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Article ; Online: The regulation mechanism of transition metal doping on Hg

Zhang, Guomeng / Jiang, Ye / Yang, Zhengda / Sun, Xin / Xu, Yichao / Cheng, Siyuan / Zhang, Xiang / Song, Jiayao

2024 Volume 927, Page(s) 172334

Abstract: The mercury oxidation performance of Ce/ ... ...

Abstract	The mercury oxidation performance of Ce/TiO
Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172334
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Article ; Online: Inadvertently enriched cyanobacteria prompted bacterial phosphorus uptake without aeration in a conventional anaerobic/oxic reactor.

Nie, Jiaxiang / Wang, Xiaoxia / Sun, Peng / Yu, Deshuang / Yu, Zhengda / Qiu, Yanling / Zhao, Ji

The Science of the total environment

2024 Volume 927, Page(s) 172313

Abstract: The enhanced biological phosphorus removal (EBPR) process requires alternate anaerobic and aerobic conditions, which are regulated respectively by aeration off and on. Recently, in an ordinary EBPR reactor, an abnormal orthophosphate concentration ( ... ...

Abstract	The enhanced biological phosphorus removal (EBPR) process requires alternate anaerobic and aerobic conditions, which are regulated respectively by aeration off and on. Recently, in an ordinary EBPR reactor, an abnormal orthophosphate concentration (PO
MeSH term(s)	Phosphorus/metabolism ; Cyanobacteria/metabolism ; Cyanobacteria/physiology ; Bioreactors/microbiology ; Anaerobiosis ; Waste Disposal, Fluid/methods ; Biofilms ; Aerobiosis
Chemical Substances	Phosphorus (27YLU75U4W)
Language	English
Publishing date	2024-04-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172313
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Article ; Online: Comprehensive Parameter Space Mapping of Cell Cycle Dynamics under Network Perturbations.

Li, Zhengda / Wang, Shiyuan / Sun, Meng / Jin, Minjun / Khain, Daniel / Yang, Qiong

ACS synthetic biology

2024 Volume 13, Issue 3, Page(s) 804–815

Abstract: Studies of quantitative systems and synthetic biology have extensively utilized models to interpret data, make predictions, and guide experimental designs. However, models often simplify complex biological systems and lack experimentally validated ... ...

Abstract	Studies of quantitative systems and synthetic biology have extensively utilized models to interpret data, make predictions, and guide experimental designs. However, models often simplify complex biological systems and lack experimentally validated parameters, making their reliability in perturbed systems unclear. Here, we developed a droplet-based synthetic cell system to continuously tune parameters at the single-cell level in multiple dimensions with full dynamic ranges, providing an experimental framework for global parameter space scans. We systematically perturbed a cell-cycle oscillator centered on cyclin-dependent kinase (Cdk1), enabling comprehensive mapping of period landscapes in response to network perturbations. The data allowed us to challenge existing models and refine a new model that matches the observed response. Our analysis demonstrated that Cdk1 positive feedback inhibition restricts the cell cycle frequency range, confirming model predictions; furthermore, it revealed new cellular responses to the inhibition of the Cdk1-counteracting phosphatase PP2A: monomodal or bimodal distributions across varying inhibition levels, underscoring the complex nature of cell cycle regulation that can be explained by our model. This comprehensive perturbation platform may be generalizable to exploring other complex dynamic systems.
MeSH term(s)	Reproducibility of Results ; Cell Cycle ; Cell Division
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ISSN	2161-5063
ISSN (online)	2161-5063
DOI	10.1021/acssynbio.3c00631
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Article ; Online: The Rehabilitation Training Simulation of High Difficulty Movement and Sports Strain Site Based on Big Data

Xiaojie Zhang / Zhengda Ma / Yongming Sun / Yanle Hu

Journal of Healthcare Engineering, Vol

2021 Volume 2021

Abstract: We study the rehabilitation training of damaged parts of ice and snow sports clock and ensure the physical safety of athletes. The results show that the RBF neural network updates the center, weight, and width of the radial basis function, and the ... ...

Abstract	We study the rehabilitation training of damaged parts of ice and snow sports clock and ensure the physical safety of athletes. The results show that the RBF neural network updates the center, weight, and width of the radial basis function, and the predicted maximum compliance is 99%, and the minimum compliance is 93%. After many analysis times, the prediction results show that the difference between the predicted degree of conformity and the actual results is less than 8%. The RBF neural network is trained according to the risk database of sports injury, and the RBF neural network will output corresponding values to realize sports injury estimation. The experimental results show that the designed model has high precision and efficiency.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Recombinant human erythropoietin protects against immature brain damage induced by hypoxic/ischemia insult.

