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  1. Article: The role of ribbons at sensory synapses.

    LoGiudice, Lisamarie / Matthews, Gary

    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

    2009  Volume 15, Issue 4, Page(s) 380–391

    Abstract: Synaptic ribbons are organelles that tether vesicles at the presynaptic active zones of sensory neurons in the visual, auditory, and vestibular systems. These neurons generate sustained, graded electrical signals in response to sensory stimuli, and ... ...

    Abstract Synaptic ribbons are organelles that tether vesicles at the presynaptic active zones of sensory neurons in the visual, auditory, and vestibular systems. These neurons generate sustained, graded electrical signals in response to sensory stimuli, and fidelity of transmission therefore requires their synapses to release neurotransmitter continuously at high rates. It has long been thought that the ribbons at the active zones of sensory synapses accomplish this task by enhancing the size and accessibility of the readily releasable pool of synaptic vesicles, which may represent the vesicles attached to the ribbon. Recent evidence suggests that synaptic ribbons immobilize vesicles in the resting cell and coordinate the transient, synchronous release of vesicles in response to stimulation, but it is not yet clear how the ribbon can efficiently mobilize and coordinate multiple vesicles for release. However, detailed anatomical, electrophysiological, and optical studies have begun to reveal the mechanics of release at ribbon synapses, and this multidisciplinary approach promises to reconcile structure, function, and mechanism at these important sensory synapses.
    MeSH term(s) Animals ; Humans ; Membrane Fusion/physiology ; Nervous System/ultrastructure ; Organelles/physiology ; Organelles/ultrastructure ; Sensory Receptor Cells/physiology ; Sensory Receptor Cells/ultrastructure ; Synapses/physiology ; Synapses/ultrastructure ; Synaptic Potentials/physiology ; Synaptic Transmission/physiology ; Synaptic Vesicles/physiology ; Synaptic Vesicles/ultrastructure
    Language English
    Publishing date 2009-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1233753-5
    ISSN 1089-4098 ; 1073-8584
    ISSN (online) 1089-4098
    ISSN 1073-8584
    DOI 10.1177/1073858408331373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4315: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: The synaptic vesicle cycle: is kissing overrated?

    LoGiudice, Lisamarie / Matthews, Gary

    Neuron

    2006  Volume 51, Issue 6, Page(s) 676–677

    Abstract: In this issue of Neuron, Granseth et al. re-examine the mechanism of endocytosis at hippocampal synapses using a new optical reporter, sypHy. They conclude that only a single slow mode of endocytosis operates at this synapse and that retrieval after ... ...

    Abstract In this issue of Neuron, Granseth et al. re-examine the mechanism of endocytosis at hippocampal synapses using a new optical reporter, sypHy. They conclude that only a single slow mode of endocytosis operates at this synapse and that retrieval after physiological stimuli is largely, if not solely, dominated by the clathrin-mediated pathway. These conclusions dispute previous assertions that "kiss-and-run" is a major mechanism of vesicle recycling at hippocampal synapses.
    MeSH term(s) Animals ; Cells, Cultured ; Clathrin/metabolism ; Clathrin-Coated Vesicles/metabolism ; Endocytosis/physiology ; Hippocampus/cytology ; Hippocampus/physiology ; Models, Biological ; Neurons/cytology ; Neurons/metabolism ; Rats ; Signal Transduction/physiology ; Synapses/physiology
    Chemical Substances Clathrin
    Language English
    Publishing date 2006-09-21
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2006.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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    Zs.MG 92: Show issues

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  3. Article: Endocytosis at ribbon synapses.

    LoGiudice, Lisamarie / Matthews, Gary

    Traffic (Copenhagen, Denmark)

    2007  Volume 8, Issue 9, Page(s) 1123–1128

    Abstract: Unlike conventional synaptic terminals that release neurotransmitter episodically in response to action potentials, neurons of the visual, auditory and vestibular systems encode sensory information in graded signals that are transmitted at their synapses ...

    Abstract Unlike conventional synaptic terminals that release neurotransmitter episodically in response to action potentials, neurons of the visual, auditory and vestibular systems encode sensory information in graded signals that are transmitted at their synapses by modulating the rate of continuous release. The synaptic ribbon, a specialized structure found at the active zones of these neurons, is necessary to sustain the high rates of exocytosis required for continuous release. To maintain the fidelity of synaptic transmission, exocytosis must be balanced by high-capacity endocytosis, to retrieve excess membrane inserted during vesicle fusion. Capacitance measurements following vesicle release in ribbon-type neurons indicate two kinetically distinct phases of compensatory endocytosis, whose relative contributions vary with stimulus intensity. The two phases can be independently regulated and may reflect different underlying mechanisms operating on separate pools of recycling vesicles. Electron microscopy shows diversity among ribbon-type synapses in the relative importance of clathrin-mediated endocytosis versus bulk membrane retrieval as mechanisms of compensatory endocytosis. Ribbon synapses, like conventional synapses, make use of multiple endocytosis pathways to replenish synaptic vesicle pools, depending on the physiological needs of the particular cell type.
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium/physiology ; Endocytosis/physiology ; Endosomes/metabolism ; Humans ; Neurons/metabolism ; Neurons/physiology ; Synapses/physiology ; Synaptic Membranes/metabolism ; Synaptic Vesicles/metabolism ; Transport Vesicles/metabolism
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1483852-7
    ISSN 1600-0854 ; 1398-9219
    ISSN (online) 1600-0854
    ISSN 1398-9219
    DOI 10.1111/j.1600-0854.2007.00591.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5634: Show issues Location:
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  4. Article ; Online: Mobility and turnover of vesicles at the synaptic ribbon.

