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  1. Article: A spanyolláz története: Nadragulya és karantén.

    Szôcs, Károly

    Orvosi hetilap

    2009  Volume 150, Issue 22, Page(s) 1043–1047

    Title translation History of the Spanish flu: atropa belladonna and quarantine.
    MeSH term(s) Animals ; Atropa belladonna ; Books ; Disease Outbreaks/history ; History, 18th Century ; History, 19th Century ; History, 20th Century ; Humans ; Influenza, Human/history ; Quarantine/history ; United States ; Writing/history
    Language Hungarian
    Publishing date 2009-05-31
    Publishing country Hungary
    Document type Historical Article ; Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/OH.2009.HO2228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Das Marfan-Syndrom ist neben einer Aorten- auch eine Systemerkrankung. Marfan syndrome is not only aortic - but also a systemic disease

    von Kodolitsch, Y. / Vogler, M. / Huntgeburth, M. / Radke, R. M. / Kallenbach, K. / Gehle, P. / Szöcs, K.

    Internistische Praxis

    2023  Volume 65, Issue 4, Page(s) 565

    Language German
    Document type Article
    ZDB-ID 209039-9
    ISSN 0020-9570
    Database Current Contents Medicine

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  3. Article: Das Marfan-Syndrom ist neben einer Aorten- auch eine Systemerkrankung. Marfan syndrome is not only aortic - but also a systemic disease

    Kodolitsch, Y. / Vogler, M. / Huntgeburth, M. / Radke, R. M. / Kallenbach, K. / Gehle, P. / Szöcs, K.

    Gynäkologische Praxis

    2023  Volume 50, Issue 4, Page(s) 656

    Language German
    Document type Article
    ZDB-ID 80452-6
    ISSN 0341-8677
    Database Current Contents Medicine

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  4. Article: Concomitant cardiovascular malformations in isolated bicuspid aortic valve disease: a retrospective cross-sectional study and meta-analysis.

    Szöcs, Katalin / Toprak, Betül / Schön, Gerhard / Rybczynski, Meike / Brinken, Tatjana / Mahlmann, Adrian / Girdauskas, Evaldas / Blankenberg, Stefan / von Kodolitsch, Yskert

    Cardiovascular diagnosis and therapy

    2022  Volume 12, Issue 4, Page(s) 400–414

    Abstract: Background: Congenital bicuspid aortic valve affects up to 2% of the general population. It occurs in complex congenital heart defects or in syndromes such as Turner, Marfan, or Loeys-Dietz. However, the majority of bicuspid aortic valves are considered ...

    Abstract Background: Congenital bicuspid aortic valve affects up to 2% of the general population. It occurs in complex congenital heart defects or in syndromes such as Turner, Marfan, or Loeys-Dietz. However, the majority of bicuspid aortic valves are considered to manifest as isolated malformations.
    Methods: We aimed to assess retrospectively associated cardiovascular malformations in 200 individuals with bicuspid aortic valve considered to occur as an isolated manifestation. All individuals underwent transthoracic echocardiography, 164 thoracoabdominal tomographic imaging, and 84 coronary artery imaging. In addition, we also performed a meta-analysis of data from the literature to assess the occurrence of associate malformations.
    Results: In our retrospective cross-sectional study collective, the mean age was 45±15 years, 154 (77%) individuals were male. Anatomy of bicuspid aortic valve according to Schaefer was type 1 in 142 (71%), type 2 in 35 (18%), type 3 in 2 (1%), unicuspid in 6 (3%), and unclassified in 15 (8%) individuals. Coarctation of the aorta had 4.2% of individuals, 3.6% had coronary anomalies. No individual had a patent ductus arteriosus, 0.5% had atrial and ventricular septal defect each, 1.5% mitral valve prolapse. No individual had a tricuspid valve prolapse. Our meta-analysis identified in cohorts with isolated bicuspid aortic valve 11.8% (95% CI: 7.7-16.0%) individuals with aortic coarctation, 3.7% (95% CI: 1.2-6.1%) with coronary anomalies, 3.3% (95% CI: 0.0-6.7%) with patent ductus arteriosus, 5.9% (95% CI: 1.3-10.5%) with ventricular septal defect and 1.6% (95% CI: 1.1-2.1%) with mitral valve prolapse.
    Conclusions: Individuals with isolated bicuspid aortic valve may exhibit a variety of associated cardiovascular malformations and therefore screening for associated malformations may be warranted.
    Language English
    Publishing date 2022-08-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 2685043-6
    ISSN 2223-3660 ; 2223-3652
    ISSN (online) 2223-3660
    ISSN 2223-3652
    DOI 10.21037/cdt-22-112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characterization and functional properties of a novel monoclonal antibody which identifies a B cell subpopulation in bursa of Fabricius.

