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Article ; Online: Liver Metastases: Correlation between Imaging Features and Pathomolecular Environments.

Ozaki, Kumi / Higuchi, Shohei / Kimura, Hirohiko / Gabata, Toshifumi

Radiographics : a review publication of the Radiological Society of North America, Inc

2022 Volume 42, Issue 7, Page(s) 1994–2013

Abstract: A wide range of imaging manifestations of liver metastases can be encountered, as various primary cancers preferably metastasize to the liver (organ-specific metastases), with the imaging characteristics largely depending on various primary tumor- ... ...

Abstract	A wide range of imaging manifestations of liver metastases can be encountered, as various primary cancers preferably metastasize to the liver (organ-specific metastases), with the imaging characteristics largely depending on various primary tumor-specific factors such as histopathologic category, degree of tumor differentiation, histologic behavior, and intratumor alterations. Characteristic imaging features potentially can help provide a more precise diagnosis in some clinical settings. These settings include those of
MeSH term(s)	Humans ; Liver Neoplasms/pathology ; Carcinoma, Pancreatic Ductal ; Adenocarcinoma ; Pancreatic Neoplasms
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.220056
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Zs.A 1751: Show issues

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Article ; Online: Electrical impedance tomography for evaluating child respiratory rehabilitation.

Kimura, Sho / Sato, Masahiko / Sano, Kentaro / Shimoyama, Kyohei / Honda, Takafumi / Yasukawa, Kumi / Takanashi, Jun-Ichi

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15572

MeSH term(s)	Humans ; Child ; Electric Impedance ; Lung ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-07-10
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15572
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Zs.A 848: Show issues

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Article: Low-grade appendiceal mucinous neoplasm with puffer ball-like appearance: A case report.

Yamazaki, Mihoko / Cho, Shinichi / Nakaya, Moto / Kimura, Kazufumi / Ohno, Hitoshi / Aita, Kumi / Ogino, Takeo

Radiology case reports

2023 Volume 18, Issue 8, Page(s) 2790–2795

Abstract: We report a case of ruptured low-grade appendiceal mucinous neoplasm with an impressive toy puffer ball-like appearance on magnetic resonance imaging. A 79-year-old woman with lower abdominal pain underwent computed tomography scanning, revealing a 6-cm ... ...

Abstract	We report a case of ruptured low-grade appendiceal mucinous neoplasm with an impressive toy puffer ball-like appearance on magnetic resonance imaging. A 79-year-old woman with lower abdominal pain underwent computed tomography scanning, revealing a 6-cm mass in the right lower abdomen. T2-weighted images showed a radial low-signal structure in the central area of the mass, which was presumed to be fibrotic. Pathology confirmed ruptured low-grade appendiceal mucinous neoplasm. The rupture point was at the tip of the appendix, coinciding with the center of radial fibrosis. The unique morphology of the puffer ball-like appearance in this case may be a characteristic of low-grade appendiceal mucinous neoplasms.
Language	English
Publishing date	2023-06-06
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2023.05.006
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Article: Multimodal MR imaging in acute exacerbation of methylmalonic acidemia.

Saito, Riho / Murofushi, Yuka / Kimura, Sho / Yasukawa, Kumi / Murayama, Kei / Takanashi, Jun-Ichi

Radiology case reports

2023 Volume 18, Issue 3, Page(s) 1010–1014

Abstract: Methylmalonic acidemia (MMA) is a disorder of methylmalonic acid metabolism caused by impaired methylmalonyl CoA mutase. Neuroimaging shows symmetric hypodensity on CT, and T2 prolongation on MRI in the globus pallidus; however, there have been only a ... ...

Abstract	Methylmalonic acidemia (MMA) is a disorder of methylmalonic acid metabolism caused by impaired methylmalonyl CoA mutase. Neuroimaging shows symmetric hypodensity on CT, and T2 prolongation on MRI in the globus pallidus; however, there have been only a few reports on MR spectroscopy findings and no previous reports on arterial spin labeling (ASL), both of which could reflect neurochemical derangement in MMA. We herein report an 18-month-old Sri Lankan boy presented with severe acute exacerbation of MMA due to bacteremia of
Language	English
Publishing date	2023-01-05
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2022.12.037
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Article ; Online: Glasdegib with intensive/nonintensive chemotherapy in Japanese patients with untreated acute myeloid leukemia or high-risk myelodysplastic syndromes.

