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Article ; Online: Development of a rocking chair for use by children with spinal cord injuries.

George, Johnathan J / Behrman, Andrea L / Roussel, Thomas J

Disability and rehabilitation. Assistive technology

2024 , Page(s) 1–8

Abstract: Purpose: Activity-based locomotor training improves intrinsic trunk control in children with spinal cord injury (SCI). To reinforce these improvements, there is a need to develop community integration activities to allow a patient to apply the retrained ...

Abstract	Purpose: Activity-based locomotor training improves intrinsic trunk control in children with spinal cord injury (SCI). To reinforce these improvements, there is a need to develop community integration activities to allow a patient to apply the retrained nervous system at home. One activity that has been explored is rocking in a rocking chair. This paper describes the design, fabrication, and evaluation of a rocking chair for children with SCI. Materials and methods: The Quality Function Deployment (QFD) design process was used. Fundamental needs and features for the rocking chair were defined in a focus group with experienced therapists, and needs were then rated for importance. A House of Quality (HOQ) matrix was developed to correlate needs with design features, and a prototype design was generated. Virtual motion studies and finite element analysis (FEA) were utilized to assess the design. The chair was fabricated and physical testing was performed, including tipping and static and dynamic load assessments. Results and conclusions: The needs identified through the QFD process were categorized into (1) safety, (2) therapeutic, (3) practical and aesthetic, and (4) data to track chair use. Features selected to meet these needs include safety stops, padding, straps, a stable base, armrests, adjustable footrest, and sensors to capture rocking data. FEA showed a factor of safety (FOS) > 5. Physical testing confirmed physical integrity, load-bearing capacity, and stability of the prototype glider rocking chair. The prototype provides a safe tool for further investigation of rocking for promotion of trunk muscle activation in children with SCI.
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2221782-4
ISSN	1748-3115 ; 1748-3107
ISSN (online)	1748-3115
ISSN	1748-3107
DOI	10.1080/17483107.2024.2310268
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Zs.A 6301: Show issues

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Article ; Online: SLST D1 strains may contribute to skin health.

Agak, George W / Thiboutot, Diane M / Zaenglein, Andrea L / Nelson, Amanda M

Experimental dermatology

2023 Volume 33, Issue 1, Page(s) e14968

Language	English
Publishing date	2023-11-15
Publishing country	Denmark
Document type	Letter
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/exd.14968
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Zs.A 3508: Show issues

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Article ; Online: Patient-reported outcome measures for primary hyperparathyroidism: a systematic review of measurement properties.

Liang, George / Kaur, Manraj N / Wade, Carrie G / Edelen, Maria O / Bates, David W / Pusic, Andrea L / Liu, Jason B

Health and quality of life outcomes

2024 Volume 22, Issue 1, Page(s) 31

Abstract: Background: The quality of patient-reported outcome measures (PROMs) used to assess the outcomes of primary hyperparathyroidism (PHPT), a common endocrine disorder that can negatively affect patients' health-related quality of life due to chronic ... ...

Abstract	Background: The quality of patient-reported outcome measures (PROMs) used to assess the outcomes of primary hyperparathyroidism (PHPT), a common endocrine disorder that can negatively affect patients' health-related quality of life due to chronic symptoms, has not been rigorously examined. This systematic review aimed to summarize and evaluate evidence on the measurement properties of PROMs used in adult patients with PHPT, and to provide recommendations for appropriate measure selection. Methods: After PROSPERO registration (CRD42023438287), Medline, EMBASE, CINAHL Complete, Web of Science, PsycINFO, and Cochrane Trials were searched for full-text articles in English investigating PROM development, pilot studies, or evaluation of at least one PROM measurement property in adult patients with any clinical form of PHPT. Two reviewers independently identified studies for inclusion and conducted the review following the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) Methodology to assess risk of bias, evaluate the quality of measurement properties, and grade the certainty of evidence. Results: From 4989 records, nine PROM development or validation studies were identified for three PROMs: the SF-36, PAS, and PHPQoL. Though the PAS demonstrated sufficient test-retest reliability and convergent validity, and the PHPQoL sufficient test-retest reliability, convergent validity, and responsiveness, the certainty of evidence was low-to-very low due to risk of bias. All three PROMs lacked sufficient evidence for content validity in patients with PHPT. Conclusions: Based upon the available evidence, the SF-36, PAS, and PHPQoL cannot currently be recommended for use in research or clinical care, raising important questions about the conclusions of studies using these PROMs. Further validation studies or the development of more relevant PROMs with strong measurement properties for this patient population are needed.
MeSH term(s)	Adult ; Humans ; Quality of Life ; Reproducibility of Results ; Hyperparathyroidism, Primary ; Patient Reported Outcome Measures ; Consensus
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2098765-1
ISSN	1477-7525 ; 1477-7525
ISSN (online)	1477-7525
ISSN	1477-7525
DOI	10.1186/s12955-024-02248-9
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Article ; Online: An introduction and practical guide to strategies for analyzing longitudinal data in clinical trials of smoking cessation treatment: Beyond dichotomous point-prevalence outcomes.

