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  1. Article ; Online: m

    Boo, Sung Ho / Ha, Hongseok / Kim, Yoon Ki

    Cell reports

    2022  Volume 40, Issue 10, Page(s) 111317

    Abstract: ... ...

    Abstract N
    MeSH term(s) Adenosine/metabolism ; RNA ; RNA Stability/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances RNA, Messenger ; RNA-Binding Proteins ; RNA (63231-63-0) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mapping m

    Baek, Alice / Rayhan, Asif / Lee, Ga-Eun / Golconda, Sarah / Yu, Hannah / Kim, Shihyoung / Limbach, Patrick A / Addepalli, Balasubrahmanyam / Kim, Sanggu

    Methods and protocols

    2024  Volume 7, Issue 1

    Abstract: ... harbor site-specific N6-methyladenosine (m ...

    Abstract The biological significance of chemical modifications to the ribonucleic acid (RNA) of human immunodeficiency virus type-1 (HIV-1) has been recognized. However, our understanding of the site-specific and context-dependent roles of these chemical modifications remains limited, primarily due to the absence of nucleotide-resolution mapping of modification sites. In this study, we present a method for achieving nucleotide-resolution mapping of chemical modification sites on HIV-1 RNA using liquid chromatography and tandem mass spectrometry (LC-MS/MS). LC-MS/MS, a powerful tool capable of directly analyzing native RNAs, has proven effective for mapping RNA modifications in small RNA molecules, including ribosomal RNA and transfer RNA. However, longer RNAs have posed challenges, such as the 9 Kb HIV-1 virion RNA, due to the complexity of and ambiguity in mass differences among RNase T1-cleaved RNA fragments in LC-MS/MS data. Here, we introduce a new target RNA enrichment method to isolate small local RNA fragments of HIV-1 RNA that potentially harbor site-specific N6-methyladenosine (m
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2409-9279
    ISSN (online) 2409-9279
    DOI 10.3390/mps7010007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  3. Article ; Online: Targeting the m

    Jung, Hae Rim / Lee, Jeonghwan / Hong, Seung-Pyo / Shin, Nayeon / Cho, Ara / Shin, Dong-Jin / Choi, Jin Woo / Kim, Jong-Il / Lee, Jung Pyo / Cho, Sung-Yup

    Experimental & molecular medicine

    2024  Volume 56, Issue 2, Page(s) 355–369

    Abstract: Kidney fibrosis is a major mechanism underlying chronic kidney disease (CKD). ... ...

    Abstract Kidney fibrosis is a major mechanism underlying chronic kidney disease (CKD). N
    MeSH term(s) Animals ; Humans ; Mice ; Kidney/pathology ; Methyltransferases/genetics ; Renal Insufficiency, Chronic/genetics ; RNA, Small Interfering ; Transforming Growth Factor beta ; Fibrosis
    Chemical Substances Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; RNA, Small Interfering ; Transforming Growth Factor beta
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1328915-9
    ISSN 2092-6413 ; 1226-3613 ; 0378-8512
    ISSN (online) 2092-6413
    ISSN 1226-3613 ; 0378-8512
    DOI 10.1038/s12276-024-01159-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4775: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Regulation of m

    Bhattarai, Poshan Yugal / Kim, Garam / Bhandari, Dibikshya / Shrestha, Pratikshya / Choi, Hong Seok

    Cells

    2023  Volume 13, Issue 1

    Abstract: ... ...

    Abstract Reversible
    MeSH term(s) Humans ; Epigenome ; Adenosine ; Knowledge ; Neoplasms/genetics ; Neoplasms/therapy ; Protein Processing, Post-Translational
    Chemical Substances Adenosine (K72T3FS567)
    Language English
    Publishing date 2023-12-28
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13010066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: tRNA m

    Strassler, Sarah E / Bowles, Isobel E / Krishnamohan, Aiswarya / Kim, Hyejeong / Edgington, Catherine B / Kuiper, Emily G / Hancock, Clio J / Comstock, Lindsay R / Jackman, Jane E / Conn, Graeme L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the 9th nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene ( ...

