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  1. Article: Rare coronary artery anomaly: left anterior descending artery origin form right coronary cusp.

    Nakajima, Tomohiro / Nakanishi, Keitaro / Shibata, Tsuyoshi / Ogura, Keishi / Kawaharada, Nobuyoshi

    Oxford medical case reports

    2024  Volume 2024, Issue 3, Page(s) omae015

    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omae015
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  2. Article ; Online: Binding Profiles of Human and Mouse Complement Component 8γ to Trisubstituted Organometallic Compounds.

    Yamamoto, Katsuya / Matsumaru, Daisuke / Ishida, Keishi / Endo, Satoshi / Hiromori, Youhei / Nakanishi, Tsuyoshi

    Chemico-biological interactions

    2024  , Page(s) 110998

    Abstract: Complement component 8gamma (C8γ), a member of the lipocalin protein family, is suggested to act as a carrier protein for various chemicals. Although C8γ has been identified in both humans and rodents for some time, our understanding of the species ... ...

    Abstract Complement component 8gamma (C8γ), a member of the lipocalin protein family, is suggested to act as a carrier protein for various chemicals. Although C8γ has been identified in both humans and rodents for some time, our understanding of the species differences in its chemical binding properties remains limited. In the present study, with the aim to elucidate the potential role of C8γ as a carrier protein in both humans and mice, we conducted a radioligand binding assay to examine the chemical binding properties of human C8γ (hC8γ) and mouse C8γ (mC8γ). Scatchard analysis revealed that [
    Language English
    Publishing date 2024-04-11
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2024.110998
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    Zs.A 686: Show issues Location:
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  3. Article: AKR1C3-negative high-risk metastatic castration-sensitive prostate cancer has long-term response to first-line treatment with abiraterone: Four case reports.

    Yoshizawa, Tsuyoshi / Nakanishi, Yoko / Obinata, Daisuke / Yamaguchi, Kenya / Masuda, Shinobu / Takahashi, Satoru

    Urology case reports

    2024  Volume 54, Page(s) 102727

    Abstract: We experienced four cases of high-risk metastatic castration-sensitive prostate cancer (mCSPC) in which first-line treatment with abiraterone showed a sustained long-term response of over 5 years. We conducted immunohistochemical staining of aldo-keto ... ...

    Abstract We experienced four cases of high-risk metastatic castration-sensitive prostate cancer (mCSPC) in which first-line treatment with abiraterone showed a sustained long-term response of over 5 years. We conducted immunohistochemical staining of aldo-keto reductase family 1 member C3 (AKR1C3) expression, which associate with poor prognosis of metastatic castration-resistant prostate cancer (mCRPC), and all prostate cancer tissue from four cases showed negative. These results suggested that AKR1C3-negative high-risk mCSPC cases may respond well to first-line treatment with abiraterone. This is the first report describing association of high-risk mCSPC and negative AKR1C3.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2024.102727
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  4. Article ; Online: Cadmium inhibits differentiation of human trophoblast stem cells into extravillous trophoblasts and disrupts epigenetic changes within the promoter region of the HLA-G gene.

    Ogushi, Shoko / Nakanishi, Tsuyoshi / Kimura, Tomoki

    Toxicological sciences : an official journal of the Society of Toxicology

    2022  Volume 191, Issue 1, Page(s) 25–33

    Abstract: Cadmium (Cd) is a toxic heavy metal widely distributed in the environment. Maternal whole-blood Cd levels during pregnancy are positively associated with the risk of early preterm birth. We hypothesized that Cd inhibits trophoblast differentiation, ... ...

    Abstract Cadmium (Cd) is a toxic heavy metal widely distributed in the environment. Maternal whole-blood Cd levels during pregnancy are positively associated with the risk of early preterm birth. We hypothesized that Cd inhibits trophoblast differentiation, resulting in the development of hypertensive disorders of pregnancy and a high risk of early preterm birth. Using the CT27 human trophoblast stem cell line, we found that exposing these cells to 0.1-0.4 µM Cd inhibited their differentiation into extravillous cytotrophoblasts (EVTs). Supporting this finding, we found that expression of the metal-binding protein metallothionein, which suppresses the toxicity of Cd, is low in EVTs. We also found that Cd exposure changes the methylation status of the promoter region of the HLA-G gene, which is specifically expressed in EVTs. Together, these results suggest that Cd inhibits placental formation by suppressing trophoblast differentiation into EVTs. This suppression may underlie the increased risk of gestational hypertension in women with high whole-blood Cd levels.
    MeSH term(s) Infant, Newborn ; Humans ; Pregnancy ; Female ; Trophoblasts/metabolism ; Placenta/metabolism ; Cadmium/toxicity ; HLA-G Antigens/metabolism ; Premature Birth/metabolism ; Cell Differentiation ; Epigenesis, Genetic ; Stem Cells/metabolism ; Promoter Regions, Genetic
    Chemical Substances Cadmium (00BH33GNGH) ; HLA-G Antigens
    Language English
    Publishing date 2022-11-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/kfac118
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    Zs.A 1709: Show issues Location:
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  5. Article ; Online: Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells.

