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Article ; Online: Una filologia della società. Antonio Gramsci e la scoperta delle scienze sociali

Michele Filippini

Scienza & Politica : per una Storia delle Dottrine, Vol 21, Iss

2009 Volume 41

Keywords	Political science (General) ; JA1-92 ; Political science ; J
Language	Italian
Publishing date	2009-12-01T00:00:00Z
Publisher	University of Bologna
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Abstract: This is a new approach to one of the greatest political theorists, Antonio Gramsci. Gramsci's ... across the world. Here, Michele Filippini proposes a new approach based on the analysis of previously ... texts, Filippini also examines the more traditional areas of Gramsci's thought, including hegemony ...

Abstract	This is a new approach to one of the greatest political theorists, Antonio Gramsci. Gramsci's Prison Notebooks are one of the most popular Marxist texts available and continue to inspire readers across the world. Here, Michele Filippini proposes a new approach based on the analysis of previously ignored concepts in his works, creating a book which stands apart. Including chapters on ideology, the individual, collective organisms, society, crisis and temporality, Using Gramsci offers a new pattern in Gramscian studies aimed to speak to the broader audience of social sciences scholars beyond the field of political theory and Marxism, while remaining firmly rooted in his writings. Working from the original Italian texts, Filippini also examines the more traditional areas of Gramsci's thought, including hegemony, organic intellectuals and civil society.This book will be perfect for all scholars and students of Gramsci's thought
Keywords	Political science (General) ; Gramsci, Antonio
Size	1 electronic resource (248 p.)
Publisher	Pluto Press
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020092819
ISBN	9780745335698 ; 9781786800077 ; 0745335691 ; 1786800071
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Autophagy impairment in human bile duct carcinoma cells.

Petrungaro, Simonetta / de Franchis, Valerio / Filippini, Antonio / Facchiano, Antonio / Gaudio, Eugenio / Giampietri, Claudia

Frontiers in physiology

2023 Volume 14, Page(s) 1249264

Abstract: Bile duct epithelial cells, named cholangiocytes, may undergo a neoplastic transformation leading to cholangiocarcinoma. The role autophagy plays in cancer is still debated and few information are available in cholangiocarcinoma. We ... ...

Abstract	Bile duct epithelial cells, named cholangiocytes, may undergo a neoplastic transformation leading to cholangiocarcinoma. The role autophagy plays in cancer is still debated and few information are available in cholangiocarcinoma. We report
Language	English
Publishing date	2023-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1249264
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Article: Endothelial Cell Metabolism in Vascular Functions.

Filippini, Antonio / Tamagnone, Luca / D'Alessio, Alessio

Cancers

2022 Volume 14, Issue 8

Abstract: The endothelium is the innermost layer of all blood and lymphatic vessels composed of a monolayer of specialized endothelial cells (ECs). It is regarded as a dynamic and multifunctional endocrine organ that takes part in essential processes, such as the ... ...

Abstract	The endothelium is the innermost layer of all blood and lymphatic vessels composed of a monolayer of specialized endothelial cells (ECs). It is regarded as a dynamic and multifunctional endocrine organ that takes part in essential processes, such as the control of blood fluidity, the modulation of vascular tone, the regulation of immune response and leukocyte trafficking into perivascular tissues, and angiogenesis. The inability of ECs to perform their normal biological functions, known as endothelial dysfunction, is multi-factorial; for instance, it implicates the failure of ECs to support the normal antithrombotic and anti-inflammatory status, resulting in the onset of unfavorable cardiovascular conditions such as atherosclerosis, coronary artery disease, hypertension, heart problems, and other vascular pathologies. Notably, it is emerging that the ability of ECs to adapt their metabolic status to persistent changes of the tissue microenvironment could be vital for the maintenance of vascular functions and to prevent adverse vascular events. The main purpose of the present article is to shed light on the unique metabolic plasticity of ECs as a prospective therapeutic target; this may lead to the development of novel strategies for cardiovascular diseases and cancer.
Language	English
Publishing date	2022-04-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14081929
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Article ; Online: Caveolae and Lipid Rafts in Endothelium: Valuable Organelles for Multiple Functions.