Kypriotakis, George / Bernstein, Steven L / Bold, Krysten W / Dziura, James D / Hedeker, Donald / Mermelstein, Robin J / Weinberger, Andrea H

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

2024

Abstract: Conceptualizing tobacco dependence as a chronic relapsing condition suggests the need to use analytic strategies that reflect that premise. However, clinical trials for smoking cessation typically define the primary endpoint as a measure of abstinence at ...

Abstract	Conceptualizing tobacco dependence as a chronic relapsing condition suggests the need to use analytic strategies that reflect that premise. However, clinical trials for smoking cessation typically define the primary endpoint as a measure of abstinence at a single timepoint distal to the intervention, typically 3-12 months. This reinforces the concept of tobacco outcomes as a dichotomous state-one is, or is not, abstinent. Fortunately, there are several approaches available to handle longitudinal data that reflect the relapsing and remitting nature of tobacco use during treatment studies. In this paper, sponsored by the Society for Research on Nicotine and Tobacco's Treatment Research Network, we present an introductory overview of these techniques and their application in smoking cessation clinical trials. Topics discussed include models to examine abstinence outcomes (e.g., trajectory models of abstinence, models for transitions in smoking behavior, models for time to event), models that examine reductions in tobacco use, and models to examine joint outcomes (e.g., examining changes in use of more than one tobacco product). Finally, we discuss three additional relevant topics (i.e., heterogeneity of effects, handling missing data, power and sample size) and provide summary information about the type of model that can be used based on the type of data collected and the focus of the study. We encourage investigators to familiarize themselves with these techniques and use them in the analysis of data from clinical trials of smoking cessation treatment. IMPLICATIONS: Clinical trials of tobacco dependence treatment typically measure abstinence 3-12 months after participant enrollment. However, because smoking is a chronic relapsing condition, these measures of intervention success may not accurately reflect the common trajectories of tobacco abstinence and relapse. Several analytical techniques facilitate this type of outcome modeling. This paper is meant to be an introduction to these concepts and techniques to the global nicotine and tobacco research community including which techniques can be used for different research questions with visual summaries of which types of models can be used for different types of data and research questions.
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1452315-2
ISSN	1469-994X ; 1462-2203
ISSN (online)	1469-994X
ISSN	1462-2203
DOI	10.1093/ntr/ntae005
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Zs.A 5789: Show issues

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Article: CRISPR-mediated germline mutagenesis for genetic sterilization of

Smidler, Andrea L / Paton, Douglas G / Church, George M / Esvelt, Kevin M / Shaw, W Robert / Catteruccia, Flaminia

bioRxiv : the preprint server for biology

2023

Abstract: Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria elimination efforts, necessitating development of alternative vector control technologies. Sterile Insect Technique (SIT) has been successfully implemented in multiple ... ...

Abstract	Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria elimination efforts, necessitating development of alternative vector control technologies. Sterile Insect Technique (SIT) has been successfully implemented in multiple insect pests to suppress field populations by the release of large numbers of sterile males, yet it has proven difficult to adapt to
Language	English
Publishing date	2023-06-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.13.544841
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Article ; Online: Cu(II) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach.

