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  1. Article ; Online: Mitochondrial fission: a new mechanism of hypertension and cardiovascular remodeling induced by Angiotensin II.

    Ueda, Kohei / Shibata, Shigeru

    Hypertension research : official journal of the Japanese Society of Hypertension

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-024-01670-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Significant efficacy of electroconvulsive therapy on the behavioural symptoms of anti-N-methyl-d-aspartate receptor encephalitis.

    Kim, Saehyeon / Horiuchi, Kohei / Ueda, Takehiro / Boku, Shuken

    BMJ case reports

    2024  Volume 17, Issue 2

    Abstract: SummaryThe common features of anti-N-methyl-d-aspartate (NMDA) receptor encephalitis are neuropsychiatric symptoms that are often challenging, treatment refractory and take years to recover. Electroconvulsive therapy (ECT) is effective in treating these ... ...

    Abstract SummaryThe common features of anti-N-methyl-d-aspartate (NMDA) receptor encephalitis are neuropsychiatric symptoms that are often challenging, treatment refractory and take years to recover. Electroconvulsive therapy (ECT) is effective in treating these symptoms in the acute phase, including catatonia and psychiatric issues.We describe the case of a man in his 30s with anti-NMDA receptor encephalitis characterised by neuropsychiatric features and treatment-refractory impulsivity, who was successfully treated with ECT. This case suggests that ECT use for behavioural symptoms can be associated with a significant response and may contribute to faster recovery from the disease.
    MeSH term(s) Male ; Humans ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis ; Electroconvulsive Therapy ; Catatonia/complications
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-258460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interrupted mosaic speech revisited: Gain and loss in intelligibility by stretchinga).

    Ueda, Kazuo / Hashimoto, Masashi / Takeichi, Hiroshige / Wakamiya, Kohei

    The Journal of the Acoustical Society of America

    2024  Volume 155, Issue 3, Page(s) 1767–1779

    Abstract: Our previous investigation on the effect of stretching spectrotemporally degraded and temporally interrupted speech stimuli showed remarkable intelligibility gains [Udea, Takeichi, and Wakamiya (2022). J. Acoust. Soc. Am. 152(2), 970-980]. In this ... ...

    Abstract Our previous investigation on the effect of stretching spectrotemporally degraded and temporally interrupted speech stimuli showed remarkable intelligibility gains [Udea, Takeichi, and Wakamiya (2022). J. Acoust. Soc. Am. 152(2), 970-980]. In this previous study, however, gap durations and temporal resolution were confounded. In the current investigation, we therefore observed the intelligibility of so-called mosaic speech while dissociating the effects of interruption and temporal resolution. The intelligibility of mosaic speech (20 frequency bands and 20 ms segment duration) declined from 95% to 78% and 33% by interrupting it with 20 and 80 ms gaps. Intelligibility improved, however, to 92% and 54% (14% and 21% gains for 20 and 80 ms gaps, respectively) by stretching mosaic segments to fill silent gaps (n = 21). By contrast, the intelligibility was impoverished to a minimum of 9% (7% loss) when stretching stimuli interrupted with 160 ms gaps. Explanations based on auditory grouping, modulation unmasking, or phonemic restoration may account for the intelligibility improvement by stretching, but not for the loss. The probability summation model accounted for "U"-shaped intelligibility curves and the gain and loss of intelligibility, suggesting that perceptual unit length and speech rate may affect the intelligibility of spectrotemporally degraded speech stimuli.
    MeSH term(s) Speech ; Cognition ; Probability ; Software
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0025132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Emotional Distress During COVID-19 by Mental Health Conditions and Economic Vulnerability: Retrospective Analysis of Survey-Linked Twitter Data With a Semisupervised Machine Learning Algorithm.

    Ueda, Michiko / Watanabe, Kohei / Sueki, Hajime

    Journal of medical Internet research

    2023  Volume 25, Page(s) e47549

    Abstract: This corrects the article DOI: 10.2196/44965.]. ...

    Abstract [This corrects the article DOI: 10.2196/44965.].
    Language English
    Publishing date 2023-03-27
    Publishing country Canada
    Document type Published Erratum
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1438-8871
    ISSN (online) 1438-8871
    ISSN 1438-8871
    DOI 10.2196/47549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reliability of the Phonon Density of States Determined by Real-Coded Genetic Algorithm from Heat Capacities of Benzoic Acid Crystals.