    LoGiudice, Lisamarie / Sterling, Peter / Matthews, Gary

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2008  Volume 28, Issue 12, Page(s) 3150–3158

    Abstract: Ribbon synapses release neurotransmitter continuously at high rates, and the ribbons tether a large pool of synaptic vesicles. To determine whether the tethered vesicles are actually released, we tracked vesicles labeled with styryl dye in mouse retinal ... ...

    Abstract Ribbon synapses release neurotransmitter continuously at high rates, and the ribbons tether a large pool of synaptic vesicles. To determine whether the tethered vesicles are actually released, we tracked vesicles labeled with styryl dye in mouse retinal bipolar cell terminals whose ribbons had been labeled with a fluorescent peptide. We photobleached vesicles in regions with ribbons and without them and then followed recovery of fluorescence as bleached regions were repopulated by labeled vesicles. In the resting terminal, fluorescence recovered by approximately 50% in non-ribbon regions but by only approximately 20% at ribbons. Thus, at rest, vesicles associated with ribbons cannot exchange freely with cytoplasmic vesicles. Depolarization stimulated vesicle turnover at ribbons as bleached, immobile vesicles were released by exocytosis and were then replaced by fluorescent vesicles from the cytoplasm, producing an additional increase in fluorescence specifically at the ribbon location. We conclude that vesicles immobilized at synaptic ribbons participate in the readily releasable pool that is tapped rapidly during depolarization.
    MeSH term(s) Alcohol Oxidoreductases ; Animals ; Co-Repressor Proteins ; DNA-Binding Proteins/metabolism ; Male ; Membrane Potentials/drug effects ; Membrane Potentials/radiation effects ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal/methods ; Microscopy, Electron/methods ; Patch-Clamp Techniques/methods ; Phosphoproteins/metabolism ; Photobleaching ; Potassium Chloride/pharmacology ; Pyridinium Compounds/metabolism ; Quaternary Ammonium Compounds/metabolism ; Retina/cytology ; Retinal Bipolar Cells/cytology ; Retinal Bipolar Cells/drug effects ; Retinal Bipolar Cells/radiation effects ; Synapses/physiology ; Synapses/ultrastructure ; Synaptic Vesicles/physiology ; Synaptic Vesicles/ultrastructure
    Chemical Substances Co-Repressor Proteins ; DNA-Binding Proteins ; FM 4-64 ; Phosphoproteins ; Pyridinium Compounds ; Quaternary Ammonium Compounds ; Potassium Chloride (660YQ98I10) ; Alcohol Oxidoreductases (EC 1.1.-) ; Ctbp2 protein, mouse (EC 1.1.-)
    Language English
    Publishing date 2008-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.5753-07.2008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
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  5. Article ; Online: Identification of calcium channel alpha1 subunit mRNA expressed in retinal bipolar neurons.

    Logiudice, Lisamarie / Henry, Diane / Matthews, Gary

    Molecular vision

    2006  Volume 12, Page(s) 184–189

    Abstract: Purpose: Glutamate release from goldfish bipolar cell terminals is driven by Ca2+ influx through L-type calcium channels that exhibit several uncommon features, including rapid kinetics of activation and deactivation, slow inactivation, and activation ... ...

    Abstract Purpose: Glutamate release from goldfish bipolar cell terminals is driven by Ca2+ influx through L-type calcium channels that exhibit several uncommon features, including rapid kinetics of activation and deactivation, slow inactivation, and activation at an unusually negative voltage range for L-type channels. The purpose of this study was to establish the molecular identities of the alpha1 subunits responsible for these distinctive properties.
    Methods: Transcripts for calcium channel alpha1 subunits expressed in individual goldfish ON-type bipolar cells were identified using single-cell reverse transcriptase polymerase chain reaction (RT-PCR). After cloning the goldfish homologs of the zebrafish and mammalian subunits, we designed sets of nested primers that are specific for Cav1.3a, and Cav1.3b L-type calcium channels.
    Results: Large-terminal, ON-type bipolar cells express transcripts of Cav1.3a and/or Cav1.3b.
    Conclusions: The endogenous expression of only one or both subunits in a single cell raises the possibility of functionally distinct classes of bipolar cells that differ in calcium current properties.
    MeSH term(s) Amino Acid Sequence ; Animals ; Calcium Channels/genetics ; Cloning, Molecular ; Goldfish ; RNA, Messenger/metabolism ; Retina/cytology ; Retina/metabolism ; Retinal Bipolar Cells/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
    Chemical Substances Calcium Channels ; RNA, Messenger
    Language English
    Publishing date 2006-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2017540-1
    ISSN 1090-0535 ; 1090-0535
    ISSN (online) 1090-0535
    ISSN 1090-0535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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