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  1. Book ; Online: Application of Antigen Cross-Presentation Research into Patient Care

    Boes, Marianne

    2017  

    Abstract: The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to ... ...

    Abstract The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view
    Keywords Immunologic diseases. Allergy ; Medicine (General)
    Size 1 electronic resource (124 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020095898
    ISBN 9782889451913 ; 2889451917
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Role of Metabolism in Regulating Immune Cell Fate Decisions

    Ohradanova-Repic, Anna / Boes, Marianne / Stockinger, Hannes

    2020  

    Keywords Medicine ; Immunology ; immunometabolism ; metabolic reprogramming ; immune cell regulation ; cell fate decisions ; T cells ; myeloid cells ; innate lymphoid cells
    Size 1 electronic resource (224 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230776
    ISBN 9782889637218 ; 2889637212
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune system.

    Boes, Marianne / Falter-Braun, Pascal

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 460

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; Immunity, Innate ; Chronic Disease ; Immune System
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01717-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cancer immunotherapy: Moving beyond checkpoint inhibition.

    Boes, Marianne

    Oncotarget

    2018  Volume 9, Issue 93, Page(s) 36545–36546

    Language English
    Publishing date 2018-11-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Long-COVID-19

    Marianne Boes / Pascal Falter-Braun

    Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

    the persisting imprint of SARS-CoV-2 infections on the innate immune system

    2023  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Correction: MHC II-EGFP Knock-in Mouse Model.

    Pačes, Jan / Grobárová, Valéria / Zadražil, Zdeněk / Knížková, Karolina / Malinská, Nikola / Tušková, Liliana / Boes, Marianne / Černý, Jan

    Current protocols

    2024  Volume 4, Issue 4, Page(s) e1050

    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Published Erratum
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.1050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Harnessing immunometabolism for cardiovascular health and cancer therapy.

    Markovska, Angela / Schipper, Henk S / Boes, Marianne

    Immunotherapy advances

    2021  Volume 1, Issue 1, Page(s) ltab021

    Language English
    Publishing date 2021-11-09
    Publishing country England
    Document type Editorial
    ISSN 2732-4303
    ISSN (online) 2732-4303
    DOI 10.1093/immadv/ltab021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Advanced omics techniques shed light on CD1d-mediated lipid antigen presentation to iNKT cells.

    Morris, Imogen / Croes, Cresci-Anne / Boes, Marianne / Kalkhoven, Eric

    Biochimica et biophysica acta. Molecular and cell biology of lipids

    2023  Volume 1868, Issue 5, Page(s) 159292

    Abstract: Invariant natural killer T cells (iNKT cells) can be activated through binding antigenic lipid/CD1d complexes to their TCR. Antigenic lipids are processed, loaded, and displayed in complex with CD1d by lipid antigen presenting cells (LAPCs). The ... ...

    Abstract Invariant natural killer T cells (iNKT cells) can be activated through binding antigenic lipid/CD1d complexes to their TCR. Antigenic lipids are processed, loaded, and displayed in complex with CD1d by lipid antigen presenting cells (LAPCs). The mechanism of lipid antigen presentation via CD1d is highly conserved with recent work showing adipocytes are LAPCs that, besides having a role in lipid storage, can activate iNKT cells and play an important role in systemic metabolic disease. Recent studies shed light on parameters potentially dictating cytokine output and how obesity-associated metabolic disease may affect such parameters. By following a lipid antigen's journey, we identify five key areas which may dictate cytokine skew: co-stimulation, structural properties of the lipid antigen, stability of lipid antigen/CD1d complexes, intracellular and extracellular pH, and intracellular and extracellular lipid environment. Recent publications indicate that the combination of advanced omics-type approaches and machine learning may be a fruitful way to interconnect these 5 areas, with the ultimate goal to provide new insights for therapeutic exploration.
    MeSH term(s) Adipocytes/metabolism ; Antigen Presentation ; Cytokines/metabolism ; Lipids ; Natural Killer T-Cells/metabolism ; Antigens, CD1d/metabolism
    Chemical Substances Cytokines ; Lipids ; Antigens, CD1d
    Language English
    Publishing date 2023-02-09
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbalip.2023.159292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: No immunological changes after factor VIII product switch: An in depth analysis in haemophilia A patients.

    Schep, Sarah J / Fischer, Kathelijn / Boes, Marianne / Schutgens, Roger E G

    Haemophilia : the official journal of the World Federation of Hemophilia

    2023  Volume 29, Issue 4, Page(s) 1039–1048

    Abstract: Background: A challenging complication in the treatment of haemophilia A is the formation of neutralizing anti-FVIII antibodies (inhibitors). There is ongoing debate on the effect of FVIII product and inhibitor risk, rendering patients and physicians ... ...

    Abstract Background: A challenging complication in the treatment of haemophilia A is the formation of neutralizing anti-FVIII antibodies (inhibitors). There is ongoing debate on the effect of FVIII product and inhibitor risk, rendering patients and physicians reluctant to switch FVIII-products.
    Aim: This study aimed to evaluate changes in the immune profile of haemophilia A patients after switching FVIII products and their possible relation to inhibitor development. Secondary, FVIII efficacy after switching were assessed.
    Methods: Patients, who switched FVIII-products between 2017-2019, were included in this single centre cohort study. Prospective comparison of immunoregulatory cells and markers by flow-cytometry before and after the switch was performed in a subgroup. For the total cohort clinical data regarding inhibitor development and FVIII efficacy 1 year before and after switching were retrospectively collected.
    Results: One-hundred patients (including 39 with prospective immunological assessment) were analyzed, of which 31% switched from plasma-derived (pdFVIII) to recombinant standard half-life FVIII (SHL-rFVIII), 47% between different SHL-rFVIII, and 22% from pdFVIII/SHL-rFVIII to rFVIII-Fc. No remarkable changes in immunoregulatory cell functions were observed after switching, regardless the type of switch. None of the patients developed an inhibitor. FVIII efficacy, that is, FVIII usage, half-life and annual bleeding rate (ABR), was similar before and after switch for the SHL products, whereas rFVIII-Fc associated with a longer half-life (13.1 vs. 15.0 h) and lower ABR (3.0 vs. 1.0).
    Conclusions: Switching to a different FVIII product was not associated with inhibitor development, nor with differences in the immune profile. Switching to rFVIII-Fc lead to lower ABR.
    MeSH term(s) Humans ; Factor VIII/therapeutic use ; Hemophilia A/drug therapy ; Cohort Studies ; Retrospective Studies ; Hemorrhage/drug therapy ; Hemostatics/therapeutic use ; Half-Life ; Antibodies, Neutralizing ; Recombinant Proteins/therapeutic use
    Chemical Substances Factor VIII (9001-27-8) ; Hemostatics ; Antibodies, Neutralizing ; Recombinant Proteins
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4249: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 450: Show issues

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  10. Article ; Online: Editorial: Role of Metabolism in Regulating Immune Cell Fate Decisions.

    Ohradanova-Repic, Anna / Boes, Marianne / Stockinger, Hannes

    Frontiers in immunology

    2020  Volume 11, Page(s) 527

    MeSH term(s) Animals ; Energy Metabolism ; Humans ; Immunity/physiology ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Metabolic Networks and Pathways/physiology ; Mice ; Myeloid Cells/immunology ; Myeloid Cells/metabolism
    Language English
    Publishing date 2020-03-24
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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