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Article ; Conference proceedings: Metastatic Endometrial Carcinoma of the Paranasal Sinuses with Cribriform Plate Involvement: A Case Report

Kominsky, Evan / Filimonov, Ivan / Filimonov, Andrey / Spock, Todd

Journal of Neurological Surgery Part B: Skull Base

2022 Volume 83, Issue S 01

Event/congress	31st Annual Meeting North American Skull Base Society, Online, 2022-02-18
Language	English
Publishing date	2022-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0042-1743895
Database	Thieme publisher's database

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Article ; Online: Patterns in Pain and Opiate Use after Endoscopic Sinus Surgery.

Ndon, Sifon / Spock, Todd / Torabi, Sina J / Manes, R Peter

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2020 Volume 162, Issue 6, Page(s) 969–978

Abstract: Objective: To evaluate postoperative opiate use and patients' opinions regarding pain management after endoscopic sinus surgery (ESS).: Study design: Case series with planned data collection.: Setting: Tertiary referral medical center.: Subjects ...

Abstract	Objective: To evaluate postoperative opiate use and patients' opinions regarding pain management after endoscopic sinus surgery (ESS). Study design: Case series with planned data collection. Setting: Tertiary referral medical center. Subjects and methods: We prospectively evaluated postoperative opiate utilization in adults undergoing ESS over a 2-year period at an academic medical facility. Exclusion criteria included use of nasal packing, intracranial or orbital procedures, tumor surgery, and any use of endoscopic drills. All patients underwent bilateral maxillary antrostomy, total ethmoidectomy, sphenoidotomy, and frontal sinusotomy with or without septoplasty. Patients were discharged with 30 oxycodone-acetaminophen (5-325 mg) and a survey assessing pain and narcotic/nonnarcotic use on postoperative days 0 to 7. Results: A total of 64 patients completed surveys. Mean ± SD narcotic use over the 7-day postoperative period was 7.7 ± 7.6 pills. Patients with high narcotic use (>6 pills total) had no differences in demographic or surgical factors from those with low use (≤6 pills) but did report a higher level of postoperative day 1 pain (4.8 ± 1.1 vs 2.0 ± 1.4, Conclusion: Our results support reduced opiate prescription and encouragement of nonnarcotic use after ESS without compromising effective pain management.
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Endoscopy/methods ; Ethmoid Sinus/surgery ; Female ; Follow-Up Studies ; Frontal Sinus/surgery ; Humans ; Male ; Middle Aged ; Pain Management/methods ; Pain, Postoperative/diagnosis ; Pain, Postoperative/drug therapy ; Prescription Drugs/supply & distribution ; Prospective Studies
Chemical Substances	Analgesics, Opioid ; Prescription Drugs
Language	English
Publishing date	2020-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1177/0194599820915472
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Article ; Online: Endoscopic Muscle Repair of Right Internal Carotid Artery Rupture Following Endovascular Procedure.

Pathak, Shravani / Spock, Todd / Gray, Mingyang / Liu, Katherine / Shrivastava, Raj / Iloreta, Alfred

The Laryngoscope

2020 Volume 131, Issue 3, Page(s) E764–E766

Abstract: Carotid artery blowout syndrome (CBS) is a deadly complication usually linked to head and neck cancer therapy. We present a different etiology of endoscopic CBS, a complication of endovascular coiling of an intracranial aneurysm, treated with ... ...