Sun, Zhengda / Song, Jiqing / Song, Qijun / Li, Lin / Tian, Xinxin / Wang, Lijun

Neuroreport

2023 Volume 34, Issue 17, Page(s) 801–810

Abstract: To investigate the neuroprotection of recombinant human erythropoietin (rhEPO) against hypoxic/ischemic (HI) insult in three-day-old rats. Postnatal day 3 (PD3) rats were randomly divided into three groups: Sham group, HI group and HI+rhEPO group. ... ...

Abstract	To investigate the neuroprotection of recombinant human erythropoietin (rhEPO) against hypoxic/ischemic (HI) insult in three-day-old rats. Postnatal day 3 (PD3) rats were randomly divided into three groups: Sham group, HI group and HI+rhEPO group. Ligation of the right common carotid artery and hypoxia to induce HI brain injury. After HI insult, the rats received intraperitoneal injection of rhEPO (5000 IU/Kg, qod) in HI+rhEPO group or equal saline in other groups. On PD10, damage of brain tissue was examined by hematoxylin-eosin (HE) staining, observation of neuronal apoptosis in the hippocampus and cortex using immunofluorescence assay (marker: TUNEL). Immunohistochemical staining or western blotting was performed to detect the expression of cyclooxygenase-2 (COX-2), Caspase-3 and phosphorylated Akt (p-Akt) protein. On PD28, cognitive ability of rats was assessed by Morris water maze test. HI injury causes brain pathological morphology and cognitive function damage in PD3 rats, which can be alleviated by rhEPO intervention. Compared with the HI group, the HI+rhEPO group showed an increase in platform discovery rate and cross platform frequency, while the search platform time was shortened (P < 0.05). The proportion of TUNEL positive neurons and the expression of COX-2 and Caspase-3 proteins in brain tissue in the hippocampus and cortex was decreased, while the expression of p-Akt protein was upregulated (P < 0.05). RhEPO could protect against the pathological and cognitive impairment of immature brain induced by HI insult. This neuroprotective activity may involve in inhibiting inflammatory and apoptosis by activation of PI3K/Akt signaling pathway.
MeSH term(s)	Humans ; Rats ; Animals ; Caspase 3/metabolism ; Rats, Sprague-Dawley ; Proto-Oncogene Proteins c-akt/metabolism ; Cyclooxygenase 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Brain/metabolism ; Hypoxia/metabolism ; Hypoxia-Ischemia, Brain/complications ; Hypoxia-Ischemia, Brain/drug therapy ; Hypoxia-Ischemia, Brain/metabolism ; Erythropoietin/pharmacology ; Erythropoietin/therapeutic use ; Ischemia/metabolism ; Animals, Newborn ; Neuroprotective Agents/pharmacology
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Erythropoietin (11096-26-7) ; Neuroprotective Agents
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1049746-8
ISSN	1473-558X ; 0959-4965
ISSN (online)	1473-558X
ISSN	0959-4965
DOI	10.1097/WNR.0000000000001957
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Article ; Online: The Rehabilitation Training Simulation of High Difficulty Movement and Sports Strain Site Based on Big Data.

Zhang, Xiaojie / Ma, Zhengda / Sun, Yongming / Hu, Yanle

publication RETRACTED

Journal of healthcare engineering

2021 Volume 2021, Page(s) 2911025

Abstract	We study the rehabilitation training of damaged parts of ice and snow sports clock and ensure the physical safety of athletes. The results show that the RBF neural network updates the center, weight, and width of the radial basis function, and the predicted maximum compliance is 99%, and the minimum compliance is 93%. After many analysis times, the prediction results show that the difference between the predicted degree of conformity and the actual results is less than 8%. The RBF neural network is trained according to the risk database of sports injury, and the RBF neural network will output corresponding values to realize sports injury estimation. The experimental results show that the designed model has high precision and efficiency.
MeSH term(s)	Athletes ; Big Data ; Computer Simulation ; Humans ; Neural Networks, Computer ; Sports
Language	English
Publishing date	2021-09-29
Publishing country	England
Document type	Journal Article ; Retracted Publication
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2021/2911025
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Article ; Online: Peroxymonosulfate activation by walnut shell activated carbon supported nano zero-valent iron for the degradation of tetracycline: Performance, degradation pathway and mechanism.

