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Article ; Online: Author Correction: Symptoms and quality of life before, during, and after a SARS‑CoV‑2 PCR positive or negative test: data from Lifelines.

Goërtz, Yvonne M J / Spruit, Martijn A / Van Herck, Maarten / Dukers-Muijrers, Nicole / van der Kallen, Carla J H / Burtin, Chris / Janssen, Daisy J A

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8390

Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58848-4
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Article: Polymorphisms in Glyoxalase I Gene Are Not Associated with Glyoxalase I Expression in Whole Blood or Markers of Methylglyoxal Stress: The CODAM Study.

Maasen, Kim / Hanssen, Nordin M J / van der Kallen, Carla J H / Stehouwer, Coen D A / van Greevenbroek, Marleen M J / Schalkwijk, Casper G

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 2

Abstract: Glyoxalase 1 (Glo1) is the rate-limiting enzyme in the detoxification of methylglyoxal (MGO) into D-lactate. MGO is a major precursor of advanced glycation endproducts (AGEs), and both are associated with development of age-related diseases. Since ... ...

Abstract	Glyoxalase 1 (Glo1) is the rate-limiting enzyme in the detoxification of methylglyoxal (MGO) into D-lactate. MGO is a major precursor of advanced glycation endproducts (AGEs), and both are associated with development of age-related diseases. Since genetic variation in
Language	English
Publishing date	2021-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10020219
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Article ; Online: Symptoms and quality of life before, during, and after a SARS-CoV-2 PCR positive or negative test: data from Lifelines.

Goërtz, Yvonne M J / Spruit, Martijn A / Van Herck, Maarten / Dukers-Muijrers, Nicole / van der Kallen, Carla J H / Burtin, Chris / Janssen, Daisy J A

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11713

Abstract: This study evaluates to what extent symptoms are present before, during, and after a positive SARS-CoV-2 polymerase chain reaction (PCR) test, and to evaluate how the symptom burden and quality of Life (QoL) compares to those with a negative PCR test. ... ...

Abstract	This study evaluates to what extent symptoms are present before, during, and after a positive SARS-CoV-2 polymerase chain reaction (PCR) test, and to evaluate how the symptom burden and quality of Life (QoL) compares to those with a negative PCR test. Participants from the Dutch Lifelines COVID-19 Cohort Study filled-out as of March 2020 weekly, later bi-weekly and monthly, questions about demographics, COVID-19 diagnosis and severity, QoL, and symptoms. The study population included those with one positive or negative PCR test who filled out two questionnaires before and after the test, resulting in 996 SARS-CoV-2 PCR positive and 3978 negative participants. Nearly all symptoms were more often reported after a positive test versus the period before the test (p < 0.05), except fever. A higher symptom prevalence after versus before a test was also found for nearly all symptoms in negatives (p < 0.05). Before the test, symptoms were already partly present and reporting of nearly all symptoms before did not differ between positives and negatives (p > 0.05). QoL decreased around the test for positives and negatives, with a larger deterioration for positives. Not all symptoms after a positive SARS-CoV-2 PCR test might be attributable to the infection and symptoms were also common in negatives.
MeSH term(s)	Humans ; COVID-19/diagnosis ; SARS-CoV-2/genetics ; Quality of Life ; COVID-19 Testing ; Cohort Studies ; Polymerase Chain Reaction
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-38223-5
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Article ; Online: Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study.

van Gennip, April C E / Gupta, Monideepa D / Houben, Alfons J H M / Berendschot, Tos T J M / Webers, Carroll A B / van Greevenbroek, Marleen M J / van der Kallen, Carla J H / Koster, Annemarie / Wesselius, Anke / Eussen, Simone J P M / Schalkwijk, Casper G / de Galan, Bastiaan E / Köhler, Sebastian / Schram, Miranda T / Stehouwer, Coen D A / van Sloten, Thomas T

Psychological medicine

2024 , Page(s) 1–10

Abstract: Background: Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. We investigated the association of retinal microvascular function, a proxy for ... ...

