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  1. Article: Endothelial Transcytosis in Acute Lung Injury: Emerging Mechanisms and Therapeutic Approaches.

    Jones, Joshua H / Minshall, Richard D

    Frontiers in physiology

    2022  Volume 13, Page(s) 828093

    Abstract: Acute Lung Injury (ALI) is characterized by widespread inflammation which in its severe form, Acute Respiratory Distress Syndrome (ARDS), leads to compromise in respiration causing hypoxemia and death in a substantial number of affected individuals. Loss ...

    Abstract Acute Lung Injury (ALI) is characterized by widespread inflammation which in its severe form, Acute Respiratory Distress Syndrome (ARDS), leads to compromise in respiration causing hypoxemia and death in a substantial number of affected individuals. Loss of endothelial barrier integrity, pneumocyte necrosis, and circulating leukocyte recruitment into the injured lung are recognized mechanisms that contribute to the progression of ALI/ARDS. Additionally, damage to the pulmonary microvasculature by Gram-negative and positive bacteria or viruses (e.g.,
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.828093
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  2. Article ; Online: The Mediating Effects of Education and Occupational Complexity Between Race and Longitudinal Change in Late Life Cognition in ACTIVE.

    Owens, Joshua H / Fiala, Jacob / Jones, Richard N / Marsiske, Michael

    Research on aging

    2024  , Page(s) 1640275241248825

    Abstract: This study examined educational and occupational inequality as two aspects of social determinants of health that might mediate the longitudinal relationship between racialization and late life cognitive level and change. Participants were 2371 ... ...

    Abstract This study examined educational and occupational inequality as two aspects of social determinants of health that might mediate the longitudinal relationship between racialization and late life cognitive level and change. Participants were 2371 individuals racialized as Black and White from the ACTIVE study who provided occupational data. Data were analyzed from baseline and five assessments over 10-years using structural equation modeling. Black/White race served as the predictor, occupational complexity (OC) and years of education as mediators, and cognitive (memory, reasoning, and speed of processing) intercept, linear slope, and quadratic slope as the dependent variables. Black/White race showed significant indirect associations through education and OC on level of performance in cognition, linear change in reasoning and memory, and quadratic change in reasoning. Education and OC accounted for 11-16% of the association between race and cognitive level and represent modifiable social determinants of health that are associated with disparities in cognitive aging.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424452-7
    ISSN 1552-7573 ; 0164-0275
    ISSN (online) 1552-7573
    ISSN 0164-0275
    DOI 10.1177/01640275241248825
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2238: Show issues Location:
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  3. Article ; Online: Determining the Effects of Zero-Field Splitting and Magnetic Exchange in Dimeric Europium(II) Complexes.

    Carpenter, Stephanie H / Mengell, Joshua / Chen, Ju / Jones, Margaret R / Kirk, Martin L / Tondreau, Aaron M

    Inorganic chemistry

    2024  

    Abstract: Related BAP [BAP = bis(acyl)phosphide] and Acac (Acac = β-diketonate) molecules perform as robust supports for both lanthanide and actinide metals. Here, a molecular bimetallic ... ...

    Abstract Related BAP [BAP = bis(acyl)phosphide] and Acac (Acac = β-diketonate) molecules perform as robust supports for both lanthanide and actinide metals. Here, a molecular bimetallic Eu
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.4c00694
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  4. Article ; Online: Lung Endothelial Transcytosis.

    Jones, Joshua H / Minshall, Richard D

    Comprehensive Physiology

    2020  Volume 10, Issue 2, Page(s) 491–508

    Abstract: Transcytosis of macromolecules through lung endothelial cells is the primary route of transport from the vascular compartment into the interstitial space. Endothelial transcytosis is mostly a caveolae-dependent process that combines receptor-mediated ... ...

    Abstract Transcytosis of macromolecules through lung endothelial cells is the primary route of transport from the vascular compartment into the interstitial space. Endothelial transcytosis is mostly a caveolae-dependent process that combines receptor-mediated endocytosis, vesicle trafficking via actin-cytoskeletal remodeling, and SNARE protein directed vesicle fusion and exocytosis. Herein, we review the current literature on caveolae-mediated endocytosis, the role of actin cytoskeleton in caveolae stabilization at the plasma membrane, actin remodeling during vesicle trafficking, and exocytosis of caveolar vesicles. Next, we provide a concise summary of experimental methods employed to assess transcytosis. Finally, we review evidence that transcytosis contributes to the pathogenesis of acute lung injury. © 2020 American Physiological Society. Compr Physiol 10:491-508, 2020.
    MeSH term(s) Actin Cytoskeleton/metabolism ; Animals ; Biological Transport ; Capillary Permeability ; Caveolae/metabolism ; Endothelial Cells/metabolism ; Endothelial Cells/physiology ; Humans ; Lung/cytology ; Lung/metabolism ; Lung/physiology ; Transcytosis/physiology
    Language English
    Publishing date 2020-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c190012
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  5. Article ; Online: Impact of ship noise on the underwater soundscape of Eclipse Sound in the northeastern Canadian Arctic.

