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  1. Article ; Online: [Clinical Training of Pharmacists after Licensure and Career Paths in Medical Institutions].

    Yamada, Kiyofumi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2022  Volume 142, Issue 9, Page(s) 965–969

    Abstract: In order to provide safe and effective pharmaceutical care to patients and their family members in clinical practice, pharmacists should receive appropriate clinical training after obtaining their license, as is standard in other medical professions. At ... ...

    Abstract In order to provide safe and effective pharmaceutical care to patients and their family members in clinical practice, pharmacists should receive appropriate clinical training after obtaining their license, as is standard in other medical professions. At present, there is no national framework in Japan for the early clinical training of pharmacists after licensure. However, pharmacy residency programs have been autonomously developed and implemented at some university hospitals and other medical institutions. This article describes the current status of clinical training of pharmacists after licensure in Japan. Furthermore, the standards for pharmacy residency programs, the outline of a core program for clinical training, and the career paths of hospital pharmacists after training are discussed.
    MeSH term(s) Education, Pharmacy ; Humans ; Licensure ; Pharmaceutical Services ; Pharmacists ; Pharmacy Residencies
    Language Japanese
    Publishing date 2022-09-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.22-00089-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
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  2. Article: [Preface].

    Yamada, Kiyofumi / Matsumoto, Naoki

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 3, Page(s) 217

    Language Japanese
    Publishing date 2023-04-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.23006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: [Preface].

    Yanagita, Toshihiko / Yamada, Kiyofumi

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2022  Volume 157, Issue 6, Page(s) 405

    Language Japanese
    Publishing date 2022-10-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.22099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genomic and Reverse Translational Analysis Discloses a Role for Small GTPase RhoA Signaling in the Pathogenesis of Schizophrenia

    Rinako Tanaka / Kiyofumi Yamada

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    Rho-Kinase as a Novel Drug Target

    2023  Volume 15623

    Abstract: Schizophrenia is one of the most serious psychiatric disorders and is characterized by reductions in both brain volume and spine density in the frontal cortex. RhoA belongs to the RAS homolog (Rho) family and plays critical roles in neuronal development ... ...

    Abstract Schizophrenia is one of the most serious psychiatric disorders and is characterized by reductions in both brain volume and spine density in the frontal cortex. RhoA belongs to the RAS homolog (Rho) family and plays critical roles in neuronal development and structural plasticity via Rho-kinase. RhoA activity is regulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). Several variants in GAPs and GEFs associated with RhoA have been reported to be significantly associated with schizophrenia. Moreover, several mouse models carrying schizophrenia-associated gene variants involved in RhoA/Rho-kinase signaling have been developed. In this review, we summarize clinical evidence showing that variants in genes regulating RhoA activity are associated with schizophrenia. In the last half of the review, we discuss preclinical evidence indicating that RhoA/Rho-kinase is a potential therapeutic target of schizophrenia. In particular, Rho-kinase inhibitors exhibit anti-psychotic-like effects not only in Arhgap10 S490P/NHEJ mice, but also in pharmacologic models of schizophrenia (methamphetamine- and MK-801-treated mice). Accordingly, we propose that Rho-kinase inhibitors may have antipsychotic effects and reduce cognitive deficits in schizophrenia despite the presence or absence of genetic variants in small GTPase signaling pathways.
    Keywords copy number variants ; CNVs ; single-nucleotide polymorphisms ; SNPs ; fasudil ; Kalirin ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Genomic and Reverse Translational Analysis Discloses a Role for Small GTPase RhoA Signaling in the Pathogenesis of Schizophrenia: Rho-Kinase as a Novel Drug Target.

    Tanaka, Rinako / Yamada, Kiyofumi

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: Schizophrenia is one of the most serious psychiatric disorders and is characterized by reductions in both brain volume and spine density in the frontal cortex. RhoA belongs to the RAS homolog (Rho) family and plays critical roles in neuronal development ... ...