Abstract	Carotid artery blowout syndrome (CBS) is a deadly complication usually linked to head and neck cancer therapy. We present a different etiology of endoscopic CBS, a complication of endovascular coiling of an intracranial aneurysm, treated with sternocleidomastoid (SCM) muscle graft packing. Case Presentation: An otherwise healthy 55-year-old female presented to the emergency room with right-sided painless vision loss of 23 days. Computed tomography angiography demonstrated a right ophthalmic ICA aneurysm eroding into the right sphenoid sinus with optic nerve compression. Attempted endovascular repair of the aneurysm was complicated by ICA rupture into the sphenoid. An endovascular balloon was inflated proximal to the aneurysm to reduce hemorrhage as ENT performed an endoscopic sphenoidotomy. A hematoma was seen overlying the aneurysm in the superior lateral sphenoid sinus. Layers of SCM muscle were morselized and packed serially. Post-repair angiography showed no further extravasation. Aggressive antiplatelet therapy was initiated. Packing was removed after 14 days. Twenty days postoperatively, the patient had profuse left-sided epistaxis requiring a left sphenopalatine artery ligation. The patient's vision recovered. Discussion: Whereas CBS is often managed by endovascular coil embolism, in our case CBS was caused by this very treatment itself. This case shows the use of SCM muscle graft as an effective repair modality of ICA rupture due to endovascular coiling. Laryngoscope, 131:E764-E766, 2021.
MeSH term(s)	Aneurysm, Ruptured/surgery ; Carotid Artery Injuries/etiology ; Carotid Artery Injuries/surgery ; Carotid Artery, Internal/surgery ; Endoscopy/methods ; Endovascular Procedures/adverse effects ; Female ; Humans ; Intracranial Aneurysm/surgery ; Medical Illustration ; Middle Aged ; Muscles/transplantation ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Rupture, Spontaneous/surgery ; Sphenoid Sinus/surgery ; Syndrome
Language	English
Publishing date	2020-08-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.28945
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Article: Multi-modality Treatment and Survival in Sinonasal Minor Salivary Gland Tumors.

Torabi, Sina J / Spock, Todd / Cardoso, Bruno / Chao, Janet / Manes, R Peter / Judson, Benjamin L

Journal of neurological surgery. Part B, Skull base

2019 Volume 81, Issue 2, Page(s) 198–205

Abstract: ... ...

Abstract	Objectives
Language	English
Publishing date	2019-04-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0039-1683437
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Article ; Online: Curcumin prevents the bile reflux-induced NF-κB-related mRNA oncogenic phenotype, in human hypopharyngeal cells.

Vageli, Dimitra P / Doukas, Sotirios G / Spock, Todd / Sasaki, Clarence T

Journal of cellular and molecular medicine

2018 Volume 22, Issue 9, Page(s) 4209–4220

Abstract: The presence of bile is not an uncommon finding in acidic oesophageal and extra-oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to neoplastic events. We recently demonstrated that acidic bile (pH ≤ 4.0) can induce NF-κB ... ...