    Jones, Joshua M / Westdal, Kristin H / Ootoowak, Alexander J / Wiggins, Sean M / Hildebrand, John A

    Marine pollution bulletin

    2023  Volume 195, Page(s) 115534

    Abstract: ... with durations lasting from a few minutes to >6 h. The impact of ship noise on the soundscape is significant ...

    Abstract Eclipse Sound, in the northeastern Canadian Arctic, has experienced a substantial increase in ship traffic due to growing tourism and industrial development in the region. This study aims to describe the natural soundscape as well as to assess the noise levels associated with shipping. Underwater sound recordings were collected at two locations: Eastern Eclipse Sound (72° 43.730 N, 76° 13.519 W, 670 m) leading to Baffin Bay, and Milne Inlet (72° 15.260 N, 80° 34.205 W, 313 m) situated near the southwest end of Eclipse Sound. To capture the dynamic nature of the soundscape, the data from these two locations were divided into three seasons: late spring, summer, and early fall. These periods were selected to account for the changing contribution of sea ice to the soundscape during the sea ice break-up, two months of open water, and the sea ice freeze-up. By analyzing ship tracks and underwater acoustic recordings, we identified patterns of ship traffic and estimated underwater noise levels due to ships. Noise emitted by ships is quantified by vessel type, including three cargo ship types, passenger ships, pleasure craft, and icebreakers. Individual ship transits through the region introduce transient noise at frequencies from <20 Hz to >20 kHz, with durations lasting from a few minutes to >6 h. The impact of ship noise on the soundscape is significant, resulting in increases in sound levels by 15 to >30 dB when ships are within 10 km and measurable ship noise below 200 Hz at distances of >50 km.
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2023.115534
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  6. Article: Vaping and smoking cue reactivity in young adult electronic cigarette users who have never smoked combustible cigarettes: A functional neuroimaging study.

    Liu, Jiaying / Shi, Zhenhao / Fabbricatore, Jessica L / McMains, Joshua T / Worsdale, Allison / Jones, Erin C / Wang, Yidi / Sweet, Lawrence H

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Introduction: The rapid growth in the use of electronic cigarettes (e-cigarettes) among young adults who have never smoked combustible cigarettes is concerning, as it raises the potential for chronic vaping and nicotine addiction. A key characteristic ... ...

    Abstract Introduction: The rapid growth in the use of electronic cigarettes (e-cigarettes) among young adults who have never smoked combustible cigarettes is concerning, as it raises the potential for chronic vaping and nicotine addiction. A key characteristic of drug addiction is the elevated neural response to conditioned drug-related cues (i.e., cue reactivity). Generalized reactivity to both vaping and smoking cues may signify an increased risk for smoking initiation in non- smoking vapers. In this study, we used functional magnetic resonance imaging (fMRI) to evaluate brain responses to vaping and smoking cues in young adult never-smoking vapers.
    Methods: Sixty-six young adult never-smoking vapers underwent functional MRI while viewing visual cues pertaining to vaping, smoking, and nicotine-unrelated unconditioned reward (i.e., food). A priori region-of-interest analysis combined with exploratory whole-brain analysis was performed to characterize neural reactivity to vaping and smoking cues in comparison to food cues.
    Results: The medial prefrontal cortex and the posterior cingulate cortex, regions that play a key role in drug cue reactivity, showed significantly increased neural response to vaping cues compared to food cues. The posterior cingulate cortex additionally showed increased neural responses to smoking cues compared to food cues.
    Conclusions: Despite never having smoked combustible cigarettes, young adult vapers exhibited heightened neural susceptibility to both vaping and smoking cues within brain systems associated with cue reactivity. The findings shed light on the mechanisms underlying nicotine addiction and smoking initiation risk in this critical population and may contribute to the development of science-based interventions and regulatory measures in the future.
    Implications: The escalating vaping prevalence among US never-smoking young adults is alarming, due to its potential ramifications for nicotine addiction development. Nicotine addiction is characterized by elevated neural response to conditioned nicotine-related cues. Using functional neuroimaging, we showed that young adult non-smoking vapers exhibited heightened neural susceptibility to both vaping and smoking cues within brain systems previously associated with cue reactivity. Such cross-reactivity to both types of nicotine cues may serve as the mechanism underlying nicotine addiction and smoking initiation risk in this population. Our findings may contribute to the development of science-based interventions and regulatory measures addressing the vaping epidemic.
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.13.575524
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  7. Article ; Online: Stereoretentive enantioconvergent reactions.

    Bennett, Steven H / Bestwick, Jacob S / Demertzidou, Vera P / Jones, David J / Jones, Helen E / Richard, François / Homer, Joshua A / Street-Jeakings, Rosie / Tiberia, Andrew F / Lawrence, Andrew L

    Nature chemistry

    2024  

    Abstract: Enantioconvergent reactions are pre-eminent in contemporary asymmetric synthesis as they convert both enantiomers of a racemic starting material into a single enantioenriched product, thus avoiding the maximum 50% yield associated with resolutions. All ... ...

