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  1. Article ; Online: Endothelial-cell inflammation and damage by reactive oxygen species are prevented by propofol via ABCA1-mediated cholesterol efflux.

    Hsu, Chih-Peng / Lin, Chih-Hung / Kuo, Chan-Yen

    International journal of medical sciences

    2018  Volume 15, Issue 10, Page(s) 978–985

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) ATP Binding Cassette Transporter 1/metabolism ; ATP Binding Cassette Transporter 1/physiology ; ATP-Binding Cassette Transporters ; Animals ; Aorta ; Cholesterol/metabolism ; Endothelial Cells ; Hypnotics and Sedatives/pharmacology ; Inflammation ; Propofol/pharmacology ; Rats ; Reactive Oxygen Species
    Chemical Substances ABCA1 protein, rat ; ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters ; Hypnotics and Sedatives ; Reactive Oxygen Species ; Cholesterol (97C5T2UQ7J) ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2018-06-14
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.24659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of expanded strong opioid availability on opioid prescription patterns in patients with cancer: A population-wide cohort study in Taiwan.

    Wu, Tsung-Che / Hsu, Chih-Hung / Sun, Wei-Zen / Chen, Ho-Min / Lin, Chih-Peng / Shao, Yu-Yun

    The Lancet regional health. Western Pacific

    2021  Volume 16, Page(s) 100255

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2021.100255
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  3. Article ; Online: Solving the deficit of cancer pain management skills by education programs.

    Shao, Yu-Yun / Lin, Wen-Ying / Lin, Chih-Peng / Lu, Li-Chun / Hsu, Chih-Hung

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2020  Volume 29, Issue 4, Page(s) 1843–1848

    Abstract: Background: Suboptimal cancer pain management is a worldwide problem. We examined whether an educational program on cancer pain management implemented during training could benefit primary care physicians.: Methods: We enrolled all the primary care ... ...

    Abstract Background: Suboptimal cancer pain management is a worldwide problem. We examined whether an educational program on cancer pain management implemented during training could benefit primary care physicians.
    Methods: We enrolled all the primary care physicians who visited the oncology ward at a medical center for the first time. Educational classes on cancer pain management were conducted. The participants' abilities in cancer pain management were measured in a pretest before the classes and approximately 2 weeks later in the first posttest. The second posttest was conducted on participants who visited the oncology ward again. All 3 tests had the same set of questions and were scored on a scale of 0 to 100.
    Results: In total, 247 participants were enrolled. Less than 10% of them considered their previous education on cancer pain management adequate. The test scores increased significantly from the pretest to the first posttest (mean 65.6 vs. 89.7, p < 0.001). The participants' self-reported cancer pain management abilities, on a scale of 0 to 100, also improved significantly (mean 57.8 vs. 75.5, p < 0.001). The pretest scores were not associated with the participants' self-reported abilities or their perceptions about the adequacy of previous training on cancer pain management. The mean score on the second posttest, conducted 234.5 days after the program, on an average, remained similar to that of the first posttest (p = 0.254).
    Conclusion: A specific educational program on cancer pain management provided to primary care physicians improved their pain management skills substantially, with persistent effects.
    MeSH term(s) Female ; Humans ; Male ; Neoplasms/therapy ; Pain Management/methods ; Patient Education as Topic/methods ; Surveys and Questionnaires
    Language English
    Publishing date 2020-08-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-020-05651-2
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    Zs.A 3697: Show issues Location:
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  4. Article ; Online: Long-term work quality of patients with mild traumatic brain injury: The associations with postconcussion symptoms.

    Lai, Wen-Hsuan / Hsu, Huan-Hsuan / Yu, Hsiu-Ting / Xiao, Sheng-Huang / Tsai, Yi-Hsin / Wang, Kuo-Chuan / Huang, Sheng-Jean / Lin, Chih-Peng / Yang, Chi-Cheng

    Applied neuropsychology. Adult

    2023  , Page(s) 1–7

    Abstract: Return to work (RTW) has always been a determinant functional outcome in patients with mild traumatic brain injury (MTBI). However, the quality of long-term RTW was still unclear. This study thus aims to examine long-term work quality and to reveal its ... ...