Abstract	The presence of bile is not an uncommon finding in acidic oesophageal and extra-oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to neoplastic events. We recently demonstrated that acidic bile (pH ≤ 4.0) can induce NF-κB activation and oncogenic mRNA phenotype in normal hypopharyngeal cells and generate premalignant changes in treated hypopharyngeal mucosa. We hypothesize that curcumin, a dietary inhibitor of NF-κB, may effectively inhibit the acidic bile-induced cancer-related mRNA phenotype, in treated human hypopharyngeal primary cells (HHPC), supporting its potential preventive use in vivo. Luciferase assay, immunofluorescence, Western blot, qPCR and PCR microarray analysis were used to explore the effect of curcumin in HHPC exposed to bile (400 μmol/L) at acidic and neutral pH. Curcumin successfully inhibited the acidic bile-induced NF-κB signalling pathway (25% of analysed genes), and overexpression of NF-κB transcriptional factors, c-REL, RELA(p65), anti-apoptotic bcl-2, oncogenic TNF-α, EGFR, STAT3, WNT5A, ΔNp63 and cancer-related IL-6. Curcumin effectively reduced bile-induced bcl-2 overexpression at both acidic and neutral pH. Our novel findings suggest that, similar to pharmacologic NF-κB inhibitor, BAY 11-7082, curcumin can suppress acidic bile-induced oncogenic mRNA phenotype in hypopharyngeal cells, encouraging its future in vivo pre-clinical and clinical explorations in prevention of bile reflux-related pre-neoplastic events mediated by NF-κB.
MeSH term(s)	Anticarcinogenic Agents/pharmacology ; Bile/chemistry ; Bile Acids and Salts/antagonists & inhibitors ; Bile Acids and Salts/pharmacology ; Curcumin/pharmacology ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Gene Expression Regulation ; Humans ; Hydrogen-Ion Concentration ; Hypopharynx/cytology ; Hypopharynx/drug effects ; Hypopharynx/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Phenotype ; Primary Cell Culture ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-rel/genetics ; Proto-Oncogene Proteins c-rel/metabolism ; RNA, Messenger/antagonists & inhibitors ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Transcription Factor RelA/genetics ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Wnt-5a Protein/genetics ; Wnt-5a Protein/metabolism
Chemical Substances	Anticarcinogenic Agents ; BCL2 protein, human ; Bile Acids and Salts ; IL6 protein, human ; Interleukin-6 ; NF-kappa B ; Proto-Oncogene Proteins c-bcl-2 ; Proto-Oncogene Proteins c-rel ; RELA protein, human ; RNA, Messenger ; STAT3 Transcription Factor ; STAT3 protein, human ; Transcription Factor RelA ; Tumor Necrosis Factor-alpha ; WNT5A protein, human ; Wnt-5a Protein ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2018-06-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.13701
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Article ; Online: Omega-3 Fatty Acid Supplementation for the Treatment of Persistent COVID-Related Olfactory Dysfunction.

Lerner, David K / Garvey, Katherine L / Arrighi-Allisan, Annie / Kominsky, Evan / Filimonov, Andrey / Al-Awady, Abdurrahman / Filip, Peter / Liu, Katherine / Ninan, Sen / Spock, Todd / Tweel, Benjamin / van Gerwen, Maaike / Schaberg, Madeleine / Colley, Patrick / Del Signore, Anthony / Govindaraj, Satish / Iloreta, Alfred Marc

American journal of rhinology & allergy

2023 Volume 37, Issue 5, Page(s) 531–540

Abstract: Objective: To evaluate the efficacy of omega-3 fatty acid (O3FA) supplementation in the treatment of COVID-related olfactory dysfunction (OD).: Methods: Patients with laboratory-confirmed or clinically-suspected COVID-19 infection and new-onset OD ... ...

Abstract	Objective: To evaluate the efficacy of omega-3 fatty acid (O3FA) supplementation in the treatment of COVID-related olfactory dysfunction (OD). Methods: Patients with laboratory-confirmed or clinically-suspected COVID-19 infection and new-onset OD from August 2020 to November 2021 were prospectively recruited. Patients with quantitative OD, defined as a brief smell identification test (BSIT) score of 9 or less, were eligible for study inclusion. The experimental group received 2 g of O3FA supplementation, while the control group received an identical placebo to be taken daily for 6 weeks. The primary outcome was a change in BSIT score between the initial and 6-week follow-up tests. Results: One hundred and seventeen patients were included in the analysis, including 57 patients in the O3FA group and 60 in the placebo group. O3FA group patients demonstrated a mean BSIT improvement of 1.12 ± 1.99 compared to 0.68 ± 1.86 in the placebo group ( Conclusion: Among patients with persistent COVID-related OD, our study showed no clear evidence of relative short-term or long-term olfactory recovery among patients receiving high doses of O3FA supplementation.
MeSH term(s)	Humans ; Fatty Acids, Omega-3/therapeutic use ; Smell ; COVID-19/complications ; Olfaction Disorders/drug therapy ; Dietary Supplements
Chemical Substances	Fatty Acids, Omega-3
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2482804-X
ISSN	1945-8932 ; 1945-8924
ISSN (online)	1945-8932
ISSN	1945-8924
DOI	10.1177/19458924231174799
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Article ; Online: Clinically node-negative head and neck mucosal melanoma: An analysis of current treatment guidelines & outcomes.