    Abstract Schizophrenia is one of the most serious psychiatric disorders and is characterized by reductions in both brain volume and spine density in the frontal cortex. RhoA belongs to the RAS homolog (Rho) family and plays critical roles in neuronal development and structural plasticity via Rho-kinase. RhoA activity is regulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). Several variants in GAPs and GEFs associated with RhoA have been reported to be significantly associated with schizophrenia. Moreover, several mouse models carrying schizophrenia-associated gene variants involved in RhoA/Rho-kinase signaling have been developed. In this review, we summarize clinical evidence showing that variants in genes regulating RhoA activity are associated with schizophrenia. In the last half of the review, we discuss preclinical evidence indicating that RhoA/Rho-kinase is a potential therapeutic target of schizophrenia. In particular, Rho-kinase inhibitors exhibit anti-psychotic-like effects not only in
    MeSH term(s) Humans ; Mice ; Animals ; rho-Associated Kinases/metabolism ; Monomeric GTP-Binding Proteins/metabolism ; Schizophrenia/drug therapy ; Schizophrenia/genetics ; Signal Transduction ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/metabolism ; Genomics
    Chemical Substances rho-Associated Kinases (EC 2.7.11.1) ; Monomeric GTP-Binding Proteins (EC 3.6.5.2) ; rhoA GTP-Binding Protein (EC 3.6.5.2) ; GTPase-Activating Proteins
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Survey on the Actual Use of and Reasons for Heated Tobacco Products in Patients with Rheumatoid Arthritis.

    Isaji, Hisaaki / Yamada, Kiyofumi

    International journal of environmental research and public health

    2022  Volume 19, Issue 19

    Abstract: The actual use of heated tobacco products (HTPs) among smokers with rheumatoid arthritis (RA) is little known. The objective of this study was to clarify the prevalence and reasons for HTP use among smokers with RA. We administered a web survey to a ... ...

    Abstract The actual use of heated tobacco products (HTPs) among smokers with rheumatoid arthritis (RA) is little known. The objective of this study was to clarify the prevalence and reasons for HTP use among smokers with RA. We administered a web survey to a research company panel in Japan between December 2020 and January 2021. After 170,000 panelists completed a primary questionnaire regarding smoking and disease status, 198 smokers with RA completed a secondary questionnaire regarding the reasons for HTP use and perceptions about the harmfulness of HTPs. The primary questionnaire revealed that smokers with RA were more likely to use HTPs than smokers without RA, and the adjusted odds ratio of RA for HTP use was one of the highest factors among other diseases (adjusted OR: 2.34, 95% CI: 1.92-2.85,
    MeSH term(s) Arthritis, Rheumatoid/epidemiology ; Electronic Nicotine Delivery Systems ; Humans ; Smokers ; Surveys and Questionnaires ; Nicotiana ; Tobacco Products ; Tobacco Use/epidemiology
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph191912465
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  7. Article: [Promotion of multidisciplinary collaboration in cancer chemotherapy- basic knowledge of medicines for clinical nurses].

    Miyazaki, Masayuki / Yamada, Kiyofumi

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2022  Volume 157, Issue 6, Page(s) 416–420

    Abstract: Cancer chemotherapy outcomes have improved markedly after the introduction of cytotoxic anticancer drugs, molecular target medicines, and immune checkpoint inhibitors (ICIs) into clinical practice. Chemotherapy regimens are specified treatment plans that ...

    Abstract Cancer chemotherapy outcomes have improved markedly after the introduction of cytotoxic anticancer drugs, molecular target medicines, and immune checkpoint inhibitors (ICIs) into clinical practice. Chemotherapy regimens are specified treatment plans that include the dose of each anticancer drug, duration of treatment, and other supportive care drugs such as antiemetics. A chemotherapy regimen leads to the standardization of cancer pharmacotherapy, leading to medical safety and efficiency. Most molecular target medicines and ICIs have companion diagnostic agents (CDxs) that predict the treatment effect based on the gene variant (driver gene) and its expression level. In addition, oncogene panel tests have recently become covered by health insurance in Japan. However, there are some strict regulations and problems with their clinical use. Most molecular target medicines and ICIs have various side effects that are different from those of cytotoxic anticancer drugs. To provide more effective care and nursing to patients receiving cancer chemotherapy, clinical nurses need to understand the basic pharmacologic characteristics of each cancer medicine and provide patients with information about side effects and potential effects on daily life.
    MeSH term(s) Humans ; Antineoplastic Agents/adverse effects ; Neoplasms/drug therapy ; Japan
    Chemical Substances Antineoplastic Agents
    Language Japanese
    Publishing date 2022-11-03
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.22048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 439: Show issues Location:
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  8. Article: [Future Outlook of the Stroke Medical Care System Based on the Stroke and Cardiovascular Disease Control Act in Japan].

