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  1. Article ; Online: Dupilumab as a useful treatment option for prurigo nodularis in an elderly patient with atopic diathesis.

    Criado, Paulo R / Pincelli, Thais P / Criado, Roberta F J

    International journal of dermatology

    2020  Volume 59, Issue 10, Page(s) e358–e361

    MeSH term(s) Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/drug therapy ; Disease Susceptibility ; Humans ; Prurigo/complications ; Prurigo/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2020-06-20
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.14994
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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.189: Show issues Location:
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  2. Article ; Online: A general computational design strategy for stabilizing viral class I fusion proteins.

    Gonzalez, Karen J / Huang, Jiachen / Criado, Miria F / Banerjee, Avik / Tompkins, Stephen M / Mousa, Jarrod J / Strauch, Eva-Maria

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1335

    Abstract: ... Furthermore, the humoral response of the redesigned RSV F protein compares to that of the recently approved ...

    Abstract Many pathogenic viruses rely on class I fusion proteins to fuse their viral membrane with the host cell membrane. To drive the fusion process, class I fusion proteins undergo an irreversible conformational change from a metastable prefusion state to an energetically more stable postfusion state. Mounting evidence underscores that antibodies targeting the prefusion conformation are the most potent, making it a compelling vaccine candidate. Here, we establish a computational design protocol that stabilizes the prefusion state while destabilizing the postfusion conformation. With this protocol, we stabilize the fusion proteins of the RSV, hMPV, and SARS-CoV-2 viruses, testing fewer than a handful of designs. The solved structures of these designed proteins from all three viruses evidence the atomic accuracy of our approach. Furthermore, the humoral response of the redesigned RSV F protein compares to that of the recently approved vaccine in a mouse model. While the parallel design of two conformations allows the identification of energetically sub-optimal positions for one conformation, our protocol also reveals diverse molecular strategies for stabilization. Given the clinical significance of viruses using class I fusion proteins, our algorithm can substantially contribute to vaccine development by reducing the time and resources needed to optimize these immunogens.
    MeSH term(s) Animals ; Mice ; Viral Fusion Proteins ; Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines ; Protein Conformation
    Chemical Substances Viral Fusion Proteins ; Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45480-z
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  3. Article ; Online: Identification of genomic regions, genetic variants and gene networks regulating candidate genes for lipid metabolism in pig muscle.

    Passols, M / Llobet-Cabau, F / Sebastià, C / Castelló, A / Valdés-Hernández, J / Criado-Mesas, L / Sánchez, A / Folch, J M

    Animal : an international journal of animal bioscience

    2023  Volume 17, Issue 12, Page(s) 101033

    Abstract: The intramuscular fat content and fatty acid composition of porcine meat have a significant impact on its quality and nutritional value. This research aimed to investigate the expression of 45 genes involved in lipid metabolism in the longissimus dorsi ... ...

    Abstract The intramuscular fat content and fatty acid composition of porcine meat have a significant impact on its quality and nutritional value. This research aimed to investigate the expression of 45 genes involved in lipid metabolism in the longissimus dorsi muscle of three experimental pig backcrosses, with a 25% of Iberian background. To achieve this objective, we conducted an expression Genome-Wide Association Study (eGWAS) using gene expression levels in muscle measured by high-throughput real-time qPCR for 45 target genes and genotypes from the PorcineSNP60 BeadChip or Axiom Porcine Genotyping Array and 65 single nucleotide polymorphisms (SNPs) located in 20 genes genotyped by a custom-designed Taqman OpenArray in a cohort of 354 animals. The eGWAS analysis identified 301 eSNPs associated with 18 candidate genes (ANK2, APOE, ARNT, CIITA, CPT1A, EGF, ELOVL6, ELOVL7, FADS3, FASN, GPAT3, NR1D2, NR1H2, PLIN1, PPAP2A, RORA, RXRA and UCP3). Three cis-eQTL (expression quantitative trait loci) were identified for GPAT3, RXRA, and UCP3 genes, which indicates that a genetic polymorphism proximal to the same gene is affecting its expression. Furthermore, 24 trans-eQTLs were detected, and eight candidate regulatory genes were located in these genomic regions. Additionally, two trans-regulatory hotspots in Sus scrofa chromosomes 13 and 15 were identified. Moreover, a co-expression analysis performed on 89 candidate genes and the fatty acid composition revealed the regulatory role of four genes (FABP5, PPARG, SCD, and SREBF1). These genes modulate the levels of α-linolenic, arachidonic, and oleic acids, as well as regulating the expression of other candidate genes associated with lipid metabolism. The findings of this study offer novel insights into the functional regulatory mechanism of genes involved in lipid metabolism, thereby enhancing our understanding of this complex biological process.
    MeSH term(s) Humans ; Animals ; Gene Regulatory Networks ; Genome-Wide Association Study/veterinary ; Lipid Metabolism/genetics ; Genomics ; Muscle, Skeletal/metabolism ; Fatty Acids/analysis ; Polymorphism, Single Nucleotide ; Fatty Acid-Binding Proteins/genetics ; Fatty Acid-Binding Proteins/metabolism
    Chemical Substances Fatty Acids ; FABP5 protein, human ; Fatty Acid-Binding Proteins
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2257920-5
    ISSN 1751-732X ; 1751-7311
    ISSN (online) 1751-732X
    ISSN 1751-7311
    DOI 10.1016/j.animal.2023.101033
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  4. Article: A general computational design strategy for stabilizing viral class I fusion proteins.