Torabi, Sina J / Benchetrit, Liliya / Spock, Todd / Cheraghlou, Shayan / Judson, Benjamin L

Oral oncology

2019 Volume 92, Page(s) 67–76

Abstract: Objectives: To analyze head and neck mucosal melanoma (MM) treatment patterns, and their association with survival, relative to National Comprehensive Cancer Network (NCCN) guidelines.: Material & methods: Adult head and neck MM patients with ... ...

Abstract	Objectives: To analyze head and neck mucosal melanoma (MM) treatment patterns, and their association with survival, relative to National Comprehensive Cancer Network (NCCN) guidelines. Material & methods: Adult head and neck MM patients with clinically-staged T3/4aN0 disease were identified in a retrospective analysis of the National Cancer Database (2010-2014) and stratified into sinonasal cavity (SN) and oral cavity, oropharynx, larynx, or hypopharynx (non-SN) cohorts. Results: We identified 353 SN and 79 non-SN MM cases. The majority of patients were treated with surgery (SN: 92.4%; non-SN 84.8%), within NCCN guidelines. Treatment within the non-SN MM NCCN recommendation of elective neck dissection (END) was approximately 26.6%. END is not recommended for SN MM and was not performed in 91.5% of cases. Radiotherapy (RT) is recommended in both SN and non-SN MM and was utilized in 63.5% of SN patients and 46.8% of non-SN patients. END was not independently associated with OS compared to surgery alone (SN HR: 1.350 [95% CI: 0.733-2.485]; non-SN HR: 3.460 [95% CI: 0.912-13.125]). RT was independently associated with improved OS in SN MM cases (HR: 0.679 [95% CI: 0.479-0.963]), but not in non-SN MM cases (HR: 0.824 [95% CI: 0.331-2.051]). Conclusion: The majority of patients with head and neck MM are not treated within NCCN guidelines. The use of recommended END in non-SN patients is low. Similarly, adjuvant RT utilization is low. Our analysis shows that while greater use of RT may increase survival rates in this disease, the utility of END is unclear.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; Databases, Factual ; Disease Management ; Female ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/therapy ; Humans ; Kaplan-Meier Estimate ; Lymph Nodes/pathology ; Male ; Melanoma/diagnosis ; Melanoma/epidemiology ; Melanoma/therapy ; Middle Aged ; Mucous Membrane/pathology ; Neoplasm Staging ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Prognosis ; Proportional Hazards Models ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2019-03-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2019.03.017
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Seeking an optimal dose of preoperative corticosteroids in chronic rhinosinusitis with nasal polyposis: A randomized controlled trial.

Kominsky, Evan / Liu, Katherine Y / Ninan, Sen / Arrighi-Allisan, Annie / Filimonov, Andrey / Kidwai, Sarah / Morton, Kathryn / Saini, Alok T / Spock, Todd / Del Signore, Anthony / Govindaraj, Satish / Iloreta, Alfred Marc

American journal of otolaryngology

2022 Volume 43, Issue 4, Page(s) 103476

Abstract: Background: Preoperative corticosteroids have been shown to improve surgical visibility and intraoperative blood loss for chronic rhinosinusitis with nasal polyposis (CRSwNP) patients undergoing endoscopic sinus surgery (ESS). However, there is no ... ...

