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Article ; Online: What we have learnt in valvular heart disease from our journal?

Pancaldi, Edoardo / Cimino, Giuliana / Metra, Marco / Adamo, Marianna

Journal of cardiovascular medicine (Hagerstown, Md.)

2022 Volume 23, Issue 7, Page(s) 427–429

MeSH term(s)	Heart Valve Diseases/diagnostic imaging ; Heart Valve Diseases/surgery ; Humans
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Editorial
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001325
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Zs.MO 559: Show issues

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Article: Drug-eluting stent restenosis treatment: an "old" stent, a "new" balloon or a "newer" scaffold?

Buccheri, Dario / Cimino, Giuliana

Journal of thoracic disease

2017 Volume 8, Issue 12, Page(s) 3478–3483

Language	English
Publishing date	2017-01-30
Publishing country	China
Document type	Editorial
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd.2016.12.21
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Article ; Online: Progressi nella terapia dello scompenso cardiaco: la continua evoluzione degli ultimi 50 anni.

Metra, Marco / Cimino, Giuliana / Pezzola, Elisa / Saccani, Nicola / Stretti, Lorenzo / Adamo, Marianna

Giornale italiano di cardiologia (2006)

2022 Volume 23, Issue 8, Page(s) 571–584

Abstract: Management of heart failure is one of the most important challenges of modern medicine. Heart failure affects a large number of patients worldwide and its prevalence is increasing. The adoption of the methodology of randomized controlled trials has led ... ...

Title translation	Advances in heart failure treatment: a summary of 50 years of evolution.
Abstract	Management of heart failure is one of the most important challenges of modern medicine. Heart failure affects a large number of patients worldwide and its prevalence is increasing. The adoption of the methodology of randomized controlled trials has led to the identification of drugs and devices that prolong life and, in many cases, also yield a better quality of life. Improvement in the diagnostic techniques and devices has also led to better treatment of most major comorbidities, another strong driver of patient's symptoms and natural history. This article aims to provide an overview of the key events that have led to such improvement.
MeSH term(s)	Clinical Trials as Topic ; Heart Failure/drug therapy ; Humans ; Quality of Life
Language	Italian
Publishing date	2022-09-28
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/3856.38387
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Article: Varicella zoster virus and cardiovascular diseases.

Cersosimo, Angelica / Riccardi, Mauro / Amore, Ludovica / Cimino, Giuliana / Arabia, Gianmarco / Metra, Marco / Vizzardi, Enrico

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2022 Volume 93, Issue 2

Abstract: Varicella zoster virus (VZV) is a Herpesviridae family double-stranded DNA virus that only affects humans. The first clinical manifestation appears to be varicella, typical of childhood. VZV, on the other hand, becomes latent in ganglion neurons ... ...

Abstract	Varicella zoster virus (VZV) is a Herpesviridae family double-stranded DNA virus that only affects humans. The first clinical manifestation appears to be varicella, typical of childhood. VZV, on the other hand, becomes latent in ganglion neurons throughout the neuroaxis after primary infection. The VZV reactivates and travels along peripheral nerve fibers in the elderly and immunocompromised individuals, resulting in Zoster. It can, however, spread centrally and infect cerebral and extracranial arteries, resulting in vasculopathy, which can lead to transient ischemic attacks, strokes, aneurysms, cavernous sinus thrombosis, giant cell arteritis, and granulomatous aortitis. Although the mechanisms of virus-induced pathological vascular remodeling are not fully understood, recent research indicates that inflammation and dysregulation of ligand-1 programmed death play a significant role. Few studies, on the other hand, have looked into the role of VZV in cardiovascular disease. As a result, the purpose of this review is to examine the relationship between VZV and cardiovascular disease, the efficacy of the vaccine as a protective mechanism, and the target population of heart disease patients who could benefit from vaccination.
MeSH term(s)	Humans ; Aged ; Herpesvirus 3, Human ; Cardiovascular Diseases/epidemiology ; Herpes Zoster/epidemiology ; Herpes Zoster/prevention & control ; Chickenpox ; Stroke/epidemiology
Language	English
Publishing date	2022-09-21
Publishing country	Italy
Document type	Review ; Journal Article
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2022.2414
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Article ; Online: Updates in heart failure: sodium glucose co-transporter 2 inhibitors and beyond - major changes are coming.

Cimino, Giuliana / Pancaldi, Edoardo / Tomasoni, Daniela / Lombardi, Carlo Mario / Metra, Marco / Adamo, Marianna

Journal of cardiovascular medicine (Hagerstown, Md.)

2022 Volume 23, Issue 12, Page(s) 761–769

Abstract: Prevalence of heart failure is increasing worldwide mainly due to the ageing of the population and the improvement in diagnosis and treatment. In recent years, huge progress has been made in the management of heart failure patients. A new definition of ... ...