    Gonzalez, Karen J / Huang, Jiachen / Criado, Miria F / Banerjee, Avik / Tompkins, Stephen / Mousa, Jarrod J / Strauch, Eva-Maria

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... of our approach. Furthermore, the immunological response of the RSV F design compared to a current clinical ...

    Abstract Many pathogenic viruses, including influenza virus, Ebola virus, coronaviruses, and Pneumoviruses, rely on class I fusion proteins to fuse viral and cellular membranes. To drive the fusion process, class I fusion proteins undergo an irreversible conformational change from a metastable prefusion state to an energetically more favorable and stable postfusion state. An increasing amount of evidence exists highlighting that antibodies targeting the prefusion conformation are the most potent. However, many mutations have to be evaluated before identifying prefusion-stabilizing substitutions. We therefore established a computational design protocol that stabilizes the prefusion state while destabilizing the postfusion conformation. As a proof of concept, we applied this principle to the fusion protein of the RSV, hMPV, and SARS-CoV-2 viruses. For each protein, we tested less than a handful of designs to identify stable versions. Solved structures of designed proteins from the three different viruses evidenced the atomic accuracy of our approach. Furthermore, the immunological response of the RSV F design compared to a current clinical candidate in a mouse model. While the parallel design of two conformations allows identifying and selectively modifying energetically less optimized positions for one conformation, our protocol also reveals diverse molecular strategies for stabilization. We recaptured many approaches previously introduced manually for the stabilization of viral surface proteins, such as cavity-filling, optimization of polar interactions, as well as postfusion-disruptive strategies. Using our approach, it is possible to focus on the most impacting mutations and potentially preserve the immunogen as closely as possible to its native version. The latter is important as sequence re-design can cause perturbations to B and T cell epitopes. Given the clinical significance of viruses using class I fusion proteins, our algorithm can substantially contribute to vaccine development by reducing the time and resources needed to optimize these immunogens.
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.16.532924
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  5. Article ; Online: Mechanisms shaping the gypsum stromatolite-like structures in the Salar de Llamara (Atacama Desert, Chile).

    Criado-Reyes, Joaquín / Otálora, Fermín / Canals, Àngels / Verdugo-Escamilla, Cristóbal / García-Ruiz, Juan-Manuel

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 678

    Abstract: The explanation of the origin of microbialites and specifically stromatolitic structures is a problem of high relevance for decoding past sedimentary environments and deciphering the biogenicity of the oldest plausible remnants of life. We have ... ...

    Abstract The explanation of the origin of microbialites and specifically stromatolitic structures is a problem of high relevance for decoding past sedimentary environments and deciphering the biogenicity of the oldest plausible remnants of life. We have investigated the morphogenesis of gypsum stromatolite-like structures currently growing in shallow ponds (puquíos) in the Salar de Llamara (Atacama Desert, Northern Chile). The crystal size, aspect ratio, and orientation distributions of gypsum crystals within the structures have been quantified and show indications for episodic nucleation and competitive growth of millimetric to centimetric selenite crystals into a radial, branched, and loosely cemented aggregate. The morphogenetical process is explained by the existence of a stable vertical salinity gradient in the ponds. Due to the non-linear dependency of gypsum solubility as a function of sodium chloride concentration, the salinity gradient produces undersaturated solutions, which dissolve gypsum crystals. This dissolution happens at a certain depth, narrowing the lower part of the structures, and producing their stromatolite-like morphology. We have tested this novel mechanism experimentally, simulating the effective dissolution of gypsum crystals in stratified ponds, thus providing a purely abiotic mechanism for these stromatolite-like structures.
    MeSH term(s) Calcium Sulfate/chemistry ; Chile ; Salinity ; Desert Climate
    Chemical Substances Calcium Sulfate (WAT0DDB505)
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-27666-5
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  6. Article: Adjuvants influence the immune cell populations present at the injection site granuloma induced by whole-cell inactivated paratuberculosis vaccines in sheep.

    Criado, Miguel / Reyes, Luis E / Marín, Juan F García / Gutiérrez-Expósito, Daniel / Zapico, David / Espinosa, José / Pérez, Valentín

    Frontiers in veterinary science

    2024  Volume 11, Page(s) 1284902

    Abstract: Vaccination is the most effective tool for paratuberculosis control. Currently, available vaccines prevent the progression of clinical disease in most animals but do not fully protect them against infection and induce the formation of an injection site ... ...