Izutsu, Koji / Ubukawa, Kumi / Morishita, Takanobu / Onishi, Yasushi / Ishizawa, Kenichi / Fujii, Yosuke / Kimura, Nobuyuki / Yokochi, Miyuu / Naoe, Tomoki

Cancer science

2024 Volume 115, Issue 4, Page(s) 1250–1260

Abstract: Glasdegib is a potent, selective, oral inhibitor of the hedgehog signaling pathway. In this phase I study, previously untreated Japanese patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes were treated with glasdegib (100 mg ...

Abstract	Glasdegib is a potent, selective, oral inhibitor of the hedgehog signaling pathway. In this phase I study, previously untreated Japanese patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes were treated with glasdegib (100 mg once daily) combinations: low-dose cytarabine (20 mg twice daily; cohort 1, n = 6; expansion cohort, n = 15); daunorubicin and cytarabine (60 mg/m
MeSH term(s)	Humans ; Japan ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Hedgehog Proteins ; Leukemia, Myeloid, Acute/metabolism ; Cytarabine/adverse effects ; Myelodysplastic Syndromes/drug therapy ; Thrombocytopenia ; Benzimidazoles ; Phenylurea Compounds
Chemical Substances	glasdegib (K673DMO5H9) ; Hedgehog Proteins ; Cytarabine (04079A1RDZ) ; Benzimidazoles ; Phenylurea Compounds
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Clinical Trial, Phase I ; Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.16054
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Article ; Online: Corrigendum to "Assessing the progression of segmental fibrosis in chronic liver disease using extracellular volume fractions" [Eur. J. Radiol. 145 (2021) 110033].

Ozaki, Kumi / Ishida, Tomokazu / Ohtani, Takashi / Shimada, Masato / Kimura, Hirohiko / Gabata, Toshifumi

European journal of radiology

2022 Volume 148, Page(s) 110179

Language	English
Publishing date	2022-01-24
Publishing country	Ireland
Document type	Published Erratum
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2022.110179
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Zs.A 1630: Show issues

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Article ; Online: Maternal Autistic Traits and Adverse Birth Outcomes.

Hosozawa, Mariko / Cable, Noriko / Ikehara, Satoyo / Aochi, Yuri / Tanigawa, Kanami / Baba, Sachiko / Hirokawa, Kumi / Kimura, Tadashi / Sobue, Tomotaka / Iso, Hiroyasu

JAMA network open

2024 Volume 7, Issue 1, Page(s) e2352809

Abstract: Importance: Women with a high level of autistic traits in the general population may experience larger health disparities during pregnancy, particularly women diagnosed with autism spectrum disorder (ASD), which in turn may be associated with increased ... ...

