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  1. Article ; Online: Internal Carotid Artery Stenosis: A Surgical Mouse Model to Study Moyamoya Syndrome.

    Roberts, Jill M / Fraser, Justin F

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2616, Page(s) 47–54

    Abstract: Moyamoya is a cerebrovascular condition that predisposes affected patients to stroke and is characterized as the progressive stenosis of the internal carotid artery (ICA) and compensatory development of collaterals at the base of the brain. Patients with ...

    Abstract Moyamoya is a cerebrovascular condition that predisposes affected patients to stroke and is characterized as the progressive stenosis of the internal carotid artery (ICA) and compensatory development of collaterals at the base of the brain. Patients with moyamoya syndrome also present with comorbidities such as various autoimmune diseases and coagulopathies. We developed a surgical method using micro-coils to induce ICA-specific stenosis in mice, which induces moyamoya-like vasculopathies. An advantage of this surgical model of hypoperfusion is that it can be combined with other comorbid models to investigate pathologies associated with moyamoya syndrome.
    MeSH term(s) Mice ; Animals ; Moyamoya Disease/complications ; Moyamoya Disease/surgery ; Moyamoya Disease/pathology ; Carotid Stenosis/complications ; Carotid Stenosis/surgery ; Constriction, Pathologic/complications ; Brain/pathology ; Stroke ; Disease Models, Animal
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2926-0_6
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  2. Article ; Online: Decoding the data: a comment on the American Heart Association/American Stroke Association (AHA/ASA) 2023 Guideline for the Management of patients with Aneurysmal Subarachnoid Hemorrhage.

    Fraser, Justin F / Heit, Jeremy J / Mascitelli, Justin R / Tsai, Jenny P

    Journal of neurointerventional surgery

    2023  Volume 15, Issue 9, Page(s) 835–837

    MeSH term(s) Humans ; Subarachnoid Hemorrhage/diagnosis ; Subarachnoid Hemorrhage/therapy ; Subarachnoid Hemorrhage/complications ; American Heart Association ; Stroke/diagnosis ; Stroke/etiology ; Stroke/therapy ; Brain Ischemia/complications
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020675
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  3. Article ; Online: Has "Publish or Perish" Become "Publish and Payment"? Navigating Neurosurgical Research in an Innovative Industry.

    Fraser, Justin F

    World neurosurgery

    2017  Volume 104, Page(s) 987–989

    MeSH term(s) Creativity ; Humans ; Publishing ; Research
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2017.05.044
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  4. Article ; Online: Reverse Translation to Develop Post-stroke Therapeutic Interventions during Mechanical Thrombectomy: Lessons from the BACTRAC Trial.

    Maglinger, Benton / Frank, Jacqueline A / Fraser, Justin F / Pennypacker, Keith R

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2616, Page(s) 391–402

    Abstract: The majority of strokes, approximately 87%, are ischemic in etiology with the remaining hemorrhagic in origin. Emergent large vessel occlusions (ELVOs) are a subtype of ischemic stroke accounting for approximately 30-40% of acute large vessel blockages. ... ...

    Abstract The majority of strokes, approximately 87%, are ischemic in etiology with the remaining hemorrhagic in origin. Emergent large vessel occlusions (ELVOs) are a subtype of ischemic stroke accounting for approximately 30-40% of acute large vessel blockages. Treatment for ELVOs focuses on recanalization of the occluded vessel by time-sensitive administration of tissue plasminogen activator (tPA) or thrombus removal using mechanical thrombectomy. Although a great deal of time and resources have focused on translational stroke research, little progress has been made in the area of identifying additional new treatments for stroke. Translational limitations include difficulty simulating human comorbid conditions in animal models, as well as the temporal nature of stroke pathology. The Blood And Clot Thrombectomy Registry And Collaboration represents an ongoing tissue registry for thrombectomy patients and includes collection of intracranial arterial blood, systemic arterial blood, thrombi, as well as a series of clinical and radiographic data points for analysis. This chapter will explore the methodologies employed and results obtained from studying BACTRAC-derived human biological specimens and how they can inform translational experimental design in animal studies.
    MeSH term(s) Animals ; Humans ; Tissue Plasminogen Activator/therapeutic use ; Brain Ischemia/therapy ; Stroke/therapy ; Stroke/drug therapy ; Thrombectomy/adverse effects ; Thrombectomy/methods ; Thrombosis/etiology ; Thrombosis/therapy ; Treatment Outcome
    Chemical Substances Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2926-0_27
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  5. Article ; Online: Standardisation of research strategies in acute ischaemic stroke.

