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Article ; Online: Impact of weight adjusted high frequency low tidal volume ventilation and atrial pacing in lesion metrics in high-power short-duration ablation: Results of a pilot study.

Vassallo, Fabricio / Volponi, Carlos / Cunha, Christiano / Corcino, Lucas / Serpa, Eduardo / Simoes, Aloyr / Gasparini, Dalbian / Barbosa, Luiz Fernando / Schmidt, Andre

Journal of cardiovascular electrophysiology

2024 Volume 35, Issue 5, Page(s) 975–983

Abstract: Introduction: Lesion size index (LSI) was introduced with the use of Tacticath™ and as a surrogate of lesion quality. The metric used to achieve the predetermined values involves combined information of contact force (CF), power and radiofrequency time. ...

Abstract	Introduction: Lesion size index (LSI) was introduced with the use of Tacticath™ and as a surrogate of lesion quality. The metric used to achieve the predetermined values involves combined information of contact force (CF), power and radiofrequency time. Rapid atrial pacing (RAP) and high-frequency low-tidal volume ventilation (HFLTV) independently or in combination improve catheter stability and CF and quality of lesions. Data of the impact of body weight adjusted HFLTV ventilation strategy associated with RAP in the lesion metrics still lacking. The study aimed to compare the results of high-power short-duration (HPSD) atrial fibrillation ablation using simultaneous weight adjusted HFLTV and RAP and standard ventilation (SV) protocol. Methods: Prospective, nonrandomized study with 136 patients undergoing de novo ablation divided into two groups; 70 in RAP (100 ppm) + HFLTV with 4 mL/kg of tidal volume and 25 breaths/min (group A) and 66 patients with SV in intrinsic sinus rhythm (group B). Ablation using 50 W, CF of 5-10 g/10-20 g and 40 mL/minute flow rate on the posterior and anterior left atrial wall, respectively. Results: No procedure-related complications. Group A: Mean LSI points 70 ± 16.5, mean total lower LSI 3.4 ± 0.5, mean total higher LSI 8.2 ± 0.4 and mean total LSI 5.6 ± 0.6. Anterior and posterior wall mean total LSI was 6.0 ± 0.4 and 4.2 ± 0.3, respectively. Mean local impedance drop (LID) points were 118.8 ± 28.4, mean LID index (%) 12.9 ± 1.5, and mean LID < 12% points 55.9 ± 23.8. Anterior and posterior wall mean total LID index were 13.6 ± 2.0 and 11.9 ± 1.7, respectively. Recurrence in 11 (15.7%) patients. Group B: Mean LSI points 56 ± 2.7, mean total lower LSI 2.9 ± 0.7, mean total higher LSI 6.9 ± 0.9, and mean total LSI 4.8 ± 0.8. Anterior and posterior wall mean total LSI was 5.1 ± 0.3 and 3.5 ± 0.5, respectively. Mean LID points were 111.4 ± 21.5, mean LID index (%) 11.4 ± 1.2, and mean LID < 12% points 54.9 ± 25.2. Anterior and posterior wall mean total LID index were 11.8 ± 1.9 and 10.3 ± 1.7, respectively. Recurrence in 14 (21.2%) patients. Mean follow up was 15.2 ± 4.4 months. Conclusion: Weight adjusted HFLTV ventilation with RAP HPSD ablation produced lower recurrence rate and better LSI and LID parameters in comparison to SV and intrinsic sinus rhythm.
MeSH term(s)	Humans ; Female ; Pilot Projects ; Male ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Atrial Fibrillation/diagnosis ; Prospective Studies ; Middle Aged ; Aged ; Catheter Ablation/adverse effects ; Treatment Outcome ; Tidal Volume ; Time Factors ; Heart Rate ; Cardiac Pacing, Artificial ; Body Weight
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article ; Comparative Study
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.16245
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Article ; Online: Siparuna guianensis Essential Oil Antitumoral Activity on Ehrlich Model and Its Effect on Oxidative Stress.

