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Article ; Online: Aquaporin Expression and Regulation in Clinical and Experimental Sepsis.

Lotsios, Nikolaos S / Keskinidou, Chrysi / Dimopoulou, Ioanna / Kotanidou, Anastasia / Orfanos, Stylianos E / Vassiliou, Alice G

International journal of molecular sciences

2023 Volume 25, Issue 1

Abstract: Sepsis is an inflammatory disorder caused by the host's dysfunctional response to infection. Septic patients present diverse clinical characteristics, and in the recent years, it has been the main cause of death in intensive care units (ICU). Aquaporins, ...

Abstract	Sepsis is an inflammatory disorder caused by the host's dysfunctional response to infection. Septic patients present diverse clinical characteristics, and in the recent years, it has been the main cause of death in intensive care units (ICU). Aquaporins, membrane proteins with a role in water transportation, have been reported to participate in numerous biological processes. Their role in sepsis progression has been studied extensively. This review aims to examine recent literature on aquaporin expression and regulation in clinical sepsis, as well as established experimental models of sepsis. We will present how sepsis affects aquaporin expression at the molecular and protein level. Moreover, we will delve into the importance of aquaporin regulation at transcriptional, post-transcriptional, translational, and post-translational levels in sepsis by presenting data on aquaporin regulation by non-coding RNAs and selected chemical molecules. Finally, we will focus on the importance of aquaporin single-nucleotide polymorphisms in the setting of sepsis.
MeSH term(s)	Humans ; Sepsis/genetics ; Aquaporins/genetics ; Intensive Care Units ; Membrane Proteins ; Polymorphism, Single Nucleotide
Chemical Substances	Aquaporins ; Membrane Proteins
Language	English
Publishing date	2023-12-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010487
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Endotheliopathy in Acute COVID-19 and Long COVID.

Vassiliou, Alice G / Vrettou, Charikleia S / Keskinidou, Chrysi / Dimopoulou, Ioanna / Kotanidou, Anastasia / Orfanos, Stylianos E

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: The pulmonary endothelium is a highly regulated organ that performs a wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play a direct role in sepsis and acute respiratory ... ...

Abstract	The pulmonary endothelium is a highly regulated organ that performs a wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play a direct role in sepsis and acute respiratory distress syndrome, its role in COVID-19 has also been extensively investigated. Indeed, apart from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised early during the pandemic, including markers of endothelial cell activation or injury. We systematically searched the literature up to 10 March 2023 for studies examining the association between acute and long COVID-19 severity and outcomes and endothelial biomarkers.
MeSH term(s)	Humans ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; Vascular Diseases/pathology ; Lung/pathology ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-05-04
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24098237
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Article ; Online: The Interplay between Aquaporin-1 and the Hypoxia-Inducible Factor 1α in a Lipopolysaccharide-Induced Lung Injury Model in Human Pulmonary Microvascular Endothelial Cells.

Keskinidou, Chrysi / Lotsios, Nikolaos S / Vassiliou, Alice G / Dimopoulou, Ioanna / Kotanidou, Anastasia / Orfanos, Stylianos E

International journal of molecular sciences

2022 Volume 23, Issue 18

Abstract: Aquaporin-1 (AQP1), a water channel, and the hypoxia-inducible factor 1α (HIF1A) are implicated in acute lung injury responses, modulating among others pulmonary vascular leakage. We hypothesized that the AQP1 and HIF1A systems interact, affecting mRNA, ... ...

Abstract	Aquaporin-1 (AQP1), a water channel, and the hypoxia-inducible factor 1α (HIF1A) are implicated in acute lung injury responses, modulating among others pulmonary vascular leakage. We hypothesized that the AQP1 and HIF1A systems interact, affecting mRNA, protein levels and function of AQP1 in human pulmonary microvascular endothelial cells (HPMECs) exposed to lipopolysaccharide (LPS). Moreover, the role of AQP1 in apoptosis and wound healing progression was examined. Both AQP1 mRNA and protein expression levels were higher in HPMECs exposed to LPS compared to untreated HPMECs. However, in the LPS-exposed
MeSH term(s)	Aquaporin 1/metabolism ; Endothelial Cells/metabolism ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Lipopolysaccharides ; Lung/metabolism ; Lung Injury/chemically induced ; RNA, Messenger/genetics
Chemical Substances	AQP1 protein, human ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Lipopolysaccharides ; RNA, Messenger ; Aquaporin 1 (146410-94-8)
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231810588
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Article: Mechanistic Understanding of Lung Inflammation: Recent Advances and Emerging Techniques.

