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  1. Article: Emerging and Future Targeted Therapies for Pediatric Acute Myeloid Leukemia: Targeting the Leukemia Stem Cells.

    Murphy, Lindsey A / Winters, Amanda C

    Biomedicines

    2023  Volume 11, Issue 12

    Abstract: Acute myeloid leukemia (AML) is a rare subtype of acute leukemia in the pediatric and adolescent population but causes disproportionate morbidity and mortality in this age group. Standard chemotherapeutic regimens for AML have changed very little in the ... ...

    Abstract Acute myeloid leukemia (AML) is a rare subtype of acute leukemia in the pediatric and adolescent population but causes disproportionate morbidity and mortality in this age group. Standard chemotherapeutic regimens for AML have changed very little in the past 3-4 decades, but the addition of targeted agents in recent years has led to improved survival in select subsets of patients as well as a better biological understanding of the disease. Currently, one key paradigm of bench-to-bedside practice in the context of adult AML is the focus on leukemia stem cell (LSC)-targeted therapies. Here, we review current and emerging immunotherapies and other targeted agents that are in clinical use for pediatric AML through the lens of what is known (and not known) about their LSC-targeting capability. Based on a growing understanding of pediatric LSC biology, we also briefly discuss potential future agents on the horizon.
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11123248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Emerging and Future Targeted Therapies for Pediatric Acute Myeloid Leukemia

    Lindsey A. Murphy / Amanda C. Winters

    Biomedicines, Vol 11, Iss 12, p

    Targeting the Leukemia Stem Cells

    2023  Volume 3248

    Abstract: Acute myeloid leukemia (AML) is a rare subtype of acute leukemia in the pediatric and adolescent population but causes disproportionate morbidity and mortality in this age group. Standard chemotherapeutic regimens for AML have changed very little in the ... ...

    Abstract Acute myeloid leukemia (AML) is a rare subtype of acute leukemia in the pediatric and adolescent population but causes disproportionate morbidity and mortality in this age group. Standard chemotherapeutic regimens for AML have changed very little in the past 3–4 decades, but the addition of targeted agents in recent years has led to improved survival in select subsets of patients as well as a better biological understanding of the disease. Currently, one key paradigm of bench-to-bedside practice in the context of adult AML is the focus on leukemia stem cell (LSC)-targeted therapies. Here, we review current and emerging immunotherapies and other targeted agents that are in clinical use for pediatric AML through the lens of what is known (and not known) about their LSC-targeting capability. Based on a growing understanding of pediatric LSC biology, we also briefly discuss potential future agents on the horizon.
    Keywords pediatric AML ; immunotherapy ; targeted therapy ; leukemia stem cell (LSC) ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Exploring maternal reflective functioning as a predictor of mother-child dyadic behaviour over time in a clinical context.

    Myers, Lindsey / Steele, Howard / Steele, Miriam / Murphy, Anne

    Research in psychotherapy (Milano)

    2022  Volume 25, Issue 1

    Abstract: The current study examined 20 participants from group attachment based intervention (GABI), who completed the adult attachment interviews (AAI; George, et al., 1985) as part of a RCT to test the efficacy of GABI compared with treatment as usual, in order ...

    Abstract The current study examined 20 participants from group attachment based intervention (GABI), who completed the adult attachment interviews (AAI; George, et al., 1985) as part of a RCT to test the efficacy of GABI compared with treatment as usual, in order to explore the possible benefits higher RF for treatment outcome in terms of interactive mother and child behaviour. Mothers' AAIs were analyzed using the reflective functioning (RF) rating scale (Fonagy, et al., 1998), yielding overall RF scores, prompted/demand RF scores, and spontaneous RF scores, and parent-child dyadic interactive behaviour was coded utilizing the coding interactive behaviour (CIB: Feldman, 1998) manual. Children's age ranged from 2-25 months, mean=14 months. 86.7% of the sample identified English as their primary language, with 13.3% identified speaking both Spanish and English. RF in AAIs obtained at intake from some GABI mothers was expected to be linked to the quality of the parent-child interaction (observed with the CIB), at intake (T1), at end-of treatment T2), and at sixmonth follow-up (T3). Results confirmed this impression insofar as lower overall RF was linked to T1 levels of higher intrusiveness from mothers. At end of treatment (T2), mothers' higher spontaneous RF scores were significantly linked to maternal praising (of the child), child positive affect, child alertness. At 6-month follow up (T3), mother's spontaneous RF scores correlated significantly and positively with maternal elaborating with child positive affect. Discussion focuses on the importance of assessing RF in parents entering therapy with their children as it may provide insight into what parent or child behaviours may be targeted. And the RF scores will highlight which mothers need special attention to stimulate their interest and attention to attachment-related processes in themselves, and in their children.
    Language English
    Publishing date 2022-04-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2654235-3
    ISSN 2239-8031 ; 2239-8031
    ISSN (online) 2239-8031
    ISSN 2239-8031
    DOI 10.4081/ripppo.2022.594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Novel Protocol for Nasal Decolonization Using Prolonged Application of an Alcohol-Based Nasal Antiseptic Reduces Surgical Site Infections in Total Joint Arthroplasty Patients: A Retrospective Cohort Study.