Viana Barbosa, Lucas Gabriel / Silva de Jesus, Ellen Nayara / Botelho Jerônimo, Lucas / Silva da Costa, Jamile / Cunha Silva, Renata / Setzer, William N / R da Silva, Joyce Kelly / da Silva Freitas, Jofre Jacob / B Figueiredo, Pablo Luis

Chemistry & biodiversity

2023 Volume 20, Issue 10, Page(s) e202301120

Abstract: This work aims to evaluate the chemical composition, in vitro antioxidant capacity, and in vivo antitumoral activity of S. guianensis essential oil against Ehrlich's ascitic carcinoma and the effects on oxidative stress. The animals (Mus musculus) ... ...

Abstract	This work aims to evaluate the chemical composition, in vitro antioxidant capacity, and in vivo antitumoral activity of S. guianensis essential oil against Ehrlich's ascitic carcinoma and the effects on oxidative stress. The animals (Mus musculus) received a daily dose of S. guianensis oil orally (100 mg/kg) for 9 days. The main constituents of essential oil were curzerenone (16.4±1.5 %), drimenol (13.7±0.2 %), and spathulenol (12.4±0.8 %). S. guianensis oil showed antioxidant activity, inhibiting 11.1 % of DPPH radicals (95.7 mgTE/g); and 15.5 % of the β-carotene peroxidation. The group treated with S. guianensis showed a significant reduction in tumor cells (59.76±12.33) compared to the tumor group (96.88±19.15). Essential oil of S. guianensis decreased MDA levels and increased SOD levels in liver tissue. The essential oil of S. guianensis reduced oxidative stress, and showed antitumor and antioxidant activity, being characterized as a new chemical profile in the investigation of pathologies such as cancer.
Language	English
Publishing date	2023-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301120
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Article ; Online: Shift in hospital opioid use during the COVID-19 pandemic in Brazil: a time-series analysis of one million prescriptions.

Carvalho, Romulo Mendonça / de Magalhães-Barbosa, Maria Clara / Bianchi, Lucas Monteiro / Rodrigues-Santos, Gustavo / da Cunha, Antônio José Ledo Alves / Bastos, Francisco Inácio / Prata-Barbosa, Arnaldo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17197

Abstract: The pronounced change in the profile of hospitalized patients during COVID-19 and the severe respiratory component of this disease, with a great need for mechanical ventilation, led to changes in the consumption pattern of some medicines and supplies. ... ...

Abstract	The pronounced change in the profile of hospitalized patients during COVID-19 and the severe respiratory component of this disease, with a great need for mechanical ventilation, led to changes in the consumption pattern of some medicines and supplies. This time-series study analyzed the in-hospital consumption of opioids during the COVID-19 pandemic in 24 Brazilian hospitals compared to the pre-pandemic period. Data included 711,883 adult patients who had opioids prescribed. In 2020, the mean consumption was significantly higher compared to 2019 for parenteral fentanyl, enteral methadone, and parenteral methadone. It was significantly lower for parenteral morphine parenteral sufentanil, and parenteral tramadol. For remifentanil, it did not differ. The number of patients in 2020 was lower but the mean consumption was higher for fentanyl, parenteral methadone, and remifentanil. It was lower for enteral methadone and parenteral sufentanil. The consumption of parenteral morphine and parenteral tramadol was stable. There was a relevant increase in hospital consumption of some potent opioids during the COVID-19 pandemic in Brazil. These results reinforce the concern about epidemiological surveillance of opioid use after periods of increased hospital use since in-hospital consumption can be the gateway to the misuse or other than the prescribed use of opioids after discharge.
MeSH term(s)	Adult ; Humans ; Analgesics, Opioid/therapeutic use ; Sufentanil ; Brazil/epidemiology ; Pandemics ; Remifentanil ; Tramadol ; COVID-19/epidemiology ; Fentanyl ; Opioid-Related Disorders/drug therapy ; Methadone/therapeutic use ; Morphine ; Prescriptions
Chemical Substances	Analgesics, Opioid ; Sufentanil (AFE2YW0IIZ) ; Remifentanil (P10582JYYK) ; Tramadol (39J1LGJ30J) ; Fentanyl (UF599785JZ) ; Methadone (UC6VBE7V1Z) ; Morphine (76I7G6D29C)
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44533-5
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Article ; Online: Incidental parasympathetic cardiac denervation during atrial fibrillation ablation using high power short duration: a marker of long-term success.