    Ueda, Kohei / Oguni, Masaharu

    The journal of physical chemistry. B

    2021  Volume 125, Issue 23, Page(s) 6322–6329

    Abstract: Constant-pressure heat capacities ( ...

    Abstract Constant-pressure heat capacities (
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.1c01722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Proarrhythmic Effect of Antitachycardia Pacing: Is Only the Pacing Algorithm to be Blamed?

    Kamakura, Tsukasa / Ueda, Nobuhiko / Wada, Mitsuru / Ishibashi, Kohei / Kusano, Kengo

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 10, Page(s) 2169–2170

    MeSH term(s) Humans ; Tachycardia, Ventricular/therapy ; Algorithms
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.07.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Immunogammopathy Maculopathy Secondary to Waldenström's Macroglobulinemia Complicated With Diabetic Retinopathy: A Case Report and Literature Review.

    Ogata, Nayumi / Ueda, Kohei / Aoki, Shuichiro

    Cureus

    2023  Volume 15, Issue 7, Page(s) e41622

    Abstract: In Waldenström's Macroglobulinemia (WM), increased immunoglobulin M causes various signs and symptoms. It sometimes presents with macular edema. A 65-year-old WM patient with a five-year history of diabetes mellitus was evaluated for ocular complications. ...

    Abstract In Waldenström's Macroglobulinemia (WM), increased immunoglobulin M causes various signs and symptoms. It sometimes presents with macular edema. A 65-year-old WM patient with a five-year history of diabetes mellitus was evaluated for ocular complications. Fundus examination and optical coherence tomography showed retinal changes consistent with non-proliferative diabetic retinopathy and foveal detachment with intraretinal cysts in the right eye, suggesting diabetic macular edema. However, on fluorescein angiography, there was no leakage over the area of foveal detachment, which led to the diagnosis of immunogammopathy maculopathy secondary to WM for macular edema and foveal detachment. The patient's ocular manifestation remained unchanged through a follow-up period of 11 months without therapeutic interventions. Immunogammopathy maculopathy, a rare ocular manifestation of monoclonal gammopathy, demands differentiation from other causes of macular edema in WM patients. The present case highlights the importance of fluorescein angiography, or silent macula, in diabetic patients to distinguish immunogammopathy maculopathy from diabetic macular edema.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.41622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Emotional Distress During COVID-19 by Mental Health Conditions and Economic Vulnerability: Retrospective Analysis of Survey-Linked Twitter Data With a Semisupervised Machine Learning Algorithm.

    Ueda, Michiko / Watanabe, Kohei / Sueki, Hajime

    Journal of medical Internet research

    2023  Volume 25, Page(s) e44965

    Abstract: Background: Monitoring the psychological conditions of social media users during rapidly developing public health crises, such as the COVID-19 pandemic, using their posts on social media has rapidly gained popularity as a relatively easy and cost- ... ...

    Abstract Background: Monitoring the psychological conditions of social media users during rapidly developing public health crises, such as the COVID-19 pandemic, using their posts on social media has rapidly gained popularity as a relatively easy and cost-effective method. However, the characteristics of individuals who created these posts are largely unknown, making it difficult to identify groups of individuals most affected by such crises. In addition, large annotated data sets for mental health conditions are not easily available, and thus, supervised machine learning algorithms can be infeasible or too costly.
    Objective: This study proposes a machine learning framework for the real-time surveillance of mental health conditions that does not require extensive training data. Using survey-linked tweets, we tracked the level of emotional distress during the COVID-19 pandemic by the attributes and psychological conditions of social media users in Japan.
    Methods: We conducted online surveys of adults residing in Japan in May 2022 and collected their basic demographic information, socioeconomic status, and mental health conditions, along with their Twitter handles (N=2432). We computed emotional distress scores for all the tweets posted by the study participants between January 1, 2019, and May 30, 2022 (N=2,493,682) using a semisupervised algorithm called latent semantic scaling (LSS), with higher values indicating higher levels of emotional distress. After excluding users by age and other criteria, we examined 495,021 (19.85%) tweets generated by 560 (23.03%) individuals (age 18-49 years) in 2019 and 2020. We estimated fixed-effect regression models to examine their emotional distress levels in 2020 relative to the corresponding weeks in 2019 by the mental health conditions and characteristics of social media users.
    Results: The estimated level of emotional distress of our study participants increased in the week when school closure started (March 2020), and it peaked at the beginning of the state of emergency (estimated coefficient=0.219, 95% CI 0.162-0.276) in early April 2020. Their level of emotional distress was unrelated to the number of COVID-19 cases. We found that the government-induced restrictions disproportionately affected the psychological conditions of vulnerable individuals, including those with low income, precarious employment, depressive symptoms, and suicidal ideation.
    Conclusions: This study establishes a framework to implement near-real-time monitoring of the emotional distress level of social media users, highlighting a great potential to continuously monitor their well-being using survey-linked social media posts as a complement to administrative and large-scale survey data. Given its flexibility and adaptability, the proposed framework is easily extendable for other purposes, such as detecting suicidality among social media users, and can be used on streaming data for continuous measurement of the conditions and sentiment of any group of interest.
    MeSH term(s) Adult ; Humans ; Adolescent ; Young Adult ; Middle Aged ; COVID-19/epidemiology ; COVID-19/psychology ; Mental Health ; Social Media ; Retrospective Studies ; Pandemics ; Machine Learning ; Supervised Machine Learning ; Psychological Distress
    Language English
    Publishing date 2023-03-16
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1438-8871
    ISSN (online) 1438-8871
    ISSN 1438-8871
    DOI 10.2196/44965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Targeted Protein Degradation Systems: Controlling Protein Stability Using E3 Ubiquitin Ligases in Eukaryotic Species.

