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  1. Article ; Online: Current status of endoscopic ultrasound guided ablation techniques.

    Chennat, Jennifer

    Gastroenterology

    2011  Volume 140, Issue 5, Page(s) 1403–1409

    MeSH term(s) Animals ; Catheter Ablation/methods ; Endosonography ; Humans ; Neoplasms/diagnostic imaging ; Neoplasms/surgery ; Reproducibility of Results
    Language English
    Publishing date 2011-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2011.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Benefits and risks of exercise on the gastrointestinal system.

    Chennat, Jennifer

    Southern medical journal

    2011  Volume 104, Issue 12, Page(s) 838

    MeSH term(s) Gastrointestinal Diseases/prevention & control ; Gastrointestinal Tract/physiology ; Humans ; Motor Activity/physiology
    Language English
    Publishing date 2011-12
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.1097/SMJ.0b013e318236c28d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A B-wildering Case of Recurrent Acute Pancreatitis.

    Umapathy, Chandraprakash / Gajendran, Mahesh / Chennat, Jennifer S

    Gastroenterology

    2015  Volume 149, Issue 1, Page(s) e9–e11

    MeSH term(s) Acute Disease ; Humans ; Laparoscopy ; Lymphoma/complications ; Lymphoma/diagnosis ; Lymphoma/pathology ; Male ; Middle Aged ; Pancreatitis/etiology ; Pancreatitis/pathology
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2014.12.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Use of p53 immunohistochemistry in conjunction with routine histology improves risk stratification of patients with Barrett's oesophagus during routine clinical care.

    Tokuyama, Minami / Geisler, Daniel / Deitrick, Christopher / Fasanella, Kenneth E / Chennat, Jennifer S / McGrath, Kevin M / Pai, Reetesh K / Davison, Jon M

    Histopathology

    2020  Volume 77, Issue 3, Page(s) 481–491

    Abstract: Aims: Abnormal p53 protein expression detected by immunohistochemistry (IHC) in Barrett's oesophagus (BO) is reported to be a prognostic biomarker for progression to high-grade dysplasia (HGD) or oesophageal adenocarcinoma (OAC). We evaluated our use of ...

    Abstract Aims: Abnormal p53 protein expression detected by immunohistochemistry (IHC) in Barrett's oesophagus (BO) is reported to be a prognostic biomarker for progression to high-grade dysplasia (HGD) or oesophageal adenocarcinoma (OAC). We evaluated our use of p53 IHC for patients with BO under surveillance from 2010 to 2016 in a single academic institution.
    Methods and results: We identified 78 patients under surveillance for BO who had biopsies evaluated for abnormal p53 expression in conjunction with routine histology and 892 patients who had histological evaluation alone. All available p53 IHC slides were rescored as wild-type or abnormal. We evaluated the risk of subsequent diagnosis with HGD and OAC. p53-tested patients were significantly more likely to be diagnosed with indefinite dysplasia (IND) or low-grade dysplasia (LGD), compared to patients who were not tested (79.5 versus 10.8%, P = 7.4 × 10
    Conclusion: In patients under surveillance for BO in a single academic institution, we found evidence that selective use of p53 IHC in conjunction with routine histology modestly improved risk stratification by identifying patients with IND at higher risk of a subsequent diagnosis of HGD or OAC.
    Language English
    Publishing date 2020-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparison of endoscopic and surgical resection of intramucosal carcinoma in Barrett's esophagus.

    Leung, Wesley D / Chennat, Jennifer

    Expert review of gastroenterology & hepatology

    2011  Volume 5, Issue 5, Page(s) 575–578

    Abstract: The optimal management of intramucosal carcinoma in Barrett's esophagus continues to be controversial. To date, there has not been a lot of research directly comparing endoscopic versus surgical management of intramucosal carcinoma. Previous studies have ...