    Bostian, Phillip A / Vaida, Justin / Brooks, William C / Chaharbakhshi, Edwin / Dietz, Matthew J / Klein, Adam E / Murphy, T Ryan / Frye, Benjamin M / Lindsey, Brock A

    Surgical infections

    2023  Volume 24, Issue 7, Page(s) 651–656

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Anti-Infective Agents, Local/therapeutic use ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control ; Retrospective Studies ; Ethanol ; Anti-Bacterial Agents ; Arthroplasty
    Chemical Substances Anti-Infective Agents, Local ; Ethanol (3K9958V90M) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440120-4
    ISSN 1557-8674 ; 1096-2964
    ISSN (online) 1557-8674
    ISSN 1096-2964
    DOI 10.1089/sur.2022.344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Randomized Trial of Postoperative Venous Thromboembolism Prophylactic Compliance: Aspirin and Mobile Compression Pumps.

    Dietz, Matthew J / Moushmoush, Obadah / Frye, Benjamin M / Lindsey, Brock A / Murphy, T Ryan / Klein, Adam E

    The Journal of the American Academy of Orthopaedic Surgeons

    2022  Volume 30, Issue 20, Page(s) e1319–e1326

    Abstract: Background: Aspirin, as a routine venous thromboembolism (VTE) prophylaxis, is approved along with pneumatic compression pumps by the American College of Chest Physicians. We assessed compliance of aspirin and pump use after total joint arthroplasty.: ...

    Abstract Background: Aspirin, as a routine venous thromboembolism (VTE) prophylaxis, is approved along with pneumatic compression pumps by the American College of Chest Physicians. We assessed compliance of aspirin and pump use after total joint arthroplasty.
    Methods: A randomized trial of aspirin alone or aspirin/mobile compression pumps after total joint arthroplasty was performed. Aspirin and pump compliance, VTE events, and satisfaction with pump use were collected. Compliance was assessed through an internal device monitor and drug log book. Patients were also contacted 90 days postoperatively for reported symptomatic VTEs.
    Results: Each group had 40 patients and greater than 94% compliance with aspirin use, with no difference between groups (P = 0.55). Overall pump compliance during the first 14 days after hospital discharge was 51% (SD ± 33), which was significantly worse than aspirin compliance at 99% (SD ± 4.1) (P < 0.0001). Only 10 patients were compliant (>20 hr/d) with recommended pump use throughout the entire recommended period. There was no notable association between aspirin compliance and VTE within 90 days. There was no notable association between pump compliance and VTE at 90 days. However, average pump use compliance was 20% in patients with VTE and 54% in patients without VTE within 90 days. With the numbers available in this compliance study, there was no significant difference (P = 0.11).
    Discussion: Aspirin compliance was notably greater than pump compliance. In this study, we found that pump compliance was not associated with lower VTE risk. In fact, no increased risk was recognized in patients with an average pump usage of >50%. Further study is warranted to define the duration of pump use required for clinical significance. The recommended use of compression pumps should continue to be examined.
    MeSH term(s) Anticoagulants/therapeutic use ; Arthroplasty, Replacement, Hip/adverse effects ; Aspirin/therapeutic use ; Humans ; Postoperative Period ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1200524-1
    ISSN 1940-5480 ; 1067-151X
    ISSN (online) 1940-5480
    ISSN 1067-151X
    DOI 10.5435/JAAOS-D-21-01063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 274: Show issues

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  6. Article ; Online: A common data model for the standardization of intensive care unit medication features.

    Sikora, Andrea / Keats, Kelli / Murphy, David J / Devlin, John W / Smith, Susan E / Murray, Brian / Buckley, Mitchell S / Rowe, Sandra / Coppiano, Lindsey / Kamaleswaran, Rishikesan

    JAMIA open

    2024  Volume 7, Issue 2, Page(s) ooae033

    Abstract: Objective: Common data models provide a standard means of describing data for artificial intelligence (AI) applications, but this process has never been undertaken for medications used in the intensive care unit (ICU). We sought to develop a common data ...