Abstract	Background: Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. We investigated the association of retinal microvascular function, a proxy for microvascular function in the brain, with incidence and trajectories of clinically relevant depressive symptoms. Methods: Longitudinal data are from The Maastricht Study of 5952 participants (59.9 ± 8.5 years/49.7% women) without clinically relevant depressive symptoms at baseline (2010-2017). Central retinal arteriolar equivalent and central retinal venular equivalent (CRAE and CRVE) and a composite score of flicker light-induced retinal arteriolar and venular dilation were assessed at baseline. We assessed incidence and trajectories of clinically relevant depressive symptoms (9-item Patient Health Questionnaire score ⩾10). Trajectories included continuously low prevalence (low, Results: After a median follow-up of 7.0 years (range 1.0-11.0), 806 (13.5%) individuals had incident clinically relevant depressive symptoms. After full adjustment, a larger CRAE and CRVE were each associated with a lower risk of clinically relevant depressive symptoms (hazard ratios [HRs] per standard deviation [s.d.]: 0.89 [95% confidence interval (CI) 0.83-0.96] and 0.93 [0.86-0.99], respectively), while a lower flicker light-induced retinal dilation was associated with a higher risk of clinically relevant depressive symptoms (HR per s.d.: 1.10 [1.01-1.20]). Compared to the low trajectory, a larger CRAE was associated with lower odds of belonging to the early-chronic trajectory (OR: 0.83 [0.69-0.99]) and a lower flicker light-induced retinal dilation was associated with higher odds of belonging to the remitting trajectory (OR: 1.23 [1.07-1.43]). Conclusions: These findings support the hypothesis that cerebral microvascular dysfunction contributes to the development of depressive symptoms.
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291724000618
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Article ; Online: Traditional lifestyle factors partly mediate the association of socioeconomic position with intrahepatic lipid content: The Maastricht study.

Ren, Zhewen / Bosma, Hans / Wesselius, Anke / Eussen, Simone J P M / Kooi, M Eline / van der Kallen, Carla J H / Koster, Annemarie / van Greevenbroek, Marleen M J / Dagnelie, Pieter / Stehouwer, Coen D A / Brouwers, Martijn C G J

JHEP reports : innovation in hepatology

2023 Volume 5, Issue 11, Page(s) 100855

Abstract: Background & aims: Recent studies have unveiled an association between socioeconomic position (SEP) and intrahepatic lipid (IHL) content. The aim of this study was to examine to what extent traditional lifestyle factors mediate the relationship between ... ...

Abstract	Background & aims: Recent studies have unveiled an association between socioeconomic position (SEP) and intrahepatic lipid (IHL) content. The aim of this study was to examine to what extent traditional lifestyle factors mediate the relationship between SEP and IHL content, independent of aetiology, and non-alcoholic fatty liver disease (NAFLD). Methods: We used cross-sectional data derived from The Maastricht Study (N = 4,001; mean age: 60 years, 49% women, 32% low education level, 21% diabetes, 21% NAFLD). Education, income, and occupation were used as indicators of SEP. Physical activity (accelerometer), intake of total energy, alcohol, saturated fat, protein, vitamin E, dietary fibre, and fructose from sugar-sweetened beverages (SSBs) and fruit juice (food frequency questionnaires) were potential mediators. IHL content was quantified by magnetic resonance imaging. Age, sex, and type 2 diabetes were covariates. Multiple parallel mediation analyses (bootstraps = 10,000) were performed. Results: Individuals with a low education level had a 1.056-fold higher IHL content (95% CI: 1.03-1.08) and a 44% greater NAFLD risk (OR:1.44; 95% CI:1.18-1.77) compared with those with higher education levels. Approximately 8.9% of educational disparity in risk of IHL content was attributable to moderate-to-vigorous physical activity; 6.3% to fructose intake from SSBs; 5.5% to dietary fibre; and -23% to alcohol. Approximately 8.7% of educational disparity in risk of NAFLD was attributable to moderate-to-vigorous physical activity; and 7.7% to fructose intake from SSBs. However, the indirect effect of these mediators was small (0.998 for IHL content and 1.045 for NAFLD) in comparison to the total effect. Similar results were found when income and occupation were used as SEP indicators. Conclusions: Societal measures may alleviate the burden of NAFLD and further studies that identify mediators other than traditional lifestyle factors are warranted to define the relationship underlying SEP and IHL content. Impact and implications: Individuals with a low or medium level of education, income, or occupational status had more fat accumulation in their livers than individuals with a higher education, income, or occupational status. This difference may be attributed to the influence of unhealthy lifestyle factors, such as reduced physical activity and a higher intake of sugar-sweetened beverages among individuals with lower socioeconomic position. Nevertheless, other yet unknown factors may also play a role.
Language	English
Publishing date	2023-07-18
Publishing country	Netherlands
Document type	Journal Article
ISSN	2589-5559
ISSN (online)	2589-5559
DOI	10.1016/j.jhepr.2023.100855
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Article ; Online: Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study.

