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  1. Article ; Online: Endothelial lipid droplets drive atherosclerosis and arterial hypertension.

    Xu, Suowen / Offermanns, Stefan

    Trends in endocrinology and metabolism: TEM

    2024  

    Abstract: Lipid droplets (LDs) are essential for cellular pathophysiology. In two recent reports, Kim et al. and Boutagy et al. show that accumulation of LDs in endothelial cells (ECs) elevates blood pressure and accelerates progression of atherosclerosis. These ... ...

    Abstract Lipid droplets (LDs) are essential for cellular pathophysiology. In two recent reports, Kim et al. and Boutagy et al. show that accumulation of LDs in endothelial cells (ECs) elevates blood pressure and accelerates progression of atherosclerosis. These findings identify a novel mechanism of EC lipid metabolism which drives cardiometabolic diseases.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2024.02.014
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    Zs.A 2999: Show issues Location:
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  2. Article ; Online: Letter by Xu Regarding Article, "Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis".

    Xu, Suowen

    Circulation

    2019  Volume 140, Issue 20, Page(s) e766–e767

    MeSH term(s) Atherosclerosis ; Humans ; Phenotype
    Language English
    Publishing date 2019-11-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.119.041169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Therapeutic potential of blood flow mimetic compounds in preventing endothelial dysfunction and atherosclerosis.

    Xu, Suowen

    Pharmacological research

    2020  Volume 155, Page(s) 104737

    Abstract: Endothelial cells (ECs), as one of the most important types of vascular cells, line the innermost layer of all blood vessels throughout human body and regulate vascular tone and homeostasis. ECs are constantly exposed to different types of shear stress ( ... ...

    Abstract Endothelial cells (ECs), as one of the most important types of vascular cells, line the innermost layer of all blood vessels throughout human body and regulate vascular tone and homeostasis. ECs are constantly exposed to different types of shear stress (one form of mechanical forces) generated by the flowing blood. Various mechanosensing molecules or complexes existing on EC membrane serve as versatile sensors (termed as mechanosensors) of different patterns and pattern alternation of blood flow. Via these mechanosensors, ECs sense and transduce flow-induced biomechanical signal into different mechano-transduction pathways, leading to altered expression/activity of mechanosensitive transcription factors (TFs), epigenetic modification enzymes, non-coding RNAs, and genes, thereby generating biological responses (i.e., the regulation of endothelial function). Dysfunction of ECs (i.e., endothelial dysfunction) represents one of the most important pathomechanisms for atherosclerosis, hypertension and diabesity. Emerging studies have demonstrated that pharmacological modulators of mechanosensors/TFs/enzymes improve endothelial dysfunction and reduce the incidence of experimental atherosclerosis. Here, I overviewed the important role of endothelial mechanoregulators in vascular endothelium, highlighting the potential of blood flow mimetic compounds to treat endothelial dysfunction and associated atherosclerotic cardiovascular diseases.
    MeSH term(s) Animals ; Atherosclerosis/physiopathology ; Blood Circulation ; Endothelial Cells/physiology ; Endothelium, Vascular/physiology ; Humans ; Stress, Mechanical
    Language English
    Publishing date 2020-02-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2020.104737
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  4. Article ; Online: Natural Products and Cardiovascular Diseases.

    Tian, Kunming / Xu, Suowen

    Current molecular pharmacology

    2022  Volume 14, Issue 6, Page(s) 923–924

    MeSH term(s) Biological Products/pharmacology ; Biological Products/therapeutic use ; Cardiovascular Diseases ; Drug Discovery ; Humans
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-03-20
    Publishing country United Arab Emirates
    Document type Editorial
    ISSN 1874-4702
    ISSN (online) 1874-4702
    DOI 10.2174/187446721406211220144326
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  5. Article ; Online: ASGR1: an emerging therapeutic target in hypercholesterolemia.

    Zhao, Wenqi / Xu, Suowen / Weng, Jianping

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 43

    MeSH term(s) Humans ; Hypercholesterolemia ; Asialoglycoprotein Receptor
    Chemical Substances ASGR1 protein, human ; Asialoglycoprotein Receptor
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01319-5
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  6. Article ; Online: ASGR1

    Wenqi Zhao / Suowen Xu / Jianping Weng

    Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

    an emerging therapeutic target in hypercholesterolemia

    2023  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Iron and Atherosclerosis: The Link Revisited.

    Xu, Suowen

    Trends in molecular medicine

    2019  Volume 25, Issue 8, Page(s) 659–661

    Abstract: The causal link between iron and atherosclerosis has been debated. Recent studies have revisited the 'iron hypothesis' by showing that dietary iron overload or elevated non-transferrin bound iron (NTBI) aggravates atherosclerosis in mice by driving ... ...

    Abstract The causal link between iron and atherosclerosis has been debated. Recent studies have revisited the 'iron hypothesis' by showing that dietary iron overload or elevated non-transferrin bound iron (NTBI) aggravates atherosclerosis in mice by driving vascular dysfunction, thus identifying NTBI as a risk factor and therapeutic target for atherosclerosis.
    MeSH term(s) Animals ; Atherosclerosis/etiology ; Atherosclerosis/metabolism ; Biomarkers ; Blood Platelets/metabolism ; Disease Models, Animal ; Disease Susceptibility ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Endothelium/metabolism ; Endothelium/pathology ; Genetic Predisposition to Disease ; Humans ; Iron/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Myocytes, Smooth Muscle/metabolism
    Chemical Substances Biomarkers ; Iron (E1UOL152H7)
    Language English
    Publishing date 2019-06-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2019.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4345: Show issues Location:
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  8. Article: Editorial: Epigenetic regulation in cardiovascular diseases, volume II.

    Xu, Suowen / Pillai, Indulekha C L / Rau, Christoph D / Wang, Zhihua

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1166268

    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1166268
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  9. Article ; Online: NAFLD and NASH: etiology, targets and emerging therapies.

    Wei, Shulin / Wang, Li / Evans, Paul C / Xu, Suowen

    Drug discovery today

    2024  Volume 29, Issue 3, Page(s) 103910

    Abstract: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) pose a significant threat to human health and cause a tremendous socioeconomic burden. Currently, the molecular mechanisms of NAFLD and NASH remain incompletely understood, ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) pose a significant threat to human health and cause a tremendous socioeconomic burden. Currently, the molecular mechanisms of NAFLD and NASH remain incompletely understood, and no effective pharmacotherapies have been approved. In the past five years, significant advances have been achieved in our understanding of the pathomechanisms and potential pharmacotherapies of NAFLD and NASH. Research advances include the investigation of the effects of the fibroblast growth factor 21 (FGF21) analog pegozafermin and the thyroid hormone receptor-β (THRβ) agonist resmetriom on hepatic fat content, NASH resolution and/or fibrosis regression. Future directions of NAFLD and NASH research (including combination therapy, organoids and humanized mouse models) are also discussed in this state-of-the-art review.
    MeSH term(s) Animals ; Mice ; Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/metabolism ; Fibrosis ; Combined Modality Therapy ; Disease Models, Animal
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2024.103910
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  10. Article ; Online: Advancing cardiovascular translational research.

    Ritchie, Rebecca H / Xu, Suowen / Zacchigna, Serena

    Trends in pharmacological sciences

    2022  Volume 43, Issue 11, Page(s) 888–890

    MeSH term(s) Cardiovascular System ; Humans ; Translational Research, Biomedical
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2022.09.001
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