neuroendocrinology
    Language English
    Size XII, 180 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004524067
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Se 148 -22,1- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Interleukin-2 Transiently Inhibits Pulsatile Growth Hormone Secretion in Young but not Older Healthy Men.

    Roelfsema, Ferdinand / Yang, Rebecca / Veldhuis, Johannes D

    The Journal of clinical endocrinology and metabolism

    2021  Volume 106, Issue 10, Page(s) 2855–2864

    Abstract: Context: Interleukin-2 (IL-2), a proinflammatory cytokine, has been used to treat malignancies. Increased cortisol and adrenocorticotropin (ACTH) were noted, but growth hormone (GH) secretion was not investigated in detail.: Objective: We quantified ... ...

    Abstract Context: Interleukin-2 (IL-2), a proinflammatory cytokine, has been used to treat malignancies. Increased cortisol and adrenocorticotropin (ACTH) were noted, but growth hormone (GH) secretion was not investigated in detail.
    Objective: We quantified GH secretion after a single subcutaneous injection of IL-2 in 17 young and 18 older healthy men in relation to dose, age, and body composition.
    Methods: This was a placebo-controlled, blinded, prospectively randomized, crossover study. At 20:00 hours IL-2 (3 or 6 million units/m2) or saline was injected subcutaneously. Lights were off between 23:00 and 07:00 hours. Blood was sampled at 10-minute intervals for 24 hours. Outcome measures included convolution analysis of GH secretion.
    Results: GH profiles were pulsatile under both experimental conditions and lower in older than young volunteers. Since the effect of IL-2 might be time limited, GH analyses were performed on the complete 24-hour series and the 6 hours after IL-2 administration. Total and pulsatile 24-hour GH secretion decreased nonsignificantly. Pulsatile secretion fell over the first 6 hours after IL-2 (P = .03), with visceral fat as a covariate (P = .003), but not age (P = .10). Plots of cumulative 2-hour bins of GH pulse mass showed a distinction by treatment and age groups: A temporary GH decrease of 32% and 28% occurred in the first 2-hour bins after midnight (P = .02 and .04) in young participants, whereas in older individuals no differences were present at any time point.
    Conclusion: This study demonstrates that IL-2 temporarily diminishes GH secretion in young, but not older, men.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cross-Over Studies ; Double-Blind Method ; Growth Hormone/drug effects ; Healthy Volunteers ; Humans ; Injections, Subcutaneous ; Interleukin-2/pharmacology ; Male ; Middle Aged ; Prospective Studies ; Secretory Pathway/drug effects ; Time Factors ; Young Adult
    Chemical Substances Interleukin-2 ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgab484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Neuroendocrinology / 1

    Veldhuis, Johannes D.

    (... ; 21,4)

    1992  

    Author's details Johannes D. Veldhuis, guest ed
    Series title ... ; 21,4
    Neuroendocrinology
    Endocrinology and metabolism clinics of North America
    Collection Neuroendocrinology
    Endocrinology and metabolism clinics of North America
    Language English
    Size XII S., S. 767 - 950 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004423803
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 148 -21,4- verfügbar in Königswinter Königswinter

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  7. Article ; Online: Changes in pituitary function with ageing and implications for patient care.

    Veldhuis, Johannes D

    Nature reviews. Endocrinology

    2013  Volume 9, Issue 4, Page(s) 205–215

    Abstract: The pituitary gland has a role in puberty, reproduction, stress-adaptive responses, sodium and water balance, uterine contractions, lactation, thyroid function, growth, body composition and skin pigmentation. Ageing is marked by initially subtle erosion ... ...

    Abstract The pituitary gland has a role in puberty, reproduction, stress-adaptive responses, sodium and water balance, uterine contractions, lactation, thyroid function, growth, body composition and skin pigmentation. Ageing is marked by initially subtle erosion of physiological signalling mechanisms, resulting in lower incremental secretory-burst amplitude, more disorderly patterns of pituitary hormone release and blunted 24 h rhythmic secretion. Almost all pituitary hormones are altered by ageing in humans, often in a manner dependent on sex, body composition, stress, comorbidity, intercurrent illness, medication use, physical frailty, caloric intake, immune status, level of exercise, and neurocognitive decline. The aim of this article is to critically discuss the mechanisms mediating clinical facets of changes in the hypothalamic-pituitary axis during ageing, and the extent to which confounding factors operate to obscure ageing-related effects.
    MeSH term(s) Aging/physiology ; Female ; Human Growth Hormone/metabolism ; Humans ; Male ; Pituitary Gland/metabolism ; Pituitary Gland/pathology ; Pituitary Hormones/metabolism
    Chemical Substances Pituitary Hormones ; Human Growth Hormone (12629-01-5)
    Language English
    Publishing date 2013-02-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/nrendo.2013.38
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in Quantification.