Filippini, Antonio / D'Alessio, Alessio

Biomolecules

2020 Volume 10, Issue 9

Abstract: Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell types and are particularly abundant in endothelial cells and adipocytes. The lipid composition of caveolae largely matches that of lipid rafts microdomains that are ... ...

Abstract	Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell types and are particularly abundant in endothelial cells and adipocytes. The lipid composition of caveolae largely matches that of lipid rafts microdomains that are particularly enriched in cholesterol, sphingomyelin, glycosphingolipids, and saturated fatty acids. Unlike lipid rafts, whose existence remains quite elusive in living cells, caveolae can be clearly distinguished by electron microscope. Despite their similar composition and the sharing of some functions, lipid rafts appear more heterogeneous in terms of size and are more dynamic than caveolae. Following the discovery of caveolin-1, the first molecular marker as well as the unique scaffolding protein of caveolae, we have witnessed a remarkable increase in studies aimed at investigating the role of these organelles in cell functions and human disease. The goal of this review is to discuss the most recent studies related to the role of caveolae and caveolins in endothelial cells. We first recapitulate the major embryological processes leading to the formation of the vascular tree. We next discuss the contribution of caveolins and cavins to membrane biogenesis and cell response to extracellular stimuli. We also address how caveolae and caveolins control endothelial cell metabolism, a central mechanism involved in migration proliferation and angiogenesis. Finally, as regards the emergency caused by COVID-19, we propose to study the caveolar platform as a potential target to block virus entry into endothelial cells.
MeSH term(s)	Animals ; Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; Caveolae/metabolism ; Caveolins/metabolism ; Endocytosis ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/virology ; Humans ; SARS-CoV-2 ; Virus Internalization
Chemical Substances	Caveolins
Keywords	covid19
Language	English
Publishing date	2020-08-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10091218
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Endolysosomal two-pore channel 2 plays opposing roles in primary and metastatic malignant melanoma cells.

Barbonari, Samantha / D'Amore, Antonella / Hanbashi, Ali A / Palombi, Fioretta / Riccioli, Anna / Parrington, John / Filippini, Antonio

Cell biology international

2024 Volume 48, Issue 4, Page(s) 521–540

Abstract: The ion channel two-pore channel 2 (TPC2), localised on the membranes of acidic organelles such as endo-lysosomes and melanosomes, has been shown to play a role in pathologies including cancer, and it is differently expressed in primary versus metastatic ...

Abstract	The ion channel two-pore channel 2 (TPC2), localised on the membranes of acidic organelles such as endo-lysosomes and melanosomes, has been shown to play a role in pathologies including cancer, and it is differently expressed in primary versus metastatic melanoma cells. Whether TPC2 plays a pro- or anti-oncogenic role in different tumour conditions is a relevant open question which we have explored in melanoma at different stages of tumour progression. The behaviour of primary melanoma cell line B16F0 and its metastatic subline B16F10 were compared in response to TPC2 modulation by silencing (by small interfering RNA), knock-out (by CRISPR/Cas9) and overexpression (by mCherry-TPC2 transfected plasmid). TPC2 silencing increased cell migration, epithelial-to-mesenchymal transition and autophagy in the metastatic samples, but abated them in the silenced primary ones. Interestingly, while TPC2 inactivation failed to affect markers of proliferation in both samples, it strongly enhanced the migratory behaviour of the metastatic cells, again suggesting that in the more aggressive phenotype TPC2 plays a specific antimetastatic role. In line with this, overexpression of TPC2 in B16F10 cells resulted in phenotype rescue, that is, a decrease in migratory ability, thus collectively resuming traits of the B16F0 primary cell line. Our research shows a novel role of TPC2 in melanoma cells that is intriguingly different in initial versus late stages of cancer progression.
MeSH term(s)	Humans ; Melanoma/metabolism ; Two-Pore Channels ; Lysosomes/metabolism ; Cell Line ; Autophagy/physiology ; Calcium/metabolism
Chemical Substances	Two-Pore Channels ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1143453-3
ISSN	1095-8355 ; 1065-6995
ISSN (online)	1095-8355
ISSN	1065-6995
DOI	10.1002/cbin.12129
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Article ; Online: Fast and portable fluorescence lifetime analysis for early warning detection of micro- and nanoplastics in water.