    Abstract Objective: Common data models provide a standard means of describing data for artificial intelligence (AI) applications, but this process has never been undertaken for medications used in the intensive care unit (ICU). We sought to develop a common data model (CDM) for ICU medications to standardize the medication features needed to support future ICU AI efforts.
    Materials and methods: A 9-member, multi-professional team of ICU clinicians and AI experts conducted a 5-round modified Delphi process employing conference calls, web-based communication, and electronic surveys to define the most important medication features for AI efforts. Candidate ICU medication features were generated through group discussion and then independently scored by each team member based on relevance to ICU clinical decision-making and feasibility for collection and coding. A key consideration was to ensure the final ontology both distinguished unique medications and met Findable, Accessible, Interoperable, and Reusable (FAIR) guiding principles.
    Results: Using a list of 889 ICU medications, the team initially generated 106 different medication features, and 71 were ranked as being core features for the CDM. Through this process, 106 medication features were assigned to 2 key feature domains: drug product-related (n = 43) and clinical practice-related (n = 63). Each feature included a standardized definition and suggested response values housed in the electronic data library. This CDM for ICU medications is available online.
    Conclusion: The CDM for ICU medications represents an important first step for the research community focused on exploring how AI can improve patient outcomes and will require ongoing engagement and refinement.
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ISSN 2574-2531
    ISSN (online) 2574-2531
    DOI 10.1093/jamiaopen/ooae033
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  7. Article ; Online: Time to transplantation and pediatric acute myeloid leukemia outcomes.

    Murphy, Lindsey A / Miller, Kristen / Winters, Amanda C / Franklin, Anna R K / Verneris, Michael R / Keating, Amy K

    Bone marrow transplantation

    2022  Volume 58, Issue 3, Page(s) 343–345

    MeSH term(s) Child ; Humans ; Leukemia, Myeloid, Acute ; Hematopoietic Stem Cell Transplantation ; Retrospective Studies
    Language English
    Publishing date 2022-12-10
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-022-01893-2
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    Zs.A 2168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Blinatumomab improves outcomes for pediatric patients with low-risk B-cell acute lymphoblastic leukemia in first marrow relapse.

    Murphy, Lindsey / Aldoss, Ibrahim

    Translational pediatrics

    2024  Volume 13, Issue 3, Page(s) 530–534

    Language English
    Publishing date 2024-03-06
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: State-Specific Prevalence of Inactivity, Self-Rated Health Status, and Severe Joint Pain Among Adults With Arthritis - United States, 2019.

    Duca, Lindsey M / Helmick, Charles G / Barbour, Kamil E / Murphy, Louise B / Guglielmo, Dana / Odom, Erica L / Boring, Michael A / Croft, Janet B

    Preventing chronic disease

    2022  Volume 19, Page(s) E23

    Abstract: Arthritis is associated with joint pain, disability, and physical inactivity, potentially resulting in poor quality of life. The Centers for Disease Control and Prevention analyzed 2019 Behavioral Risk Factor Surveillance System data to estimate state- ... ...

    Abstract Arthritis is associated with joint pain, disability, and physical inactivity, potentially resulting in poor quality of life. The Centers for Disease Control and Prevention analyzed 2019 Behavioral Risk Factor Surveillance System data to estimate state-specific arthritis prevalence and, among adults with arthritis, the prevalence of physical inactivity, fair/poor self-rated health status, and severe joint pain. Among adults with arthritis, age-standardized prevalences of physical inactivity, fair/poor health status, and severe joint pain were high in all states and highest in southeastern states. Increased promotion and use of evidence-based public health interventions for arthritis may improve health-promoting behaviors and health outcomes among adults with arthritis.
    MeSH term(s) Adult ; Arthralgia/complications ; Arthralgia/epidemiology ; Arthritis/complications ; Arthritis/epidemiology ; Health Status ; Humans ; Pain ; Prevalence ; Quality of Life ; Sedentary Behavior ; United States/epidemiology
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2135684-1
    ISSN 1545-1151 ; 1545-1151
    ISSN (online) 1545-1151
    ISSN 1545-1151
    DOI 10.5888/pcd19.210346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A pediatric case of

    Murphy, Lindsey / Siegele, Bradford / Carstens, Billie / Hartman, Lisa / Faulk, Kelly

    Leukemia & lymphoma

    2024  , Page(s) 1–5

    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2024.2315159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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