Abstract	Importance: Women with a high level of autistic traits in the general population may experience larger health disparities during pregnancy, particularly women diagnosed with autism spectrum disorder (ASD), which in turn may be associated with increased risk of adverse birth outcomes. Objective: To investigate the association between maternal autistic traits and the risk of adverse birth outcomes in the general population. Design, setting, and participants: This cohort study included mothers of singletons from a nationwide, multicenter prospective birth cohort, the Japan Environmental Children's Study. Expecting mothers were recruited between January 2011 and March 2014. Data were analyzed between June 2021 and November 2023. Exposures: Autistic traits were self-reported during the second and third trimesters using the short form of the Autism-Spectrum Quotient Japanese version (AQ-J10) (score range, 0-10; clinical range, ≥7). Main outcomes and measures: Data on preterm birth (<37 weeks' gestation) and neonates born small for gestational age (SGA) were transcribed from medical records. Additional analysis of gestational age groups (very preterm birth, <32 weeks' gestation; moderate-to-late preterm birth, 32-36 weeks' gestation) was also performed. Results: Among 87 687 women (mean [SD] age, 31.2 [5.0] years) included in the study, 2350 (2.7%) had AQ-J10 scores within the clinical range yet only 18 (0.02%) were diagnosed with ASD. A higher AQ-J10 score was associated with an increased risk of all birth outcomes, including preterm births (relative risk [RR] per 1-SD increase, 1.06; 95% CI, 1.03-1.09), moderate-to-late preterm births (RR per 1-SD increase, 1.05; 95% CI, 1.01-1.08), very preterm births (RR per 1-SD increase, 1.16; 95% CI, 1.06-1.26), and child born SGA (RR per 1-SD increase, 1.04; 95% CI, 1.01-1.06) after adjusting for maternal and pregnancy-related factors. The risks of all outcomes increased with higher AQ-J10 scores; compared with women below the clinical range, women within the clinical range had greater risk of preterm births (RR, 1.16; 95% CI, 1.07-1.26), moderate-to-late preterm births (RR, 1.12; 95% CI, 1.03-1.22), very preterm births (RR, 1.49; 95% CI, 1.18-1.89), and a child born SGA (RR, 1.11; 95% CI, 1.04-1.19). Conclusions and relevance: In this cohort study, higher level of maternal autistic traits was associated with increased risk of adverse birth outcomes, particularly very preterm birth. Acknowledging the risks and providing tailored and timely antenatal care support to women with a high level of autistic traits in the general population, particularly women with autistic traits within the clinical range, regardless of formal diagnosis, is warranted.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Pregnancy ; Autism Spectrum Disorder/epidemiology ; Autistic Disorder ; Cohort Studies ; Mothers ; Premature Birth/epidemiology ; Prospective Studies ; Multicenter Studies as Topic ; Adult
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.52809
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Article ; Online: Factors influencing the development of infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion.

Yasukohchi, Madoka / Omata, Taku / Ochiai, Kenta / Sano, Kentaro / Murofushi, Yuka / Kimura, Sho / Takase, Nanako / Honda, Takafumi / Yasukawa, Kumi / Takanashi, Jun-Ichi

Journal of the neurological sciences

2024 Volume 457, Page(s) 122904

Abstract: Background: Infantile traumatic brain injury (TBI) with a biphasic clinical course and late reduced diffusion (TBIRD) has been reported as a type of TBI. However, it remains uncertain which pediatric patients with TBI develop TBIRD.: Methods: ... ...

Abstract	Background: Infantile traumatic brain injury (TBI) with a biphasic clinical course and late reduced diffusion (TBIRD) has been reported as a type of TBI. However, it remains uncertain which pediatric patients with TBI develop TBIRD. Methods: Patients with TBI who were admitted to our hospital and underwent magnetic resonance imaging (MRI) between December 2006 and October 2022 were included in this study. A diagnosis of TBIRD was made in patients with or suspected TBI, with initial symptoms being convulsions or disturbance of consciousness and late-onset subcortical reduced diffusion, the so-called bright tree appearance. Clinical features, neuroimaging (computed tomography (CT) and MRI) findings, laboratory data, and Tada score were retrospectively compared between TBIRD and non-TBIRD patients. Neurological prognosis was assessed using the Pediatric Cerebral Performance Category scale. Results: Of 21 patients who met the inclusion criteria, a diagnosis of TBIRD was made in 7 patients (median age: 8 months). The factors contributing to TBIRD development were seizures lasting over 30 min as the initial symptom (5/7 in TBIRD vs. 0/14 in non-TBIRD), tracheal intubation during initial treatment (5/7 vs. 0/14), and brain parenchymal lesions on CT (3/7 vs. 0/14), suggesting that severe TBI may progress to TBIRD. The Tada score was more positive in patients with TBIRD (6/7) than in those without (0/14). Conclusions: It is important to monitor infant patients with severe TBI for the development of TBIRD. The Tada score can be a useful tool for TBIRD prediction.
MeSH term(s)	Infant ; Humans ; Child ; Retrospective Studies ; Seizures/diagnosis ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnostic imaging ; Magnetic Resonance Imaging ; Disease Progression
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2024.122904
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Article ; Online: A Nursing Pre-Transplant Intervention to Reduce Patients' Uncertainty about Allogeneic Hematopoietic Stem Cell Transplantation.

