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  1. Article: In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca

    Ahumada-Castro, Ulises / Bustos, Galdo / Silva-Pavez, Eduardo / Puebla-Huerta, Andrea / Lovy, Alenka / Cárdenas, César

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 629522

    Abstract: In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)- ...

    Abstract In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca
    Language English
    Publishing date 2021-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.629522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target.

    Bustos, Galdo / Cruz, Pablo / Lovy, Alenka / Cárdenas, César

    Frontiers in oncology

    2017  Volume 7, Page(s) 199

    Abstract: Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to establish the relationship between ... ...

    Abstract Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to establish the relationship between cancer and mitochondria; however, he interpreted enhanced aerobic glycolysis as mitochondrial dysfunction. Today it is accepted that many cancer cell types need fully functional mitochondria to maintain their homeostasis. Calcium (Ca
    Language English
    Publishing date 2017-09-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2017.00199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The ER-mitochondria Ca

    Bustos, Galdo / Ahumada-Castro, Ulises / Silva-Pavez, Eduardo / Puebla, Andrea / Lovy, Alenka / Cesar Cardenas, J

    International review of cell and molecular biology

    2021  Volume 363, Page(s) 49–121

    Abstract: Cancer is a leading cause of death worldwide. All major tumor suppressors and oncogenes are now recognized to have fundamental connections with metabolic pathways. A hallmark feature of cancer cells is a reprogramming of their metabolism even when ... ...

    Abstract Cancer is a leading cause of death worldwide. All major tumor suppressors and oncogenes are now recognized to have fundamental connections with metabolic pathways. A hallmark feature of cancer cells is a reprogramming of their metabolism even when nutrients are available. Increasing evidence indicates that most cancer cells rely on mitochondrial metabolism to sustain their energetic and biosynthetic demands. Mitochondria are functionally and physically coupled to the endoplasmic reticulum (ER), the major calcium (Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Signaling ; Disease Progression ; Endoplasmic Reticulum/metabolism ; Humans ; Mitochondria/metabolism ; Neoplasms/metabolism ; Neoplasms/physiopathology
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-04-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2021.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.317: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: In the Right Place at the Right Time

    Ulises Ahumada-Castro / Galdo Bustos / Eduardo Silva-Pavez / Andrea Puebla-Huerta / Alenka Lovy / César Cárdenas

    Frontiers in Cell and Developmental Biology, Vol

    Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes

    2021  Volume 9

    Abstract: In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)- ...

    Abstract In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+ communication on organelle function as well as catabolism and anabolism, particularly in cancer.
    Keywords IP3Rs ; calcium ; endoplasmic reticulum ; mitochondria ; lysosome ; metabolism ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca

    Lovy, Alenka / Ahumada-Castro, Ulises / Bustos, Galdo / Farias, Paula / Gonzalez-Billault, Christian / Molgó, Jordi / Cardenas, Cesar

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 378

    Abstract: Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. ... ...

    Abstract Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. Ca
    Language English
    Publishing date 2020-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.00378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells.

    Cruz, Pablo / Ahumada-Castro, Ulises / Bustos, Galdo / Molgó, Jordi / Sauma, Daniela / Lovy, Alenka / Cárdenas, César

    International journal of molecular sciences

    2021  Volume 22, Issue 2

    Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an ... ...

    Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an interesting therapeutic target given its essential role in maintaining bioenergetic and metabolic homeostasis. T-ALL cells are characterized by high levels of mitochondrial respiration, making them suitable for this type of intervention. Mitochondrial function is sustained by a constitutive transfer of calcium from the endoplasmic reticulum to mitochondria through the inositol 1,4,5-trisphosphate receptor (InsP3R), making T-ALL cells vulnerable to its inhibition. Here, we determine the bioenergetic profile of the T-ALL cell lines CCRF-CEM and Jurkat and evaluate their sensitivity to InsP3R inhibition with the specific inhibitor, Xestospongin B (XeB). Our results show that T-ALL cell lines exhibit higher mitochondrial respiration than non-malignant cells, which is blunted by the inhibition of the InsP3R. Prolonged treatment with XeB causes T-ALL cell death without affecting the normal counterpart. Moreover, the combination of XeB and glucocorticoids significantly enhanced cell death in the CCRF-CEM cells. The inhibition of InsP3R with XeB rises as a potential therapeutic alternative for the treatment of T-ALL.
    MeSH term(s) Biomarkers ; Cell Death ; Cell Line, Tumor ; Cell Respiration/drug effects ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/antagonists & inhibitors ; Leukocytes, Mononuclear/metabolism ; Macrocyclic Compounds/pharmacology ; Mitochondria/drug effects ; Mitochondria/metabolism ; Oxazoles/pharmacology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/etiology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism
    Chemical Substances Biomarkers ; Inositol 1,4,5-Trisphosphate Receptors ; Macrocyclic Compounds ; Oxazoles ; xestospongin B (88840-01-1)
    Language English
    Publishing date 2021-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22020651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells

    Pablo Cruz / Ulises Ahumada-Castro / Galdo Bustos / Jordi Molgó / Daniela Sauma / Alenka Lovy / César Cárdenas

    International Journal of Molecular Sciences, Vol 22, Iss 2, p

    2021  Volume 651

    Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an ... ...

    Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an interesting therapeutic target given its essential role in maintaining bioenergetic and metabolic homeostasis. T-ALL cells are characterized by high levels of mitochondrial respiration, making them suitable for this type of intervention. Mitochondrial function is sustained by a constitutive transfer of calcium from the endoplasmic reticulum to mitochondria through the inositol 1,4,5-trisphosphate receptor (InsP3R), making T-ALL cells vulnerable to its inhibition. Here, we determine the bioenergetic profile of the T-ALL cell lines CCRF-CEM and Jurkat and evaluate their sensitivity to InsP3R inhibition with the specific inhibitor, Xestospongin B (XeB). Our results show that T-ALL cell lines exhibit higher mitochondrial respiration than non-malignant cells, which is blunted by the inhibition of the InsP3R. Prolonged treatment with XeB causes T-ALL cell death without affecting the normal counterpart. Moreover, the combination of XeB and glucocorticoids significantly enhanced cell death in the CCRF-CEM cells. The inhibition of InsP3R with XeB rises as a potential therapeutic alternative for the treatment of T-ALL.
    Keywords calcium ; cancer ; metabolism ; bioenergetics ; T-ALL ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca2+ Transfer to Mitochondria

    Alenka Lovy / Ulises Ahumada-Castro / Galdo Bustos / Paula Farias / Christian Gonzalez-Billault / Jordi Molgó / Cesar Cardenas

    Frontiers in Cell and Developmental Biology, Vol

    2020  Volume 8

    Abstract: Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. Ca2+ regulates many aspects of mitochondrial physiology by modulating the activity of several mitochondrial proteins. We previously showed that inhibition of ... ...

    Abstract Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. Ca2+ regulates many aspects of mitochondrial physiology by modulating the activity of several mitochondrial proteins. We previously showed that inhibition of constitutive IP3R-mediated Ca2+ transfer to the mitochondria leads to a metabolic cellular stress and eventually cell death. Here, we show that the decline of mitochondrial function generated by a lack of Ca2+ transfer induces a DRP-1 independent mitochondrial fragmentation that at an early time is mediated by an increase in the NAD+/NADH ratio and activation of SIRT1. Subsequently, AMPK predominates and drives the fragmentation. SIRT1 activation leads to the deacetylation of cortactin, favoring actin polymerization, and mitochondrial fragmentation. Knockdown of cortactin or inhibition of actin polymerization prevents fragmentation. These data reveal SIRT1 as a new player in the regulation of mitochondrial fragmentation induced by metabolic/bioenergetic stress through regulating the actin cytoskeleton.
    Keywords IP3R channel ; mitochondrial dynamics ; actin ; cortactin acetylation ; Drp-1 ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Complex I and II are required for normal mitochondrial Ca

    Jaña, Fabian / Bustos, Galdo / Rivas, José / Cruz, Pablo / Urra, Felix / Basualto-Alarcón, Carla / Sagredo, Eduardo / Ríos, Melany / Lovy, Alenka / Dong, Zhiwei / Cerda, Oscar / Madesh, Muniswamy / Cárdenas, César

    Mitochondrion

    2019  Volume 49, Page(s) 73–82

    Abstract: Cytosolic calcium ( ...

    Abstract Cytosolic calcium (
    MeSH term(s) Calcium/metabolism ; Electron Transport Complex I/genetics ; Electron Transport Complex I/metabolism ; Homeostasis ; Humans ; MCF-7 Cells ; Membrane Potential, Mitochondrial/genetics ; Mitochondria/enzymology ; Mitochondria/genetics ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Succinate Dehydrogenase/genetics ; Succinate Dehydrogenase/metabolism
    Chemical Substances Mitochondrial Proteins ; NDUFAF3 protein, human ; SDHB protein, human (EC 1.3.5.1) ; Succinate Dehydrogenase (EC 1.3.99.1) ; Electron Transport Complex I (EC 7.1.1.2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-07-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056923-3
    ISSN 1872-8278 ; 1567-7249
    ISSN (online) 1872-8278
    ISSN 1567-7249
    DOI 10.1016/j.mito.2019.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca

    Cardenas, Cesar / Lovy, Alenka / Silva-Pavez, Eduardo / Urra, Felix / Mizzoni, Craig / Ahumada-Castro, Ulises / Bustos, Galdo / Jaňa, Fabian / Cruz, Pablo / Farias, Paula / Mendoza, Elizabeth / Huerta, Hernan / Murgas, Paola / Hunter, Martin / Rios, Melany / Cerda, Oscar / Georgakoudi, Irene / Zakarian, Armen / Molgó, Jordi /
    Foskett, J Kevin

    Science signaling

    2020  Volume 13, Issue 640

    Abstract: Spontaneous ... ...

    Abstract Spontaneous Ca
    MeSH term(s) Calcium/metabolism ; Cell Line, Tumor ; Cell Survival ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/pathology ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Oxidative Phosphorylation
    Chemical Substances Mitochondrial Proteins ; Neoplasm Proteins ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.aay1212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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