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  1. Article ; Online: Are We Ready for Biomarker-Guided Immune Modulation in Critical Care?

    Leligdowicz, Aleksandra

    Critical care medicine

    2023  Volume 51, Issue 12, Page(s) 1827–1829

    MeSH term(s) Humans ; Biomarkers ; Critical Care
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
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  2. Article ; Online: The Challenge and the Promise of Identifying More Homogeneous Subgroups in Acute Respiratory Distress Syndrome.

    Leligdowicz, Aleksandra

    Critical care medicine

    2019  Volume 47, Issue 12, Page(s) 1806–1808

    MeSH term(s) Humans ; Prognosis ; Respiratory Distress Syndrome, Adult ; Severity of Illness Index
    Language English
    Publishing date 2019-11-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gaps and opportunities in sepsis translational research.

    Marshall, John C / Leligdowicz, Aleksandra

    EBioMedicine

    2022  Volume 86, Page(s) 104387

    Abstract: Infection initiates sepsis, but the clinical disease arises through the innate immune response of the host. A rapidly evolving understanding of the biology of that response has not been paralleled by the development of successful new treatment. The COVID- ...

    Abstract Infection initiates sepsis, but the clinical disease arises through the innate immune response of the host. A rapidly evolving understanding of the biology of that response has not been paralleled by the development of successful new treatment. The COVID-19 pandemic has begun to change this revealing the promise of distinct therapeutic approaches and the feasibility of new approaches to evaluate them. We review the history of mediator-targeted therapy for sepsis and explore the conceptual, biological, technological, and organizational challenges that must be addressed to enable the development of effective treatments for a leading cause of global morbidity and mortality.
    MeSH term(s) Humans ; Translational Research, Biomedical ; Pandemics ; COVID-19/complications ; Sepsis/diagnosis ; Sepsis/therapy ; Sepsis/etiology ; Immunity, Innate
    Language English
    Publishing date 2022-12-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Circulating protein and lipid markers of early sepsis diagnosis and prognosis: a scoping review.

    Barber, Gemma / Tanic, Jelena / Leligdowicz, Aleksandra

    Current opinion in lipidology

    2023  Volume 34, Issue 2, Page(s) 70–81

    Abstract: Purpose of review: Sepsis is the extreme response to infection associated with high mortality, yet reliable biomarkers for its identification and stratification are lacking.: Recent findings: Our scoping review of studies published from January 2017 ... ...

    Abstract Purpose of review: Sepsis is the extreme response to infection associated with high mortality, yet reliable biomarkers for its identification and stratification are lacking.
    Recent findings: Our scoping review of studies published from January 2017 to September 2022 that investigated circulating protein and lipid markers to inform non-COVID-19 sepsis diagnosis and prognosis identified interleukin (IL)-6, IL-8, heparin-binding protein (HBP), and angiopoietin-2 as having the most evidence. Biomarkers can be grouped according to sepsis pathobiology to inform biological data interpretation and four such physiologic processes include: immune regulation, endothelial injury and coagulopathy, cellular injury, and organ injury. Relative to proteins, the pleiotropic effects of lipid species' render their categorization more difficult. Circulating lipids are relatively less well studied in sepsis, however, low high-density lipoprotein (HDL) is associated with poor outcome.
    Summary: There is a lack of robust, large, and multicenter studies to support the routine use of circulating proteins and lipids for sepsis diagnosis or prognosis. Future studies will benefit from standardizing cohort design as well as analytical and reporting strategies. Incorporating biomarker dynamic changes and clinical data in statistical modeling may improve specificity for sepsis diagnosis and prognosis. To guide future clinical decisions at the bedside, point-of-care circulating biomarker quantification is needed.
    MeSH term(s) Humans ; Sepsis/diagnosis ; Lipoproteins, HDL ; Lipoproteins, LDL
    Chemical Substances Lipoproteins, HDL ; Lipoproteins, LDL
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1045394-5
    ISSN 1473-6535 ; 0957-9672
    ISSN (online) 1473-6535
    ISSN 0957-9672
    DOI 10.1097/MOL.0000000000000870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3010: Show issues Location:
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  5. Article ; Online: Carbonic Anhydrase IX: Scaring Away the Grim Reaper in Acute Lung Injury?

    Leligdowicz, Aleksandra / Matthay, Michael A

    American journal of respiratory cell and molecular biology

    2021  Volume 65, Issue 6, Page(s) 573–575

    MeSH term(s) Acute Lung Injury ; Carbonic Anhydrase IX ; Carbonic Anhydrase Inhibitors ; Carbonic Anhydrases ; Humans
    Chemical Substances Carbonic Anhydrase Inhibitors ; Carbonic Anhydrase IX (EC 4.2.1.1) ; Carbonic Anhydrases (EC 4.2.1.1)
    Language English
    Publishing date 2021-09-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2021-0310ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2851: Show issues Location:
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  6. Article ; Online: An Evaluation of Human Immunodeficiency Virus Pathogenicity and Treatment Using Glycobiology

    Aleksandra M. Leligdowicz

    McGill Journal of Medicine, Vol 7, Iss

    2020  Volume 2

    Abstract: ... N/ ... ...

    Abstract N/A
    Keywords human immunodeficiency virus ; glycobiology ; hiv ; therapy ; Medicine ; R
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher McGill University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Immune Modulation in Sepsis, ARDS, and Covid-19 - The Road Traveled and the Road Ahead.

    Leligdowicz, Aleksandra / Harhay, Michael O / Calfee, Carolyn S

    NEJM evidence

    2022  Volume 1, Issue 11, Page(s) EVIDra2200118

    Abstract: Immune Modulation in Sepsis, ARDS, and Covid-19Leligdowicz et al. consider the history and future of immunomodulating therapies in sepsis and ARDS, including ARDS due to Covid-19, and remark on the larger challenge of clinical research on therapies for ... ...

    Abstract Immune Modulation in Sepsis, ARDS, and Covid-19Leligdowicz et al. consider the history and future of immunomodulating therapies in sepsis and ARDS, including ARDS due to Covid-19, and remark on the larger challenge of clinical research on therapies for syndromes with profound clinical and biologic heterogeneity.
    MeSH term(s) Humans ; COVID-19 ; Sepsis ; Respiratory Distress Syndrome/drug therapy
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDra2200118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Heterogeneity in sepsis: new biological evidence with clinical applications.

    Leligdowicz, Aleksandra / Matthay, Michael A

    Critical care (London, England)

    2019  Volume 23, Issue 1, Page(s) 80

    Abstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the ... ...

    Abstract This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .
    MeSH term(s) Critical Care/trends ; Humans ; Intensive Care Units/organization & administration ; Sepsis/classification ; Sepsis/physiopathology
    Language English
    Publishing date 2019-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-019-2372-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Pharmacokinetics of recombinant human annexin A5 (SY-005) in patients with severe COVID-19.

    Tschirhart, Brent J / Lu, Xiangru / Mokale Kognou, Aristide Laurel / Martin, Claudio M / Slessarev, Marat / Fraser, Douglas D / Leligdowicz, Aleksandra / Urquhart, Bradley / Feng, Qingping

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1299613

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1299613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: AIMing Immunomodulation Therapy at Sepsis.

    Leligdowicz, Aleksandra / Matthay, Michael A

    American journal of respiratory cell and molecular biology

    2018  Volume 60, Issue 3, Page(s) 253–254

    MeSH term(s) Apoptosis ; Humans ; Immunomodulation ; Macrophages ; Sepsis
    Language English
    Publishing date 2018-11-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2018-0338ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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