    Keenan, Daniel M / Veldhuis, Johannes D

    Physiology (Bethesda, Md.)

    2016  Volume 31, Issue 1, Page(s) 34–50

    Abstract: Neuroendocrine systems control many of the most fundamental physiological processes, e.g., reproduction, growth, adaptations to stress, and metabolism. Each such system involves the hypothalamus, the pituitary, and a specific target gland or organ. In ... ...

    Abstract Neuroendocrine systems control many of the most fundamental physiological processes, e.g., reproduction, growth, adaptations to stress, and metabolism. Each such system involves the hypothalamus, the pituitary, and a specific target gland or organ. In the quantification of the interactions among these components, biostatistical modeling has played an important role. In the present article, five key challenges to an understanding of the interactions of these systems are illustrated and discussed critically.
    MeSH term(s) Humans ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiology ; Hypothalamus/metabolism ; Hypothalamus/physiology ; Pituitary Gland/metabolism ; Pituitary Gland/physiology ; Pituitary Hormones/metabolism
    Chemical Substances Pituitary Hormones
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00027.2015
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  9. Article ; Online: Differential Effects of Estradiol and Progesterone on Cardiovascular Risk Factors in Postmenopausal Women.

    Roelfsema, Ferdinand / Yang, Rebecca J / Veldhuis, Johannes D

    Journal of the Endocrine Society

    2018  Volume 2, Issue 7, Page(s) 794–805

    Abstract: Context: Controlled, blinded studies of sex-hormone replacement in postmenopausal women using natural estradiol (E: Objective: To delineate the effect of E: Design: A placebo-controlled, double-masked, prospectively randomized study of 40 healthy, ...

    Abstract Context: Controlled, blinded studies of sex-hormone replacement in postmenopausal women using natural estradiol (E
    Objective: To delineate the effect of E
    Design: A placebo-controlled, double-masked, prospectively randomized study of 40 healthy, postmenopausal volunteers assigned to four treatment groups: placebo, intramuscular E
    Results: Treatment with E
    Conclusion: In this study, there were individual and interactive effects of E
    Language English
    Publishing date 2018-06-14
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/js.2018-00073
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  10. Article ; Online: Growth Hormone Dynamics in Healthy Adults Are Related to Age and Sex and Strongly Dependent on Body Mass Index.

    Roelfsema, Ferdinand / Veldhuis, Johannes D

    Neuroendocrinology

    2016  Volume 103, Issue 3-4, Page(s) 335–344

    Abstract: Background: Studies on 24-hour growth hormone (GH) secretion are rare. The influences of sex, age, and adiposity are well recognized but generally derived from specific, selected subject groups, not spanning sexes, many age decades, and a range of body ... ...

    Abstract Background: Studies on 24-hour growth hormone (GH) secretion are rare. The influences of sex, age, and adiposity are well recognized but generally derived from specific, selected subject groups, not spanning sexes, many age decades, and a range of body weights.
    Objective: Our goal was to investigate GH dynamics in a group of 130 healthy adult subjects, both men and women, across 5 age decades as well as a 2.5-fold range of body mass index (BMI) values.
    Methods: GH was measured by a sensitive immunofluorometric assay. Secretion parameters were quantified by automated deconvolution and relative pattern randomness by approximate entropy (ApEn).
    Results: The median age was 40 years (range 20-77). The median BMI was 26 (range 18.3-49.8). Pulsatile 24-hour GH secretion was negatively correlated with age (p = 0.002) and BMI (p < 0.0001). Basal GH secretion negatively correlated with BMI (p = 0.003) but not with age. The sex- dependent GH secretion (greater in women) was no longer detectable after 50 years of age. Insulin-like growth factor (IGF)-1 levels were lower in women over 50 years of age compared with men of a similar age. ApEn showed an age-related increase in both sexes and was higher in premenopausal and postmenopausal women than in men of comparable age (p < 0.0001). A single fasting GH measurement is not informative of 24-hour GH secretion.
    Conclusions: BMI dominates the negative regulation of 24-hour GH secretion across 5 decades of age in this up till now largest cohort of healthy adults who underwent 24-hour blood sampling. Sex also impacts GH secretion before the age of 50 years as well as its regularity at all ages. Differences in serum IGF-1 partly depend on the pre- or postmenopausal state. Finally, a single GH measurement is not informative of 24-hour GH secretion.
    MeSH term(s) Adult ; Aged ; Aging/blood ; Body Mass Index ; Entropy ; Female ; Growth Hormone/blood ; Healthy Volunteers ; Humans ; Insulin-Like Growth Factor I/metabolism ; Linear Models ; Male ; Middle Aged ; Nonlinear Dynamics ; Radioimmunoassay ; Sex Characteristics ; Young Adult
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 123303-8
    ISSN 1423-0194 ; 0028-3835
    ISSN (online) 1423-0194
    ISSN 0028-3835
    DOI 10.1159/000438904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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