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  1. Article: An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure.

    Patel, Pratik / Bekkerman, Mikhael / Varallo-Rodriguez, Cristina / Rampersaud, Rajendra

    Case reports in critical care

    2016  Volume 2016, Page(s) 3438080

    Abstract: Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, ... ...

    Abstract Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism. Myxedema coma has also been known to manifest in a number of unusual and dangerous forms. Here, we present the case of a woman we diagnosed with an uncharacteristic expression of myxedema coma and nonconvulsive seizure complicated by a right middle cerebral artery infarct.
    Language English
    Publishing date 2016-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2927720-6
    ISSN 2090-6439 ; 2090-6420
    ISSN (online) 2090-6439
    ISSN 2090-6420
    DOI 10.1155/2016/3438080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An Atypical Case of Myxedema Coma with Concomitant Nonconvulsive Seizure

    Pratik Patel / Mikhael Bekkerman / Cristina Varallo-Rodriguez / Rajendra Rampersaud

    Case Reports in Critical Care, Vol

    2016  Volume 2016

    Abstract: Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, ... ...

    Abstract Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism. Myxedema coma has also been known to manifest in a number of unusual and dangerous forms. Here, we present the case of a woman we diagnosed with an uncharacteristic expression of myxedema coma and nonconvulsive seizure complicated by a right middle cerebral artery infarct.
    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article: Endoscopic Management of Foreign Bodies in the Gastrointestinal Tract: A Review of the Literature.

    Bekkerman, Mikhael / Sachdev, Amit H / Andrade, Javier / Twersky, Yitzhak / Iqbal, Shahzad

    Gastroenterology research and practice

    2016  Volume 2016, Page(s) 8520767

    Abstract: Foreign body ingestion is a common diagnosis that presents in emergency departments throughout the world. Distinct foreign bodies predispose to particular locations of impaction in the gastrointestinal tract, commonly meat boluses in the esophagus above ... ...

    Abstract Foreign body ingestion is a common diagnosis that presents in emergency departments throughout the world. Distinct foreign bodies predispose to particular locations of impaction in the gastrointestinal tract, commonly meat boluses in the esophagus above a preexisting esophageal stricture or ring in adults and coins in children. Several other groups are at high risk of foreign body impaction, mentally handicapped individuals or those with psychiatric illness, abusers of drugs or alcohol, and the geriatric population. Patients with foreign body ingestion typically present with odynophagia, dysphagia, sensation of having an object stuck, chest pain, and nausea/vomiting. The majority of foreign bodies pass through the digestive system spontaneously without causing any harm, symptoms, or necessitating any further intervention. A well-documented clinical history and thorough physical exam is critical in making the diagnosis, if additional modalities are needed, a CT scan and diagnostic endoscopy are generally the preferred modalities. Various tools can be used to remove foreign bodies, and endoscopic treatment is safe and effective if performed by a skilled endoscopist.
    Language English
    Publishing date 2016-10-11
    Publishing country Egypt
    Document type Review ; Journal Article
    ZDB-ID 2435460-0
    ISSN 1687-630X ; 1687-6121
    ISSN (online) 1687-630X
    ISSN 1687-6121
    DOI 10.1155/2016/8520767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chemoreception regulates chemical access to mouse vomeronasal organ: role of solitary chemosensory cells.

    Ogura, Tatsuya / Krosnowski, Kurt / Zhang, Lana / Bekkerman, Mikhael / Lin, Weihong

    PloS one

    2010  Volume 5, Issue 7, Page(s) e11924

    Abstract: Controlling stimulus access to sensory organs allows animals to optimize sensory reception and prevent damage. The vomeronasal organ (VNO) detects pheromones and other semiochemicals to regulate innate social and sexual behaviors. This semiochemical ... ...

