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Article: Jk(a) (Kidd-A) Variant in a Sickle Cell Disease Patient.

Barouqa, Mohammad / Zhang, Xuebao / Walde, Ryan / Ahmed, Zan / Mohammed, Rasha

2023 Volume 15, Issue 11, Page(s) e49451

Abstract: Sickle cell disease (SCD) is a chronic and prevalent hemoglobin disorder with various manifestations and complications depending on the organs involved. Red cell transfusion either simple or exchange is crucial due to its prophylactic and therapeutic ... ...

Abstract	Sickle cell disease (SCD) is a chronic and prevalent hemoglobin disorder with various manifestations and complications depending on the organs involved. Red cell transfusion either simple or exchange is crucial due to its prophylactic and therapeutic roles. We present a case showing serologic discrepancy between the red cells phenotype and the developed alloantibodies to emphasize the crucial role of molecular testing in SCD patients requiring chronic blood transfusion.
Language	English
Publishing date	2023-11-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.49451
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Accurate prognostic prediction for patients with clear cell renal cell carcinoma using a ferroptosis-related long non-coding RNA risk model.

Xiang, Xuebao / Guo, Yi / Chen, Zhongyuan / Zhang, Fangxin / Qin, Yan

Cancer biomarkers : section A of Disease markers

2023 Volume 37, Issue 2, Page(s) 95–107

Abstract: Introduction: Ferroptosis is a recently discovered type of programmed cell death that plays a crucial role in tumor occurrence and progression. However, no prognostic model has been established yet for clear cell renal cell carcinoma (ccRCC) using ... ...

Abstract	Introduction: Ferroptosis is a recently discovered type of programmed cell death that plays a crucial role in tumor occurrence and progression. However, no prognostic model has been established yet for clear cell renal cell carcinoma (ccRCC) using ferroptosis-related long non-coding RNAs (lncRNAs). Methods: In the present study, lncRNA expression profiles, sex, age, TMN stage, and other clinical data of ccRCC samples were extracted from The Cancer Genome Atlas database. In addition, ferroptosis-related lncRNAs were identified using co-expression analysis, and the risk model was established using Cox regression and least absolute shrinkage and selection operator regression analyses. Log-rank test and Kaplan-Meier analysis were performed to evaluate the predictive accuracy of the risk model for the overall survival (OS) of patients with ccRCC. Moreover, the functional enrichment of ferroptosis-related lncRNAs was performed and visualized using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Results: Eight prognostic ferroptosis-related lncRNAs were identified, such as LINC01615, AC026401.3, LINC00944, AL590094.1, DLGAP1-AS2, AC016773.1, AC147651.1, and AP000439.2, making up the ferroptosis-related lncRNA risk model. The risk model effectively divided patients with ccRCC into high- and low-risk groups, and their survival time was calculated. The high-risk group showed significantly shorter OS compared to the low-risk group. The nomogram to predict the survival rate of the patients revealed that the risk score was the most critical factor affecting OS in patients with ccRCC. The ferroptosis-related lncRNA risk model was an independent predictor of prognostic risk assessment in patients with ccRCC. Conclusion: The ferroptosis-related lncRNAs risk model and genomic clinicopathological nomogram have the potential to accurately predict the prognosis of patients with ccRCC and could serve as potential therapeutic targets in the future.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/genetics ; RNA, Long Noncoding/genetics ; Ferroptosis/genetics ; Prognosis ; Carcinoma ; Kidney Neoplasms/genetics
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2023-05-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2203517-5
ISSN	1875-8592 ; 1574-0153 ; 1875-8592
ISSN (online)	1875-8592 ; 1574-0153
ISSN	1875-8592
DOI	10.3233/CBM-210445
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Article: Synthesis and biological evaluation of novel benzothiazole derivatives as potential anticancer and antiinflammatory agents.