Vassallo, Fabricio / Corcino, Lucas / Cunha, Christiano / Serpa, Eduardo / Lovatto, Carlos / Simoes, Aloyr / Carloni, Hermes / Hespanhol, Dalton / Gasparini, Dalbian / Barbosa, Luiz Fernando / Schmidt, Andre

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2023

Abstract: Background: There are multiple factors in both technique and substrate that lead to recurrence of atrial fibrillation after ablation. We sought to examine whether the degree of heart rate increase (HRI) caused by concurrent high-power-short-duration ( ... ...

Abstract	Background: There are multiple factors in both technique and substrate that lead to recurrence of atrial fibrillation after ablation. We sought to examine whether the degree of heart rate increase (HRI) caused by concurrent high-power-short-duration (HPSD) incidental parasympathetic denervation during AF ablation predicts long term success. Between December 2018 and December 2021, prospectively enrolled 214 patients who presented in sinus rhythm at AF ablation. Used 50 W of power and contact force (CF) of 5-15 g and 10-20 g at a flow rate of 40 mL/min on the anterior and posterior left atrial walls, respectively. Results: Males were 143 (66.8%) and paroxysmal was 124 (57.9%) patients. Mean age 61.1 ± 12.3 years and follow-up time was 32.8 ± 13.2 months. Arrhythmia occurred after 90 days in 39 (18.2%) patients, 19 (48.7%) from the paroxysmal and 20 (51.3%) from the persistent AF patients. Recurrence group showed a lower HRI from a mean of 57 ± 7.7 to 64.4 ± 10.4 bpm (12.3%) while in success group HRI was from 53.8 ± 9.7 to 66.8 ± 11.6 bpm [(24.2%) p = 0.04]. We divided HRI in 3 percentiles of ≤ 8%, > 8 ≤ 37% and > 37%. A predictor of recurrence was identified in those in the first (< 8%, p = 0.006) and a predictor of success in the later (> 37%, p = 0.01) HRI percentile. Conclusion: Atrial fibrillation ablation with HPSD incidental cardiac parasympathetic denervation identified that patients with lower heart rate increase are prone to recurrence while those with higher heart rate increase had higher maintenance of sinus rhythm at a long-term follow-up.
Language	English
Publishing date	2023-09-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-023-01653-2
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Article ; Online: Photobiomodulation does not provide incremental benefits to patients with knee osteoarthritis who receive a strengthening exercises program: a randomized controlled trial.

Jorge, Ana Elisa Serafim / Dantas, Lucas Ogura / Aburquerque-Sendín, Francisco / Ferrari, Angélica Viana / Cunha, Jonathan Emanuel / Dantas, Glauko André de Figueiredo / Barbosa, Germanna Medeiros / Serrão, Paula Regina Mendes da Silva / Salvini, Tania de Fátima

Brazilian journal of physical therapy

2023 Volume 27, Issue 4, Page(s) 100519

Abstract: Background: There is lack of agreement in the literature about the effectiveness of photobiomodulation (PBM) for reducing pain-related symptoms in patients with knee osteoarthritis (OA).: Objective: To evaluate whether PBM, when combined to exercises, ...