    Abstract Controlling stimulus access to sensory organs allows animals to optimize sensory reception and prevent damage. The vomeronasal organ (VNO) detects pheromones and other semiochemicals to regulate innate social and sexual behaviors. This semiochemical detection generally requires the VNO to draw in chemical fluids, such as bodily secretions, which are complex in composition and can be contaminated. Little is known about whether and how chemical constituents are monitored to regulate the fluid access to the VNO. Using transgenic mice and immunolabeling, we found that solitary chemosensory cells (SCCs) reside densely at the entrance duct of the VNO. In this region, most of the intraepithelial trigeminal fibers innervate the SCCs, indicating that SCCs relay sensory information onto the trigeminal fibers. These SCCs express transient receptor potential channel M5 (TRPM5) and the phospholipase C (PLC) beta2 signaling pathway. Additionally, the SCCs express choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) for synthesizing and packaging acetylcholine, a potential transmitter. In intracellular Ca2+ imaging, the SCCs responded to various chemical stimuli including high concentrations of odorants and bitter compounds. The responses were suppressed significantly by a PLC inhibitor, suggesting involvement of the PLC pathway. Further, we developed a quantitative dye assay to show that the amount of stimulus fluid that entered the VNOs of behaving mice is inversely correlated to the concentration of odorous and bitter substances in the fluid. Genetic knockout and pharmacological inhibition of TRPM5 resulted in larger amounts of bitter compounds entering the VNOs. Our data uncovered that chemoreception of fluid constituents regulates chemical access to the VNO and plays an important role in limiting the access of non-specific irritating and harmful substances. Our results also provide new insight into the emerging role of SCCs in chemoreception and regulation of physiological actions.
    MeSH term(s) Animals ; Cells, Cultured ; Chemoreceptor Cells/metabolism ; Chemoreceptor Cells/physiology ; Choline O-Acetyltransferase/metabolism ; Immunohistochemistry ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Phospholipase C beta/genetics ; Phospholipase C beta/metabolism ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; Vomeronasal Organ/cytology ; Vomeronasal Organ/metabolism
    Chemical Substances TRPM Cation Channels ; Trpm5 protein, mouse ; Choline O-Acetyltransferase (EC 2.3.1.6) ; Phospholipase C beta (EC 3.1.4.11) ; Plcb2 protein, mouse (EC 3.1.4.11)
    Language English
    Publishing date 2010-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, American Recovery and Reinvestment Act ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0011924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Chemoreception regulates chemical access to mouse vomeronasal organ

    Tatsuya Ogura / Kurt Krosnowski / Lana Zhang / Mikhael Bekkerman / Weihong Lin

    PLoS ONE, Vol 5, Iss 7, p e

    role of solitary chemosensory cells.

    2010  Volume 11924

    Abstract: Controlling stimulus access to sensory organs allows animals to optimize sensory reception and prevent damage. The vomeronasal organ (VNO) detects pheromones and other semiochemicals to regulate innate social and sexual behaviors. This semiochemical ... ...

    Abstract Controlling stimulus access to sensory organs allows animals to optimize sensory reception and prevent damage. The vomeronasal organ (VNO) detects pheromones and other semiochemicals to regulate innate social and sexual behaviors. This semiochemical detection generally requires the VNO to draw in chemical fluids, such as bodily secretions, which are complex in composition and can be contaminated. Little is known about whether and how chemical constituents are monitored to regulate the fluid access to the VNO. Using transgenic mice and immunolabeling, we found that solitary chemosensory cells (SCCs) reside densely at the entrance duct of the VNO. In this region, most of the intraepithelial trigeminal fibers innervate the SCCs, indicating that SCCs relay sensory information onto the trigeminal fibers. These SCCs express transient receptor potential channel M5 (TRPM5) and the phospholipase C (PLC) beta2 signaling pathway. Additionally, the SCCs express choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) for synthesizing and packaging acetylcholine, a potential transmitter. In intracellular Ca2+ imaging, the SCCs responded to various chemical stimuli including high concentrations of odorants and bitter compounds. The responses were suppressed significantly by a PLC inhibitor, suggesting involvement of the PLC pathway. Further, we developed a quantitative dye assay to show that the amount of stimulus fluid that entered the VNOs of behaving mice is inversely correlated to the concentration of odorous and bitter substances in the fluid. Genetic knockout and pharmacological inhibition of TRPM5 resulted in larger amounts of bitter compounds entering the VNOs. Our data uncovered that chemoreception of fluid constituents regulates chemical access to the VNO and plays an important role in limiting the access of non-specific irritating and harmful substances. Our results also provide new insight into the emerging role of SCCs in chemoreception and regulation of physiological actions.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2010-07-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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