    Abstract Enantioconvergent reactions are pre-eminent in contemporary asymmetric synthesis as they convert both enantiomers of a racemic starting material into a single enantioenriched product, thus avoiding the maximum 50% yield associated with resolutions. All currently known enantioconvergent processes necessitate the loss or partial loss of the racemic substrate's stereochemical information, thus limiting the potential substrate scope to molecules that contain labile stereogenic units. Here we present an alternative approach to enantioconvergent reactions that can proceed with full retention of the racemic substrate's configuration. This uniquely stereo-economic approach is possible if the two enantiomers of a racemic starting material are joined together to form one enantiomer of a non-meso product. Experimental validation of this concept is presented using two distinct strategies: (1) a direct asymmetric coupling approach, and (2) a multicomponent approach, which exhibits statistical amplification of enantiopurity. Thus, the established dogma that enantioconvergent reactions require substrates that contain labile stereogenic units is shown to be incorrect.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/s41557-024-01504-1
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  8. Article ; Online: Palliative Radiotherapy for Advanced Cancers: Indications and Outcomes.

    Williams, Graeme R / Manjunath, Shwetha H / Butala, Anish A / Jones, Joshua A

    Surgical oncology clinics of North America

    2021  Volume 30, Issue 3, Page(s) 563–580

    Abstract: Palliative radiotherapy (PRT) is well-tolerated, effective treatment for pain, bleeding, obstruction, and other symptoms/complications of advanced cancer. It is an important component of multidisciplinary management. It should be considered even for ... ...

    Abstract Palliative radiotherapy (PRT) is well-tolerated, effective treatment for pain, bleeding, obstruction, and other symptoms/complications of advanced cancer. It is an important component of multidisciplinary management. It should be considered even for patients with poor prognosis, because it can offer rapid symptomatic relief. Furthermore, expanding indications for treatment of noncurable disease have shown that PRT can extend survival for select patients. For those with good prognosis, advanced PRT techniques may improve the therapeutic ratio, maximizing tumor control while limiting toxicity. PRT referral should be considered for any patient with symptomatic or asymptomatic sites of disease where local control is desired.
    MeSH term(s) Humans ; Neoplasms/radiotherapy ; Palliative Care ; Radiation Oncology ; Radiotherapy ; Treatment Outcome
    Language English
    Publishing date 2021-05-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2021.02.007
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  9. Article ; Online: Residential proximity to dioxin emissions and risk of breast cancer in the sister study cohort.

    Rhee, Jongeun / Medgyesi, Danielle N / Fisher, Jared A / White, Alexandra J / Sampson, Joshua N / Sandler, Dale P / Ward, Mary H / Jones, Rena R

    Environmental research

    2023  Volume 222, Page(s) 115297

    Abstract: Some dioxins are carcinogenic, but few studies have investigated the relationship between ambient polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) and risk of breast cancer. We evaluated associations between proximity-based residential ... ...

    Abstract Some dioxins are carcinogenic, but few studies have investigated the relationship between ambient polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) and risk of breast cancer. We evaluated associations between proximity-based residential exposure to industrial emissions of PCDD/F and breast cancer risk in a large U.S. cohort. Sister Study participants at enrollment (2003-2009) were followed for incident breast cancer through September 2018. After restricting to participants with ≥10 years of residential history prior to enrollment (n = 35,908), we generated 10-year distance- and toxic equivalency quotient (TEQ)-weighted average emissions indices (AEI [g TEQ/km
    MeSH term(s) Humans ; Female ; Dioxins/analysis ; Breast Neoplasms ; Air Pollutants/analysis ; Polychlorinated Dibenzodioxins/analysis ; Risk ; Dibenzofurans, Polychlorinated
    Chemical Substances Dioxins ; Air Pollutants ; Polychlorinated Dibenzodioxins ; Dibenzofurans, Polychlorinated
    Language English
    Publishing date 2023-01-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.115297
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Heterogeneous Polymer Dynamics Explored Using Static

    Alam, Todd M / Allers, Joshua P / Jones, Brad H

    International journal of molecular sciences

    2020  Volume 21, Issue 15

    Abstract: NMR spectroscopy continues to provide important molecular level details of dynamics in different polymer materials, ranging from rubbers to highly crosslinked composites. It has been argued that thermoset polymers containing dynamic and chemical ... ...

    Abstract NMR spectroscopy continues to provide important molecular level details of dynamics in different polymer materials, ranging from rubbers to highly crosslinked composites. It has been argued that thermoset polymers containing dynamic and chemical heterogeneities can be fully cured at temperatures well below the final glass transition temperature (T
    MeSH term(s) Cyclodecanes/chemistry ; Magnetic Resonance Spectroscopy/methods ; Molecular Dynamics Simulation ; Motion ; Phloroglucinol/chemistry ; Polymers/chemistry ; Proton Magnetic Resonance Spectroscopy/methods ; Protons ; Temperature
    Chemical Substances Cyclodecanes ; Polymers ; Protons ; Phloroglucinol (DHD7FFG6YS)
    Language English
    Publishing date 2020-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21155176
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