Xu, Xuemei / Zhu, Zhaojingtao / Chen, Siyu / Fu, Yanneng / Zhang, Jinxia / Guo, Yangyang / Xu, Zhouyang / Xi, Yingying / Wang, Xuebao / Ye, Faqing / Chen, Huijun / Yang, Xiaojiao

Frontiers in chemistry

2024 Volume 12, Page(s) 1384301

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2024-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2024.1384301
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Article ; Online: FSH can improve semen parameters in patients with idiopathic oligoasthenoteratozoospermia: A systematic review and meta-analysis.

Zhang, Xuebao / Chen, Jie / Cui, Yuanqing / Jin, Yinshan / Wang, Xiong

Andrologia

2022 Volume 54, Issue 11, Page(s) e14596

Abstract: Follicle-stimulating hormone (FSH) is commonly used in assisted reproductive technology to promote the development and maturation of follicles in female patients. However, there is no consensus on treating FSH in males with idiopathic ... ...

Abstract	Follicle-stimulating hormone (FSH) is commonly used in assisted reproductive technology to promote the development and maturation of follicles in female patients. However, there is no consensus on treating FSH in males with idiopathic oligoasthenoteratozoospermia (iOAT), especially in patients with normal serum FSH levels. To determine the role of FSH in improving semen quality in patients with iOAT, we conducted a detailed search in the commonly used database to find all studies on FSH in the treatment of iOAT. We compared the results, including semen volume, sperm count, sperm concentration, percentage of forward sperm motility, percentage of total sperm motility, percentage of normal forms and DNA fragmentation index (DFI) between the two groups treated with FSH or not. A total of 12 randomized controlled trials and one retrospective case-control study, including 924 people, were included in our meta-analysis. We found that sperm counts (MD 17.75; 95% CI 11.53-23.98 and p < 0.00001) were significantly increased in patients treated with FSH, along with improvements in sperm concentration (MD 4.52; 95% CI 1.46-7.58 and p = 0.004), percentage of normal forms (MD 2.87; 95% CI 0.19-5.56 and p = 0.04) and DFI (MD -12.62; 95% CI -19.27-5.97 and p = 0.002). However, we found no significant differences in the two groups' changes in other semen parameters. The use of FSH can improve some semen parameters in patients with iOAT, such as sperm count, percentage of normal forms, sperm concentration and DFI.
MeSH term(s)	Humans ; Male ; Asthenozoospermia/drug therapy ; Case-Control Studies ; Follicle Stimulating Hormone/therapeutic use ; Infertility, Male/drug therapy ; Oligospermia/drug therapy ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Semen ; Semen Analysis ; Sperm Count ; Sperm Motility ; Spermatozoa
Chemical Substances	Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2022-09-14
Publishing country	Germany
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	7280-1
ISSN	1439-0272 ; 0303-4569
ISSN (online)	1439-0272
ISSN	0303-4569
DOI	10.1111/and.14596
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Article: Assessment of Three-Dimensional Reconstruction in Percutaneous Nephrolithotomy for Complex Renal Calculi Treatment.

Tan, Haotian / Xie, Yaqi / Zhang, Xuebao / Wang, Wenting / Yuan, Hejia / Lin, Chunhua

Frontiers in surgery

2021 Volume 8, Page(s) 701207

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2021.701207
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Article ; Online: Urinary stone composition analysis of 3684 patients in the eastern Shandong region of China

Xuebao Zhang / Jiajia Ma / Ning Wang / Chunhua Lin

Journal of International Medical Research, Vol

2020 Volume 48

Abstract: Objective There has not been a study that analyzed the composition of urinary stones from patients in the eastern Shandong region of China. Thus, we explored the composition of urinary stones in the eastern Shandong region of China and discuss the ... ...

Abstract	Objective There has not been a study that analyzed the composition of urinary stones from patients in the eastern Shandong region of China. Thus, we explored the composition of urinary stones in the eastern Shandong region of China and discuss the clinical significance of the findings. Methods A total of 3684 urinary calculi from the eastern Shandong region were collected in our study. Compositions of the stones were analyzed using an Automatic Infrared Spectrum Analysis System (type LIIR-20). The results were verified through manual analysis of the spectrograms, which was accompanied by polarizing microscopy and chemical analysis if necessary. Results Among the 3684 specimens, there were 1767 single-component stones and 1917 mixed-component stones. According to the main components of the stones, the stones were divided into the following types: calcium oxalate monohydrate stones (1779, 48.3%), anhydrous uric acid stones (1105, 30.0%), carbonate apatite stones (590, 16.0%), ammonium magnesium phosphate hexahydrate stones (143, 3.9%), calcium oxalate dihydrate stones (36, 1.0%), and cystine stones (31, 0.8%). Conclusions There was a relatively high rate of uric acid stones in patients from the eastern Shandong region of China.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Xanthogranulomatous pyelonephritis infected with the Providencia stuartii: a case report and literature review.