Werkman, Nikki C C / García-Sáez, Gema / Nielen, Johannes T H / Tapia-Galisteo, Jose / Somolinos-Simón, Francisco J / Hernando, Maria E / Wang, Junfeng / Jiu, Li / Goettsch, Wim G / van der Kallen, Carla J H / Koster, Annemarie / Schalkwijk, Casper G / de Vries, Hein / de Vries, Nanne K / Eussen, Simone J P M / Driessen, Johanna H M / Stehouwer, Coen D A

Diabetologia

2024 Volume 67, Issue 4, Page(s) 690–702

Abstract: Aims/hypothesis: Type 2 diabetes is a highly heterogeneous disease for which new subgroups ('clusters') have been proposed based on disease severity: moderate age-related diabetes (MARD), moderate obesity-related diabetes (MOD), severe insulin-deficient ...

Abstract	Aims/hypothesis: Type 2 diabetes is a highly heterogeneous disease for which new subgroups ('clusters') have been proposed based on disease severity: moderate age-related diabetes (MARD), moderate obesity-related diabetes (MOD), severe insulin-deficient diabetes (SIDD) and severe insulin-resistant diabetes (SIRD). It is unknown how disease severity is reflected in terms of quality of life in these clusters. Therefore, we aimed to investigate the cluster characteristics and cluster-wise evolution of quality of life in the previously defined clusters of type 2 diabetes. Methods: We included individuals with type 2 diabetes from the Maastricht Study, who were allocated to clusters based on a nearest centroid approach. We used logistic regression to evaluate the cluster-wise association with diabetes-related complications. We plotted the evolution of HbA Results: We included 127 newly diagnosed and 585 already diagnosed individuals. Already diagnosed people in the SIDD cluster were less likely to reach glycaemic control than people in the other clusters, with an HR compared with MARD of 0.31 (95% CI 0.22, 0.43). There were few differences in the mental component score of the SF-36 in both newly and already diagnosed individuals. In both groups, the MARD cluster had a higher physical component score of the SF-36 than the other clusters, and the MOD cluster scored similarly to the SIDD and SIRD clusters. Conclusions/interpretation: Disease severity suggested by the clusters of type 2 diabetes is not entirely reflected in quality of life. In particular, the MOD cluster does not appear to be moderate in terms of quality of life. Use of the suggested cluster names in practice should be carefully considered, as the non-neutral nomenclature may affect disease perception in individuals with type 2 diabetes and their healthcare providers.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2 ; Quality of Life ; Diabetes Complications ; Insulin ; Insulin Resistance
Chemical Substances	Insulin
Language	English
Publishing date	2024-01-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-023-06082-4
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Zs.A 279: Show issues

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Article ; Online: Both short and long sleep durations are associated with type 2 diabetes, independent from traditional lifestyle risk factors-The Maastricht Study.

Albers, Jeroen D / Meertens, Ree M / Savelberg, Hans H C M / Köhler, Sebastian / Wesselius, Anke / Schram, Miranda T / Stehouwer, Coen D A / de Galan, Bastiaan E / van Greevenbroek, Marleen M J / van der Kallen, Carla J H / Eussen, Simone J P M / Bosma, Hans / Schaper, Nicolaas C / Koster, Annemarie

Sleep health

2023 Volume 9, Issue 5, Page(s) 733–741

Abstract: Objectives: This study examined the cross-sectional association between sleep duration, prediabetes, and type 2 diabetes, and its independence from the traditional lifestyle risk factors diet, physical activity, smoking behavior, and alcohol consumption. ...

