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  1. Article: Editorial: Endothelial-to-mesenchymal transition in cardiovascular disease.

    Alfaidi, Mabruka / Evans, Paul C / Pickering, J Geoffrey

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1290050

    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1290050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epitaxial Stabilization and Persistent Nucleation of the 3C Polymorph of Ba

    Zhou, Catherine / Evans, Charles / Dickey, Elizabeth C / Rohrer, Gregory S / Salvador, Paul A

    ACS applied materials & interfaces

    2024  Volume 16, Issue 4, Page(s) 4873–4885

    Abstract: Ba-rich compositions in the ... ...

    Abstract Ba-rich compositions in the Ba
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c11934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Wages, Employment, and STEM Education in Ohio, Pennsylvania, and West Virginia

    Gonzalez, Gabriella C / Siler-Evans, Kyle / Hunter, Gerald Paul / Baird, Matthew D

    Report No. 1 (2016)

    2016  

    Keywords Curriculum planning & development ; History of the Americas ; Energy industries & utilities ; Education ; History ; Law
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030609926
    ISBN 9780833095206 ; 083309520X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: NAFLD and NASH: etiology, targets and emerging therapies.

    Wei, Shulin / Wang, Li / Evans, Paul C / Xu, Suowen

    Drug discovery today

    2024  Volume 29, Issue 3, Page(s) 103910

    Abstract: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) pose a significant threat to human health and cause a tremendous socioeconomic burden. Currently, the molecular mechanisms of NAFLD and NASH remain incompletely understood, ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) pose a significant threat to human health and cause a tremendous socioeconomic burden. Currently, the molecular mechanisms of NAFLD and NASH remain incompletely understood, and no effective pharmacotherapies have been approved. In the past five years, significant advances have been achieved in our understanding of the pathomechanisms and potential pharmacotherapies of NAFLD and NASH. Research advances include the investigation of the effects of the fibroblast growth factor 21 (FGF21) analog pegozafermin and the thyroid hormone receptor-β (THRβ) agonist resmetriom on hepatic fat content, NASH resolution and/or fibrosis regression. Future directions of NAFLD and NASH research (including combination therapy, organoids and humanized mouse models) are also discussed in this state-of-the-art review.
    MeSH term(s) Animals ; Mice ; Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/metabolism ; Fibrosis ; Combined Modality Therapy ; Disease Models, Animal
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2024.103910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4725: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Heterochronic shift in gene expression leads to ontogenetic morphological divergence between two closely related polyploid species.

    Searle, Peter C / Shiozawa, Dennis K / Evans, R Paul / Hill, Jonathon T / Suli, Arminda / Stark, Michael R / Belk, Mark C

    iScience

    2024  Volume 27, Issue 4, Page(s) 109566

    Abstract: Heterochrony-alteration to the rate or timing of development-is an important mechanism of trait differentiation associated with speciation. Heterochrony may explain the morphological divergence between two polyploid species, June sucker ( ...

    Abstract Heterochrony-alteration to the rate or timing of development-is an important mechanism of trait differentiation associated with speciation. Heterochrony may explain the morphological divergence between two polyploid species, June sucker (
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cognitive Intra-individual Variability in the Laboratory Is Associated With Greater Executive Dysfunction in the Daily Lives of Older Adults With HIV.

    Ridgely, Natalie C / Woods, Steven Paul / Webber, Troy A / Mustafa, Andrea I / Evans, Darrian

    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

    2024  Volume 37, Issue 1, Page(s) 32–39

    Abstract: Background: Executive dysfunction, which is common among persons with HIV (PWH), can have an adverse impact on health behaviors and quality of life. Intra-individual variability (IIV) is a measure of within-person variability across cognitive tests that ...

    Abstract Background: Executive dysfunction, which is common among persons with HIV (PWH), can have an adverse impact on health behaviors and quality of life. Intra-individual variability (IIV) is a measure of within-person variability across cognitive tests that is higher in PWH and is thought to reflect cognitive dyscontrol.
    Objective: To assess whether cognitive IIV in the laboratory is associated with self-reported executive dysfunction in daily life among older PWH.
    Method: Participants included 71 PWH aged ≥50 years who completed six subtests from the Cogstate battery and two subscales from the Frontal Systems Behavior Scale (FrSBe; self-report version). Cognitive IIV was calculated from the Cogstate as the coefficient of variation derived from age-adjusted normative T scores.
    Results: Cognitive IIV as measured by the Cogstate showed a significant, positive, medium-sized association with current FrSBe ratings of executive dysfunction but not disinhibition.
    Conclusion: Higher cognitive IIV in the laboratory as measured by the Cogstate may be related to the expression of HIV-associated symptoms of executive dysfunction in daily life for older PWH.
    MeSH term(s) Humans ; Aged ; Quality of Life ; Cognitive Dysfunction/complications ; Neuropsychological Tests ; Cognition/physiology ; HIV Infections/complications
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108112-8
    ISSN 1543-3641 ; 1543-3633
    ISSN (online) 1543-3641
    ISSN 1543-3633
    DOI 10.1097/WNN.0000000000000358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2439: Show issues Location:
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  7. Article ; Online: A Workflow to Track and Analyze Endothelial Migration During Vascular Development in Zebrafish Embryos Using Lightsheet Microscopy.