Abstract	Background: Preoperative corticosteroids have been shown to improve surgical visibility and intraoperative blood loss for chronic rhinosinusitis with nasal polyposis (CRSwNP) patients undergoing endoscopic sinus surgery (ESS). However, there is no consensus on the optimal dosing regimen. Methods: A randomized, controlled trial was conducted to compare low, medium, and high dose corticosteroids prior to ESS. Patients with CRSwNP refractory to medical management were randomized to low (N = 8), medium (N = 10), or high (N = 5) dosing regimens of corticosteroids prior to ESS. Baseline disease severity was measured with the 22-item Sino-nasal Outcome Test and Lund-Mackay scores. Modified Lund-Kennedy endoscopic scores (MLKES) were measured at baseline and after corticosteroid treatment. Intraoperative parameters were measured including Boezaart surgical visibility score, intraoperative blood loss, and operative time. Results: Medium dose corticosteroids demonstrated a superior surgical visibility score to low dose and comparable results to high dose, but these results were not significant (p = 0.33). No significant difference was observed between groups for total blood loss (p = 0.15), operative time (p = 0.87), or change in MLKES (p = 0.27). Conclusions: Current recommendations include the use of preoperative corticosteroids in patients with CRSwNP undergoing ESS, but there is no consensus on dose or duration. We did not find a statistically significant difference in surgical field visibility, intraoperative blood loss, or operative time between different dosing regimens. Further studies are needed to evaluate the efficacy of a low-dose preoperative regimen with the goal of reducing cumulative patient exposure to systemic corticosteroids.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Blood Loss, Surgical/prevention & control ; Chronic Disease ; Endoscopy/methods ; Humans ; Nasal Polyps/complications ; Nasal Polyps/drug therapy ; Nasal Polyps/surgery ; Rhinitis/complications ; Rhinitis/drug therapy ; Rhinitis/surgery ; Sinusitis/complications ; Sinusitis/drug therapy ; Sinusitis/surgery ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2022.103476
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Article: Transoral submandibular ganglion neurectomy: an anatomical feasibility study.

Spock, Todd / Hoffman, Henry T / Joshi, Arjun S

The Annals of otology, rhinology, and laryngology

2015 Volume 124, Issue 5, Page(s) 341–344

Abstract: Background: The management of sialorrhea can be difficult for both the patient and the clinician. Current management includes behavioral modification, anticholinergics, botulinum injections, and a variety of surgical options, which all have demonstrated ...

Abstract	Background: The management of sialorrhea can be difficult for both the patient and the clinician. Current management includes behavioral modification, anticholinergics, botulinum injections, and a variety of surgical options, which all have demonstrated some efficacy. As minimally invasive procedures flourish, we explore the feasibility of highly selective transoral submandibular neurectomy (TOSN) for the management of sialorrhea. Methods: Ten human cadaver dissections of the floor of mouth were performed bilaterally, for a total of 20 separate cases. An intraoral technique for highly selective, submandibular ganglion neurectomy is demonstrated. Results: A transoral submandibular ganglion neurectomy was performed in 10 cadavers (20 neurectomies) easily and reliably, without injury to the submandibular duct or the main trunk of the lingual nerve. Conclusion: Transoral submandibular neurectomy is an attractive addition to the armamentarium of surgical options for the treatment of medically intractable sialorrhea. Further study in selected patients would need to be performed to demonstrate clinical feasibility.
MeSH term(s)	Cadaver ; Feasibility Studies ; Ganglia, Parasympathetic/surgery ; Humans ; Lingual Nerve/surgery ; Mouth ; Natural Orifice Endoscopic Surgery/methods ; Parasympathectomy/methods ; Sialorrhea/surgery ; Submandibular Gland/innervation
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/0003489414557019
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Article ; Conference proceedings: Evaluation of Potential Nasoseptal Flap Size in Relationship to Flap Size Necessary for Frontal and Sphenoid Skull Base Reconstruction

Filimonov, Andrey / Lerner, David / Filip, Peter / Kong, Derek / Spock, Todd / Shrivastava, Raj / Iloreta, Alfred M.

Journal of Neurological Surgery Part B: Skull Base

2021 Volume 82, Issue S 02

Event/congress	Special Virtual Symposium of the North American Skull Base Society, Online, 2021-02-13
Language	English
Publishing date	2021-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0041-1725406
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