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  1. Article ; Online: Hemi-Hamate Autograft Arthroplasty for the Proximal Interphalangeal Joint Revisited: A New Surgical Approach.

    Goon, Patrick K Y / Vaghela, Kalpesh R / Stougie, Shirley / Coert, Jan H

    The journal of hand surgery Asian-Pacific volume

    2018  Volume 23, Issue 2, Page(s) 297–301

    Abstract: The hemi-hamate arthroplasty for proximal interphalangeal joint (PIPJ) dorsal fracture dislocations relies on complete dislocation of the joint using the 'shotgun' approach which provides excellent exposure but damages the delicate intrinsic joint ... ...

    Abstract The hemi-hamate arthroplasty for proximal interphalangeal joint (PIPJ) dorsal fracture dislocations relies on complete dislocation of the joint using the 'shotgun' approach which provides excellent exposure but damages the delicate intrinsic joint stabilisers. We present a new approach to the PIPJ when performing the hemi-hamate arthroplasty. The volar surgical approach involves freeing up the whole tendon sheath-periosteal unit as a single layer, and retracting this to one side. The articular surface of the joint can then be accessed with a little distraction and hyperextension. The method does not breach the tendon sheath, nor does it damage the collateral ligaments or volar plate. It is akin to the radical total anterior teno-arthrolysis (TATA) technique used for contracted joints, with some crucial differences. We postulate that the new approach causes far less iatrogenic damage and reduces the risk of contractures developing, and in chronic cases, allows concurrent joint release.
    MeSH term(s) Autografts ; Contracture/prevention & control ; Finger Injuries/surgery ; Finger Joint/surgery ; Fracture Dislocation/surgery ; Hamate Bone/transplantation ; Hemiarthroplasty/methods ; Humans ; Iatrogenic Disease/prevention & control ; Postoperative Complications/prevention & control
    Language English
    Publishing date 2018-05-07
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2848651-1
    ISSN 2424-8363 ; 2424-8355
    ISSN (online) 2424-8363
    ISSN 2424-8355
    DOI 10.1142/S2424835518710029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with "Smoking Guns" or "Smoke and Mirrors" in the Operating Theatre?

    Goon, Peter K C / Goon, Patrick K Y / Tan, Eunice K H / Crawford, Robin A F / Levell, Nick J / Sudhoff, Holger

    Dermatology and therapy

    2017  Volume 7, Issue 2, Page(s) 249–254

    Abstract: Introduction: Human papillomavirus (HPV) alone is thought to cause ~610,000 cases of cancer per year, and is the dominant aetiological agent for ano-genital (esp. cervical) and head and neck cancers (esp. oropharyngeal). Merkel cell polyomavirus (MCV) ... ...

    Abstract Introduction: Human papillomavirus (HPV) alone is thought to cause ~610,000 cases of cancer per year, and is the dominant aetiological agent for ano-genital (esp. cervical) and head and neck cancers (esp. oropharyngeal). Merkel cell polyomavirus (MCV) is a more recently discovered virus which causes Merkel cell carcinoma, a rare but highly aggressive skin malignancy.
    Methods: We explored the available published evidence to see if transmission of live HPV or MCV virus in smoke generated by laser or diathermy was feasible, and would pose an infection risk. Long-term infection with such carcinogenic viruses would then pose an increased risk for the development of virus-induced cancers in medical personnel.
    Results: The morphological structures of both HPV and MCV are very similar, and the size, external capsids and genomic structures show striking similarity. Both viruses have a non-enveloped external protein capsid consisting of 72 capsomeres, and a double-stranded DNA core. Sizes of both viruses range from 50 to 60 nm. There are now recent data demonstrating live and infectious HPV in smoke, and that these viruses can be used to infect cells in vitro. Further, anecdotal reports of virus transmission leading to disease causation in the production of respiratory airway viral warts (benign disease), and, finally, reports of HPV-induced oropharyngeal carcinoma (malignant disease) in two gynaecological surgeons as an occupational health hazard have been published recently.
    Conclusion: There is now sufficient evidence to support the hypotheses that live infectious carcinogenic viruses can be transmitted via smoke generated from surgical procedures, and, in rare instances, actually cause significant disease. Protective measures such as smoke extraction and airway protection should be instituted for all healthcare personnel, particularly those with multiple repeated exposures such as gynaecological surgeons.
    Language English
    Publishing date 2017-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680284-3
    ISSN 2190-9172 ; 2193-8210
    ISSN (online) 2190-9172
    ISSN 2193-8210
    DOI 10.1007/s13555-017-0182-5
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  3. Article: Reconstruction of Distal Radius Osteochondral Defects Using Metatarsal Autografts: a Multi-case Series

    Goon, Patrick K.Y. / Stougie, Shirley D. / Vaghela, Kalpesh R. / Coert, J. Henk

    Revista Iberoamericana de Cirugía de la Mano

    2019  Volume 47, Issue 01, Page(s) 3–9

    Abstract: Objective: Delayed reconstruction of the articular surface of the distal radius after trauma is a difficult problem for hand surgeons, and the common solution is usually partial or total wrist fusion, relieving pain but sacrificing motion. A relative ... ...