Abstract	Objectives: This study examined the cross-sectional association between sleep duration, prediabetes, and type 2 diabetes, and its independence from the traditional lifestyle risk factors diet, physical activity, smoking behavior, and alcohol consumption. Methods: Cross-sectional data from 5561 people aged 40-75 years recruited into The Maastricht Study between 2010 and 2018 were used (1:1 female:male and mean age: 60.1 years [standard deviation: 8.6]). Sleep duration was operationalized as in-bed time, algorithmically derived from activPAL3 accelerometer data (median 7 nights, IQR 1). Glucose metabolism status was determined with an oral glucose tolerance test. Multinomial logistic regression was used to assess the association of sleep duration as restricted cubic spline with prediabetes and type 2 diabetes. We adjusted for sex, age, educational level, the use of sleep medication or antidepressants, and the following lifestyle risk factors: diet quality, physical activity, smoking behavior, and alcohol consumption. Results: A U-shaped association between sleep duration and type 2 diabetes was found. Compared to those with a sleep duration of 8 hours, participants with a sleep duration of 5 and 12 hours had higher odds of type 2 diabetes (OR: 2.9 [95% CI 1.9 to 4.4] and OR 3.2 [2.0 to 5.2], respectively). This association remained after further adjustment for the lifestyle risk factors (OR: 2.6 [1.7 to 4.1] and OR 1.8 [1.1 to 3.1]). No such association was observed between sleep duration and prediabetes. Conclusions: Both short and long sleep durations are associated positively and independently of lifestyle and cardiovascular risk factors with type 2 diabetes, but not with prediabetes.
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2813299-3
ISSN	2352-7226 ; 2352-7218
ISSN (online)	2352-7226
ISSN	2352-7218
DOI	10.1016/j.sleh.2023.06.009
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Article ; Online: Circulating and adipose tissue immune cells in tissue-specific insulin resistance in humans with overweight and obesity.

Trouwborst, Inez / Wouters, Kristiaan / Jocken, Johan W / Jardon, Kelly M / Gijbels, Anouk / Dagnelie, Pieter C / van Greevenbroek, Marleen M J / van der Kallen, Carla J / Stehouwer, Coen D A / Schalkwijk, Casper G / Richard, Nathalie / Bendik, Igor / Afman, Lydia A / Blaak, Ellen E / Goossens, Gijs H

Obesity (Silver Spring, Md.)

2023 Volume 31, Issue 5, Page(s) 1326–1337

Abstract: Objective: A proinflammatory adipose tissue (AT) microenvironment and systemic low-grade inflammation may differentially affect tissue-specific insulin sensitivity. This study investigated the relationships of abdominal subcutaneous AT (aSAT) and ... ...

Abstract	Objective: A proinflammatory adipose tissue (AT) microenvironment and systemic low-grade inflammation may differentially affect tissue-specific insulin sensitivity. This study investigated the relationships of abdominal subcutaneous AT (aSAT) and circulating immune cells, aSAT gene expression, and circulating inflammatory markers with liver and skeletal muscle insulin sensitivity in people with overweight and obesity. Methods: Individuals with overweight and obesity from the PERSonalized Glucose Optimization Through Nutritional Intervention (PERSON) Study (n = 219) and the Maastricht Study (replication cohort; n = 1256) underwent a seven-point oral glucose tolerance test to assess liver and muscle insulin sensitivity, and circulating inflammatory markers were determined. In subgroups, flow cytometry was performed to identify circulating and aSAT immune cells, and aSAT gene expression was evaluated. Results: The relative abundances of circulating T cells, nonclassical monocytes, and CD56dim CD16+ natural killer cells were inversely associated with liver, but not muscle, insulin sensitivity in the PERSON Study. The inverse association between circulating (classical) monocytes and liver insulin sensitivity was confirmed in the Maastricht Study. In aSAT, immune cell populations were not related to insulin sensitivity. Furthermore, aSAT gene expression of interleukin 6 and CD14 was positively associated with muscle, but not liver, insulin sensitivity. Conclusions: The present findings demonstrate that circulating immune cell populations and inflammatory gene expression in aSAT show distinct associations with liver and muscle insulin sensitivity.
MeSH term(s)	Humans ; Overweight/metabolism ; Insulin Resistance/physiology ; Subcutaneous Fat/metabolism ; Adipose Tissue/metabolism ; Obesity/metabolism ; Muscle, Skeletal/metabolism
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23714
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 87: Show issues

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Article ; Online: Retinal Functional and Structural Neural Indices: Potential Biomarkers for the Monitoring of Cerebral Neurodegeneration: The Maastricht Study.

van der Heide, Frank C T / Mokhtar, Sara / Khanna, Anjani / Said, Mozhda / Henry, Ronald M A / Kroon, Abraham A / Dagnelie, Pieter C / Eussen, Simone J P M / Berendschot, Tos T J M / Schouten, Jan S A G / Schram, Miranda T / van der Kallen, Carla J H / van Greevenbroek, Marleen M J / Wesselius, Anke / Savelberg, Hans H C M / Schaper, Nicolaas C / Webers, Carroll A B / Stehouwer, Coen D A

Journal of Alzheimer's disease : JAD

2023 Volume 93, Issue 4, Page(s) 1471–1483

Abstract: Background: If retinal indices of neurodegeneration are to be biomarkers for the monitoring of cerebral neurodegeneration, it is important to establish whether potentially modifiable risk factors for dementia are associated with retinal ... ...

