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Article: [Resected Right Upper Lobe Lung Cancer with Displaced Bronchus and Anomalous Pulmonary Vein].

Katsuya, Ryotaro / Sato, Keiyu / Ishida, Junzo / Yamashita, Ryo

Kyobu geka. The Japanese journal of thoracic surgery

2024 Volume 77, Issue 3, Page(s) 177–181

Abstract: The patient is a 77-year-old man. He was referred to our hospital after a chest computed tomography (CT) scan revealed a 6.5 cm-sized mass in the right lung apex. Bronchoscopy revealed adenocarcinoma, clinical stageⅡB, and the patient was referred for ... ...

Abstract	The patient is a 77-year-old man. He was referred to our hospital after a chest computed tomography (CT) scan revealed a 6.5 cm-sized mass in the right lung apex. Bronchoscopy revealed adenocarcinoma, clinical stageⅡB, and the patient was referred for surgery. Preoperative 3D-CT revealed the presence of a displaced bronchus, probably B1a, branching from the right main bronchus centrally from the upper lobe bronchus, and an abnormal vessel (V2) running dorsal to the upper lobe bronchus and the right main bronchus, and returning directly to the left atrium. Surgery was performed by resectioning the right upper lobe through a posterolateral incision, combined resection of the wall pleura, and lymph node dissection (ND2a-2). Because lung cancer surgery is sometimes accompanied by abnormal bronchial and pulmonary vascular branches, it is essential to thoroughly examine the patient before surgery for checking abnormal branches by bronchoscopy and 3D-CT.
MeSH term(s)	Male ; Humans ; Aged ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Lung Neoplasms/complications ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Pulmonary Veins/abnormalities ; Lung ; Bronchi/diagnostic imaging ; Bronchi/surgery ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/surgery ; Heart Defects, Congenital/complications
Language	Japanese
Publishing date	2024-01-19
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	603899-2
ISSN	0021-5252
ISSN	0021-5252
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Article ; Online: Zn

Tsutsumi, Chika / Uegaki, Kaiku / Yamashita, Riyuji / Ushioda, Ryo / Nagata, Kazuhiro

Cell reports

2024 Volume 43, Issue 2, Page(s) 113682

Abstract: ERp18 is an endoplasmic reticulum (ER)-resident thioredoxin (Trx) family protein, similar to cytosolic Trx1. The Trx-like domain occupies a major portion of the whole ERp18 structure, which is postulated to be an ER paralog of cytosolic Trx1. Here, we ... ...

Abstract	ERp18 is an endoplasmic reticulum (ER)-resident thioredoxin (Trx) family protein, similar to cytosolic Trx1. The Trx-like domain occupies a major portion of the whole ERp18 structure, which is postulated to be an ER paralog of cytosolic Trx1. Here, we elucidate that zinc ion (Zn
MeSH term(s)	Animals ; Caenorhabditis elegans ; Hydrogen Peroxide ; Thioredoxins ; Endoplasmic Reticulum ; Zinc
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Thioredoxins (52500-60-4) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113682
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Article ; Online: A rare case of tumor-to-tumor metastasis from thymic carcinoma to an ovarian mature teratoma.

Sasada, Tsuyoshi / Shirakawa, Chigusa / Tachikawa, Ryo / Yamashita, Daisuke / Tomii, Keisuke

Thoracic cancer

2024 Volume 15, Issue 11, Page(s) 934–937

Abstract: Metastasis from one neoplasm to another is referred to as tumor-to-tumor metastasis (TTM). TTM is rarely observed. Here, we present a patient with TTM from a thymic carcinoma to an ovarian mature teratoma. A 25-year-old woman, diagnosed with unresectable ...