Abstract	Background: There is lack of agreement in the literature about the effectiveness of photobiomodulation (PBM) for reducing pain-related symptoms in patients with knee osteoarthritis (OA). Objective: To evaluate whether PBM, when combined to exercises, provides incremental therapeutic benefits for pain, physical function, and quality of life (QoL) in patients with knee OA. Methods: A six-month double-blind placebo-controlled randomized trial was conducted. Patients with knee OA were randomly assigned to one of three treatment groups: Exercise, Exercise plus Active PBM, or Exercise plus Placebo PBM. Treatment was provided over an eight-week period, three times per week. The primary outcomes were pain at rest and upon movement, assessed by a visual analogue scale (VAS). WOMAC global score, QoL, and a core-set of performance-based tests were measured as secondary outcomes. All outcomes were collected at baseline, immediately after treatment, and after three- and six-month post-treatment. Results: 127 participants were allocated as follows: Exercise, N = 41; Exercise plus Active PBM, N = 44; and Exercise plus Placebo PBM, N = 42. There was no between-groups difference in improvement in pain, physical function, and QoL for all follow-up times. However, all groups presented significant, clinically relevant improvements in pain, physical function, and QoL immediately and three months after treatment compared with baseline measures. Conclusion: Patients with knee OA who received a strengthening exercises program did not experience incremental benefits regarding pain, physical function, or QoL when adding PBM to their therapeutic exercises.
MeSH term(s)	Humans ; Osteoarthritis, Knee ; Quality of Life ; Exercise Therapy ; Pain ; Movement ; Treatment Outcome
Language	English
Publishing date	2023-06-23
Publishing country	Brazil
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2252917-2
ISSN	1809-9246 ; 1809-9246
ISSN (online)	1809-9246
ISSN	1809-9246
DOI	10.1016/j.bjpt.2023.100519
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Article ; Online: Calorie restriction changes lipidomic profiles and maintains mitochondrial function and redox balance during isoproterenol-induced cardiac hypertrophy.

David, Cícera Edna Barbosa / Lucas, Aline Maria Brito / Cunha, Pedro Lourenzo Oliveira / Viana, Yuana Ivia Ponte / Yoshinaga, Marcos Yukio / Miyamoto, Sayuri / Filho, Adriano Brito Chaves / Varela, Anna Lídia Nunes / Kowaltowski, Alicia Juliana / Facundo, Heberty Tarso

Journal of physiology and biochemistry

2022 Volume 78, Issue 1, Page(s) 283–294

Abstract: Typically, healthy cardiac tissue utilizes more fat than any other organ. Cardiac hypertrophy induces a metabolic shift leading to a preferential consumption of glucose over fatty acids to support the high energetic demand. Calorie restriction is a ... ...

Abstract	Typically, healthy cardiac tissue utilizes more fat than any other organ. Cardiac hypertrophy induces a metabolic shift leading to a preferential consumption of glucose over fatty acids to support the high energetic demand. Calorie restriction is a dietary procedure that induces health benefits and lifespan extension in many organisms. Given the beneficial effects of calorie restriction, we hypothesized that calorie restriction prevents cardiac hypertrophy, lipid content changes, mitochondrial and redox dysregulation. Strikingly, calorie restriction reversed isoproterenol-induced cardiac hypertrophy. Isolated mitochondria from hypertrophic hearts produced significantly higher levels of succinate-driven H
MeSH term(s)	Caloric Restriction ; Cardiomegaly/chemically induced ; Cardiomegaly/drug therapy ; Cardiomegaly/prevention & control ; Humans ; Hydrogen Peroxide/metabolism ; Isoproterenol/metabolism ; Isoproterenol/toxicity ; Lipidomics ; Mitochondria/metabolism ; Oxidation-Reduction ; Oxidative Stress
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Isoproterenol (L628TT009W)
Language	English
Publishing date	2022-01-13
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1325104-1
ISSN	1877-8755 ; 0034-9402 ; 1138-7548
ISSN (online)	1877-8755
ISSN	0034-9402 ; 1138-7548
DOI	10.1007/s13105-021-00863-4
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Zs.B 198: Show issues

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Article ; Online: Interactive gerontechnology for fall prevention in the elderly: a descriptive study.