Xiao, Siyao / Filippini, Antonio / Casadei, Marco / Caracciolo, Giulio / Digiacomo, Luca / Rossetta, Alessandro

Environmental research

2023 Volume 244, Page(s) 117936

Abstract: The presence of plastic fragments in aquatic environments, particularly at the micro- and nano-scale, has become a significant global concern. However, current detection methods are limited in their ability to reveal the presence of such particles in ... ...

Abstract	The presence of plastic fragments in aquatic environments, particularly at the micro- and nano-scale, has become a significant global concern. However, current detection methods are limited in their ability to reveal the presence of such particles in liquid samples. In this study, we propose the use of a fluorescence lifetime analysis system for the detection of micro- and nanoplastics in water. This approach relies on the inherent endogenous fluorescence of plastic materials and involves the collection of single photons emitted by plastic fragments upon exposure to a pulsed laser beam. Briefly, a pulsed laser beam (repetition frequency = 40 MHz) shines onto a sample solution, and the emitted light is filtered, collected, and used to trace the time distributions of the photons with high temporal resolution. Finally, the fluorescence lifetime was measured using fitting procedures and a phasor analysis. Phasor analysis is a fit-free method that allows the measurement of the fluorescence lifetime of a sample without any assumptions or prior knowledge of the sample decay pattern. The developed instrument was tested using fluorescence references and validated using unlabelled micro- and nano-scale particles. Our system successfully detected polystyrene particles in water, achieving a remarkable sensitivity with a detection limit of 0.01 mg/mL, without the need for sample pre-treatment or visual inspection. Although further studies are necessary to enhance the detection limit of the technique and distinguish between different plastic materials, this proof-of-concept study suggests the potential of the fluorescence lifetime-based approach as a rapid, robust, and cost-effective method for early warning detection and identification of plastic contaminants in aquatic environments.
MeSH term(s)	Microplastics/analysis ; Water ; Fluorescence ; Water Pollutants, Chemical/analysis ; Polystyrenes/analysis ; Plastics/analysis
Chemical Substances	Microplastics ; Water (059QF0KO0R) ; Water Pollutants, Chemical ; Polystyrenes ; Plastics
Language	English
Publishing date	2023-12-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.117936
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cholangiocarcinoma Malignant Traits Are Promoted by Schwann Cells through TGFβ Signaling in a Model of Perineural Invasion.

de Franchis, Valerio / Petrungaro, Simonetta / Pizzichini, Elisa / Camerini, Serena / Casella, Marialuisa / Somma, Francesca / Mandolini, Enrico / Carpino, Guido / Overi, Diletta / Cardinale, Vincenzo / Facchiano, Antonio / Filippini, Antonio / Gaudio, Eugenio / Fabrizi, Cinzia / Giampietri, Claudia

Cells

2024 Volume 13, Issue 5

Abstract: The term cholangiocarcinoma (CCA) defines a class of epithelial malignancies originating from bile ducts. Although it has been demonstrated that CCA patients with perineural invasion (PNI) have a worse prognosis, the biological features of this ... ...

Abstract	The term cholangiocarcinoma (CCA) defines a class of epithelial malignancies originating from bile ducts. Although it has been demonstrated that CCA patients with perineural invasion (PNI) have a worse prognosis, the biological features of this phenomenon are yet unclear. Our data show that in human intrahepatic CCA specimens with documented PNI, nerve-infiltrating CCA cells display positivity of the epithelial marker cytokeratin 7, lower with respect to the rest of the tumor mass. In an in vitro 3D model, CCA cells move towards a peripheral nerve explant allowing contact with Schwann cells (SCs) emerging from the nerve. Here, we show that SCs produce soluble factors that favor the migration, invasion, survival and proliferation of CCA cells in vitro. This effect is accompanied by a cadherin switch, suggestive of an epithelial-mesenchymal transition. The influence of SCs in promoting the ability of CCA cells to migrate and invade the extracellular matrix is hampered by a specific TGFβ receptor 1 (TGFBR1) antagonist. Differential proteomic data indicate that the exposure of CCA cells to SC secreted factors induces the upregulation of key oncogenes and the concomitant downregulation of some tumor suppressors. Taken together, these data concur in identifying SCs as possible promoters of a more aggressive CCA phenotype, ascribing a central role to TGFβ signaling in regulating this process.
MeSH term(s)	Humans ; Bile Duct Neoplasms/pathology ; Bile Ducts, Intrahepatic/pathology ; Cell Line, Tumor ; Cholangiocarcinoma/pathology ; Phenotype ; Proteomics ; Schwann Cells/pathology ; Transforming Growth Factor beta/genetics ; Neoplasm Invasiveness
Chemical Substances	Transforming Growth Factor beta
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13050366
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Caveolae and Lipid Rafts in Endothelium