    Fraser, Justin F

    The Lancet. Neurology

    2016  Volume 15, Issue 8, Page(s) 784–785

    MeSH term(s) Brain Ischemia ; Humans ; Ischemia ; Research Design ; Stroke
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(16)30080-1
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  6. Article ; Online: Simultaneous transarterial and transvenous contrast injection to reveal the fistulous point in carotid cavernous fistula: illustrative case.

    Rupareliya, Chintan / Fraser, Justin F / Sheikhi, Lila

    Journal of neurosurgery. Case lessons

    2022  Volume 3, Issue 8

    Abstract: Background: Access of the cavernous sinus (CS) via venous route from the inferior petrosal sinus (IPS) can sometimes be challenging during the treatment of carotid cavernous fistulas (CCF), largely because of anatomical variations, tortuosity, and/or ... ...

    Abstract Background: Access of the cavernous sinus (CS) via venous route from the inferior petrosal sinus (IPS) can sometimes be challenging during the treatment of carotid cavernous fistulas (CCF), largely because of anatomical variations, tortuosity, and/or difficult visualization of IPS given high retrograde flow through the fistulous connection.
    Observations: A 58-year-old male was transferred to our university hospital center after suspected diagnosis of CCF at another hospital by head computerized tomography-angiogram. His symptoms included three weeks of right eye pain that was later complicated by redness, diplopia, and blurry vision. In a diagnostic angiogram, separate contrast injections from the arterial side via internal carotid artery (ICA) and from the venous side via IPS did not reveal a connection point. Injecting contrast simultaneously from both arterial and venous ends resulted in visualization of a connection point allowing entry into the CS.
    Lessons: Technique of simultaneous contrast injection from ICA and internal jugular vein is comparatively simple and saves an operator prolonged time and complexity of approach. In our case, it revealed fistulous point allowing navigation and completing the coiling.
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE21456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In Reply to "Brain Infarct and Abscess-A Very Common Disease and a Rare Association".

    Fraser, Justin F

    World neurosurgery

    2016  Volume 93, Page(s) 477

    MeSH term(s) Brain ; Brain Abscess ; Brain Infarction ; Humans
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2016.06.083
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  8. Article ; Online: Now that the door is open: an update on ischemic stroke pharmacotherapeutics for the neurointerventionalist.

    Fraser, Justin F / Pahwa, Shivani / Maniskas, Michael / Michas, Christopher / Martinez, Mesha / Pennypacker, Keith R / Dornbos, David

    Journal of neurointerventional surgery

    2024  Volume 16, Issue 4, Page(s) 425–428

    Abstract: The last 10 years have seen a major shift in management of large vessel ischemic stroke with changes towards ever-expanding use of reperfusion therapies (intravenous thrombolysis and mechanical thrombectomy). These strategies 'open the door' to acute ... ...

    Abstract The last 10 years have seen a major shift in management of large vessel ischemic stroke with changes towards ever-expanding use of reperfusion therapies (intravenous thrombolysis and mechanical thrombectomy). These strategies 'open the door' to acute therapeutics for ischemic tissue, and we should investigate novel therapeutic approaches to enhance survival of recently reperfused brain. Key insights into new approaches have been provided through translational research models and preclinical paradigms, and through detailed research on ischemic mechanisms. Additional recent clinical trials offer exciting salvos into this new strategy of pairing reperfusion with neuroprotective therapy. This pairing strategy can be employed using drugs that have shown neuroprotective efficacy; neurointerventionalists can administer these during or immediately after reperfusion therapy. This represents a crucial moment when we emphasize reperfusion, and have the technological capability along with the clinical trial experience to lead the way in multiprong approaches to stroke treatment.
    MeSH term(s) Humans ; Ischemic Stroke/drug therapy ; Brain Ischemia/drug therapy ; Stroke/drug therapy ; Thrombolytic Therapy ; Thrombectomy ; Treatment Outcome ; Fibrinolytic Agents/therapeutic use
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2022-019293
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  9. Article ; Online: Use of Artemis Neuro Evacuation Device in Resection of Pituitary Adenoma: Initial Technical Note.