Abstract	Prevalence of heart failure is increasing worldwide mainly due to the ageing of the population and the improvement in diagnosis and treatment. In recent years, huge progress has been made in the management of heart failure patients. A new definition of chronic heart failure based on left ventricular ejection fraction and its possible trajectories has been reported. New drug classes have been introduced for the treatment of chronic heart failure. In particular, the prognostic benefit of sodium glucose co-transporter 2 inhibitors was demonstrated across all the heart failure phenotypes. Therapies for patients with advanced heart failure (long-term mechanical circulatory supports and heart transplantation) are now indicated also in the case of mild-to-moderate symptoms but with high risk of progression. In patients with acute heart failure, monitoring of urinary sodium and the use of acetazolamide may lead to better decongestion. Importantly, pre- and postdischarge assessment should lead to optimal treatment. Devices and telemonitoring can also be of help. Cardiovascular and noncardiovascular comorbidities are major determinants of the clinical course and need proper management. This review will summarize these important advances.
MeSH term(s)	Humans ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Stroke Volume ; Aftercare ; Ventricular Function, Left ; Patient Discharge ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Chronic Disease ; Symporters/therapeutic use ; Glucose/therapeutic use ; Sodium ; Diabetes Mellitus, Type 2/drug therapy
Chemical Substances	Sodium-Glucose Transporter 2 Inhibitors ; Symporters ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001409
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Article ; Online: Obesity, heart failure with preserved ejection fraction, and the role of glucagon-like peptide-1 receptor agonists.

Cimino, Giuliana / Vaduganathan, Muthiah / Lombardi, Carlo M / Pagnesi, Matteo / Vizzardi, Enrico / Tomasoni, Daniela / Adamo, Marianna / Metra, Marco / Inciardi, Riccardo M

ESC heart failure

2023 Volume 11, Issue 2, Page(s) 649–661

Abstract: Heart failure with preserved ejection fraction (HFpEF) has a high prevalence, affecting more than 50% of patients with heart failure. HFpEF is associated with multiple comorbidities, and obesity is one of the most common. A distinct phenotype has been ... ...

Abstract	Heart failure with preserved ejection fraction (HFpEF) has a high prevalence, affecting more than 50% of patients with heart failure. HFpEF is associated with multiple comorbidities, and obesity is one of the most common. A distinct phenotype has been proposed for obese patients with HFpEF. Recent data show the beneficial role of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for weight loss in diabetic and non-diabetic patients with obesity or overweight when given as adjunctive therapy to diet and exercise. The mechanisms of action are related to paracrine and endocrine signalling pathways within the gastrointestinal tract, pancreas, and central nervous system that delay gastric emptying, decrease appetite, augment pancreatic beta-cell insulin secretion, and suppress pancreatic glucagon release. These drugs are therefore potentially indicated for treatment of patients with HFpEF and obesity or overweight. Efficacy and safety need to be shown by clinical trials with a first one, Semaglutide Treatment Effect in People with obesity and heart failure with preserved ejection fraction (STEP HFpEF), recently concluded. The aim of the present review is to provide the pathophysiological and pharmacological rationale for GLP-1 RA administration to obese patients with HFpEF.
MeSH term(s)	Humans ; Heart Failure ; Glucagon-Like Peptide-1 Receptor Agonists ; Stroke Volume/physiology ; Overweight ; Obesity ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide 1/therapeutic use
Chemical Substances	Glucagon-Like Peptide-1 Receptor Agonists ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14560
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cardiac biomarkers and mortality in COVID-19 infection: A review.

Cersosimo, Angelica / Cimino, Giuliana / Amore, Ludovica / Calvi, Emiliano / Pascariello, Greta / Inciardi, Riccardo Maria / Lombardi, Carlo Mario / Vizzardi, Enrico / Metra, Marco

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2022 Volume 93, Issue 1

Abstract: Lots of meta-analysis emphasize that a great number of hospitalized patients with moderate and severe forms of COVID-19 developed acute myocardial damage, defined as an increase of cardiac biomarkers, such N-terminal pro-B-type natriuretic peptide (NT- ... ...

Abstract	Lots of meta-analysis emphasize that a great number of hospitalized patients with moderate and severe forms of COVID-19 developed acute myocardial damage, defined as an increase of cardiac biomarkers, such N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), creatine kinase-myocardial band (CK-MB) and of all type of troponins. The highest mortality rate is related with progressively increasing biomarkers levels and with a history of cardiovascular disease. In fact, the biomarkers dosage should be considered as a prognostic marker in all patients with COVID-19 disease at admission, during hospitalization and in the case of clinical deterioration. The purpose of this review is to evaluate cardiovascular prognostic factors in COVID-19 disease throughout the analysis of cardiac biomarkers to early identify the most serious patients and to optimize their outcomes.
MeSH term(s)	Humans ; Biomarkers ; COVID-19 ; Hospitalization ; Myocardium ; Prognosis
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-06-23
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2022.2276
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Zs.B 65: Show issues

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Article ; Online: Impact and predictors of device-related thrombus after percutaneous left atrial appendage closure.