Xu, Zhunan / Cai, Tong / Zhang, Xuebao / Wu, Jitao / Liu, Chu

BMC nephrology

2021 Volume 22, Issue 1, Page(s) 356

Abstract: Background: Xanthogranulomatous pyelonephritis (XGP) is a rare and severe chronic inflammatory disease of the renal parenchyma, which is most commonly associated with super-infections by bacteria such as E. coli, Proteus mirabilis, and occasionally ... ...

Abstract	Background: Xanthogranulomatous pyelonephritis (XGP) is a rare and severe chronic inflammatory disease of the renal parenchyma, which is most commonly associated with super-infections by bacteria such as E. coli, Proteus mirabilis, and occasionally Pseudomonas species. Case presentation: Herein, we present a rare case of a patient with XGP infected with Providencia stuartii. Initially, the patient refused nephrectomy and underwent holmium laser lithotripsy and right ureteral stenting, followed by meropenem treatment of 7 days. Relapse occurred in the third month after discharge from the hospital, due to which she underwent a radical nephrectomy. Discussion: The diagnosis of XGP is confirmed by histopathology. The standard treatment for XGP is antibiotic therapy and radical nephrectomy, but partial nephrectomy may be appropriate in select cases.
MeSH term(s)	Adult ; Enterobacteriaceae Infections ; Female ; Humans ; Providencia ; Pyelonephritis, Xanthogranulomatous/microbiology
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-021-02565-x
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Article ; Online: Environmental viromes reveal the global distribution signatures of deep-sea DNA viruses.

He, Tianliang / Jin, Min / Cui, Pei / Sun, Xumei / He, Xuebao / Huang, Yaqin / Xiao, Xi / Zhang, Tingting / Zhang, Xiaobo

Journal of advanced research

2023 Volume 57, Page(s) 107–117

Abstract: Introduction: Viruses are abundant and ecologically significant in marine ecosystems. However, the virome of deep-sea sediments is not extensively investigated.: Objectives: To explore the distribution pattern of deep-sea viruses on a global scale, ... ...

Abstract	Introduction: Viruses are abundant and ecologically significant in marine ecosystems. However, the virome of deep-sea sediments is not extensively investigated. Objectives: To explore the distribution pattern of deep-sea viruses on a global scale, the viromes of DNA viruses isolated from 138 sediments of 5 deep-sea ecosystems were characterized. Methods: The viral particles were purified from each sediment sample. Then the viral DNAs were extracted and subjected to viral metagenomic analysis. Results: Here, we constructed a global deep-sea environmental virome dataset by analyzing the viral DNA of 138 sediment samples. A total of 347,737 viral operational taxonomic units (vOTUs) were identified, of which 84.94% were hitherto unknown, indicating that deep sea was a reservoir of novel DNA viruses. Furthermore, circular viral genome analysis revealed 98,581 complete genomes. The classified vOTUs included eukaryotic (44.55%) and prokaryotic (25.75%) viruses, and were taxonomically assigned to 63 viral families. The composition and abundance of the deep-sea sediment viromes were dependent on the deep-sea ecosystem as opposed to geographical region. Further analysis revealed that the viral community differentiation in different deep-sea ecosystems was driven by the virus-mediated energy metabolism. Conclusion: Our findings showed that deep-sea ecosystems are a reservoir of novel DNA viruses and the viral community is shaped by the environmental characteristics of deep-sea ecosystems, thus presenting critical information for determining the ecological significance of viruses in global deep-sea ecosystems.
MeSH term(s)	Humans ; Ecosystem ; Virome ; DNA Viruses/genetics ; DNA, Viral/genetics ; Energy Metabolism
Chemical Substances	DNA, Viral
Language	English
Publishing date	2023-04-17
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2541849-X
ISSN	2090-1224 ; 2090-1224
ISSN (online)	2090-1224
ISSN	2090-1224
DOI	10.1016/j.jare.2023.04.009
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Article ; Online: Cutaneous manifestations of blastic plasmacytoid dendritic cell neoplasm: a retrospective study of morphological and immunophenotypic features.