    Abstract The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the 9th nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene (
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.01.526536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: tRNA m

    Strassler, Sarah E / Bowles, Isobel E / Krishnamohan, Aiswarya / Kim, Hyejeong / Edgington, Catherine B / Kuiper, Emily G / Hancock, Clio J / Comstock, Lindsay R / Jackman, Jane E / Conn, Graeme L

    The Journal of biological chemistry

    2023  Volume 299, Issue 12, Page(s) 105443

    Abstract: The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the ninth nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene (TRMT10A) have been linked to neurological ... ...

    Abstract The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the ninth nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene (TRMT10A) have been linked to neurological disorders such as microcephaly and intellectual disability, as well as defects in glucose metabolism. Of the 26 tRNAs in yeast with guanosine at position 9, only 13 are substrates for Trm10. However, no common sequence or other posttranscriptional modifications have been identified among these substrates, suggesting the presence of some other tRNA feature(s) that allow Trm10 to distinguish substrate from nonsubstrate tRNAs. Here, we show that substrate recognition by Saccharomyces cerevisiae Trm10 is dependent on both intrinsic tRNA flexibility and the ability of the enzyme to induce specific tRNA conformational changes upon binding. Using the sensitive RNA structure-probing method SHAPE, conformational changes upon binding to Trm10 in tRNA substrates, but not nonsubstrates, were identified and mapped onto a model of Trm10-bound tRNA. These changes may play an important role in substrate recognition by allowing Trm10 to gain access to the target nucleotide. Our results highlight a novel mechanism of substrate recognition by a conserved tRNA modifying enzyme. Further, these studies reveal a strategy for substrate recognition that may be broadly employed by tRNA-modifying enzymes which must distinguish between structurally similar tRNA species.
    MeSH term(s) Humans ; Nucleic Acid Conformation ; Nucleotides/metabolism ; RNA, Transfer/chemistry ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Substrate Specificity ; tRNA Methyltransferases/chemistry ; tRNA Methyltransferases/metabolism
    Chemical Substances Nucleotides ; RNA, Transfer (9014-25-9) ; TRM10 protein, S cerevisiae (EC 2.1.1.-) ; TRMT10A protein, human (EC 2.1.1.-) ; tRNA Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: m

    Baumann, Kim

    Nature reviews. Molecular cell biology

    2019  Volume 20, Issue 9, Page(s) 512–513

    MeSH term(s) Methylation ; Protein Processing, Post-Translational ; RNA, Messenger
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2019-08-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-019-0167-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5446: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 26: Show issues

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  8. Article: Resolving m

    Yoon, Ki-Jun / Kim, Yoon Ki

    Trends in genetics : TIG

    2022  Volume 38, Issue 11, Page(s) 1099–1100

    Abstract: A recent study by Hu et al. describes ... ...

    Abstract A recent study by Hu et al. describes N
    MeSH term(s) Adenosine/genetics ; Adenosine/metabolism ; Nucleotides ; Transcriptome/genetics
    Chemical Substances Nucleotides ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-07-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2022.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2272: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Current Insights into m

    Chuong, Nguyen Nguyen / Doan, Phan Phuong Thao / Wang, Lanshuo / Kim, Jin Hee / Kim, Jeongsik

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: ... ...

    Abstract N6
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12030624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Mechanochemical Pretreated M

    Cho, Inho / Selvaraj, Aravindha Raja / Bak, Jinsoo / Kim, Heeje / Prabakar, Kandasamy

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 11

    Abstract: Two-dimensional (2D) MXenes sheet-like micro-structures have attracted attention as an effective electrochemical energy storage material due to their efficient electrolyte/cation interfacial charge transports inside the 2D sheets which results in ... ...

    Abstract Two-dimensional (2D) MXenes sheet-like micro-structures have attracted attention as an effective electrochemical energy storage material due to their efficient electrolyte/cation interfacial charge transports inside the 2D sheets which results in ultrahigh rate capability and high volumetric capacitance. In this article, Ti
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13111741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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