    Abstract The optimal management of intramucosal carcinoma in Barrett's esophagus continues to be controversial. To date, there has not been a lot of research directly comparing endoscopic versus surgical management of intramucosal carcinoma. Previous studies have shown that both modalities to have excellent outcomes. The reviewed article is a matched retrospective cohort study from two high-volume centers, which shows both modalities to be effective, but an associated higher morbidity rate and risk for procedure-related mortality in the surgical group, and higher recurrence rate in the endoscopic therapy group. The study is discussed in the context of the current state of knowledge regarding Barrett's esophagus and intramucosal carcinoma, in particular outcomes and limitations of the present study.
    Language English
    Publishing date 2011-10
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1586/egh.11.65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Endoscopic interventions in Barrett's esophagus: Do the dollars make sense?

    Chennat, Jennifer / Ferguson, Mark K

    Gastrointestinal endoscopy clinics of North America

    2011  Volume 21, Issue 1, Page(s) 145–153

    Abstract: Advances in the development of endoscopic therapies for Barrett's esophagus have resulted in the emergence of an important paradigm shift for management of early neoplasia and represent an opportunity to alter the natural history of the disease. Clinical ...

    Abstract Advances in the development of endoscopic therapies for Barrett's esophagus have resulted in the emergence of an important paradigm shift for management of early neoplasia and represent an opportunity to alter the natural history of the disease. Clinical incorporation of these endoscopic modalities may have significant implications for disease management and health care delivery from a cost perspective. This article reviews the current literature on the cost analyses of commonly used Barrett endoscopic interventions and summarizes the overall cost-effectiveness of these treatments as compared with surveillance or surgery.
    MeSH term(s) Barrett Esophagus/economics ; Barrett Esophagus/therapy ; Esophagoscopy/economics ; Esophagoscopy/methods ; Humans ; Precancerous Conditions/economics ; Precancerous Conditions/therapy ; Quality of Life ; Quality-Adjusted Life Years
    Language English
    Publishing date 2011-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1313994-0
    ISSN 1558-1950 ; 1052-5157
    ISSN (online) 1558-1950
    ISSN 1052-5157
    DOI 10.1016/j.giec.2010.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pathologic Complete Response in a Large Gastric GIST: Using Molecular Markers to Achieve Maximal Response to Neoadjuvant Imatinib.

    Brown, Joshua B / Pai, Reetesh K / Burgess, Melissa A / Chennat, Jennifer / Zureikat, Amer H

    Journal of the National Comprehensive Cancer Network : JNCCN

    2018  Volume 16, Issue 12, Page(s) 1424–1428

    Abstract: Gastrointestinal stromal tumors (GISTs) represent 1% of alimentary tract neoplasms. Up to 90% of GISTs are driven by activating mutations in tyrosine ... ...

    Abstract Gastrointestinal stromal tumors (GISTs) represent 1% of alimentary tract neoplasms. Up to 90% of GISTs are driven by activating mutations in tyrosine kinase
    MeSH term(s) Aged ; Biomarkers, Tumor/genetics ; Biopsy ; Female ; Gastrectomy ; Gastrointestinal Stromal Tumors/diagnostic imaging ; Gastrointestinal Stromal Tumors/genetics ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/therapy ; Humans ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Mutation ; Neoadjuvant Therapy/methods ; Positron Emission Tomography Computed Tomography ; Prognosis ; Proto-Oncogene Proteins c-kit/genetics ; Stomach/diagnostic imaging ; Stomach/pathology ; Stomach/surgery ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/genetics ; Stomach Neoplasms/therapy ; Treatment Outcome
    Chemical Substances Biomarkers, Tumor ; Imatinib Mesylate (8A1O1M485B) ; KIT protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2018-12-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2018.7063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A rare cause of chronic diarrhea and weight loss.

    Proksell, Siobhan / Chennat, Jennifer / Hashash, Jana G

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2014  Volume 12, Issue 8, Page(s) A21–2

    MeSH term(s) Aged ; Diarrhea/complications ; Diarrhea/etiology ; Diarrhea/pathology ; Female ; Humans ; Pancreatic Diseases/complications ; Pancreatic Diseases/diagnosis ; Pancreatic Diseases/pathology ; Pelvis/diagnostic imaging ; Radiography, Abdominal ; Tomography, X-Ray Computed ; Weight Loss
    Language English
    Publishing date 2014-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2013.12.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Endoscopic treatment of Barrett’s esophagus

    Jennifer Chennat, Irving Waxman

    World Journal of Gastroenterology, Vol 16, Iss 30, Pp 3780-

    From metaplasia to intramucosal carcinoma

    2010  Volume 3785

    Abstract: The annual incidence of adenocarcinoma arising from Barrett’s esophagus (BE) is approximately 0.5%. Through a process of gradual transformation from low-grade dysplasia to high-grade dysplasia (HGD), adenocarcinoma can develop in the setting of BE. The ... ...