Keskinidou, Chrysi / Vassiliou, Alice G / Dimopoulou, Ioanna / Kotanidou, Anastasia / Orfanos, Stylianos E

Journal of inflammation research

2022 Volume 15, Page(s) 3501–3546

Abstract: Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury characterized by an acute inflammatory response in the lung parenchyma. Hence, it is considered as the most appropriate clinical syndrome to study pathogenic mechanisms of lung ... ...

Abstract	Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury characterized by an acute inflammatory response in the lung parenchyma. Hence, it is considered as the most appropriate clinical syndrome to study pathogenic mechanisms of lung inflammation. ARDS is associated with increased morbidity and mortality in the intensive care unit (ICU), while no effective pharmacological treatment exists. It is very important therefore to fully characterize the underlying pathobiology and the related mechanisms, in order to develop novel therapeutic approaches. In vivo and in vitro models are important pre-clinical tools in biological and medical research in the mechanistic and pathological understanding of the majority of diseases. In this review, we will present data from selected experimental models of lung injury/acute lung inflammation, which have been based on clinical disorders that can lead to the development of ARDS and related inflammatory lung processes in humans, including ventilation-induced lung injury (VILI), sepsis, ischemia/reperfusion, smoke, acid aspiration, radiation, transfusion-related acute lung injury (TRALI), influenza,
Language	English
Publishing date	2022-06-15
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S282695
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Article ; Online: Prognostic Value of HIF-1α-Induced Genes in Sepsis/Septic Shock.

Lotsios, Nikolaos S / Keskinidou, Chrysi / Jahaj, Edison / Mastora, Zafeiria / Dimopoulou, Ioanna / Orfanos, Stylianos E / Vassilaki, Niki / Vassiliou, Alice G / Kotanidou, Anastasia

Medical sciences (Basel, Switzerland)

2023 Volume 11, Issue 2

Abstract: Hypoxia is characterized as one of the main consequences of sepsis, which is recognized as the leading cause of death in intensive care unit (ICU) patients. In this study, we aimed to examine whether the expression levels of genes regulated under hypoxia ...

Abstract	Hypoxia is characterized as one of the main consequences of sepsis, which is recognized as the leading cause of death in intensive care unit (ICU) patients. In this study, we aimed to examine whether the expression levels of genes regulated under hypoxia could be utilized as novel biomarkers for sepsis prognosis in ICU patients. Whole blood expression levels of hypoxia-inducible factor-1α (
MeSH term(s)	Humans ; Shock, Septic/diagnosis ; Shock, Septic/genetics ; Prognosis ; Vascular Endothelial Growth Factor A ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Intensive Care Units ; Sepsis/diagnosis ; Sepsis/genetics
Chemical Substances	Vascular Endothelial Growth Factor A ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2023-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2754473-4
ISSN	2076-3271 ; 2076-3271
ISSN (online)	2076-3271
ISSN	2076-3271
DOI	10.3390/medsci11020041
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Article: Family Burden of ICU Survivors and Correlations with Patient Quality of Life and Psychometric Scores - A Pilot Study.

Mantziou, Vassiliki / Vrettou, Charikleia S / Vassiliou, Alice G / Orfanos, Stylianos E / Kotanidou, Anastasia / Dimopoulou, Ioanna

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)

2022 Volume 8, Issue 4, Page(s) 242–248

Abstract: Introduction: Post intensive care syndrome (PICS) affects an increasing number of critical illness survivors and their families, with serious physical and psychological sequelae. Since little is known about the burden of critical illness on ICU survivor ...