Duan, Pingping / Kong, Fanlong / Fu, Xiuzheng / Han, Zhijie / Sun, Guangwei / Yu, Zhengda / Wang, Sen / Cui, Yuqian

Environmental research

2023 Volume 245, Page(s) 117971

Abstract: In this study, activated carbon (WS-AC) was prepared from walnut shell. Nano-zero-valent iron (nZVI) was loaded on walnut shell activated carbon by liquid phase reduction method and used as catalyst (WS-AC/nZVI) to activate peroxymonosulfate (PMS) to ... ...

Abstract	In this study, activated carbon (WS-AC) was prepared from walnut shell. Nano-zero-valent iron (nZVI) was loaded on walnut shell activated carbon by liquid phase reduction method and used as catalyst (WS-AC/nZVI) to activate peroxymonosulfate (PMS) to efficiently degrade tetracycline (TC) in solution. The composite material with a mass ratio of WS-AC to nZVI of 1:1 has the highest catalytic performance for activating PMS to degrade TC. The results showed that under the conditions of TC concentration of 100 ppm, PMS dosage of 0.2 mM and WS-AC/nZVI dosage of 0.1 g/L, the removal efficiency of TC could reach 81%. Based on quenching experiments and electron spin resonance (EPR), it was verified that •OH, SO
MeSH term(s)	Charcoal ; Juglans ; Iron/chemistry ; Water Pollutants, Chemical/chemistry ; Anti-Bacterial Agents ; Tetracycline/chemistry ; Peroxides
Chemical Substances	peroxymonosulfate (22047-43-4) ; Charcoal (16291-96-6) ; Iron (E1UOL152H7) ; Water Pollutants, Chemical ; Anti-Bacterial Agents ; Tetracycline (F8VB5M810T) ; Peroxides
Language	English
Publishing date	2023-12-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.117971
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Article ; Online: Integrated bioinformatics approaches to investigate alterations in transcriptomic profiles of monkeypox infected human cell line model

Gangga Anuraga / Jilu Lang / Do Thi Minh Xuan / Hoang Dang Khoa Ta / Jia-Zhen Jiang / Zhengda Sun / Sanskriti Dey / Sachin Kumar / Ayushi Singh / Gagan Kajla / Wei-Jan Wang / Chih-Yang Wang

Journal of Infection and Public Health, Vol 17, Iss 1, Pp 60-

2024 Volume 69

Abstract: Background: The recent re-emergence of the monkeypox (mpox) epidemic in nonendemic regions has raised concerns regarding a potential global outbreak. The mpox virus (MPV) is a smallpox-like virus belonging to the genus Orthopoxvirus (family: Poxviridae). ...

Abstract	Background: The recent re-emergence of the monkeypox (mpox) epidemic in nonendemic regions has raised concerns regarding a potential global outbreak. The mpox virus (MPV) is a smallpox-like virus belonging to the genus Orthopoxvirus (family: Poxviridae). Although studies suggest that MPV infection suppresses the Toll-like receptor-3- and tumor necrosis factor-α-related signaling pathways, whether MPV regulates other immune-related pathways remains unclear. Methods: In this study, two distinct temporal patterns were used for establishing an MPV-infected human immortal epithelial cancer cell line (HeLa). These two durations 2 and 12 h of incubation were selected to identify the coregulated genes and pathways affected by MPV infection. Results: The use of the Gene Ontology framework, Kyoto Encyclopedia of Genes and Genome database, and MetaCore software yielded valuable insights. Specifically, various pathways were found to be enriched in HeLa cells infected with MPV for 2 and 12 h. These pathways included Notch, CD40, CD95, hypoxia-inducible factor-1-α, interleukin (IL)− 1, IL-6, phosphoinositide 3-kinase, nuclear factor-κB, mitogen-activated protein kinase, and oxidative stress–induced signalling pathways. Clusters and pathways of metabolism and viral replication cycles were significantly associated with the 2-hour infection group. This association was identified based on the regulation of genes such as HSPG2, RHPN2, MYL1, ASPHD2, CA9, VIPR1, SNX12, MGC2752, SLC25A1, PEX19, and AREG. Furthermore, clusters and pathways related to immunity and cell movement were found to be associated with the 12-hour infection group. This association was identified based on the regulation of genes such as C1orf21, C19orf48, HRK, IL8, GULP1, SCAND2, ATP5C1, FEZ1, SGSH, TACC2, CYP4X1, MMP1, CPB1, P2RY13, WDR27, PRPF4, and ENDOD1. Conclusions: This study can improve our understanding of the mechanisms underlying the pathophysiology and post-infection sequelae of mpox. Our findings provide valuable insights into the various modes of ...
Keywords	Monkeypox (mpox) ; Viral replication ; Cellular metabolism ; Cell movement ; Immune response ; Bioinformatics ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	570
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Detection system of the lobster eye telescope with large field of view.