    Fejszák, Nóra / Kocsis, Katalin / Halasy, Viktória / Szőcs, Emőke / Soós, Ádám / Roche, Dominik von La / Härtle, Sonja / Nagy, Nándor

    Poultry science

    2022  Volume 101, Issue 4, Page(s) 101711

    Abstract: The bursa of Fabricius (BF) plays a central role in the development of B lymphocytes in birds. During embryonic development the BF primordium is colonized by myeloid and lymphoid prebursal stem cells to form the follicle buds, which ultimately develop ... ...

    Abstract The bursa of Fabricius (BF) plays a central role in the development of B lymphocytes in birds. During embryonic development the BF primordium is colonized by myeloid and lymphoid prebursal stem cells to form the follicle buds, which ultimately develop into lymphoid follicles with a central medullary and an outer cortical region. Lympho-myeloid differentiation within the medulla is fundamental to normal B cell development. In contrast, the complexity of the cellular composition of the follicular cortex and its role in B cell differentiation has only recently begun to be studied. As an effort to characterize the different bursal cells we have produced a large panel of monoclonal antibodies (mAbs) by immunizing mice with a BF cell suspension of guinea fowl (Numida meleagris). One of these antibodies (clone: 7H3) was found to recognize a 80 kDa cell surface antigen expressed first in the yolk sac blood island of 2-day-old guinea fowl and chicken embryos, and later detected in the embryonic circulation and primary lymphoid organs. Double immunofluorescence revealed that chB6+ (Bu-1+) B cells of embryonic BF co-express the 7H3 antigen. 7H3 immunoreactivity of the bursal follicles gradually diminished after hatching and only a subpopulation of cortical B cells expressed the 7H3 antigen. In addition, in post-hatched birds 7H3 mAb recognizes all T lymphocytes of the thymus, peripheral lymphoid organs and blood. Embryonic BF injected with the 7H3 mAb showed a near complete block of lymphoid follicle formation In conclusion, 7H3 mAb labels a new differentiation antigen specific for avian hematopoietic cells, which migrate through the embryonic mesenchyme, colonize the developing BF lymphoid follicles, and differentiate into a subpopulation of cortical B cells. The staining pattern of the 7H3 mAb and the correlation of expression with cell migration suggest that the antigen will serve as valuable immunological marker for studying the ontogeny of avian B cells.
    MeSH term(s) Animals ; Antibodies, Monoclonal ; B-Lymphocytes ; Bursa of Fabricius ; Cell Differentiation ; Chick Embryo ; Chickens ; Galliformes ; Mice
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2022.101711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Context-Dependent Role of Glucocorticoid Receptor Alpha and Beta in Breast Cancer Cell Behaviour.

    Butz, Henriett / Saskői, Éva / Krokker, Lilla / Vereczki, Viktória / Alpár, Alán / Likó, István / Tóth, Erika / Szőcs, Erika / Cserepes, Mihály / Nagy, Katalin / Kacskovics, Imre / Patócs, Attila

    Cells

    2023  Volume 12, Issue 5

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Female ; Glucocorticoids/pharmacology ; Breast Neoplasms ; Ligands ; Protein Isoforms
    Chemical Substances glucocorticoid receptor alpha ; Glucocorticoids ; Ligands ; Protein Isoforms
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12050784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Differential neurocognitive profiles in adult attention-deficit/hyperactivity disorder subtypes revealed by the Cambridge Neuropsychological Test Automated Battery.

    Somogyi, Szilvia / Kilencz, Tünde / Szőcs, Katalin / Klein, Izabella / Balogh, Lívia / Molnár, Rebeka / Bálint, Sára / Pulay, Attila J / Nemoda, Zsófia / Baradits, Máté / Réthelyi, János M

    European archives of psychiatry and clinical neuroscience

    2023  

    Abstract: Adult attention-deficit/hyperactivity disorder (aADHD) represents a heterogeneous entity incorporating different subgroups in terms of symptomatology, course, and neurocognition. Although neurocognitive dysfunction is generally associated with aADHD, its ...