Abstract	Introduction: Post intensive care syndrome (PICS) affects an increasing number of critical illness survivors and their families, with serious physical and psychological sequelae. Since little is known about the burden of critical illness on ICU survivor families, we conducted a prospective observational study aiming to assess this, and investigate correlations of the patients' psychometric and health-related quality of life (HRQOL) scores with family burden. Materials and methods: Twenty-nine patients were evaluated in the presence of a family member. Participants were assessed with the use of validated scales for anxiety, depression, post-traumatic stress disorder, cognitive decline, and the family burden scale (FBS). Results: High burden was present in 27.6% of family members. Statistically significant correlations were observed between the FBS score and trait anxiety, depression, and the physical and psychological components of HRQOL. Conclusions: Our results suggest that family burden following critical illness is common, suggesting that its assessment should be incorporated in the evaluation of PICS-family in large observational studies.
Language	English
Publishing date	2022-11-12
Publishing country	Poland
Document type	Journal Article
ISSN	2393-1809
ISSN	2393-1809
DOI	10.2478/jccm-2022-0027
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Article: Post-Intensive Care Syndrome in Survivors from Critical Illness including COVID-19 Patients: A Narrative Review.

Vrettou, Charikleia S / Mantziou, Vassiliki / Vassiliou, Alice G / Orfanos, Stylianos E / Kotanidou, Anastasia / Dimopoulou, Ioanna

Life (Basel, Switzerland)

2022 Volume 12, Issue 1

Abstract: Current achievements in medical science and technological advancements in intensive care medicine have allowed better support of critically ill patients in intensive care units (ICUs) and have increased survival probability. Post-intensive care syndrome ( ...

Abstract	Current achievements in medical science and technological advancements in intensive care medicine have allowed better support of critically ill patients in intensive care units (ICUs) and have increased survival probability. Post-intensive care syndrome (PICS) is a relatively new term introduced almost 10 years ago, defined as "new or worsening impairments in physical, cognitive, or mental health status arising after critical illness and persisting beyond acute care hospitalization". A significant percentage of critically ill patients suffer from PICS for a prolonged period of time, with physical problems being the most common. The exact prevalence of PICS is unknown, and many risk factors have been described well. Coronavirus disease 2019 (COVID-19) survivors seem to be at especially high risk for developing PICS. The families of ICU survivors can also be affected as a response to the stress suffered during the critical illness of their kin. This separate entity is described as PICS family (PICS-F). A multidisciplinary approach is warranted for the treatment of PICS, involving healthcare professionals, clinicians, and scientists from different areas. Improving outcomes is both challenging and imperative for the critical care community. The review of the relevant literature and the study of the physical, cognitive, and mental sequelae could lead to the prevention and timely management of PICS and the subsequent improvement of the quality of life for ICU survivors.
Language	English
Publishing date	2022-01-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12010107
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Article: Changes in Cortisol Secretion and Corticosteroid Receptors in COVID-19 and Non COVID-19 Critically Ill Patients with Sepsis/Septic Shock and Scope for Treatment.

Ilias, Ioannis / Vassiliou, Alice G / Keskinidou, Chrysi / Vrettou, Charikleia S / Orfanos, Stylianos / Kotanidou, Anastasia / Dimopoulou, Ioanna

Biomedicines

2023 Volume 11, Issue 7

Abstract: Sepsis is associated with dysregulated cortisol secretion, leading to abnormal levels of cortisol in the blood. In the early stages of the condition, cortisol levels are typically elevated due to increased secretion from the adrenal glands. However, as ... ...