Abstract	Background: If retinal indices of neurodegeneration are to be biomarkers for the monitoring of cerebral neurodegeneration, it is important to establish whether potentially modifiable risk factors for dementia are associated with retinal neurodegenerative changes. Objective: To study associations of dementia risk factors with retinal sensitivity, an index of retinal neural function, and retinal nerve fiber layer (RNFL) thickness, an index of retinal neural structure. Methods: We used cross-sectional data from The Maastricht Study (up to 5,666 participants, 50.5% men, mean age 59.7), and investigated associations with regression analyses (adjusted for potential confounders). Results: Most risk factors under study (i.e., hyperglycemia, unhealthy diet, lower cardiorespiratory fitness, smoking, alcohol consumption, and hypertension) were significantly associated with lower retinal sensitivity and lower RNFL thickness. Conclusion: Findings of this population-based study support the concept that retinal neural indices may be biomarkers for the monitoring of therapeutic strategies that aim to prevent early-stage cerebral neurodegeneration and, ultimately, dementia.
MeSH term(s)	Male ; Humans ; Female ; Cross-Sectional Studies ; Nerve Fibers ; Retina ; Biomarkers ; Dementia ; Tomography, Optical Coherence
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-05-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-230104
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Article ; Online: Microvascular Dysfunction and Whole-Brain White Matter Connectivity: The Maastricht Study.

Beran, Magdalena / van Gennip, April C E / Stehouwer, Coen D A / Jansen, Jacobus F A / Gupta, Monideepa D / Houben, Alfons J H M / Berendschot, Tos T J M / Webers, Carroll A B / Wesselius, Anke / Schalkwijk, Casper G / Backes, Walter H / de Jong, Joost J A / van der Kallen, Carla J H / van Greevenbroek, Marleen M J / Köhler, Sebastian / Vonk, Jet M J / Geerlings, Mirjam I / Schram, Miranda T / van Sloten, Thomas T

Journal of the American Heart Association

2024 Volume 13, Issue 3, Page(s) e9112

Abstract: Background: Microvascular dysfunction is involved in the development of various cerebral disorders. It may contribute to these disorders by disrupting white matter tracts and altering brain connectivity, but evidence is scarce. We investigated the ... ...

Abstract	Background: Microvascular dysfunction is involved in the development of various cerebral disorders. It may contribute to these disorders by disrupting white matter tracts and altering brain connectivity, but evidence is scarce. We investigated the association between multiple biomarkers of microvascular function and whole-brain white matter connectivity. Methods and results: Cross-sectional data from The Maastricht Study, a Dutch population-based cohort (n=4326; age, 59.4±8.6 years; 49.7% women). Measures of microvascular function included urinary albumin excretion, central retinal arteriolar and venular calibers, composite scores of flicker light-induced retinal arteriolar and venular dilation, and plasma biomarkers of endothelial dysfunction (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin, and von Willebrand factor). White matter connectivity was calculated from 3T diffusion magnetic resonance imaging to quantify the number (average node degree) and organization (characteristic path length, global efficiency, clustering coefficient, and local efficiency) of white matter connections. A higher plasma biomarkers of endothelial dysfunction composite score was associated with a longer characteristic path length (β per SD, 0.066 [95% CI, 0.017-0.114]) after adjustment for sociodemographic, lifestyle, and cardiovascular factors but not with any of the other white matter connectivity measures. After multiple comparison correction, this association was nonsignificant. None of the other microvascular function measures were associated with any of the connectivity measures. Conclusions: These findings suggest that microvascular dysfunction as measured by indirect markers is not associated with whole-brain white matter connectivity.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Male ; White Matter/pathology ; Cross-Sectional Studies ; Brain/diagnostic imaging ; Brain/pathology ; Diffusion Magnetic Resonance Imaging ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031573
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