Nakano, Kimiko / Fujii, Shiro / Fujioka, Ayame / Kimura, Kumi / Abe, Yoshiki / Abe, Masahiro / Yamamoto, Sena / Arao, Harue

Blood cell therapy

2023 Volume 7, Issue 1, Page(s) 14–24

Abstract: Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) procedures often experience high levels of uncertainty. In this study, we developed and implemented a nursing intervention program to help patients recognize and reduce pre- ... ...

Abstract	Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) procedures often experience high levels of uncertainty. In this study, we developed and implemented a nursing intervention program to help patients recognize and reduce pre-transplant uncertainty. This study used a pretest-posttest single-group design without a control group. Eighteen patients undergoing HSCT participated in the intervention program-which included informational support, confirmation that the patients understood the information provided, and emotional support. Outpatients received the intervention at their initial outpatient visits after their procedure dates were determined, while inpatients received it at discharge following their procedures. The Universal Uncertainty in Illness Scale (UUIS), which consists of 26 items and six subscales, was used as the primary outcome measure. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and the Hospital Anxiety and Depression Scale were used as secondary outcome measures. The sample included 18 individuals (13 male and five female participants; median age, 52 years). Most participants had acute lymphoblastic leukemia and had previously undergone bone marrow transplantations. Following our intervention, the total UUIS score significantly decreased, from 80.83 ± 18.42 before the intervention to 63.06 ± 23.53 afterward (
Language	English
Publishing date	2023-12-28
Publishing country	Japan
Document type	Journal Article
ISSN	2432-7026
ISSN (online)	2432-7026
DOI	10.31547/bct-2023-013
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Article: Treatment of T-Cell Prolymphocytic Leukemia with Central Nervous System Involvement Using Intrathecal Alemtuzumab Administration.

Mori, Jinichi / Oshima, Kumi / Kimura, Satoshi / Ikezoe, Takayuki

Case reports in hematology

2020 Volume 2020, Page(s) 8822172

Abstract: T-cell prolymphocytic leukemia (T-PLL) is a rare hematologic cancer with a dismal prognosis. Although a small number of patients have central nervous system (CNS) involvement, a standard treatment approach for these patients has not been established. ... ...

Abstract	T-cell prolymphocytic leukemia (T-PLL) is a rare hematologic cancer with a dismal prognosis. Although a small number of patients have central nervous system (CNS) involvement, a standard treatment approach for these patients has not been established. Herein, we present a case of T-PLL with CNS involvement that was treated with a higher dose of intrathecal alemtuzumab than that previously reported. A 66-year-old man who had T-PLL with CNS involvement was admitted to our hospital. Intravenously administered alemtuzumab, a monoclonal antibody against the CD52 antigen, successfully reduced leukemia cells in peripheral blood; however, intrathecal treatment with methotrexate, cytarabine, and prednisone had a limited effect on the CNS involvement. Therefore, we intrathecally injected alemtuzumab as an experimental treatment. Although we escalated the dose of intrathecal alemtuzumab up to 5 mg, no adverse reaction was noted; however, this treatment did not completely clear the leukemia cells from the patient's cerebrospinal fluid (CSF). We performed whole brain and whole spinal irradiation therapies and subsequently performed allogeneic transplantation from a human leukocyte antigen-matched sibling donor with a conditioning regimen containing total body irradiation. At 21 days after transplantation, leukemia cells remained in his CSF. Although intrathecal alemtuzumab did not eliminate the CNS-invading leukemia cells, it was well-tolerated in our case. Further accumulation of similar cases is needed to determine the benefits and safety of intrathecal alemtuzumab administration.
Language	English
Publishing date	2020-07-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627639-2
ISSN	2090-6579 ; 2090-6560
ISSN (online)	2090-6579
ISSN	2090-6560
DOI	10.1155/2020/8822172
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