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  1. Article ; Online: Platelets in COVID-19 disease: friend, foe, or both?

    Smęda, Marta / Hosseinzadeh Maleki, Ebrahim / Pełesz, Agnieszka / Chłopicki, Stefan

    Pharmacological reports : PR

    2022  Volume 74, Issue 6, Page(s) 1182–1197

    Abstract: Immuno-thrombosis of COVID-19 results in the activation of platelets and coagulopathy. Antiplatelet therapy has been widely used in COVID-19 patients to prevent thrombotic events. However, recent analysis of clinical trials does not support the major ... ...

    Abstract Immuno-thrombosis of COVID-19 results in the activation of platelets and coagulopathy. Antiplatelet therapy has been widely used in COVID-19 patients to prevent thrombotic events. However, recent analysis of clinical trials does not support the major effects of antiplatelet therapy on mortality in hospitalized COVID-19 patients, despite the indisputable evidence for an increased risk of thrombotic complications in COVID-19 disease. This apparent paradox calls for an explanation. Platelets have an important role in sensing and orchestrating host response to infection, and several platelet functions related to host defense response not directly related to their well-known hemostatic function are emerging. In this paper, we aim to review the evidence supporting the notion that platelets have protective properties in maintaining endothelial barrier integrity in the course of an inflammatory response, and this role seems to be of particular importance in the lung. It might, thus, well be that the inhibition of platelet function, if affecting the protective aspect of platelet activity, might diminish clinical benefits resulting from the inhibition of the pro-thrombotic phenotype of platelets in immuno-thrombosis of COVID-19. A better understanding of the platelet-dependent mechanisms involved in the preservation of the endothelial barrier is necessary to design the antiplatelet therapeutic strategies that inhibit the pro-thrombotic activity of platelets without effects on the vaso-protective function of platelets safeguarding the pulmonary endothelial barrier during multicellular host defense in pulmonary circulation.
    MeSH term(s) Humans ; COVID-19/complications ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2022-12-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2186248-5
    ISSN 2299-5684 ; 1734-1140
    ISSN (online) 2299-5684
    ISSN 1734-1140
    DOI 10.1007/s43440-022-00438-0
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  2. Article ; Online: Endothelial barrier integrity in COVID-19-dependent hyperinflammation: does the protective facet of platelet function matter?

    Smeda, Marta / Chlopicki, Stefan

    Cardiovascular research

    2020  Volume 116, Issue 10, Page(s) e118–e121

    MeSH term(s) Betacoronavirus/pathogenicity ; Blood Platelets/virology ; COVID-19 ; Coronavirus Infections/virology ; Endothelium/virology ; Hemostasis/physiology ; Humans ; Inflammation/virology ; Pandemics ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa190
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  3. Article ; Online: The endothelial barrier and cancer metastasis: Does the protective facet of platelet function matter?

    Smeda, Marta / Przyborowski, Kamil / Stojak, Marta / Chlopicki, Stefan

    Biochemical pharmacology

    2020  Volume 176, Page(s) 113886

    Abstract: Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet-cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the ... ...

    Abstract Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet-cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer-related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet-dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis.
    MeSH term(s) Animals ; Blood Platelets/cytology ; Blood Platelets/physiology ; Cell Communication ; Endothelium/cytology ; Endothelium/physiology ; Humans ; Inflammation/blood ; Neoplasm Metastasis ; Neoplasms/blood ; Neoplasms/blood supply ; Neoplasms/pathology ; Platelet Activation ; Thrombosis/blood
    Language English
    Publishing date 2020-02-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2020.113886
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  5. Article ; Online: Endothelial barrier integrity in COVID-19-dependent hyperinflammation

    Smeda, Marta / Chlopicki, Stefan

    Cardiovascular Research

    does the protective facet of platelet function matter?