Abstract	Metastasis from one neoplasm to another is referred to as tumor-to-tumor metastasis (TTM). TTM is rarely observed. Here, we present a patient with TTM from a thymic carcinoma to an ovarian mature teratoma. A 25-year-old woman, diagnosed with unresectable thymic carcinoma, presented with a cyst with a solid tumor component in her right ovary. Laparoscopic cystectomy of the right ovary revealed that the solid tumor was a distant metastasis of the thymic carcinoma in an ovarian mature teratoma. The possibility of malignant transformation of the ovarian mature teratoma was ruled out, enabling accurate staging of the thymic carcinoma. This case emphasizes the need for clinicians to consider TTM and the importance of pathological confirmation of TTM when investigating potential distant metastases.
MeSH term(s)	Female ; Humans ; Adult ; Thymoma/surgery ; Ovarian Neoplasms/surgery ; Ovarian Neoplasms/pathology ; Teratoma/surgery ; Teratoma/pathology ; Thymus Neoplasms/surgery
Language	English
Publishing date	2024-03-11
Publishing country	Singapore
Document type	Case Reports
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.15277
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Zs.A 6921: Show issues

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Article ; Online: Irregular rupture propagation and geometric fault complexities during the 2010 Mw 7.2 El Mayor-Cucapah earthquake.

Yamashita, Shinji / Yagi, Yuji / Okuwaki, Ryo

Scientific reports

2022 Volume 12, Issue 1, Page(s) 4575

Abstract: ... The 2010 ... ...

Abstract	The 2010 M
Language	English
Publishing date	2022-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-08671-6
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Article ; Online: Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study.

Yamashita, Ryo / Izumi, Yusuke / Nakada, Koji / Hiramoto, Jun

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 365

Abstract: Background: Presepsin is produced during the phagocytosis of bacteria by granulocytes. Presepsin increases at the site of infection; however, the significance of urinary presepsin in pyelonephritis is unknown. This study aimed to evaluate whether ... ...

Abstract	Background: Presepsin is produced during the phagocytosis of bacteria by granulocytes. Presepsin increases at the site of infection; however, the significance of urinary presepsin in pyelonephritis is unknown. This study aimed to evaluate whether measuring urinary presepsin can distinguish between pyelonephritis and nonpyelonephritis. Methods: A cross-sectional study of patients with suspected pyelonephritis was conducted. Urinary presepsin at admission was compared between the pyelonephritis and nonpyelonephritis groups using the Mann-Whitney test. The predictive accuracy of urinary presepsin for diagnosing pyelonephritis was evaluated by the area under the receiver operating characteristics (ROC) analysis curve. Results: A total of 35 eligible participants were included in the pyelonephritis group and 25 in the nonpyelonephritis group. The median urinary presepsin level was 2232.0 (interquartile range [IQR], 1029.0-3907.0) pg/mL in the pyelonephritis group and 1348.0 (IQR, 614.5-2304.8) pg/mL in the nonpyelonephritis group. Urinary presepsin concentrations were significantly higher in the pyelonephritis group than in the nonpyelonephritis group (P = 0.023). ROC analysis of urinary presepsin revealed a cutoff value of 3650 pg/mL to distinguish between the pyelonephritis and nonpyelonephritis groups. Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio for the diagnosis of pyelonephritis were 0.40 (95% confidence interval [CI], 0.24-0.58), 0.96 (95% CI, 0.79-1.00), 0.93 (95% CI, 0.68-1.00), 0.52 (95% CI, 0.37-0.68), 9.60 (95% CI, 1.35-68.23), and 0.62 (95% CI, 0.47-0.83), respectively. Conclusions: The measurement of urinary presepsin is useful in differentiating pyelonephritis from other diseases.
MeSH term(s)	Humans ; Biomarkers/analysis ; Cross-Sectional Studies ; Pyelonephritis/diagnosis ; ROC Curve ; Predictive Value of Tests ; Lipopolysaccharide Receptors/analysis ; Peptide Fragments/analysis ; Sepsis/diagnosis ; C-Reactive Protein/analysis
Chemical Substances	Biomarkers ; Lipopolysaccharide Receptors ; Peptide Fragments ; C-Reactive Protein (9007-41-4) ; presepsin protein, human
Language	English
Publishing date	2023-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08353-2
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Article: Epidermoid cyst of the testis: A report of three cases.

Usui, Kimitsugu / Yamashita, Ryo / Sakura, Yuma / Nakamura, Masafumi / Shinsaka, Hideo / Matsuzaki, Masato / Niwakawa, Masashi

Clinical case reports

2024 Volume 12, Issue 4, Page(s) e8577

Abstract: Testicular epidermoid cysts have characteristic findings. Testicular tumor markers are negative in patients with epidermoid cysts. Clear margins and sole and small testicular tumors (20 mm or less) suggest the possibility of epidermoid cyst. Testicular- ... ...

