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  1. Article ; Online: Clarifying the Role of Diaphragm Ultrasound Imaging in the Discontinuation of Mechanical Ventilation.

    Laghi, Franco

    Anesthesiology

    2023  Volume 140, Issue 1, Page(s) 4–7

    MeSH term(s) Respiration, Artificial/methods ; Diaphragm/diagnostic imaging ; Ultrasonography/methods ; Thorax
    Language English
    Publishing date 2023-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004810
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  2. Article ; Online: Prostate cancer: 1HMRS-DCEMR at 3T versus [(18)F]choline PET/CT in the detection of local prostate cancer recurrence in men with biochemical progression after radical retropubic prostatectomy (RRP).

    Panebianco, Valeria / Sciarra, Alessandro / Lisi, Danilo / Galati, Francesca / Buonocore, Valeria / Catalano, Carlo / Gentile, Vincenzo / Laghi, Andrea / Passariello, Roberto

    European journal of radiology

    2012  Volume 81, Issue 4, Page(s) 700–708

    Abstract: ... 18)F]choline PET/computed tomography (CT) in the detection of local prostate cancer recurrence ...

    Abstract Objectives: This study compares proton magnetic resonancespectroscopic imaging (1H-MRSI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) combined techniques at 3T magnet versus [(18)F]choline PET/computed tomography (CT) in the detection of local prostate cancer recurrence in patients with biochemical progression after radical retropubic prostatectomy (RRP).
    Materials and methods: 84 consecutive patients at high risk of local recurrence underwent combined 1HMRSI-DCEMR and 18-Fcholine- PET/CT. MR scan protocol included turbo spin echo (TSE) T2-weighted sequences in the axial, sagittal and coronal planes; three-dimensional (3D) chemical shift imaging (CSI) sequences with spectral/spatial pulses optimized for quantitative detection of choline and citrate; dynamic contrast enhanced gradient-echo (GRE) T1-weighted sequence. The population was divided into two groups. Group A included 28 patients with a lesion size ranging between 5.00mm and 7.2mm and PSA reduction following radiation therapy. Group B included 56 patients with a lesion size between 7.6mm and 19.4mm. Sensitivity, specificity, positive predictive value (PPV) and accuracy were evaluated and receiver operating characteristic (ROC) curves were performed.
    Results: In Group A combined 1H-MRSI and DCE-MRI showed a sensitivity of 92%, a specificity of 75% (PPV 96%) while PET-CT examination showed a sensitivity of 62% and a specificity of 50% (PPV 88%) in identifying local recurrence. The accuracy of MRI was 89% while PET-CT showed an accuracy of 60%. Areas under the ROC curve (AUC) values for MR and PET-CT were 0.833 and 0.562, respectively. In Group B combined 1H-MRSI and DCEMR showed a sensitivity of 94% and a specificity of 100% (PPV 100%) with accuracy of 94%. PET-CT had a sensitivity of 92% and a specificity of 33% (PPV 98%) with accuracy of 91%. The AUCs for MR and PET-CT values were 0.971 and 0.837, respectively.
    Conclusion: The diagnostic accuracy of combined 1HMRSI-DCEMR was higher than PET/CT to identify local prostate cancer recurrence, mostly in patients with low biochemical progression after RRP (0.2-2ng/mL).
    MeSH term(s) Aged ; Choline/analogs & derivatives ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy/methods ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/prevention & control ; Positron-Emission Tomography/methods ; Prognosis ; Prostate-Specific Antigen/blood ; Prostatectomy ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/surgery ; Protons ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity ; Subtraction Technique ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemical Substances Protons ; Radiopharmaceuticals ; fluoromethylcholine ; Prostate-Specific Antigen (EC 3.4.21.77) ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2012-04
    Publishing country Ireland
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2011.01.095
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  3. Article: Pearls and pitfalls of respiratory testing in a patient with amyotrophic lateral sclerosis and COPD.

    Littleton, Stephen W / Laghi, Franco

    Breathe (Sheffield, England)

    2023  Volume 19, Issue 2, Page(s) 230043

    Abstract: Interpretation of pulmonary function testing in patients with amyotrophic lateral sclerosis must account for coexisting lung diseases, when making patient care decisions. ...

    Abstract Interpretation of pulmonary function testing in patients with amyotrophic lateral sclerosis must account for coexisting lung diseases, when making patient care decisions.
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0043-2023
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  4. Article: Peer victimization and social anxiety in adolescence: a comparison between migrant and native students in Italy.

    Di Tata, Daniele / Bianchi, Dora / Laghi, Fiorenzo

    Frontiers in psychology

    2024  Volume 15, Page(s) 1346373

    Abstract: The first aim of this study is to investigate the relationship between bullying victimization and social anxiety in native and migrant adolescents in Italy. Specifically, it was hypothesized that migrant adolescents (in comparison with natives) ... ...

    Abstract The first aim of this study is to investigate the relationship between bullying victimization and social anxiety in native and migrant adolescents in Italy. Specifically, it was hypothesized that migrant adolescents (in comparison with natives) experience more frequent episodes of bullying victimization, which in turn, may be a risk factor for the development of social anxiety symptoms. The second aim of the study is to explore the relationships from reflected minority categorization to perceived ethnic discrimination at school and social anxiety symptoms, in the subgroup of migrant students. Results showed that the migrant (vs. native) status was predictive of higher scores in social anxiety dimensions (Fear of Negative Evaluation, Social Avoidance and Distress in New Situations, and General Social Avoidance Distress), via the mediating effect of increased peer victimization. Moreover, in the subgroup of migrant participants, an indirect effect of reflected minority categorization on social anxiety was observed, mediated by perceived ethnic discrimination at school. These findings may contribute to the understanding of health inequalities among migrant and native people in the Italian context. Limitations and practical implications of the study were discussed.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1346373
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  5. Article ; Online: Physical Rehabilitation in the ICU: Is It Worth the Effort?