    Abstract Return to work (RTW) has always been a determinant functional outcome in patients with mild traumatic brain injury (MTBI). However, the quality of long-term RTW was still unclear. This study thus aims to examine long-term work quality and to reveal its associating factors. A total of 110 patients with MTBI was prospectively recruited. Post-concussion symptoms (PCS) and RTW were evaluated by the Checklist of Post-Concussion Symptoms (CPCS) and Work Quality Index (WQI) respectively at one-week and long-term evaluation (
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2673736-X
    ISSN 2327-9109 ; 2327-9095
    ISSN (online) 2327-9109
    ISSN 2327-9095
    DOI 10.1080/23279095.2023.2186232
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    Zs.A 4952: Show issues Location:
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  5. Article ; Online: Impact of expanded strong opioid availability on opioid prescription patterns in patients with cancer

    Tsung-Che Wu / Chih-Hung Hsu / Wei-Zen Sun / Ho-Min Chen / Chih-Peng Lin / Yu-Yun Shao

    The Lancet Regional Health. Western Pacific, Vol 16, Iss , Pp 100255- (2021)

    A population-wide cohort study in Taiwan

    2021  

    Abstract: Background One of the major barriers to adequate cancer pain management in Taiwan is the limited prescription options regarding strong opioids. Internationally recommended strong opioids, including oxycodone and hydromorphone, were not introduced in ... ...

    Abstract Background One of the major barriers to adequate cancer pain management in Taiwan is the limited prescription options regarding strong opioids. Internationally recommended strong opioids, including oxycodone and hydromorphone, were not introduced in Taiwan until late 2014. We analysed the patterns in opioid prescription for cancer pain management, after the introduction of new opioid options.Methods All inpatient and outpatient clinical visits from January 1, 2012, to December 31, 2017, with the diagnosis of cancer and the analgesic prescriptions were collected from the database of National Health Insurance, Taiwan, and analysed. Opioids were grouped into strong opioids, weak opioids, and guideline non-recommended opioids.Findings A total of 1, 292, 905 patients with cancers were included. Approximately 50% of patients used analgesics, 50% of which were opioids; the proportions were stable during the study period. The annual cumulative opioid use per patient (defined daily dose, DDD) significantly decreased from 36•41±102•59 (Mean±SD) in 2012 to 32•42±100•99 in 2017 (p < •001). The annual cumulative strong opioid use per patient increased significantly from 17•54±89•23 in 2012 to 19•28±94•97 in 2017 (+9•90%, p < •001). In parallel, the annual cumulative weak opioids use per patient decreased from 18•64±40•81 in 2012 to 13•04±26•79 in 2017 (−30•04%, p < •001). Among extended-release strong opioids, the use of transdermal fentanyl significantly decreased after oxycodone and hydromorphone were introduced (p < •001).Interpretation Increased therapeutic options in strong opioid prescriptions led opioid prescription patterns to evolve towards international cancer pain management guidelines. In addition, increased accessibility to a wider range of different strong opioids may facilitate more efficient opioid titration and rotation - and thus decrease, not increase, the opioid usage.Funding This study was supported by Ministry of Science and Technology, Taiwan (MOST-106-2314-B-002-213 and ...
    Keywords Cancer pain ; Opioids ; Transdermal fentanyl ; Hydromorphone ; Oxycodone ; Public aspects of medicine ; RA1-1270
    Subject code 001
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  6. Article ; Online: Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death.

    Lin, Chih-Peng / Wu, Shu-Hui / Lin, Tzu-Yin / Chu, Chia-Hui / Lo, Leu-Wei / Kuo, Ching-Chuan / Chang, Jang-Yang / Hsu, Szu-Chun / Ko, Bor-Sheng / Yao, Ming / Hsiao, Jong-Kai / Wang, Shih-Wei / Huang, Dong-Ming

    Pharmacological research

    2023  Volume 197, Page(s) 106945

    Abstract: Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. Nanoparticles as drug delivery systems (DDSs) show promise for MDR cancer therapy. However, current DDSs require sophisticated design and construction based on xenogeneic ... ...