Selaković, Snežana / Rodić, Marko V / Novaković, Irena / Matić, Ivana Z / Stanojković, Tatjana / Pirković, Andrea / Živković, Lada / Spremo-Potparević, Biljana / Milčić, Miloš / Medaković, Vesna / Dimiza, Filitsa / Psomas, George / Anđelković, Katarina / Šumar-Ristović, Maja

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 6, Page(s) 2770–2788

Abstract: ... of the compounds are [Cu(bipy)(L)(BF ...

Abstract	Copper(II) complexes with an α-diimine show a wide variety of biological activities, such as antibacterial, antifungal, antioxidant and anticancer. In this work, we synthesized and structurally characterized two novel Cu(II) complexes with methyl 3-formyl-4-hydroxybenzoate (HL) and α-diimines: 2,2'-bipyridine (bipy) and 1,10-phenanthroline (phen). Crystal structure analysis shows that the formulas of the compounds are [Cu(bipy)(L)(BF
MeSH term(s)	Animals ; Cattle ; Humans ; HeLa Cells ; Copper/pharmacology ; Copper/chemistry ; Coordination Complexes/chemistry ; Molecular Docking Simulation ; Ligands ; Hydrogen Peroxide ; Anti-Bacterial Agents/pharmacology ; Crystallography, X-Ray ; Aldehydes
Chemical Substances	Copper (789U1901C5) ; salicylaldehyde (17K64GZH20) ; Coordination Complexes ; Ligands ; Hydrogen Peroxide (BBX060AN9V) ; Anti-Bacterial Agents ; Aldehydes
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt03862a
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Article: Unbiased Plasmonic-Assisted Integrated Graphene Photodetectors.

Vangelidis, Ioannis / Bellas, Dimitris V / Suckow, Stephan / Dabos, George / Castilla, Sebastián / Koppens, Frank H L / Ferrari, Andrea C / Pleros, Nikos / Lidorikis, Elefterios

ACS photonics

2022 Volume 9, Issue 6, Page(s) 1992–2007

Abstract: Photonic integrated circuits (PICs) for next-generation optical communication interconnects and all-optical signal processing require efficient (∼A/W) and fast (≥25 ... ...

Abstract	Photonic integrated circuits (PICs) for next-generation optical communication interconnects and all-optical signal processing require efficient (∼A/W) and fast (≥25 Gbs
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article
ISSN	2330-4022
ISSN	2330-4022
DOI	10.1021/acsphotonics.2c00100
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Article ; Online: CRISPR-mediated germline mutagenesis for genetic sterilization of Anopheles gambiae males.

Smidler, Andrea L / Marrogi, Eryney / Kauffman, Jamie / Paton, Douglas G / Westervelt, Kathleen A / Church, George M / Esvelt, Kevin M / Shaw, W Robert / Catteruccia, Flaminia

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4057

Abstract: Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria elimination efforts, necessitating development of alternative vector control technologies. Sterile insect technique (SIT) has been successfully implemented in multiple ... ...

Abstract	Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria elimination efforts, necessitating development of alternative vector control technologies. Sterile insect technique (SIT) has been successfully implemented in multiple insect pests to suppress field populations by the release of large numbers of sterile males, yet it has proven difficult to adapt to Anopheles vectors. Here we outline adaptation of a CRISPR-based genetic sterilization system to selectively ablate male sperm cells in the malaria mosquito Anopheles gambiae. We achieve robust mosaic biallelic mutagenesis of zero population growth (zpg, a gene essential for differentiation of germ cells) in F1 individuals after intercrossing a germline-expressing Cas9 transgenic line to a line expressing zpg-targeting gRNAs. Approximately 95% of mutagenized males display complete genetic sterilization, and cause similarly high levels of infertility in their female mates. Using a fluorescence reporter that allows detection of the germline leads to a 100% accurate selection of spermless males, improving the system. These males cause a striking reduction in mosquito population size when released at field-like frequencies in competition cages against wild type males. These findings demonstrate that such a genetic system could be adopted for SIT against important malaria vectors.
MeSH term(s)	Humans ; Animals ; Male ; Female ; Anopheles/genetics ; Mosquito Control/methods ; Mosquito Vectors/genetics ; Semen ; RNA, Guide, CRISPR-Cas Systems ; Infertility, Male/genetics ; Malaria ; Mutagenesis ; Germ Cells
Chemical Substances	RNA, Guide, CRISPR-Cas Systems
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54498-8
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Article ; Online: Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection.