    Ogushi, Shoko / Nakanishi, Tsuyoshi / Kimura, Tomoki

    The Journal of toxicological sciences

    2022  Volume 47, Issue 8, Page(s) 309–315

    Abstract: Cadmium (Cd) is an environmental pollutant. Blood Cd levels in pregnant women have been associated with premature births, infant birth size, placenta previa, and placenta accreta. There have been concerns on the reproductive developmental toxicity of Cd. ...

    Abstract Cadmium (Cd) is an environmental pollutant. Blood Cd levels in pregnant women have been associated with premature births, infant birth size, placenta previa, and placenta accreta. There have been concerns on the reproductive developmental toxicity of Cd. The choriocarcinoma cell line BeWo, a cellular in vitro model for studying syncytial fusion, has been widely used to study the reproductive and developmental toxic effects of pollutants. Here, we examine the inhibitory effect of Cd against forskolin (FSK)-induced BeWo differentiation. Results showed that Cd exposure inhibited the FSK-induced expression of syncytiotrophoblast-related genes LGALS13, ERVFRD1, SDC1, and CGB3. Inhibition of LGALS13 expression was due to the inhibition of the PKA pathway, whereas the inhibition of the other three genes could be due to the inhibition of the other pathways. These findings could help clarify the reproductive and developmental toxicity of Cd.
    MeSH term(s) Cadmium/toxicity ; Cell Differentiation ; Cell Line, Tumor ; Choriocarcinoma/metabolism ; Colforsin/metabolism ; Colforsin/pharmacology ; Environmental Pollutants/toxicity ; Female ; Galectins/metabolism ; Humans ; Placenta ; Pregnancy ; Pregnancy Proteins/genetics ; Pregnancy Proteins/metabolism ; Trophoblasts/metabolism
    Chemical Substances Environmental Pollutants ; Galectins ; LGALS13 protein, human ; Pregnancy Proteins ; Cadmium (00BH33GNGH) ; Colforsin (1F7A44V6OU)
    Language English
    Publishing date 2022-07-20
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 770623-6
    ISSN 1880-3989 ; 0388-1350
    ISSN (online) 1880-3989
    ISSN 0388-1350
    DOI 10.2131/jts.47.309
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    Zs.A 1682: Show issues Location:
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  6. Article ; Online: Sporadic Late-onset Nemaline Myopathy Associated with Sjögren's Syndrome: A Case Report.

    Hamaguchi, Tsuyoshi / Nishino, Ichizo / Hirano, Yasuki / Uchida, Nobuaki / Fujita-Nakata, Michiyo / Nakanishi, Megumi / Sakai, Tomoyuki / Asahina, Masato

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: We report the case of a 46-year-old female patient who developed a subacute progression of axial and proximal muscle weakness. Laboratory findings revealed mildly elevated serum creatine kinase levels. No monoclonal gammopathy was detected. A muscle ... ...

    Abstract We report the case of a 46-year-old female patient who developed a subacute progression of axial and proximal muscle weakness. Laboratory findings revealed mildly elevated serum creatine kinase levels. No monoclonal gammopathy was detected. A muscle biopsy revealed that she had nemaline myopathy. Serological tests and a lip biopsy revealed Sjögren's syndrome (SjS). We diagnosed her as having sporadic late-onset nemaline myopathy without monoclonal gammopathy of undetermined significance associated with SjS. Her symptoms improved after methylprednisolone pulse therapy followed by intravenous immunoglobulin therapy. A good response to immunotherapy demonstrates the necessity of making a correct diagnosis, for which a muscle biopsy is required.
    Language English
    Publishing date 2024-03-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3092-23
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    Zs.A 240: Show issues Location:
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  7. Article ; Online: Correction to: Growth references for Japanese individuals with Noonan syndrome.