Zhang, Ying / Xiong, Jingshu / Li, Siqi / Li, Yan / Shao, Xuebao / Zhang, Wei / Xu, Xiulian / Jiang, Yiqun / Sun, Jianfang / Chen, Hao

European journal of dermatology : EJD

2022 Volume 32, Issue 1, Page(s) 70–76

MeSH term(s)	Dendritic Cells ; Hematologic Neoplasms/complications ; Humans ; Immunophenotyping ; Retrospective Studies ; Skin Neoplasms
Language	English
Publishing date	2022-02-16
Publishing country	France
Document type	Journal Article
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2022.4195
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Zs.A 3484: Show issues

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Article ; Online: The activation of spliced X-box binding protein 1 by isorhynchophylline therapy improves diabetic encephalopathy.

Wang, Jian / Wang, Xuebao / Zhang, Minxue / Lang, Yan / Chen, Baihui / Ye, Yiru / Bai, Yongheng / Ding, Saidan

Cell biology and toxicology

2023 Volume 39, Issue 6, Page(s) 2587–2613

Abstract: The primary symptom of diabetic encephalopathy (DE), a kind of central diabetic neuropathy caused by diabetes mellitus (DM), is cognitive impairment. In addition, the tetracyclic oxindole alkaloid isorhynchophylline (IRN) helps lessen cognitive ... ...

Abstract	The primary symptom of diabetic encephalopathy (DE), a kind of central diabetic neuropathy caused by diabetes mellitus (DM), is cognitive impairment. In addition, the tetracyclic oxindole alkaloid isorhynchophylline (IRN) helps lessen cognitive impairment. However, it is still unclear how IRN affects DM and DE and what mechanisms are involved. The effectiveness of IRN on brain insulin resistance was carefully examined in this work, both in vitro and in vivo. We found that IRN accelerates spliced form of X-box binding protein 1 (sXBP1) translocation into the nucleus under high glucose conditions in vitro. IRN also facilitates the nuclear association of pCREB with sXBP1 and the binding of regulatory subunits of phosphatidylinositol 3-kinase (PI3K) p85α or p85β with XBP1 to restore high glucose impairment. Also, IRN treatment improves high glucose-mediated impairment of insulin signaling, endoplasmic reticulum stress, and pyroptosis/apoptosis by depending on sXBP1 in vitro. In vivo studies suggested that IRN attenuates cognitive impairment, ameliorating peripheral insulin resistance, activating insulin signaling, inactivating activating transcription factor 6 (ATF6) and C/EBP homology protein (CHOP), and mitigating pyroptosis/apoptosis by stimulation of sXBP1 nuclear translocation in the brain. In summary, these data indicate that IRN contributes to maintaining insulin homeostasis by activating sXBP1 in the brain. Thus, IRN is a potent antidiabetic agent as well as an sXBP1 activator that has promising potential for the prevention or treatment of DE.
MeSH term(s)	Humans ; Oxindoles/pharmacology ; X-Box Binding Protein 1 ; Insulin Resistance ; Phosphatidylinositol 3-Kinases ; Endoplasmic Reticulum Stress ; Insulin ; Glucose ; Diabetes Mellitus/drug therapy
Chemical Substances	rhyncophylline (46BQ79VJ8D) ; Oxindoles ; X-Box Binding Protein 1 ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Insulin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	48824-0
ISSN	1573-6822 ; 0742-2091
ISSN (online)	1573-6822
ISSN	0742-2091
DOI	10.1007/s10565-022-09789-z
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