Maia, Juliana Cunha / Diniz, Jamylle Lucas / Sousa, Caroline Ribeiro de / Oliveira, Francisco Gerlai Lima / Evangelista, Brenda Pinheiro / Coutinho, Janaína Fonseca Victor / Marques, Marília Braga / Barbosa, Rachel Gabriel Bastos

Revista brasileira de enfermagem

2023 Volume 76, Issue 2, Page(s) e20220739

Abstract: Objectives: to develop interactive gerontechnology for the prevention of falls in the elderly at home.: Methods: an exploratory and descriptive study that consisted of gerontechnology development and evaluation by experts and the target audience. For ...

Abstract	Objectives: to develop interactive gerontechnology for the prevention of falls in the elderly at home. Methods: an exploratory and descriptive study that consisted of gerontechnology development and evaluation by experts and the target audience. For evaluation, researchers used the Agreement Index (AI), considering values greater than 80%. Results: the three-dimensional virtual scale model was elaborated through the SketchUp program, with the distribution of rooms and floors, constituting Prototype 1 (P1). Fifty-four judges evaluated the P1, and all presented agreement above the established, with a minimum AI of 88% and a maximum of 100%, producing Prototype 2 (P2). Thirty elderly participants from a philanthropic institution evaluated Prototype 2. On all items, AI ranged from 83% a 100%, resulting in the final version. Conclusions: the product of this research reveals itself as an innovative and scientifically based tool aimed at preventing falls in the elderly.
MeSH term(s)	Aged ; Humans ; Accidental Falls/prevention & control ; Health Facilities ; Research Personnel
Language	Portuguese
Publishing date	2023-05-08
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731983-6
ISSN	1984-0446 ; 0034-7167
ISSN (online)	1984-0446
ISSN	0034-7167
DOI	10.1590/0034-7167-2022-0739
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Article ; Online: Nonlinear and vibrational microscopy for label-free characterization of amyloid-β plaques in Alzheimer's disease model.

Cunha, Renan / Lafeta, Lucas / Fonseca, Emerson A / Barbosa, Alexandre / Romano-Silva, Marco A / Vieira, Rafael / Jorio, Ado / Malard, Leandro M

The Analyst

2021 Volume 146, Issue 9, Page(s) 2945–2954

Abstract: Given the long subclinical stage of Alzheimer's disease (AD), the study of biomarkers is relevant both for early diagnosis and the fundamental understanding of the pathophysiology of AD. Biomarkers provided by Amyloid-β (Aβ) plaques have led to an ... ...

Abstract	Given the long subclinical stage of Alzheimer's disease (AD), the study of biomarkers is relevant both for early diagnosis and the fundamental understanding of the pathophysiology of AD. Biomarkers provided by Amyloid-β (Aβ) plaques have led to an increasing interest in characterizing this hallmark of AD due to its promising potential. In this work, we characterize Aβ plaques by label-free multimodal imaging: we combine two-photon excitation autofluorescence (TPEA), second harmonic generation (SHG), spontaneous Raman scattering (SpRS), coherent anti-Stokes Raman scattering (CARS), and stimulated Raman scattering (SRS) to describe and compare high-resolution images of Aβ plaques in brain tissues of an AD mouse model. Comparing single-laser techniques images, we discuss the origin of the SHG, which can be used to locate the plaque core reliably. We study both the core and the halo with vibrational microscopy and compare SpRS and SRS microscopies for different frequencies. We also combine SpRS spectroscopy with SRS microscopy and present two core biomarkers unexplored with SRS microscopy: phenylalanine and amide B. We provide high-resolution SRS images with the spatial distribution of these biomarkers in the plaque and compared them with images of the amide I distribution. The obtained spatial correlation corroborates the feasibility of these biomarkers in the study of Aβ plaques. Furthermore, since amide B enables rapid imaging, we discuss its potential as a novel fingerprint for diagnostic applications.
MeSH term(s)	Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides ; Animals ; Mice ; Microscopy ; Plaque, Amyloid/diagnostic imaging ; Spectrum Analysis, Raman
Chemical Substances	Amyloid beta-Peptides
Language	English
Publishing date	2021-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d1an00074h
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Article ; Online: Association of deleterious sucking habits with the occurrence of otitis in newborns, infants, preschool children, and children: a systematic review protocol.

