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  1. Article: [TRANSLATIONAL MEDICINE - THE FRONTLINE OF MEDICAL RESEARCH].

    Blum, Arnon

    Harefuah

    2024  Volume 163, Issue 2, Page(s) 85–87

    Abstract: Introduction: In this journal we collected original papers and review papers in translational medicine. Translational medicine is a bio-medical field of research that translates findings discovered in the laboratory to clinical life, for example: ... ...

    Abstract Introduction: In this journal we collected original papers and review papers in translational medicine. Translational medicine is a bio-medical field of research that translates findings discovered in the laboratory to clinical life, for example: diagnostic methods, new cutting-edge medications, high-tech tools, and novel public health policy. This research combines different fields in science using new advanced technologies to improve medical care and wellbeing. The most significant impact was accomplished by the National Institutes of Health (NIH) twenty years ago, when a National Center for Translational Research was built. One of the achievements was the opening of a genetic research center that focused on RNA, circular RNAs and interference RNA. This research discovered the importance of these RNA particles in neurological and metabolic diseases, which were found to be applicable for treatment of these diseases. In this journal, original papers and reviews will express the diversity and the capabilities of this research field that has inspired so many physicians and researchers.
    MeSH term(s) United States ; Humans ; Translational Science, Biomedical ; Biomedical Research ; Translational Research, Biomedical ; Physicians ; RNA
    Chemical Substances RNA (63231-63-0)
    Language Hebrew
    Publishing date 2024-02-29
    Publishing country Israel
    Document type English Abstract ; Journal Article
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 291: Show issues Location:
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  2. Article: Colchicine: An Ancient Medication Rejuvenated?

    Blum, Arnon

    The Israel Medical Association journal : IMAJ

    2022  Volume 24, Issue 3, Page(s) 198–200

    MeSH term(s) Colchicine/therapeutic use ; Gout/drug therapy ; Humans
    Chemical Substances Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2022-03-29
    Publishing country Israel
    Document type Editorial ; Comment
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5470: Show issues Location:
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  3. Article: Artificial Intelligence in Medicine: An Endeavor to the Future.

    Dvir, Yoad M / Blum, Arnon

    The Israel Medical Association journal : IMAJ

    2024  Volume 26, Issue 2, Page(s) 71–73

    MeSH term(s) Humans ; Artificial Intelligence ; Medicine ; Forecasting
    Language English
    Publishing date 2024-02-26
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Peripheral Medical Centers in Israel: Narrowing the Gap - A Personal Perspective.

    Blum, Arnon

    The Israel Medical Association journal : IMAJ

    2019  Volume 21, Issue 3, Page(s) 171–174

    MeSH term(s) Hospitals, Community ; Humans ; Israel
    Language English
    Publishing date 2019-03-21
    Publishing country Israel
    Document type Journal Article ; Personal Narrative
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Improvement in Endothelial Function in Men Taking Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction.

    Konstantinovsky, Alex / Kuchersky, Nina / Kridin, Khalaf / Blum, Arnon

    The American journal of medicine

    2023  Volume 136, Issue 10, Page(s) 1041–1043

    Abstract: Background: The purpose of this research was to explore the mechanistic protective cardiovascular effects of phosphodiesterase-5 inhibitors (PDE5-Is) in males with erectile dysfunction. Erectile dysfunction and endothelial dysfunction both precede ... ...

    Abstract Background: The purpose of this research was to explore the mechanistic protective cardiovascular effects of phosphodiesterase-5 inhibitors (PDE5-Is) in males with erectile dysfunction. Erectile dysfunction and endothelial dysfunction both precede clinical atherosclerosis. Studies have shown that treatment for erectile dysfunction with PDE5-Is decreased death, heart failure, myocardial infarction, and revascularization in males with erectile dysfunction who had previous myocardial infarction, and cardiovascular events.
    Methods: This was a pilot study that recruited 5 men with erectile dysfunction without cardiovascular disease. Endothelial function (flow-mediated percent change of the diameter of the brachial artery), erectile dysfunction grade, high-sensitivity C-reactive protein, and body mass index were measured before and 3 months after starting treatment with tadalafil, 5 mg daily. Pearson's analysis was performed to study a correlation between the change in erectile dysfunction and the change in endothelial function.
    Results: A significant correlation was found between changes in flow-mediated percent change of the diameter of the brachial artery and changes in erectile dysfunction following the administration of tadalafil (P = .010; Pearson correlation coefficient = 0.959). No change was observed in C-reactive protein or weight.
    Conclusions: Erectile dysfunction and endothelial dysfunction are risk factors for cardiovascular disease. Our study showed that PDE5-Is improved endothelial function and erectile dysfunction (with a significant correlation). Improving endothelial function could be the mechanism that leads to a reduction in cardiovascular events and death in men with erectile dysfunction treated with PDE5-Is.
    MeSH term(s) Male ; Humans ; Phosphodiesterase 5 Inhibitors/adverse effects ; Erectile Dysfunction/drug therapy ; Erectile Dysfunction/etiology ; Tadalafil/therapeutic use ; C-Reactive Protein ; Pilot Projects ; Carbolines/pharmacology ; Carbolines/therapeutic use ; Myocardial Infarction/complications ; Treatment Outcome
    Chemical Substances Phosphodiesterase 5 Inhibitors ; Tadalafil (742SXX0ICT) ; C-Reactive Protein (9007-41-4) ; Carbolines
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2023.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: RETRACTED: Rheumatoid arthritis (RA) and cardiovascular disease.

    Blum, Arnon / Adawi, Mohammad

    Autoimmunity reviews

    2020  Volume 19, Issue 9, Page(s) 102601

    Language English
    Publishing date 2020-08-01
    Publishing country Netherlands
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2020.102601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5913: Show issues Location:
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  7. Article: On the anti-correlation between COVID-19 infection rate and natural UV light in the UK.