    Miyamoto, Susumu / Yamada, Kiyofumi

    No shinkei geka. Neurological surgery

    2021  Volume 49, Issue 2, Page(s) 445–451

    Abstract: Clinical evidence of mechanical thrombectomy for acute ischemic stroke(AIS)has been reported since 2015, and there is an urgent need for the preparation of medical treatment systems for AIS. The Japan Stroke Society and the Japan Circulation Society ... ...

    Abstract Clinical evidence of mechanical thrombectomy for acute ischemic stroke(AIS)has been reported since 2015, and there is an urgent need for the preparation of medical treatment systems for AIS. The Japan Stroke Society and the Japan Circulation Society published a 5-year plan for stopping CVD in December 2016. In December 2018, the Stroke and Cardiovascular Disease Control Act was enacted in Japan. In this review, we present the future plan of medical treatment systems for stroke.
    MeSH term(s) Brain Ischemia ; Cardiovascular Diseases ; Humans ; Japan/epidemiology ; Stroke/epidemiology ; Stroke/therapy ; Thrombectomy ; Treatment Outcome
    Language Japanese
    Publishing date 2021-03-24
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 197053-7
    ISSN 1882-1251 ; 0301-2603
    ISSN (online) 1882-1251
    ISSN 0301-2603
    DOI 10.11477/mf.1436204412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 268: Show issues

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  9. Article ; Online: Risk factors for recurrent ischemic events in symptomatic carotid artery stenosis on CT angiography.

    Tsutsui, Takeyoshi / Yamada, Kiyofumi / Ikedo, Taichi / Morita, Yoshiaki / Hamano, Eika / Imamura, Hirotoshi / Mori, Hisae / Iihara, Koji / Kataoka, Hiroharu

    Vascular medicine (London, England)

    2024  Volume 29, Issue 2, Page(s) 211–212

    MeSH term(s) Humans ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Computed Tomography Angiography ; Stroke/etiology ; Tomography, X-Ray Computed ; Ischemia ; Risk Factors
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Letter
    ZDB-ID 1311628-9
    ISSN 1477-0377 ; 1358-863X
    ISSN (online) 1477-0377
    ISSN 1358-863X
    DOI 10.1177/1358863X231225463
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  10. Article ; Online: New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction.

    Tsuneura, Yumi / Nakai, Tsuyoshi / Mizoguchi, Hiroyuki / Yamada, Kiyofumi

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Reelin is an extracellular matrix protein that is mainly produced in Cajal-Retzius cells and controls neuronal migration, which is important for the proper formation of cortical layers in the developmental stage of the brain. In the adult brain, Reelin ... ...

    Abstract Reelin is an extracellular matrix protein that is mainly produced in Cajal-Retzius cells and controls neuronal migration, which is important for the proper formation of cortical layers in the developmental stage of the brain. In the adult brain, Reelin plays a crucial role in the regulation of
    MeSH term(s) Animals ; Gene Expression Regulation, Developmental ; Humans ; Learning ; Mental Disorders/drug therapy ; Mental Disorders/metabolism ; Mice ; Molecular Targeted Therapy ; Reelin Protein/genetics ; Reelin Protein/metabolism
    Chemical Substances Reelin Protein ; RELN protein, human (EC 3.4.21.-) ; Reln protein, mouse (EC 3.4.21.-)
    Language English
    Publishing date 2022-02-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031829
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