Castro-Cunha, Ana Claudia / Gonçalves, Isabela Costa / Martins-Júnior, Paulo Antônio / Fernandes, Izabella Barbosa / Abreu, Lucas Guimarães / Paiva, Saul Martins / Bendo, Cristiane Baccin

JBI evidence synthesis

2021 Volume 19, Issue 12, Page(s) 3372–3377

Abstract: Objective: The objective of this review is to determine whether deleterious sucking habits contribute to otitis in newborns, infants, preschool children, and children.: Introduction: Otitis is one of the most prevalent diseases in infants. Diverse ... ...

Abstract	Objective: The objective of this review is to determine whether deleterious sucking habits contribute to otitis in newborns, infants, preschool children, and children. Introduction: Otitis is one of the most prevalent diseases in infants. Diverse studies have suggested that deleterious sucking habits, such as pacifier use, bottle-feeding, and finger-sucking, may be risk factors for the development of otitis in young individuals. Inclusion criteria: This systematic review will include observational studies in which the association between deleterious sucking habits and otitis was assessed in newborns, infants, preschool children, and children. Studies will compare caregiver reporting of sucking habits in this population to those with no deleterious sucking habits or those who exclusively breastfeed. The primary outcome will be the presence of otitis. Methods: The searches will be carried out in six electronic databases, and gray literature will also be screened. A three-step search strategy will be used, with no date or language restrictions. Studies whose full text meets the eligibility criteria will be included in the systematic review. Study screening and selection, critical appraisal, and data extraction will be performed by two independent reviewers. The Grading of Recommendations, Assessment, Development and Evaluation approach will be used to assess the certainty of the evidence. Meta-analysis will be performed if there is relative homogeneity among included studies. Systematic review registration number: PROSPERO CRD42020197162.
MeSH term(s)	Bottle Feeding/adverse effects ; Child, Preschool ; Fingersucking/adverse effects ; Habits ; Humans ; Infant ; Infant, Newborn ; Meta-Analysis as Topic ; Otitis ; Sucking Behavior ; Systematic Reviews as Topic
Language	English
Publishing date	2021-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2689-8381
ISSN (online)	2689-8381
DOI	10.11124/JBIES-20-00519
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Article: A new circular economy approach for integrated production of tomatoes and mushrooms.

Oliveira Vieira, Vandinelma / Almeida Conceição, Aparecido / Raisa Barbosa Cunha, Joice / Enis Virginio Machado, Antony / Gonzaga de Almeida, Euziclei / Souza Dias, Eustáquio / Magalhães Alcantara, Lucas / Neil Gerard Miller, Robert / Gonçalves de Siqueira, Félix

Saudi journal of biological sciences

2022 Volume 29, Issue 4, Page(s) 2756–2765

Abstract: Spent mushroom Substrate is the by-product generated at the end of the mushroom growing cycle. It can be used in agriculture for different purposes, including seedling production, soil conditioning or application as an organic fertilizer. Tomato is one ... ...

Abstract	Spent mushroom Substrate is the by-product generated at the end of the mushroom growing cycle. It can be used in agriculture for different purposes, including seedling production, soil conditioning or application as an organic fertilizer. Tomato is one of the world́s most important crops, requiring considerable care, in terms of both nutrition and disease control. The objective of this study was to investigate the viability of spent mushroom substrate as a nutrient source for tomato seedlings and develop an integrated tomato and mushroom co-production system. For seedling production, different compositions were evaluated with spent mushroom substrate from
Language	English
Publishing date	2022-01-03
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2021.12.058
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