    Blum, Arnon / Nicolaou, Constantina / Henghes, Ben / Lahav, Ofer

    medRxiv : the preprint server for health sciences

    2022  

    Abstract: While it is well established that the rate of COVID-19 infections can be suppressed by social distancing, environmental effects may also affect it. We consider the hypothesis that natural Ultra-Violet (UV) light is reducing COVID-19 infections by ... ...

    Abstract While it is well established that the rate of COVID-19 infections can be suppressed by social distancing, environmental effects may also affect it. We consider the hypothesis that natural Ultra-Violet (UV) light is reducing COVID-19 infections by enhancing human immunity through increasing levels of Vitamin-D and Nitric Oxide or by suppressing the virus itself. We focus on the United Kingdom (UK), by examining daily COVID-19 infections (F) and UV Index (UVI) data from 23 March 2020 to 10 March 2021. We find an intriguing empirical anti-correlation between log
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2020.11.28.20240242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New oral nitric oxide-dependent medications for patients with coronary artery disease who have persistent angina pectoris.

    Blum, Arnon

    Coronary artery disease

    2015  Volume 26, Issue 8, Page(s) 639–641

    MeSH term(s) Administration, Oral ; Angina, Stable/drug therapy ; Coronary Artery Disease/drug therapy ; Humans ; Nitric Oxide/metabolism ; Ranolazine/therapeutic use ; Sodium Channel Blockers/therapeutic use ; Trimetazidine/therapeutic use ; Vasodilator Agents/therapeutic use
    Chemical Substances Sodium Channel Blockers ; Vasodilator Agents ; Nitric Oxide (31C4KY9ESH) ; Ranolazine (A6IEZ5M406) ; Trimetazidine (N9A0A0R9S8)
    Language English
    Publishing date 2015-12
    Publishing country England
    Document type Editorial
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000000287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3039: Show issues Location:
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  9. Article: Endoethelial Progenitor Cells are Affected by Medications and Estrogen.

    Blum, Arnon

    The Israel Medical Association journal : IMAJ

    2015  Volume 17, Issue 9, Page(s) 578–580

    Abstract: EPCs constitute an essential cornerstone in the building and maintenance of the endothelial blood vessels, as well as the functioning of most of the systems of our body, including the endocrine, neurological, hematological, immune and inflammatory ... ...

    Abstract EPCs constitute an essential cornerstone in the building and maintenance of the endothelial blood vessels, as well as the functioning of most of the systems of our body, including the endocrine, neurological, hematological, immune and inflammatory systems as well as organs such as kidney, heart, lungs and brain. Moreover, they serve as gatekeepers, preventing degenerative processes that affect every organ and tissue. It is important to know and understand that medications and hormones have an effect on these cells. This knowledge may help us to stimulate and maintain EPCs as well as plan future pharmacological interventions.
    MeSH term(s) Endothelial Progenitor Cells/drug effects ; Endothelial Progenitor Cells/metabolism ; Endothelium, Vascular/cytology ; Estrogens/metabolism ; Humans
    Chemical Substances Estrogens
    Language English
    Publishing date 2015-09
    Publishing country Israel
    Document type Journal Article ; Review
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Effect of Metformin on Vitamin B12 Deficiency and Stroke.

    Horrany, Nizar / Abu Dahoud, Wadie / Moallem, Yara / Hajouj, Taleb / Zreik, Merna / Blum, Arnon

    The Israel Medical Association journal : IMAJ

    2023  Volume 25, Issue 2, Page(s) 122–125

    Abstract: Background: Type 2 diabetes mellitus (T2DM) is a known risk factor for cardiovascular disease and stroke. Metformin is an old, relatively safe, first line therapy for T2DM; however, it has been associated with stroke.: Objectives: To study the ... ...

    Abstract Background: Type 2 diabetes mellitus (T2DM) is a known risk factor for cardiovascular disease and stroke. Metformin is an old, relatively safe, first line therapy for T2DM; however, it has been associated with stroke.
    Objectives: To study the effects of metformin use and vitamin B12 deficiency on stroke rate among patients with T2DM.
    Methods: We conducted a prospective study of patients admitted with ischemic stroke within 12 months (starting March 2020). We studied the clinical impact of metformin on vitamin B12 deficiency and stroke evolution. Student's t-test and ANOVA were used to compare the groups of patients and to determine whether there was any direct or indirect effect of metformin use on vitamin B12 deficiency and stroke.
    Results: In total, 80 patients were admitted with ischemic stroke. Clinical status and biochemical data were collected and compared with healthy volunteers. There were 39 diabetic patients, 16 took metformin for at least 1 year. Among those who took metformin for at least 1 year, 9 had vitamin B12 level < 240 pg/ml (56.2%); 23 diabetic patients did not get metformin and only 4 had vitamin B12 level < 240 pg/ml (17.4%) (P = 0.014).
    Conclusions: T2DM is a significant risk factor to the development of ischemic stroke. We found an association between metformin use and vitamin B12 deficiency and an association between vitamin B12 deficiency and stroke risk in patients with T2DM. Diabetic patients who are taking metformin should monitor their vitamin B12 level.
    MeSH term(s) Humans ; Metformin/adverse effects ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/adverse effects ; Prospective Studies ; Vitamin B 12 ; Vitamin B 12 Deficiency/epidemiology ; Vitamin B 12 Deficiency/complications ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Ischemic Stroke/chemically induced ; Ischemic Stroke/complications ; Ischemic Stroke/drug therapy
    Chemical Substances Metformin (9100L32L2N) ; Hypoglycemic Agents ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2023-02-25
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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