    Abstract The annual incidence of adenocarcinoma arising from Barrett’s esophagus (BE) is approximately 0.5%. Through a process of gradual transformation from low-grade dysplasia to high-grade dysplasia (HGD), adenocarcinoma can develop in the setting of BE. The clinical importance of appropriate identification and treatment of BE in its various stages, from intestinal metaplasia to intramucosal carcinoma (IMC) hinges on the dramatically different prognostic status between early neoplasia and more advanced stages. Once a patient has symptoms of adenocarcinoma, there is usually locally advanced disease with an approximate 5-year survival rate of about 20%. Esophagectomy has been the gold standard treatment for BE with HGD, due to the suspected risk of harboring occult invasive carcinoma, which was traditionally estimated to be as high as 40%. In recent years, the paradigm of BE early neoplasia management has recently evolved, and endoscopic therapies (endoscopic mucosal resection, radiofrequency ablation, and cryotherapy) have entered the clinical forefront as acceptable non-surgical alternatives for HGD and IMC. The goal of endoscopic therapy for HGD or IMC is to ablate all BE epithelium (both dysplastic and non-dysplastic) due to risk of synchronous/metachronous lesion development in the remaining BE segment.
    Keywords Barrett’s esophagus ; High-grade dysplasia ; Intramucosal carcinoma ; Esophagectomy ; Endoscopic mucosal resection ; Radiofrequency ablation ; Cryotherapy ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2010-08-01T00:00:00Z
    Publisher Baishideng Publishing Group Co. Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Endoscopic treatment of Barrett's esophagus: From metaplasia to intramucosal carcinoma.

    Chennat, Jennifer / Waxman, Irving

    World journal of gastroenterology

    2010  Volume 16, Issue 30, Page(s) 3780–3785

    Abstract: The annual incidence of adenocarcinoma arising from Barrett's esophagus (BE) is approximately 0.5%. Through a process of gradual transformation from low-grade dysplasia to high-grade dysplasia (HGD), adenocarcinoma can develop in the setting of BE. The ... ...

    Abstract The annual incidence of adenocarcinoma arising from Barrett's esophagus (BE) is approximately 0.5%. Through a process of gradual transformation from low-grade dysplasia to high-grade dysplasia (HGD), adenocarcinoma can develop in the setting of BE. The clinical importance of appropriate identification and treatment of BE in its various stages, from intestinal metaplasia to intramucosal carcinoma (IMC) hinges on the dramatically different prognostic status between early neoplasia and more advanced stages. Once a patient has symptoms of adenocarcinoma, there is usually locally advanced disease with an approximate 5-year survival rate of about 20%. Esophagectomy has been the gold standard treatment for BE with HGD, due to the suspected risk of harboring occult invasive carcinoma, which was traditionally estimated to be as high as 40%. In recent years, the paradigm of BE early neoplasia management has recently evolved, and endoscopic therapies (endoscopic mucosal resection, radiofrequency ablation, and cryotherapy) have entered the clinical forefront as acceptable non-surgical alternatives for HGD and IMC. The goal of endoscopic therapy for HGD or IMC is to ablate all BE epithelium (both dysplastic and non-dysplastic) due to risk of synchronous/metachronous lesion development in the remaining BE segment.
    MeSH term(s) Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Barrett Esophagus/pathology ; Barrett Esophagus/surgery ; Catheter Ablation ; Cryosurgery ; Disease Progression ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophagoscopy/methods ; Esophagus/pathology ; Esophagus/surgery ; Humans ; Metaplasia ; Mucous Membrane/pathology ; Mucous Membrane/surgery ; Photochemotherapy ; Precancerous Conditions/pathology ; Precancerous Conditions/surgery ; Treatment Outcome
    Language English
    Publishing date 2010-08-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v16.i30.3780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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