Abstract	Sepsis is associated with dysregulated cortisol secretion, leading to abnormal levels of cortisol in the blood. In the early stages of the condition, cortisol levels are typically elevated due to increased secretion from the adrenal glands. However, as the disease progresses, cortisol levels may decline due to impaired adrenal function, leading to relative adrenal insufficiency. The latter is thought to be caused by a combination of factors, including impaired adrenal function, decreased production of corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) by the hypothalamus and pituitary gland, and increased breakdown of cortisol. The dysregulation of cortisol secretion in sepsis is thought to contribute to the pathophysiology of the disease by impairing the body's ability to mount an appropriate inflammatory response. Given the dysregulation of cortisol secretion and corticosteroid receptors in sepsis, there has been considerable interest in the use of steroids as a treatment. However, clinical trials have yielded mixed results and corticosteroid use in sepsis remains controversial. In this review, we will discuss the changes in cortisol secretion and corticosteroid receptors in critically ill patients with sepsis/septic shock. We will also make special note of COVID-19 patients, who presented a recent challenge for ICU management, and explore the scope for corticosteroid administration in both COVID-19 and non-COVID-19 septic patients.
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11071801
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Article: A Prospective Study on Neural Biomarkers in Patients with Long-COVID Symptoms.

Vrettou, Charikleia S / Vassiliou, Alice G / Keskinidou, Chrysi / Mourelatos, Panagiotis / Asimakos, Andreas / Spetsioti, Stavroula / Diamantopoulos, Aristidis / Jahaj, Edison / Antonoglou, Archontoula / Katsaounou, Paraskevi / Vassiliadi, Dimitra A / Kotanidou, Anastasia / Dimopoulou, Ioanna

Journal of personalized medicine

2024 Volume 14, Issue 3

Abstract: Background: this prospective observational study aims to assess serum levels of glial fibrillary acidic protein (GFAP), s100b, and total Tau in long-COVID patients, exploring correlations with symptoms, cognitive decline, mental health, and quality of ... ...

Abstract	Background: this prospective observational study aims to assess serum levels of glial fibrillary acidic protein (GFAP), s100b, and total Tau in long-COVID patients, exploring correlations with symptoms, cognitive decline, mental health, and quality of life. Methods: Long-COVID patients visiting our outpatient clinic (February 2021-December 2022) were screened alongside age- and sex-matched controls. GFAP, s100b, and total Tau in serum were measured with ELISA. Cognitive function, depression, anxiety, post-traumatic stress disorder, and quality of life were evaluated using MoCA, HADS (depression and anxiety), IES-R, and SF-36, respectively. Results: Sixty-five long-COVID patients and 20 controls were included. GFAP levels were significantly higher in long-COVID patients ( Conclusions: in this long-COVID cohort with substantial psychological and cognitive symptoms, GFAP levels were elevated compared to controls, though not correlating with the presence of long-COVID symptoms.
Language	English
Publishing date	2024-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14030313
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Article ; Online: Aquaporin Expression and Regulation in Clinical and Experimental Sepsis

Nikolaos S. Lotsios / Chrysi Keskinidou / Ioanna Dimopoulou / Anastasia Kotanidou / Stylianos E. Orfanos / Alice G. Vassiliou

International Journal of Molecular Sciences, Vol 25, Iss 1, p

2023 Volume 487

Abstract: Sepsis is an inflammatory disorder caused by the host’s dysfunctional response to infection. Septic patients present diverse clinical characteristics, and in the recent years, it has been the main cause of death in intensive care units (ICU). Aquaporins, ...

Abstract	Sepsis is an inflammatory disorder caused by the host’s dysfunctional response to infection. Septic patients present diverse clinical characteristics, and in the recent years, it has been the main cause of death in intensive care units (ICU). Aquaporins, membrane proteins with a role in water transportation, have been reported to participate in numerous biological processes. Their role in sepsis progression has been studied extensively. This review aims to examine recent literature on aquaporin expression and regulation in clinical sepsis, as well as established experimental models of sepsis. We will present how sepsis affects aquaporin expression at the molecular and protein level. Moreover, we will delve into the importance of aquaporin regulation at transcriptional, post-transcriptional, translational, and post-translational levels in sepsis by presenting data on aquaporin regulation by non-coding RNAs and selected chemical molecules. Finally, we will focus on the importance of aquaporin single-nucleotide polymorphisms in the setting of sepsis.
Keywords	aquaporin ; sepsis ; acute respiratory distress syndrome ; single-nucleotide polymorphisms ; lnRNA ; miRNA ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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