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  1. Article ; Online: Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

    Bell, Robert D / Winkler, Ethan A / Singh, Itender / Sagare, Abhay P / Deane, Rashid / Wu, Zhenhua / Holtzman, David M / Betsholtz, Christer / Armulik, Annika / Sallstrom, Jan / Berk, Bradford C / Zlokovic, Berislav V

    Nature

    2023  Volume 617, Issue 7961, Page(s) E12

    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06118-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Splice variants of human beta 1 integrins: origin, biosynthesis and functions.

    Armulik, Annika

    Frontiers in bioscience : a journal and virtual library

    2002  Volume 7, Page(s) d219–27

    Abstract: The integrin beta1 subfamily of adhesion receptors consists of 12 members and forms the biggest subfamily among integrins. Human integrin subunit beta1 has five cytoplasmic splice variants (beta1A, beta1B, beta1C-1, beta1-C2, beta1D). Even though ... ...

    Abstract The integrin beta1 subfamily of adhesion receptors consists of 12 members and forms the biggest subfamily among integrins. Human integrin subunit beta1 has five cytoplasmic splice variants (beta1A, beta1B, beta1C-1, beta1-C2, beta1D). Even though cytoplasmic splice variants do not change the ligand-specificity of a beta1 integrin, clustering of these different splice variants triggers signaling pathways that lead to a different cellular response. The main focus of this review is on the origin and specific functions of the less abundant human integrin beta1 splice variants (B, C-1, C-2, D).
    MeSH term(s) Alternative Splicing/genetics ; Alternative Splicing/physiology ; Amino Acid Sequence/genetics ; Amino Acid Sequence/physiology ; Animals ; Base Sequence/genetics ; Base Sequence/physiology ; Humans ; Integrin beta1/biosynthesis ; Integrin beta1/chemistry ; Integrin beta1/genetics ; Integrin beta1/physiology ; Molecular Sequence Data
    Chemical Substances Integrin beta1
    Language English
    Publishing date 2002-01-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2141320-4
    ISSN 1093-9946
    ISSN 1093-9946
    DOI 10.2741/A721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5867: Show issues Location:
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  3. Article: Pericytes and the blood-brain barrier: recent advances and implications for the delivery of CNS therapy.

    Armulik, Annika / Mäe, Maarja / Betsholtz, Christer

    Therapeutic delivery

    2011  Volume 2, Issue 4, Page(s) 419–422

    Abstract: Once the regulation of brain endothelial transcytosis is understood at the molecular level, it should be possible to exploit these mechanisms as targets for facilitated CNS drug delivery". ...

    Abstract "Once the regulation of brain endothelial transcytosis is understood at the molecular level, it should be possible to exploit these mechanisms as targets for facilitated CNS drug delivery".
    MeSH term(s) Animals ; Biological Transport ; Blood-Brain Barrier/physiology ; Brain/blood supply ; Central Nervous System Agents/administration & dosage ; Drug Delivery Systems/methods ; Humans ; Pericytes/physiology
    Chemical Substances Central Nervous System Agents
    Language English
    Publishing date 2011-11-08
    Publishing country England
    Document type Editorial
    ISSN 2041-5990
    ISSN 2041-5990
    DOI 10.4155/tde.11.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Studies on the transmembrane signaling of ß1 integrins

    Armulik, Annika

    (Comprehensive summaries of Uppsala dissertations from the Faculty of Medicine ; 963)

    2000  

    Author's details by Annika Armulik
    Series title Comprehensive summaries of Uppsala dissertations from the Faculty of Medicine ; 963
    Language English
    Size 92 S.
    Publisher Univ
    Publishing place Uppsala
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Uppsala, 2000
    ISBN 9154448321 ; 9789154448326
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article: Homeostatic functions of vascular endothelial growth factor in adult microvasculature.