Frumento, Nicole / Sinnis-Bourozikas, Ariadne / Paul, Harry T / Stavrakis, Georgia / Zahid, Muhammad N / Wang, Shuyi / Ray, Stuart C / Flyak, Andrew I / Shaw, George M / Cox, Andrea L / Bailey, Justin R

Immunity

2024 Volume 57, Issue 1, Page(s) 40–51.e5

Abstract: Individuals who clear primary hepatitis C virus (HCV) infections clear subsequent reinfections more than 80% of the time, but the mechanisms are poorly defined. Here, we used HCV variants and plasma from individuals with repeated clearance to ... ...

Abstract	Individuals who clear primary hepatitis C virus (HCV) infections clear subsequent reinfections more than 80% of the time, but the mechanisms are poorly defined. Here, we used HCV variants and plasma from individuals with repeated clearance to characterize longitudinal changes in envelope glycoprotein E2 sequences, function, and neutralizing antibody (NAb) resistance. Clearance of infection was associated with early selection of viruses with NAb resistance substitutions that also reduced E2 binding to CD81, the primary HCV receptor. Later, peri-clearance plasma samples regained neutralizing capacity against these variants. We identified a subset of broadly NAbs (bNAbs) for which these loss-of-fitness substitutions conferred resistance to unmutated bNAb ancestors but increased sensitivity to mature bNAbs. These data demonstrate a mechanism by which neutralizing antibodies contribute to repeated immune-mediated HCV clearance, identifying specific bNAbs that exploit fundamental vulnerabilities in E2. The induction of bNAbs with these specificities should be a goal of HCV vaccine development.
MeSH term(s)	Humans ; Antibodies, Neutralizing ; Broadly Neutralizing Antibodies ; Hepatitis C Antibodies/chemistry ; Hepatitis C ; Hepacivirus ; Viral Envelope Proteins/genetics
Chemical Substances	Antibodies, Neutralizing ; Broadly Neutralizing Antibodies ; Hepatitis C Antibodies ; Viral Envelope Proteins
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2023.12.004
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Chemical features of melanoma tumor resident TRG CDR3s associated with better survival probabilities.

Agnila, Deo Rei L / Huda, Taha I / Eakins, Rachel A / Patel, Dhruv N / Hsiang, Monica / Chobrutskiy, Andrea / Chobrutskiy, Boris I / Blanck, George

Melanoma research

2023 Volume 33, Issue 4, Page(s) 275–282

Abstract: We assessed the T-cell receptor gamma (TRG) recombination reads from the cancer genome atlas melanoma tumor exome files and the TRG recombination reads from an independent, melanoma exome file dataset, from the Moffitt Cancer Center. TRG complementarity ... ...

Abstract	We assessed the T-cell receptor gamma (TRG) recombination reads from the cancer genome atlas melanoma tumor exome files and the TRG recombination reads from an independent, melanoma exome file dataset, from the Moffitt Cancer Center. TRG complementarity determining region-3 (CDR3) amino acid (AA) sequences were assessed for chemical complementarity to cancer testis antigens, with such complementarity for FAM133A and CRISP2 associated with better survival probabilities for both datasets. These results, along with related TRG CDR3 AA chemical feature assessments provided in this report, have indicated opportunities for melanoma patient stratifications based on the recovery of TRG recombination reads from both tumor and blood samples, and the results may point towards novel, effective melanoma antigens.
MeSH term(s)	Male ; Humans ; Melanoma/genetics ; Skin Neoplasms/genetics ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Complementarity Determining Regions/chemistry ; Complementarity Determining Regions/genetics ; Cell Adhesion Molecules
Chemical Substances	Receptors, Antigen, T-Cell, gamma-delta ; Complementarity Determining Regions ; CRISP2 protein, human ; Cell Adhesion Molecules
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1095779-0
ISSN	1473-5636 ; 0960-8931
ISSN (online)	1473-5636
ISSN	0960-8931
DOI	10.1097/CMR.0000000000000899
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