    Laghi, Franco / Shaikh, Hameeda

    Critical care medicine

    2022  Volume 50, Issue 3, Page(s) 504–507

    MeSH term(s) Intensive Care Units ; Quality of Life
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005289
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    Zs.A 1261: Show issues Location:
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  6. Article: Comment on Gassenmaier et al. Accelerated T2-Weighted TSE Imaging of the Prostate Using Deep Learning Image Reconstruction: A Prospective Comparison with Standard T2-Weighted TSE Imaging.

    Pucciarelli, Francesco / Laghi, Andrea / Caruso, Damiano

    Cancers

    2023  Volume 15, Issue 2

    Abstract: Magnetic resonance imaging (MRI) plays a central role in oncology without using ionizing radiation or radioactive markers [ ... ]. ...

    Abstract Magnetic resonance imaging (MRI) plays a central role in oncology without using ionizing radiation or radioactive markers [...].
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15020370
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  7. Article ; Online: Expiratory Muscles, Neglected No More.

    Laghi, Franco / Cacciani, Nicola

    Anesthesiology

    2021  Volume 134, Issue 5, Page(s) 680–682

    MeSH term(s) Exhalation ; Respiration, Artificial ; Respiratory Muscles
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000003753
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  8. Article ; Online: Program for the Education and Enrichment of Relational Skills (PEERS

    Fatta, Laura Maria / Laugeson, Elizabeth A / Bianchi, Dora / Laghi, Fiorenzo / Scattoni, Maria Luisa

    Journal of autism and developmental disorders

    2024  

    Abstract: The Program for the Education and Enrichment of Relational Skills ( ... ...

    Abstract The Program for the Education and Enrichment of Relational Skills (PEERS
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-023-06211-3
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    Zs.A 765: Show issues Location:
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  9. Article ; Online: NOD2 and Crohn's Disease Clinical Practice: From Epidemiology to Diagnosis and Therapy, Rewired.

    Kayali, Stefano / Fantasia, Stefano / Gaiani, Federica / Cavallaro, Lucas Giovanni / de'Angelis, Gian Luigi / Laghi, Luigi

    Inflammatory bowel diseases

    2024  

    Abstract: Crohn's disease (CD) is a chronic inflammatory bowel disease with a multifactorial pathogenesis involving environmental and genetic factors. Since the late 20th century, the discovery of the first susceptibility gene (NOD2, previously referred to as ... ...

    Abstract Crohn's disease (CD) is a chronic inflammatory bowel disease with a multifactorial pathogenesis involving environmental and genetic factors. Since the late 20th century, the discovery of the first susceptibility gene (NOD2, previously referred to as CARD15) for CD has paved the way for further investigations into the correlations between clinical features and genetics, and its potential impact on clinical practice has fueled the research in the last 2 decades. Recent therapeutic advancements involving novel biologic drugs and small molecules have shifted inflammatory bowel disease management from a disease-centered to a patient-centric approach. To date, the role of NOD2 has not been fully understood yet. Recent data suggest that its clinical impact may be greater than currently recognized. This review overviews the most common NOD2 variants' role in real-life clinical practice. These genetic variants increase the risk of developing the disease and can aid in tailoring diagnosis and treatment. They are associated with the stricturing phenotype and ileal involvement and increase the risk of steroid refractoriness. In the meantime, limited and inconclusive evidence exists regarding their predictive role in response to azathioprine, biologic drugs, and small molecules. Eventually, their role in increasing the risk for surgery is evident, especially in those with the L1007fs variant. If further trials will support the initial evidence reported so far, NOD2 genetic variants will emerge as possible candidates for developing precision medicine in CD.
    Language English
    Publishing date 2024-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izae075
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  10. Article ; Online: Microsatellite Instability and Immune Response: From Microenvironment Features to Therapeutic Actionability-Lessons from Colorectal Cancer.

    Greco, Luana / Rubbino, Federica / Dal Buono, Arianna / Laghi, Luigi

    Genes

    2023  Volume 14, Issue 6

    Abstract: Microsatellite instability (MSI) can be found in 15-20% of all colorectal cancers (CRC) and is the key feature of a defective DNA mismatch repair (MMR) system. Currently, MSI has been established as a unique and pivotal biomarker in the diagnosis, ... ...

    Abstract Microsatellite instability (MSI) can be found in 15-20% of all colorectal cancers (CRC) and is the key feature of a defective DNA mismatch repair (MMR) system. Currently, MSI has been established as a unique and pivotal biomarker in the diagnosis, prognosis, and treatment of CRC. MSI tumors display a strong lymphocytic activation and a shift toward a tumoral microenvironment restraining metastatic potential and ensuing in a high responsiveness to immunotherapy of MSI CRC. Indeed, neoplastic cells with an MMR defect overexpress several immune checkpoint proteins, such as programmed death-1 (PD-1) and programmed death-ligand 1(PD-L1), that can be pharmacologically targeted, allowing for the revival the cytotoxic immune response toward the tumor. This review aims to illustrate the role of MSI in the tumor biology of colorectal cancer, focusing on the immune interactions with the microenvironment and their therapeutic implications.
    MeSH term(s) Humans ; Microsatellite Instability ; Prognosis ; Antineoplastic Agents ; Immunotherapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Colorectal Neoplasms/pathology ; Tumor Microenvironment/genetics
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14061169
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