    Betsholtz, Christer / Armulik, Annika

    American journal of physiology. Heart and circulatory physiology

    2006  Volume 290, Issue 2, Page(s) H509–11

    MeSH term(s) Adult ; Blood Vessels/physiology ; Homeostasis/physiology ; Humans ; Microcirculation/physiology ; Vascular Endothelial Growth Factor A/physiology
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2006-01-05
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.01075.2005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
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  6. Article ; Online: Getting to know the cast - cellular interactions and signaling at the neurovascular unit.

    Mäe, Maarja / Armulik, Annika / Betsholtz, Christer

    Current pharmaceutical design

    2011  Volume 17, Issue 26, Page(s) 2750–2754

    Abstract: The neurovascular unit (NVU), consisting of endothelial cells, basement membrane, pericytes, astrocytes and microglial cells, couples local neuronal function to local cerebral blood flow and regulates transport of blood-borne molecules across the blood- ... ...

    Abstract The neurovascular unit (NVU), consisting of endothelial cells, basement membrane, pericytes, astrocytes and microglial cells, couples local neuronal function to local cerebral blood flow and regulates transport of blood-borne molecules across the blood-brain barrier (BBB). The building blocks and the phenotype of the NVU are well-established but the intercellular signaling between the different components remains elusive. A better understanding of the cellular interactions and signaling within the NVU is critical for the development of efficient therapeutics for the treatment of a variety of brain diseases, such as brain cancer, stroke, neuroinflammation and neurodegeneration. This review gives an overview about the current in vivo knowledge of the NVU and the communication between its different cellular constituents. We also discuss the usefulness of various model organisms for studies of the brain vasculature.
    MeSH term(s) Animals ; Biological Transport ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Brain/physiopathology ; Brain Diseases/drug therapy ; Brain Diseases/physiopathology ; Cell Communication ; Drug Design ; Humans ; Signal Transduction/physiology
    Language English
    Publishing date 2011-08-04
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161211797440113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

    Armulik, Annika / Genové, Guillem / Betsholtz, Christer

    Developmental cell

    2011  Volume 21, Issue 2, Page(s) 193–215

    Abstract: Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic ... ...

    Abstract Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic retinopathy and tissue fibrosis, and they are potential stromal targets for cancer therapy. Some pericytes are probably mesenchymal stem or progenitor cells, which give rise to adipocytes, cartilage, bone, and muscle. However, there is still confusion about the identity, ontogeny, and progeny of pericytes. Here, we review the history of these investigations, indicate emerging concepts, and point out problems and promise in the field of pericyte biology.
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Collagen Type IV/metabolism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/embryology ; Models, Biological ; Neovascularization, Pathologic/pathology ; Neovascularization, Pathologic/physiopathology ; Neovascularization, Physiologic/physiology ; Pericytes/pathology ; Pericytes/physiology ; Pericytes/ultrastructure ; Signal Transduction/physiology
    Chemical Substances Collagen Type IV
    Language English
    Publishing date 2011-08-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2011.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5742: Show issues Location:
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    Zs.MG 76: Show issues

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  8. Article: Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

    Armulik, Annika / Genové, Guillem / Betsholtz, Christer

    Developmental cell. 2011 Aug. 16, v. 21, no. 2

    2011  

    Abstract: Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic ... ...

    Abstract Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic retinopathy and tissue fibrosis, and they are potential stromal targets for cancer therapy. Some pericytes are probably mesenchymal stem or progenitor cells, which give rise to adipocytes, cartilage, bone, and muscle. However, there is still confusion about the identity, ontogeny, and progeny of pericytes. Here, we review the history of these investigations, indicate emerging concepts, and point out problems and promise in the field of pericyte biology.
    Keywords adipocytes ; blood cells ; cartilage ; diabetic retinopathy ; fibrosis ; homeostasis ; morphogenesis ; muscles ; ontogeny ; progeny ; stem cells ; therapeutics
    Language English
    Dates of publication 2011-0816
    Size p. 193-215.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2011.07.001
    Database NAL-Catalogue (AGRICOLA)

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    Z 2005/721: Show issues

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  9. Article ; Online: Endothelial-mural cell signaling in vascular development and angiogenesis.