    Chen, Yan / Evans, Paul C / Wilkinson, Robert N

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2441, Page(s) 19–28

    Abstract: Zebrafish allow unrivalled in vivo imaging of vascular development due to their optical translucency and the availability of transgenic lines which fluorescently label cells and tissues of interest. Advances in light sheet fluorescence microscopy allow ... ...

    Abstract Zebrafish allow unrivalled in vivo imaging of vascular development due to their optical translucency and the availability of transgenic lines which fluorescently label cells and tissues of interest. Advances in light sheet fluorescence microscopy allow longer and faster imaging of live embryos at higher resolutions than previously possible, which facilitates study of dynamic cellular and molecular mechanisms underlying vessel formation and function. Here we describe a workflow using lightsheet microscopy to quantify endothelial cell (EC) migration dynamics during vascular development. Tracking movement of EC nuclei and analyzing the properties of EC migration trajectories permit detailed studies of angiogenesis and vascular remodeling in different contexts.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Microscopy, Fluorescence/methods ; Morphogenesis ; Workflow ; Zebrafish
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2059-5_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Osteoarthritis gene therapy in 2022.

    Evans, Christopher H / Ghivizzani, Steven C / Robbins, Paul D

    Current opinion in rheumatology

    2022  Volume 35, Issue 1, Page(s) 37–43

    Abstract: Purpose of review: To assess the present status of gene therapy for osteoarthritis (OA).: Recent findings: An expanding list of cDNAs show therapeutic activity when introduced into the joints of animals with experimental models of OA. In vivo ... ...

    Abstract Purpose of review: To assess the present status of gene therapy for osteoarthritis (OA).
    Recent findings: An expanding list of cDNAs show therapeutic activity when introduced into the joints of animals with experimental models of OA. In vivo delivery with adenovirus or adeno-associated virus is most commonly used for this purpose. The list of encoded products includes cytokines, cytokine antagonists, enzymes, enzyme inhibitors, growth factors and noncoding RNA. Elements of CRISPR-Cas have also been delivered to mouse knees to ablate key genes. Several human trials have been initiated, using transgenes encoding transforming growth factor-β1, interleukin-1 receptor antagonist, interferon-β, the NKX3.2 transcription factor or variant interleukin-10. The first of these, using ex vivo delivery with allogeneic chondrocytes, gained approval in Korea which was subsequently retracted. However, it is undergoing Phase III clinical trials in the United States. The other trials are in Phase I or II. No gene therapy for OA has current marketing approval in any jurisdiction.
    Summary: Extensive preclinical data support the use of intra-articular gene therapy for treating OA. Translation is beginning to accelerate and six gene therapeutics are in clinical trials. Importantly, venture capital has begun to flow and at least seven companies are developing products. Significant progress in the future can be expected.
    MeSH term(s) Humans ; Mice ; Animals ; Osteoarthritis/therapy ; Osteoarthritis/drug therapy ; Genetic Therapy ; Chondrocytes/metabolism ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Cytokines/metabolism ; Cartilage, Articular/metabolism
    Chemical Substances Interleukin 1 Receptor Antagonist Protein ; Cytokines
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3028: Show issues Location:
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  9. Article ; Online: Shear stress: the dark energy of atherosclerotic plaques.

    Evans, Paul C / Fragiadaki, Maria / Morris, Paul D / Serbanovic-Canic, Jovana

    Cardiovascular research

    2020  Volume 117, Issue 8, Page(s) 1811–1813

    MeSH term(s) Carotid Arteries ; Humans ; Plaque, Atherosclerotic ; Stress, Mechanical
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  10. Article ; Online: Scientists on the Spot: A matter of blood flow.

    Chiva-Blanch, Gemma / Evans, Paul C

    Cardiovascular research

    2021  Volume 117, Issue 12, Page(s) e162–e163

    MeSH term(s) Animals ; Arteries/pathology ; Arteries/physiopathology ; Atherosclerosis/history ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Atherosclerosis/physiopathology ; Biomedical Research/history ; Hemodynamics ; History, 20th Century ; History, 21st Century ; Humans ; Mechanotransduction, Cellular ; Plaque, Atherosclerotic ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Regional Blood Flow ; Stress, Mechanical
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2021-10-30
    Publishing country England
    Document type Biography ; Historical Article ; Interview ; Video-Audio Media
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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