    2020  Volume 116, Issue 10, Page(s) e118–e121

    Keywords Physiology (medical) ; Physiology ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa190
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  6. Article ; Online: Myoglobin deficiency impairs maximal oxygen uptake and exercise performance: a lesson from Mb

    Zoladz, Jerzy A / Grandys, Marcin / Smeda, Marta / Kij, Agnieszka / Kurpinska, Anna / Kwiatkowski, Grzegorz / Karasinski, Janusz / Hendgen-Cotta, Ulrike / Chlopicki, Stefan / Majerczak, Joanna

    The Journal of physiology

    2024  Volume 602, Issue 5, Page(s) 855–873

    Abstract: Myoglobin (Mb) plays an important role at rest and during exercise as a reservoir of oxygen and has been suggested to regulate ... ...

    Abstract Myoglobin (Mb) plays an important role at rest and during exercise as a reservoir of oxygen and has been suggested to regulate NO
    MeSH term(s) Mice ; Animals ; Myoglobin/genetics ; Nitrogen Dioxide ; Running/physiology ; Oxygen ; Exercise Test ; Mice, Knockout ; Oxygen Consumption/physiology
    Chemical Substances Myoglobin ; Nitrogen Dioxide (S7G510RUBH) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP285067
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  7. Article ; Online: High-Resolution Fourier Transform Infrared (FT-IR) Spectroscopic Imaging for Detection of Lung Structures and Cancer-Related Abnormalities in a Murine Model.

    Augustyniak, Karolina / Chrabaszcz, Karolina / Smeda, Marta / Stojak, Marta / Marzec, Katarzyna M / Malek, Kamilla

    Applied spectroscopy

    2021  Volume 76, Issue 4, Page(s) 439–450

    Abstract: Label-free molecular imaging is a promising utility to study tissues in terms of the identification of their compartments as well as chemical features and alterations induced by disease. The aim of this work was to assess if higher magnification of ... ...

    Abstract Label-free molecular imaging is a promising utility to study tissues in terms of the identification of their compartments as well as chemical features and alterations induced by disease. The aim of this work was to assess if higher magnification of optics in the Fourier transform infrared (FT-IR) microscope coupled with the focal plane detector resulted in better resolution of lung structures and if the histopathological features correlated with clustering of spectral images. FT-IR spectroscopic imaging was performed on paraffinized lung tissue sections from mice with optics providing a total magnification of 61× and 36×. Then, IR images were subjected to unsupervised cluster analysis and, subsequently, cluster maps were compared with hematoxylin and eosin staining of the same tissue section. Based on these results, we observed minute features such as cellular compartments in single alveoli and bronchiole, blood cells and megakaryocytes in a vessel as well as atelectasis of the lung. In the case of the latter, differences in composition were also noted between the tissue from the non-cancerous and cancerous specimen. This study demonstrated the ability of high-definition FT-IR imaging to evaluate the chemical features of well-resolved lung structures that could complement the histological examination widely used in animal models of disease.
    MeSH term(s) Animals ; Disease Models, Animal ; Fourier Analysis ; Lung/diagnostic imaging ; Mice ; Neoplasms ; Spectroscopy, Fourier Transform Infrared/methods
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Journal Article
    ISSN 1943-3530
    ISSN (online) 1943-3530
    DOI 10.1177/00037028211025540
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  8. Article: Direct Thrombin Inhibitor Dabigatran Compromises Pulmonary Endothelial Integrity in a Murine Model of Breast Cancer Metastasis to the Lungs; the Role of Platelets and Inflammation-Associated Haemostasis.

    Smeda, Marta / Stojak, Marta / Przyborowski, Kamil / Sternak, Magdalena / Suraj-Prazmowska, Joanna / Kus, Kamil / Derszniak, Katarzyna / Jasztal, Agnieszka / Kij, Agnieszka / Kurpinska, Anna / Kieronska-Rudek, Anna / Wojnar-Lason, Kamila / Buczek, Elzbieta / Mohaissen, Tasnim / Chlopicki, Stefan

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 834472

    Abstract: Activation of the coagulation cascade favours metastatic spread, but antithrombotic therapy might also have detrimental effects on cancer progression. In this study, we characterized the effects of dabigatran, a direct reversible thrombin inhibitor, on ... ...