    Isojima, Tsuyoshi / Sakazume, Satoru / Hasegawa, Tomonobu / Ogata, Tsutomu / Nakanishi, Toshio / Nagai, Toshiro / Yokoya, Susumu

    Pediatric research

    2022  

    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-022-02123-7
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    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  8. Article ; Online: Autochthonous Cryptococcus gattii genotype VGIIb infection in a Japanese patient with anti-granulocyte-macrophage colony-stimulating factor antibodies.

    Hamaguchi, Tsuyoshi / Uchida, Nobuaki / Fujita-Nakata, Michiyo / Nakanishi, Megumi / Tsuchido, Yasuhiro / Nagao, Miki / Iinuma, Yoshitsugu / Asahina, Masato

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2024  

    Abstract: A 31-year-old Japanese man presented with cerebral and pulmonary cryptococcosis. Cryptococcus gattii (C. gattii) genotype VGIIb was detected in the patient's sputum and cerebrospinal fluid specimens. The serum levels of anti-granulocyte-macrophage colony- ...

    Abstract A 31-year-old Japanese man presented with cerebral and pulmonary cryptococcosis. Cryptococcus gattii (C. gattii) genotype VGIIb was detected in the patient's sputum and cerebrospinal fluid specimens. The serum levels of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies were elevated in this patient, which has been associated with pulmonary alveolar proteinosis and is considered a risk factor for C. gattii infection. After undergoing >12 months of antifungal treatments, the patient showed improvements in symptoms and findings on brain and lung imaging. Several Japanese patients who develop C. gattii infection have also been reported; however, most of these patients have been infected outside Japan, as C. gattii infection is rare in Japan. Only one patient with C. gattii genotype VGIIb infection has been reported in Japan, and it is believed that this patient contracted the infection in China. In the present case, our patient has never been outside Japan, indicating that the infection originated in Japan. Our findings suggest that C. gattii might be spreading in Japan. Therefore, patients with positive serum anti-GM-CSF antibodies should be thoroughly monitored for C. gattii infection, even those living in Japan.
    Language English
    Publishing date 2024-03-12
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2024.03.009
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    Zs.A 5236: Show issues Location:
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  9. Article: Corrigendum to "Validation of auxological reference values for Japanese children with Noonan syndrome and comparison with growth in children with Turner syndrome".

    Isojima, Tsuyoshi / Sakazume, Satoru / Hasegawa, Tomonobu / Ogata, Tsutomu / Nakanishi, Toshio / Nagai, Toshiro / Yokoya, Susumu

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology

    2022  Volume 31, Issue 3, Page(s) 210

    Abstract: This corrects the article DOI: 10.1297/cpe.26.153.]. ...

    Abstract [This corrects the article DOI: 10.1297/cpe.26.153.].
    Language English
    Publishing date 2022-07-13
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 2079760-6
    ISSN 0918-5739
    ISSN 0918-5739
    DOI 10.1297/cpe.31.210
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    Zs.A 5710: Show issues Location:
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  10. Article ; Online: CpG Site-Specific Regulation of Metallothionein-1 Gene Expression.

    Ogushi, Shoko / Yoshida, Yuya / Nakanishi, Tsuyoshi / Kimura, Tomoki

    International journal of molecular sciences

    2020  Volume 21, Issue 17

    Abstract: Metal-binding inducible proteins called metallothioneins (MTs) protect cells from heavy-metal toxicity. Their transcription is regulated by metal response element (MRE)-binding transcription factor-1 (MTF1), which is strongly recruited to MREs in the MT ... ...

    Abstract Metal-binding inducible proteins called metallothioneins (MTs) protect cells from heavy-metal toxicity. Their transcription is regulated by metal response element (MRE)-binding transcription factor-1 (MTF1), which is strongly recruited to MREs in the MT promoters, in response to Zn and Cd. Mouse
    MeSH term(s) Animals ; Cell Line, Tumor ; Cells, Cultured ; CpG Islands ; DNA Methylation ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Metallothionein/genetics ; Metallothionein/metabolism ; Mice ; Mutation ; Promoter Regions, Genetic ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription Factor MTF-1
    Chemical Substances DNA-Binding Proteins ; Transcription Factors ; metallothionein-1, mouse ; Metallothionein (9038-94-2)
    Language English
    Publishing date 2020-08-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21175946
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