    Abstract Adult attention-deficit/hyperactivity disorder (aADHD) represents a heterogeneous entity incorporating different subgroups in terms of symptomatology, course, and neurocognition. Although neurocognitive dysfunction is generally associated with aADHD, its severity, association with self-reported symptoms, and differences between subtypes remain unclear. We investigated 61 outpatients (65.6% male, mean age 31.5 ± 9.5) diagnosed using DSM-5 criteria together with age-, sex-, and education-matched healthy controls (HC) (n = 58, 63.8% male, mean age 32.3 ± 9.6). Neurocognitive alterations were assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and compared between groups using the generalized linear model (GLM) method. Multivariate effects were tested by principal component analysis combined with multivariate pattern analysis. Self-reported symptom severity was tested for correlations with neurocognitive performance. GLM analyses revealed nominally significant differences between the aADHD and HC groups in several domains, however, only the Rapid Visual Information Processing measures survived correction, indicating impaired sustained attention and response inhibition in the aADHD group. Comparison of the predominantly inattentive and the hyperactive-impulsive/combined subtypes yielded nominally significant differences with higher levels of dysfunction in the inattentive group. In the stepwise discriminant analysis aADHD and HC groups were best separated with 2 factors representing sustained attention and reaction time. We found only weak correlations between symptom severity and CANTAB factors. aADHD patients are neuropsychologically heterogeneous and subtypes show different neurocognitive profiles. Differences between the aADHD and HC groups were driven primarily by the inattentive subtype. Sustained attention and its factor derivative showed the most significant alterations in aADHD patients.
    Language English
    Publishing date 2023-11-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-023-01702-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  8. Article: Das Marfan-Syndrom ist neben einer Aorten- auch eine Systemerkrankung. Marfan syndrome is not only aortic - but also a systemic disease

    von Kodolitsch, Y. / Vogler, M. / Huntgeburth, M. / Radke, R. M. / Kallenbach, K. / Gehle, P. / Szöcs, K.

    Internistische Praxis

    2022  Volume 65, Issue 4, Page(s) 565

    Language German
    Document type Article
    ZDB-ID 209039-9
    ISSN 0020-9570
    Database Current Contents Medicine

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  9. Article: Maximum likelihood-based estimation of diffusion coefficient is quick and reliable method for analyzing estradiol actions on surface receptor movements.

    Makkai, Geza / Abraham, Istvan M / Barabas, Klaudia / Godo, Soma / Ernszt, David / Kovacs, Tamas / Kovacs, Gergely / Szocs, Szilard / Janosi, Tibor Z

    Frontiers in neuroinformatics

    2023  Volume 17, Page(s) 1005936

    Abstract: The rapid effects of estradiol on membrane receptors are in the focus of the estradiol research field, however, the molecular mechanisms of these non-classical estradiol actions are poorly understood. Since the lateral diffusion of membrane receptors is ... ...

    Abstract The rapid effects of estradiol on membrane receptors are in the focus of the estradiol research field, however, the molecular mechanisms of these non-classical estradiol actions are poorly understood. Since the lateral diffusion of membrane receptors is an important indicator of their function, a deeper understanding of the underlying mechanisms of non-classical estradiol actions can be achieved by investigating receptor dynamics. Diffusion coefficient is a crucial and widely used parameter to characterize the movement of receptors in the cell membrane. The aim of this study was to investigate the differences between maximum likelihood-based estimation (MLE) and mean square displacement (MSD) based calculation of diffusion coefficients. In this work we applied both MSD and MLE to calculate diffusion coefficients. Single particle trajectories were extracted from simulation as well as from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor tracking in live estradiol-treated differentiated PC12 (dPC12) cells. The comparison of the obtained diffusion coefficients revealed the superiority of MLE over the generally used MSD analysis. Our results suggest the use of the MLE of diffusion coefficients because as it has a better performance, especially for large localization errors or slow receptor movements.
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452979-5
    ISSN 1662-5196
    ISSN 1662-5196
    DOI 10.3389/fninf.2023.1005936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A szív-tüdó-átültetésról és a Marfan-szindrómáról.

    Szócs, K

    Orvosi hetilap

    2000  Volume 141, Issue 28, Page(s) 1598

    Title translation Heart-lung transplantation and the Marfan syndrome.
    MeSH term(s) Ethics, Medical ; Germany ; Heart Transplantation/legislation & jurisprudence ; Humans ; Hungary ; Lung Transplantation/legislation & jurisprudence ; Marfan Syndrome/surgery ; Netherlands
    Language Hungarian
    Publishing date 2000-07-09
    Publishing country Hungary
    Document type Letter
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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