    Abstract Activation of the coagulation cascade favours metastatic spread, but antithrombotic therapy might also have detrimental effects on cancer progression. In this study, we characterized the effects of dabigatran, a direct reversible thrombin inhibitor, on the pulmonary endothelial barrier and metastatic spread in a murine model of breast cancer metastasis. Dabigatran etexilate (100 mg kg
    Language English
    Publishing date 2022-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.834472
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  9. Article ; Online: Tracking Extracellular Matrix Remodeling in Lungs Induced by Breast Cancer Metastasis. Fourier Transform Infrared Spectroscopic Studies.

    Chrabaszcz, Karolina / Kaminska, Katarzyna / Augustyniak, Karolina / Kujdowicz, Monika / Smeda, Marta / Jasztal, Agnieszka / Stojak, Marta / Marzec, Katarzyna M / Malek, Kamilla

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 1

    Abstract: This work focused on a detailed assessment of lung tissue affected by metastasis of breast cancer. We used large-area chemical scanning implemented in Fourier transform infrared (FTIR) spectroscopic imaging supported with classical histological and ... ...

    Abstract This work focused on a detailed assessment of lung tissue affected by metastasis of breast cancer. We used large-area chemical scanning implemented in Fourier transform infrared (FTIR) spectroscopic imaging supported with classical histological and morphological characterization. For the first time, we differentiated and defined biochemical changes due to metastasis observed in the lung parenchyma, atelectasis, fibrous, and muscle cells, as well as bronchi ciliate cells, in a qualitative and semi-quantitative manner based on spectral features. The results suggested that systematic extracellular matrix remodeling with the progress of the metastasis process evoked a decrease in the fraction of the total protein in atelectasis, fibrous, and muscle cells, as well as an increase of fibrillar proteins in the parenchyma. We also detected alterations in the secondary conformations of proteins in parenchyma and atelectasis and changes in the level of hydroxyproline residues and carbohydrate moieties in the parenchyma. The results indicate the usability of FTIR spectroscopy as a tool for the detection of extracellular matrix remodeling, thereby enabling the prediction of pre-metastatic niche formation.
    MeSH term(s) Animals ; Breast Neoplasms/pathology ; Disease Models, Animal ; Extracellular Matrix/chemistry ; Extracellular Matrix/metabolism ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Mice ; Spectroscopy, Fourier Transform Infrared
    Language English
    Publishing date 2020-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25010236
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  10. Article: Fourier Transform Infrared Polarization Contrast Imaging Recognizes Proteins Degradation in Lungs upon Metastasis from Breast Cancer.

    Chrabaszcz, Karolina / Kaminska, Katarzyna / Song, Cai Li / Morikawa, Junko / Kujdowicz, Monika / Michalczyk, Ewelina / Smeda, Marta / Stojak, Marta / Jasztal, Agnieszka / Kazarian, Sergei G / Malek, Kamilla

    Cancers

    2021  Volume 13, Issue 2

    Abstract: The current understanding of mechanisms underlying the formation of metastatic tumors has required multi-parametric methods. The tissue micro-environment in secondary organs is not easily evaluated due to complex interpretation with existing tools. Here, ...

    Abstract The current understanding of mechanisms underlying the formation of metastatic tumors has required multi-parametric methods. The tissue micro-environment in secondary organs is not easily evaluated due to complex interpretation with existing tools. Here, we demonstrate the detection of structural modifications in proteins using emerging Fourier Transform Infrared (FTIR) imaging combined with light polarization. We investigated lungs affected by breast cancer metastasis in the orthotopic murine model from the pre-metastatic phase, through early micro-metastasis, up to an advanced phase, in which solid tumors are developed in lung parenchyma. The two IR-light polarization techniques revealed, for the first time, the orientational ordering of proteins upon the progression of pulmonary metastasis of breast cancer. Their distribution was complemented by detailed histological examination. Polarized contrast imaging recognised tissue structures of lungs and showed deformations in protein scaffolds induced by inflammatory infiltration, fibrosis, and tumor growth. This effect was recognised by not only changes in absorbance of the spectral bands but also by the band shifts and the appearance of new signals. Therefore, we proposed this approach as a useful tool for evaluation of progressive and irreversible molecular changes that occur sequentially in the metastatic process.
    Language English
    Publishing date 2021-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13020162
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