Branca, Luca / Tomasoni, Daniela / Cimino, Giuliana / Cersosimo, Angelica / Lombardi, Carlo Mario / Chizzola, Giuliano / Metra, Marco / Adamo, Marianna

Journal of cardiovascular medicine (Hagerstown, Md.)

2022 Volume 24, Issue 1, Page(s) 12–19

Abstract: Device-related thrombus (DRT) is a known complication occurring in up to 7% of patients undergoing percutaneous left atrial appendage closure (LAAC). Since the target population of LAAC is generally ineligible for oral anticoagulant therapies, DRT raises ...

Abstract	Device-related thrombus (DRT) is a known complication occurring in up to 7% of patients undergoing percutaneous left atrial appendage closure (LAAC). Since the target population of LAAC is generally ineligible for oral anticoagulant therapies, DRT raises important concerns. The aim of this review will be to summarize available evidence on DRT after LAAC focusing on its possible impact on outcomes. Recent findings showed a tighter association between DRT and neurological ischemic events. Antithrombotic regimen adopted after LAAC may have a protective effect against DRT. Many patient-related and procedural factors have been identified as possible predictors of DRT. A tailored approach, which takes into account DRT, is needed in the patient selection for LAAC and in the postprocedural follow-up.
MeSH term(s)	Humans ; Atrial Appendage/diagnostic imaging ; Atrial Fibrillation/epidemiology ; Treatment Outcome ; Thrombosis/etiology ; Thrombosis/complications ; Anticoagulants/therapeutic use ; Stroke/etiology ; Stroke/prevention & control
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-11-22
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001394
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Article: Endothelial function evaluation in idiopathic vs. ischemic dilated cardiomyopathy.

Pancaldi, Edoardo / Tedino, Chiara / Riccardi, Mauro / Alghisi, Fabio / Cimino, Giuliana / Pascariello, Greta / Calvi, Emiliano / Sciatti, Edoardo / Vizzardi, Enrico / Metra, Marco

American journal of cardiovascular disease

2022 Volume 12, Issue 3, Page(s) 136–142

Abstract: Aims: In the latest years an emerging interest has risen towards the role of endothelial dysfunction (ED) in the pathogenesis of heart failure (HF) since the very first steps of the disease. Since the prevalent etiology of HF is ischemic cardiomyopathy ( ...

Abstract	Aims: In the latest years an emerging interest has risen towards the role of endothelial dysfunction (ED) in the pathogenesis of heart failure (HF) since the very first steps of the disease. Since the prevalent etiology of HF is ischemic cardiomyopathy (ICM), it is still not clear whether the connection with ED is linked to HF itself or to atherosclerosis. The aim is to determine the presence of ED in subjects with idiopathic dilated cardiomyopathy (IDCM) compared to ICM. Methods: In this observational study 107 patients were enrolled, 65 of them suffering from IDCM and 42 from ICM. ED was assessed as peripheral arterial tonometry by means of EndoPAT device. The Reactive Hyperaemia Index (RHI) was calculated, ED being established with RHI values ≤1.67 and normal endothelial function >2.00 (grey area between 1.67 and 2.00). Results: ED, expressed both as RHI ≤1.67 and RHI ≤2.00, showed a similar prevalence in the two groups. However, they differed as regards sex, dyslipidemia and statin use. Conclusion: Endothelial function, evaluated through peripheral artery tonometry, seems equally compromised in patients with IDCM and ICM.
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2616844-3
ISSN	2160-200X
ISSN	2160-200X
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Article ; Online: Cardiac biomarkers and mortality in COVID-19 infection

Angelica Cersosimo / Giuliana Cimino / Ludovica Amore / Emiliano Calvi / Greta Pascariello / Riccardo Maria Inciardi / Carlo Mario Lombardi / Enrico Vizzardi / Marco Metra

Monaldi Archives for Chest Disease (2022)

A review

2022

Abstract	Lots of meta-analysis emphasize that a great number of hospitalized patients with moderate and severe forms of COVID-19 developed acute myocardial damage, defined as an increase of cardiac biomarkers, such N-terminal pro–B-type natriuretic peptide (NT-pro-BNP), creatine kinase-myocardial band (CK-MB) and of all type of troponins. The highest mortality rate is related with progressively increasing biomarkers levels and with a history of cardiovascular disease. In fact, the biomarkers dosage should be considered as a prognostic marker in all patients with COVID-19 disease at admission, during hospitalization and in the case of clinical deterioration. The purpose of this review is to evaluate cardiovascular prognostic factors in COVID-19 disease throughout the analysis of cardiac biomarkers to early identify the most serious patients and to optimize their outcomes.
Keywords	Covid-19 ; Cardiovascular Disease ; Myocardial Injury ; Troponin ; Mortality ; Biomarkers ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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