    Yu, Qian / Fraser, Justin F

    World neurosurgery

    2019  Volume 126, Page(s) 37–40

    Abstract: Background: Endoscopic transsphenoidal resection has become the primary approach for resection of pituitary macroadenomas. However, challenges such as narrow sinuses, dense tumor consistency, and invasion of surrounding structures exist.: Methods: We ...

    Abstract Background: Endoscopic transsphenoidal resection has become the primary approach for resection of pituitary macroadenomas. However, challenges such as narrow sinuses, dense tumor consistency, and invasion of surrounding structures exist.
    Methods: We report a case in which the Artemis Neuro Evacuation device was used to endonasally remove a pituitary macroadenoma with suprasellar and parasellar extensions. The methodology and technical aspects of this device's novel use are illustrated.
    Results: The long and narrow wand of the Artemis system allowed the operators to navigate through patient's narrow sinuses. Despite a dense tumor that did not come easily into a suction, the entire tumor debulking procedure lasted <10 minutes with the preservation of an intact arachnoid membrane using the Artemis. No perioperative complication was encountered, and the patient's neurologic deficits resolved.
    Conclusions: To the authors' knowledge, this represents the first reported case of the Artemis system's utility in the treatment of pituitary tumor beyond cranial hematoma and hemorrhage.
    MeSH term(s) Adenoma/diagnostic imaging ; Adenoma/surgery ; Cytoreduction Surgical Procedures/methods ; Endoscopy/instrumentation ; Endoscopy/methods ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Neoplasm, Residual/surgery ; Neuronavigation ; Neurosurgical Procedures/instrumentation ; Neurosurgical Procedures/methods ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/surgery ; Retrospective Studies ; Sphenoid Bone/surgery ; Treatment Outcome
    Language English
    Publishing date 2019-03-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2019.02.113
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  10. Article ; Online: 16886 Moyamoya-Like Vasculopathies Observed In a Novel Mouse Surgical Model

    Justin F. Fraser / Laura Whitnel / Jill Roberts

    Journal of Clinical and Translational Science, Vol 5, Pp 21-

    2021  Volume 21

    Abstract: ABSTRACT IMPACT: Development of our animal model of moyamoya will provide a meaningful assessment of therapeutic efficacy of interventions applicable to the clinical setting. OBJECTIVES/GOALS: Moyamoya is a cerebrovascular condition with progressive ... ...

    Abstract ABSTRACT IMPACT: Development of our animal model of moyamoya will provide a meaningful assessment of therapeutic efficacy of interventions applicable to the clinical setting. OBJECTIVES/GOALS: Moyamoya is a cerebrovascular condition with progressive stenosis of the internal carotid arteries (ICA) and formation of abnormal vascular collaterals at the base of the brain, all of which result in ischemic and hemorrhagic strokes. We aim to develop a needed animal model of this condition in order to develop new therapeutics. METHODS/STUDY POPULATION: Male and female C57Bl/6J mice (4 months old) underwent surgery for the unilateral placement of a microcoil (0.16 mm ID) onto the proximal ICA or sham control. After 30 and 60 days (N = 6-8/time point), the brain blood vessels were examined for changes in diameter, number of anastomoses, and development of new collaterals using DiI stain. Brain tissue was examined for micro-hemorrhages using Prussian blue stain, and cross-sections of blood vessels were examined for intimal thickening using H&E and smooth muscle actin. Expression of vascular endothelial growth factor (VEGF), which is associated with angiogenesis and moyamoya syndrome, was quantified by qPCR. Blood samples were also analyzed for inflammatory biomarkers using ELISA. RESULTS/ANTICIPATED RESULTS: Within 30 days, the distal ICA and anterior cerebral artery (ACA) had significantly decreased diameters at the Circle of Willis, with an initial decrease in the number of cortical anastomoses. Histology demonstrated smaller lumen diameter and alterations to in the various layers of the blood vessels, indicating intimal thickening and stenosis of the affected blood vessels. There was also a significant increase in the number of intracranial micro-bleeds, suggesting a compromised vascular integrity. This may be due, in part, to a significant upregulation in VEGF gene expression within the striatum, a region of hemorrhagic occurrence in moyamoya patients. DISCUSSION/SIGNIFICANCE OF FINDINGS: We report the development ...
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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