Abstract	Testicular epidermoid cysts have characteristic findings. Testicular tumor markers are negative in patients with epidermoid cysts. Clear margins and sole and small testicular tumors (20 mm or less) suggest the possibility of epidermoid cyst. Testicular-sparing surgery with intraoperative frozen section examination should be performed when suspecting epidermoid cysts. Testicular epidermoid cysts are rare tumors that account for 1% of all testicular tumors and are often clinically misdiagnosed as malignant lesions. We report three cases of epidermoid cysts. The chief manifestations were scrotal induration in two patients and pruritus scrotum in one. The median age of the patients was 23 years (18-30). All tumors were determined to be sole lesions (<20 mm in diameter). Testing for tumor markers in all patients revealed negative results. We could not rule out malignancy; hence, we performed high inguinal orchiectomy in all cases. Histologically, the inner walls of the cysts were lined with stratified squamous epithelium; their contents were keratinized. All patients were diagnosed with epidermoid cysts.
Language	English
Publishing date	2024-03-31
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8577
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Article: Successful sutureless repair of multiple left ventricular free wall ruptures due to Takotsubo cardiomyopathy: a case report.

Yasumura, Hiroto / Tao, Koji / Imada, Ryo / Yamashita, Yushi / Tateishi, Naoki / Kinjo, Tamahiro

Surgical case reports

2024 Volume 10, Issue 1, Page(s) 47

Abstract: Background: Takotsubo cardiomyopathy (TCM) is a temporary and reversible systolic abnormality of the left ventricular apical area resembling a myocardial infarction. Cardiac rupture due to TCM is a rare but fatal complication. Without cardiac surgery, ... ...

Abstract	Background: Takotsubo cardiomyopathy (TCM) is a temporary and reversible systolic abnormality of the left ventricular apical area resembling a myocardial infarction. Cardiac rupture due to TCM is a rare but fatal complication. Without cardiac surgery, 94% of patients with left ventricular free wall rupture (LVFWR) due to TCM die. Furthermore, successful surgical cases are rare. We report herein the successful treatment of multiple LVFWRs due to TCM using a sutureless repair. Case presentation: An 80-year-old man quarreled with his daughter and had a sudden onset of chest pain. He was transferred to our hospital in shock. Electrocardiography showed ST elevation and contrast-enhanced computed tomography revealed a bloody pericardial effusion. Emergent coronary angiography showed no significant stenosis. Cardiac arrest ensued because of cardiac tamponade. Emergent surgery was undertaken and three oozing lacerations on the lateral and inferior walls were noted. A sutureless repair was performed using TachoSil® patches. We also applied Surgicel Nu-Knit® absorbable hemostat with Hydrofit® where TachoSil® failed to completely adhere because of hematoma formation and achieved complete hemostasis. We diagnosed the ruptures due to TCM according to the Mayo criteria. The patient was discharged on postoperative day 71. Conclusions: A sutureless repair using TachoSil® patches and Surgicel® with Hydrofit® is a minimally invasive and effective method for the treatment of multiple LVFWRs due to TCM.
Language	English
Publishing date	2024-02-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2809613-7
ISSN	2198-7793
ISSN	2198-7793
DOI	10.1186/s40792-024-01848-3
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Article: Influence of Simulated Loss of Posterior Occlusal Support on Three-dimensional Condylar Displacement.

Sakai, Ryo / Yamashita, Shuichiro

The Bulletin of Tokyo Dental College

2021 Volume 62, Issue 3, Page(s) 137–150

Abstract: The objective of this study was to verify whether loss of posterior occlusal support induced displacement of the mandibular condyles from a physiological point of view. Stabilization-type splints were fabricated for 12 healthy dentulous individuals. Each ...