Antonio Filippini / Alessio D’Alessio

Biomolecules, Vol 10, Iss 1218, p

Valuable Organelles for Multiple Functions

2020 Volume 1218

Abstract	Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell types and are particularly abundant in endothelial cells and adipocytes. The lipid composition of caveolae largely matches that of lipid rafts microdomains that are particularly enriched in cholesterol, sphingomyelin, glycosphingolipids, and saturated fatty acids. Unlike lipid rafts, whose existence remains quite elusive in living cells, caveolae can be clearly distinguished by electron microscope. Despite their similar composition and the sharing of some functions, lipid rafts appear more heterogeneous in terms of size and are more dynamic than caveolae. Following the discovery of caveolin-1, the first molecular marker as well as the unique scaffolding protein of caveolae, we have witnessed a remarkable increase in studies aimed at investigating the role of these organelles in cell functions and human disease. The goal of this review is to discuss the most recent studies related to the role of caveolae and caveolins in endothelial cells. We first recapitulate the major embryological processes leading to the formation of the vascular tree. We next discuss the contribution of caveolins and cavins to membrane biogenesis and cell response to extracellular stimuli. We also address how caveolae and caveolins control endothelial cell metabolism, a central mechanism involved in migration proliferation and angiogenesis. Finally, as regards the emergency caused by COVID-19, we propose to study the caveolar platform as a potential target to block virus entry into endothelial cells.
Keywords	angiogenesis ; caveolae ; caveolin ; cavin ; COVID-19 ; endocytosis ; Microbiology ; QR1-502 ; covid19
Subject code	571
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A commentary on the inhibition of human TPC2 channel by the natural flavonoid naringenin: Methods, experiments, and ideas.

Minicozzi, Velia / Qi, Tianwen / Gradogna, Antonella / Pozzolini, Marina / Milenkovic, Stefan / Filippini, Antonio / Ceccarelli, Matteo / Carpaneto, Armando

Biomolecular concepts

2023 Volume 14, Issue 1

Abstract: Human endo-lysosomes possess a class of proteins called TPC channels on their membrane, which are essential for proper cell functioning. This protein family can be functionally studied by expressing them in plant vacuoles. Inhibition of hTPC activity by ... ...

Abstract	Human endo-lysosomes possess a class of proteins called TPC channels on their membrane, which are essential for proper cell functioning. This protein family can be functionally studied by expressing them in plant vacuoles. Inhibition of hTPC activity by naringenin, one of the main flavonoids present in the human diet, has the potential to be beneficial in severe human diseases such as solid tumor development, melanoma, and viral infections. We attempted to identify the molecular basis of the interaction between hTPC2 and naringenin, using ensemble docking on molecular dynamics (MD) trajectories, but the specific binding site remains elusive, posing a challenge that could potentially be addressed in the future by increased computational power in MD and the combined use of microscopy techniques such as cryo-EM.
MeSH term(s)	Humans ; Female ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Flavanones/pharmacology ; Flavanones/therapeutic use ; Binding Sites ; Endometriosis
Chemical Substances	naringenin (HN5425SBF2) ; Flavonoids ; Flavanones
Language	English
Publishing date	2023-09-07
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2557908-3
ISSN	1868-503X ; 1868-5021
ISSN (online)	1868-503X
ISSN	1868-5021
DOI	10.1515/bmc-2022-0036
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