    Ogawa, Yoshitaka / Ueda, Taisei P / Obara, Keisuke / Nishimura, Kohei / Kamura, Takumi

    Cells

    2024  Volume 13, Issue 2

    Abstract: This review explores various methods for modulating protein stability to achieve target protein degradation, which is a crucial aspect in the study of biological processes and drug design. Thirty years have passed since the introduction of heat-inducible ...

    Abstract This review explores various methods for modulating protein stability to achieve target protein degradation, which is a crucial aspect in the study of biological processes and drug design. Thirty years have passed since the introduction of heat-inducible degron cells utilizing the N-end rule, and methods for controlling protein stability using the ubiquitin-proteasome system have moved from academia to industry. This review covers protein stability control methods, from the early days to recent advancements, and discusses the evolution of techniques in this field. This review also addresses the challenges and future directions of protein stability control techniques by tracing their development from the inception of protein stability control methods to the present day.
    MeSH term(s) Proteolysis ; Proteasome Endopeptidase Complex ; Cytoplasm ; Protein Stability ; Ubiquitin-Protein Ligases
    Chemical Substances Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13020175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Biomechanical properties measured with dynamic Scheimpflug analyzer in central serous chorioretinopathy.

    Aoki, Shuichiro / Asaoka, Ryo / Azuma, Keiko / Kitamoto, Kohdai / Ueda, Kohei / Inoue, Tatsuya / Obata, Ryo

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2024  

    Abstract: Purpose: Recent evidence suggests that venous congestion at the vortex vein significantly contributes to the development of central serous chorioretinopathy (CSCR), and sclera is observed to be thicker in affected eyes. This study aims to investigate ... ...

    Abstract Purpose: Recent evidence suggests that venous congestion at the vortex vein significantly contributes to the development of central serous chorioretinopathy (CSCR), and sclera is observed to be thicker in affected eyes. This study aims to investigate whether eyes with CSCR exhibit stiff corneas, measured using Corneal Visualization Scheimflug Technology (Corvis ST), which may serve as an indicator of scleral stiffness.
    Methods: This retrospective case-control study comprises 52 eyes from 33 patients diagnosed with CSCR and 52 eyes from 32 normal controls without CSCR. We compared biomechanical parameters measured with Corvis ST and anterior scleral thickness measured using anterior segment swept-source optical coherence tomography between the two groups.
    Results: Age, sex, axial length, intraocular pressure, and central corneal thickness showed no significant differences between the two groups (p > 0.05, linear mixed model). Three biomechanical parameters-peak distance, maximum deflection amplitude, and integrated inverse radius-indicated less deformability in CSCR eyes compared to control eyes. The stress-strain index (SSI), a measure of stiffness, and anterior scleral thickness (AST) at temporal and nasal points were significantly higher in the CSCR eyes. SSI and AST were not correlated, yet both were significantly and independently associated with CSCR in a multivariate logistic regression model.
    Conclusions: Eyes affected by CSCR have stiffer corneas, irrespective of thicker scleral thickness. This suggests that stiffer sclera may play a role in the pathogenesis of CSCR.
    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-024-06378-0
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