    Abstract Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. Nanoparticles as drug delivery systems (DDSs) show promise for MDR cancer therapy. However, current DDSs require sophisticated design and construction based on xenogeneic nanomaterials, evoking feasibility and biocompatibility concerns. Herein, a simple but versatile biological DDS (bDDS) composed of human red blood cell (RBC)-derived vesicles (RDVs) with excellent biocompatibility was surface-linked with doxorubicin (Dox) using glutaraldehyde (glu) to form Dox-gluRDVs that remarkably suppressed MDR in uterine sarcoma through a lysosomal-mitochondrial axis-dependent cell death mechanism. Dox-gluRDVs can efficiently deliver and accumulate Dox in lysosomes, bypassing drug efflux transporters and facilitating cellular uptake and retention of Dox in drug-resistant MES-SA/Dx5 cells. The transfer of lysosomal calcium to the mitochondria during mitochondria-lysosome contact due to lysosomal Dox accumulation may result in mitochondrial ROS overproduction, mitochondrial membrane potential loss, and activation of apoptotic signaling for the superior anti-MDR activity of Dox-gluRDVs in vitro and in vivo. This work highlights the great promise of RDVs to serve as a bDDS of Dox to overcome MDR cancers but also opens up a reliable strategy for lysosomal-mitochondrial axis-dependent cell death for fighting against other inoperable cancers.
    MeSH term(s) Humans ; Pharmaceutical Preparations ; Neoplasms ; Cell Death ; Lysosomes ; Mitochondria ; Erythrocytes ; Doxorubicin/pharmacology
    Chemical Substances Pharmaceutical Preparations ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-10-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106945
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
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  7. Article: Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients.

    Chen, Yi-Ling / Lee, Kuo-Ting / Wang, Chih-Yang / Shen, Che-Hung / Chen, Sheau-Chiann / Chung, Wei-Pang / Hsu, Ya-Ting / Kuo, Yao-Lung / Chen, Pai-Sheng / Cheung, Chun Hei Antonio / Chang, Chih-Peng / Shen, Meng-Ru / Hsu, Hui-Ping

    American journal of cancer research

    2022  Volume 12, Issue 5, Page(s) 2084–2101

    Abstract: The incidence of breast cancer is increasing, and is one of the leading causes of cancer death worldwide. Dysregulation of NOTCH1 signaling is reported in breast cancer. In present study, bioinformatics was utilized to study the expression ... ...

    Abstract The incidence of breast cancer is increasing, and is one of the leading causes of cancer death worldwide. Dysregulation of NOTCH1 signaling is reported in breast cancer. In present study, bioinformatics was utilized to study the expression of
    Language English
    Publishing date 2022-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
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  8. Article ; Online: Effectiveness of Electroencephalography Neurofeedback for Improving Working Memory and Episodic Memory in the Elderly: A Meta-Analysis.

    Lin, Yu-Ru / Hsu, Tien-Wei / Hsu, Che-Wei / Chen, Peng-Yu / Tseng, Ping-Tao / Liang, Chih-Sung

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 3

    Abstract: Background and ... ...

    Abstract Background and Objective
    MeSH term(s) Aged ; Humans ; Memory, Short-Term ; Neurofeedback/methods ; Memory, Episodic ; Electroencephalography ; Cognition
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60030369
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  9. Article ; Online: COVID-19 mimicking dengue fever with the initial manifestation of retro-orbital pain – A Rare Case

    Walis Ruiy / Shih-Yung Hsu / Hsien-Lung Tsai / Chen-Te Chen / Chih-Peng Tseng / Wei-Teing Chen

    Journal of the Formosan Medical Association, Vol 119, Iss 11, Pp 1715-

    2020  Volume 1716

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  10. Article: COVID-19 mimicking dengue fever with the initial manifestation of retro-orbital pain - A Rare Case.

    Ruiy, Walis / Hsu, Shih-Yung / Tsai, Hsien-Lung / Chen, Chen-Te / Tseng, Chih-Peng / Chen, Wei-Teing

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2020  Volume 119, Issue 11, Page(s) 1715–1716

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Dengue/complications ; Dengue/diagnosis ; Diagnosis, Differential ; Female ; Fever/diagnosis ; Fever/virology ; Headache/diagnosis ; Headache/virology ; Humans ; Middle Aged ; Pandemics ; Philippines ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; Symptom Assessment ; Travel
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country Singapore
    Document type Case Reports ; Letter
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2020.05.039
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