Chen, Yifan / Sun, Xiaojin / Li, Zhengda / Wang, Chengbin / Zhang, Chen / Sun, Shengli

Applied optics

2022 Volume 61, Issue 29, Page(s) 8813–8818

Abstract: The lobster eye telescope is promising for large-field x ray imaging in astronomy. The special structure of the lobster eye system makes the focal plane a sphere, resulting in detector defocus when the field is large. In this study, we established a ... ...

Abstract	The lobster eye telescope is promising for large-field x ray imaging in astronomy. The special structure of the lobster eye system makes the focal plane a sphere, resulting in detector defocus when the field is large. In this study, we established a model based on the principle of lobster eye imaging and simulated the imaging at different image distances. The results reveal the relationship between the defocus and position accuracy and angular resolution. To ensure the optical performance of the large field lobster eye telescope, we propose a detection system design method using multiple detectors stitched together to form a spherical-like surface and apply it to the development of the Einstein Probe/wide-field x ray telescope (EP/WXT) submodule. About 70% of the detection area is out of focus within 0.5 mm. The scanning image of the integrated WXT submodule shows good uniformity of the point spread function (PSF) for various incident angles, and the effect of defocus on imaging is acceptable.
MeSH term(s)	Animals ; Telescopes ; Nephropidae ; X-Rays ; Astronomy ; Vision, Ocular
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.469433
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Article ; Online: Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease.

Shrestha, Pradeep / Turan, Ali / Batra, Lalit / Gulen, Ayse Ece / Sun, Zhengda / Tan, Helen / Askenasy, Nadir / Shirwan, Haval / Yolcu, Esma S

Blood advances

2023 Volume 7, Issue 10, Page(s) 2181–2195

Abstract: Alloreactive T-effector cells (Teffs) are the major culprit of acute graft-versus-host disease (aGVHD) associated with hematopoietic stem cell transplantation. Ex vivo nonspecific depletion of T cells from the donor graft impedes stem cell engraftment ... ...

Abstract	Alloreactive T-effector cells (Teffs) are the major culprit of acute graft-versus-host disease (aGVHD) associated with hematopoietic stem cell transplantation. Ex vivo nonspecific depletion of T cells from the donor graft impedes stem cell engraftment and posttransplant immune reconstitution. Teffs upregulate Fas after activation and undergo Fas ligand (FasL)-mediated restimulation-induced cell death (RICD), an important mechanism of immune homeostasis. We targeted RICD as a means to eliminate host-reactive Teffs in vivo for the prevention of aGVHD. A novel form of FasL protein chimeric with streptavidin (SA-FasL) was transiently displayed on the surface of biotinylated lymphocytes, taking advantage of the high-affinity interaction between biotin and streptavidin. SA-FasL-engineered mouse and human T cells underwent apoptosis after activation in response to alloantigens in vitro and in vivo. SA-FasL on splenocytes was effective in preventing aGVHD in >70% of lethally irradiated haploidentical mouse recipients after cotransplantation with bone marrow cells, whereas all controls that underwent transplantation with nonengineered splenocytes developed aGVHD. Prevention of aGVHD was associated with an increased ratio of CD4+CD25+FoxP3+ T regulatory (Tregs) to Teffs and significantly reduced transcripts for proinflammatory cytokines in the lymphoid organs and target tissues. Depletion of Tregs from the donor graft abrogated the protection conferred by SA-FasL. This approach was also effective in a xenogeneic aGVHD setting where SA-FasL-engineered human PBMCs were transplanted into NSG mice. Direct display of SA-FasL protein on donor cells as an effective means of eliminating alloreactive Teffs in the host represents a practical approach with significant translation potential for the prevention of aGVHD.
MeSH term(s)	Mice ; Humans ; Animals ; Fas Ligand Protein ; Streptavidin ; Graft vs Host Disease/prevention & control ; T-Lymphocytes ; Lymphocytes
Chemical Substances	Fas Ligand Protein ; Streptavidin (9013-20-1)
Language	English
Publishing date	2023-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022008495
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