    Abstract Vaccination is the most effective tool for paratuberculosis control. Currently, available vaccines prevent the progression of clinical disease in most animals but do not fully protect them against infection and induce the formation of an injection site granuloma. The precise mechanisms that operate in response to vaccination and granuloma development, as well as the effect that adjuvants could trigger, have not been fully investigated. Therefore, this study aimed to investigate the injection site granulomas induced by two inactivated paratuberculosis vaccines, which differ in the adjuvant employed. Two groups of 45-day-old lambs were immunized with two commercially available vaccines-one (
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2024.1284902
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  7. Article ; Online: Urticarial vasculitis revealing immunolabelled nucleocapsid protein of SARS-CoV-2 in two Brazilian asymptomatic patients: the tip of the COVID-19 hidden iceberg?

    Criado, P R / Criado, R F J / Gianotti, R / Abdalla, B A Z / Pincelli, T P H / Michalany, A O / Michalany, N S

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2021  Volume 35, Issue 9, Page(s) e563–e566

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Nucleocapsid Proteins ; SARS-CoV-2 ; Vasculitis/diagnosis
    Chemical Substances Antibodies, Viral ; Nucleocapsid Proteins
    Language English
    Publishing date 2021-06-09
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.17391
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 413: Show issues

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  8. Article ; Online: Low Pathogenicity H7N3 Avian Influenza Viruses Have Higher Within-Host Genetic Diversity Than a Closely Related High Pathogenicity H7N3 Virus in Infected Turkeys and Chickens.

    Leyson, Christina M / Criado, Miriã F / Youk, Sungsu / Pantin-Jackwood, Mary J

    Viruses

    2022  Volume 14, Issue 3

    Abstract: Within-host viral diversity offers a view into the early stages of viral evolution occurring after a virus infects a host. In recent years, advances in deep sequencing have allowed for routine identification of low-frequency variants, which are important ...

    Abstract Within-host viral diversity offers a view into the early stages of viral evolution occurring after a virus infects a host. In recent years, advances in deep sequencing have allowed for routine identification of low-frequency variants, which are important sources of viral genetic diversity and can potentially emerge as a major virus population under certain conditions. We examined within-host viral diversity in turkeys and chickens experimentally infected with closely related H7N3 avian influenza viruses (AIVs), specifically one high pathogenicity AIV (HPAIV) and two low pathogenicity AIV (LPAIVs) with different neuraminidase protein stalk lengths. Consistent with the high mutation rates of AIVs, an abundance of intra-host single nucleotide variants (iSNVs) at low frequencies of 2-10% was observed in all samples collected. Furthermore, a small number of common iSNVs were observed between turkeys and chickens, and between directly inoculated and contact-exposed birds. Notably, the LPAIVs have significantly higher iSNV diversities and frequencies of nonsynonymous changes than the HPAIV in both turkeys and chickens. These findings highlight the dynamics of AIV populations within hosts and the potential impact of genetic changes, including mutations in the hemagglutinin gene that confers the high pathogenicity pathotype, on AIV virus populations and evolution.
    MeSH term(s) Animals ; Chickens ; Genetic Variation ; Influenza A Virus, H7N3 Subtype/genetics ; Influenza in Birds ; Poultry Diseases ; Turkeys ; Virulence/genetics
    Language English
    Publishing date 2022-03-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14030554
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  9. Article ; Online: M2 macrophage polarization in chronic spontaneous urticaria refractory to antihistamine treatment.

    Criado, Roberta F J / Criado, Paulo Ricardo / Pagliari, Carla / Sotto, Mirian N / Machado Filho, Carlos D'Apparecida / Bianco, Bianca

    Allergology international : official journal of the Japanese Society of Allergology

    2021  Volume 70, Issue 4, Page(s) 504–506

    MeSH term(s) Biomarkers ; Biopsy ; Chronic Urticaria/diagnosis ; Chronic Urticaria/etiology ; Chronic Urticaria/therapy ; Disease Management ; Disease Susceptibility ; Drug Resistance/drug effects ; Histamine Antagonists/pharmacology ; Histamine Antagonists/therapeutic use ; Humans ; Immunohistochemistry ; Macrophage Activation/drug effects ; Macrophage Activation/immunology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Skin/metabolism ; Skin/pathology ; Treatment Outcome
    Chemical Substances Biomarkers ; Histamine Antagonists
    Language English
    Publishing date 2021-05-11
    Publishing country England
    Document type Letter
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2021.03.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5248: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Assessment of rhBMP-2-loaded bovine hydroxyapatite granules in the guided bone regeneration of critical bone defect in rat mandible bone.

    López-Andaluz, J / Flores-Fraile, J / Javier-Borrajo / Blanco-Antona, L / García-Carrodeguas, R / López-Montañés, D / García-Cenador, M B / García-Criado, F J

    Journal of dental sciences

    2023  Volume 19, Issue 1, Page(s) 276–284

    Language English
    Publishing date 2023-04-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2023.04.016
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