    Gaengel, Konstantin / Genové, Guillem / Armulik, Annika / Betsholtz, Christer

    Arteriosclerosis, thrombosis, and vascular biology

    2009  Volume 29, Issue 5, Page(s) 630–638

    Abstract: Mural cells are essential components of blood vessels and are necessary for normal development, homeostasis, and organ function. Alterations in mural cell density or the stable attachment of mural cells to the endothelium is associated with several human ...

    Abstract Mural cells are essential components of blood vessels and are necessary for normal development, homeostasis, and organ function. Alterations in mural cell density or the stable attachment of mural cells to the endothelium is associated with several human diseases such as diabetic retinopathy, venous malformation, and hereditary stroke. In addition mural cells are implicated in regulating tumor growth and have thus been suggested as potential antiangiogenic targets in tumor therapy. In recent years our knowledge of mural cell function and endothelial-mural cell signaling has increased dramatically, and we now begin to understand the mechanistic basis of the key signaling pathways involved. This is mainly thanks to sophisticated in vivo experiments using a broad repertoire of genetic technologies. In this review, we summarize the five currently best understood signaling pathways implicated in mural cell biology. We discuss PDGFB/PDGFRbeta- dependent pericyte recruitment, as well as the role of angiopoietins and Tie receptors in vascular maturation. In addition, we highlight the effects of sphingosine-1-phosphate signaling on adherens junction assembly and vascular stability, as well as the role of TGF-beta-signaling in mural cell differentiation. We further reflect recent data suggesting an important function for Notch3 signaling in mural cell maturation.
    MeSH term(s) Adherens Junctions/physiology ; Angiopoietins/physiology ; Animals ; Lysophospholipids/physiology ; Mice ; Mice, Knockout ; Neovascularization, Pathologic/physiopathology ; Neovascularization, Physiologic/physiology ; Pericytes/physiology ; Receptor, Notch3 ; Receptor, Platelet-Derived Growth Factor beta/physiology ; Receptors, Notch/physiology ; Receptors, TIE/physiology ; Signal Transduction/physiology ; Sphingosine/analogs & derivatives ; Sphingosine/physiology
    Chemical Substances Angiopoietins ; Lysophospholipids ; NOTCH3 protein, human ; Receptor, Notch3 ; Receptors, Notch ; sphingosine 1-phosphate (26993-30-6) ; Receptor, Platelet-Derived Growth Factor beta (EC 2.7.10.1) ; Receptors, TIE (EC 2.7.10.1) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2009-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.107.161521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Pericytes and vascular stability.

    von Tell, Desiree / Armulik, Annika / Betsholtz, Christer

    Experimental cell research

    2006  Volume 312, Issue 5, Page(s) 623–629

    Abstract: Newly formed endothelial tubes are initially unstable and subsequently become stabilized through the formation of a perivascular matrix and the association with pericytes. The presence of pericyte per se is not sufficient for vascular stability. Instead, ...

    Abstract Newly formed endothelial tubes are initially unstable and subsequently become stabilized through the formation of a perivascular matrix and the association with pericytes. The presence of pericyte per se is not sufficient for vascular stability. Instead, specific qualities of the cells are required that seem to correlate with marker expression and the nature of the endothelial-pericyte contacts. Most likely, specific intercellular signals are required as mediators of endothelial and pericyte cell function and vascular stability. Several ligand-receptor systems have been implicated in endothelial-pericyte interactions. Here, we discuss the role of some of these signaling systems in the regulation of vascular stability.
    MeSH term(s) Animals ; Blood Vessels/physiology ; Cell Line, Tumor ; Endothelium, Vascular/physiology ; Fibroblast Growth Factors/physiology ; Humans ; Pericytes/physiology ; Signal Transduction/physiology
    Chemical Substances Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2006-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1016/j.yexcr.2005.10.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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