Abstract	The objective of this study was to verify whether loss of posterior occlusal support induced displacement of the mandibular condyles from a physiological point of view. Stabilization-type splints were fabricated for 12 healthy dentulous individuals. Each splint was designed to cover the bilateral maxillary teeth up to the second molars. To reproduce loss of posterior occlusal support, the extent of the splint was reduced one tooth at a time, bilaterally, starting from the back and moving forward sequentially. Tapping movement and lateral excursions were performed with each splint and a jaw movement tracking device with 6-degrees of freedom used to observe condylar displacement. Evaluation of 3-dimensional (3-D) displacement of the kinematic axis of the condyle during experimental jaw movement was performed under each occlusal condition with occlusal contact on all teeth, including the maxillary second molars. The habitual closing position was used as the reference. An increase was observed in 3-D displacement of the kinematic axis at the terminal point of the tapping movement with loss of occlusal support, and significant differences were observed in both condyles. An increase was also observed in 3-D displacement of the kinematic axis on the working side during lateral excursion with loss of occlusal support, and a statistically significant difference was observed in the left condyle. A small increase was observed in 3-D displacement of the kinematic axis on the non-working side during lateral excursion with loss of occlusal support. The results of this study suggest that loss of posterior occlusal support induces displacement of the mandibular condyles, suggesting that occlusal support in the molar region is an important factor in stabilization of the condylar position.
MeSH term(s)	Humans ; Mandibular Condyle ; Molar ; Movement ; Splints ; Tooth
Language	English
Publishing date	2021-08-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	968071-8
ISSN	0040-8891
ISSN	0040-8891
DOI	10.2209/tdcpublication.2020-0052
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Article: A Case of Drug-Resistant Myoclonus Improved by Only Slight Adjustment to the Hemodialysis Setting.

Sasaki, Ryo / Matsuoka, Chika / Yamashita, Toru / Kinomura, Masaru / Abe, Koji

Cureus

2023 Volume 15, Issue 3, Page(s) e36104

Abstract: Myoclonus, a rare complication in patients with end-stage renal disease, is typically ameliorated through hemodialysis. The present case concerns an 84-year-old male with chronic renal failure undergoing hemodialysis, presenting involuntary movements in ... ...

Abstract	Myoclonus, a rare complication in patients with end-stage renal disease, is typically ameliorated through hemodialysis. The present case concerns an 84-year-old male with chronic renal failure undergoing hemodialysis, presenting involuntary movements in his limbs, which gradually worsened from the initiation of hemodialysis without constant elevation of serum blood urea nitrogen and electrolytes levels. Surface electromyography revealed characteristic findings consistent with myoclonus. He was diagnosed with subcortical-nonsegmental myoclonus related to hemodialysis, and the myoclonus was significantly alleviated after slightly increasing the post-dialysis target weight even though drug treatment was ineffective. This case suggests that drug-resistant myoclonus in patients with renal failure may be improved by adjusting hemodialysis settings, even in cases of atypical dialysis disequilibrium syndrome.
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.36104
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Article ; Online: Enantioselective Synthesis of Bromodifluoromethyl-containing Oxazolines by Concerted Lewis/Brønsted Base Catalysis with Chiral Bisphosphine Oxide.

Hirokawa, Ryo / Nakahara, Yuki / Uchida, Shotaro / Yamashita, Kenji / Hamashima, Yoshitaka

Chemistry, an Asian journal

2023 Volume 18, Issue 8, Page(s) e202300141

Abstract: We describe regio- and enantioselective bromocyclization of difluoroalkenes catalyzed by chiral bisphosphine oxides. Owing to the simultaneous activation of both the brominating reagent and amide substrate, the desired cyclization reaction proceeds ... ...

Abstract	We describe regio- and enantioselective bromocyclization of difluoroalkenes catalyzed by chiral bisphosphine oxides. Owing to the simultaneous activation of both the brominating reagent and amide substrate, the desired cyclization reaction proceeds smoothly even at low temperature to provide bromodifluoromethyl-containing oxazolines with a chiral quaternary center in a highly enantioselective fashion (up to 99% ee). This protocol features the use of commercially available brominating reagents and readily accessible chiral catalysts. The regioselectivity and enantioselectivity are influenced by the catalyst structure, the brominating reagent, and the reaction temperature. Under the optimal conditions, 5-exo cyclization proceeds preferentially compared with 6-endo cyclization, depending on the electronic properties of the alkene substrates. A gram-scale synthesis of chiral oxazoline was achieved with as little as 1 mol % of the catalyst.
Language	English
Publishing date	2023-03-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2233006-9
ISSN	1861-471X ; 1861-4728
ISSN (online)	1861-471X
ISSN	1861-4728
DOI	10.1002/asia.202300141
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