    Abstract Objective: Delayed reconstruction of the articular surface of the distal radius after trauma is a difficult problem for hand surgeons, and the common solution is usually partial or total wrist fusion, relieving pain but sacrificing motion. A relative novel reconstructive technique addresses the problem with a free microvascular osteochondral flap, using the 3 rd metatarsal (3MT) bone. We investigate the possibility of using the same donor as a graft rather than a free flap.
    Methods: This was a prospective clinical study of patients with isolated lunate facet damage following trauma who underwent surgery to remove the damaged articular surface and in whom the defect was reconstructed with an osteochondral graft from the base of the 3MT. All of the patients were followed-up at specific time intervals, with pre- and postoutcome measures taken, including pain, grip strength, range of motion (ROM), and postoperative radiographs and computed tomography (CT) scans to evaluate graft resorption and union. Only patients with isolated distal radius defects were included.
    Results: The average follow-up period was of 51 months (range: 14–73 months). The results of 7 patients included an average improvement of the pain score in the visual analogue scale (VAS) by 3 points, with an average arc of motion of 135°. In all, there was radiographic evidence of full incorporation of the graft, with no resorption. Donor site morbidity was minimal.
    Conclusions: The current gold standard for distal radius articular surface reconstruction remains a free 3MT osteochondral flap. However, our results using the base of the 3MT as a graft shows promise, and if further follow-up confirms comparable results to the free flap technique, this would mean an easier and equally robust reconstruction without complicated microsurgery.
    Level of Evidence: Therapeutic, Level V case series.
    Keywords metatarsal ; reconstruction ; distal radius ; metatarsiano ; reconstrucción ; radio distal
    Language English
    Publishing date 2019-05-01
    Publisher Thieme Revinter Publicações Ltda
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2874929-7
    ISSN 1698-840X ; 1698-8396
    ISSN (online) 1698-840X
    ISSN 1698-8396
    DOI 10.1055/s-0039-1688972
    Database Thieme publisher's database

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  4. Article: Circulating endothelial cells in obstructive sleep apnea: an important methodological lesson.

    Goon, Patrick K Y / Watson, Timothy / Lip, Gregory Y H

    American journal of respiratory and critical care medicine

    2007  Volume 175, Issue 12, Page(s) 1346; author reply 1347

    MeSH term(s) Apoptosis/physiology ; CD146 Antigen/physiology ; Endothelial Cells/pathology ; Endothelial Cells/physiology ; Humans ; Leukocyte Disorders ; Sleep Apnea, Obstructive/blood ; Sleep Apnea, Obstructive/pathology ; Sleep Apnea, Obstructive/physiopathology
    Chemical Substances CD146 Antigen
    Language English
    Publishing date 2007-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 1073-449X ; 0003-0805
    ISSN (online) 1535-4970
    ISSN 1073-449X ; 0003-0805
    DOI 10.1164/ajrccm.175.12.1346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Endothelial progenitor cells, endothelial cell dysfunction and much more: observations from cardiac syndrome X.

    Goon, Patrick K Y / Lip, Gregory Y H

    Heart (British Cardiac Society)

    2007  Volume 93, Issue 9, Page(s) 1020–1021

    MeSH term(s) Endothelial Cells/physiology ; Endothelium, Vascular/pathology ; Endothelium, Vascular/physiopathology ; Humans ; Microvascular Angina/blood ; Microvascular Angina/physiopathology ; Stem Cells/physiology
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/hrt.2006.112664
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    Zs.MO 112: Show issues

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  6. Article: Endothelial progenitor cells, endothelial dysfunction, inflammation, and oxidative stress in hypertension.

    Watson, Timothy / Goon, Patrick K Y / Lip, Gregory Y H

    Antioxidants & redox signaling

    2008  Volume 10, Issue 6, Page(s) 1079–1088

    Abstract: With a prevalence in excess of 20%, hypertension is a common finding among Western adult populations. Hypertension is directly implicated in the pathophysiology of various cardiovascular disease states and is a significant contributor to ill health, ... ...

    Abstract With a prevalence in excess of 20%, hypertension is a common finding among Western adult populations. Hypertension is directly implicated in the pathophysiology of various cardiovascular disease states and is a significant contributor to ill health, leading to an excess of both morbidity and mortality. The etiology of hypertension has been explored in depth, but the pathophysiology is multifactorial, complex, and poorly understood. Recent interest has been directed toward investigating the purported role of the endothelium, which acts as an important regulator of vascular homeostasis. Endothelial dysfunction is now recognized to occur in hypertension, regardless of whether the etiology is essential or secondary to endocrine or renal processes. Nitric oxide (NO) is a volatile gas produced by endothelial cells that acts to maintain vascular tone. Reduced bioavailability of NO appears to be the key process through which endothelial dysfunction is manifested in hypertension. The result is of an imbalance of counteracting mechanisms, normally designed to maintain vascular homeostasis, leading to vasoconstriction and impaired vascular function. It has become increasingly apparent that these changes may be effected in response to enhanced oxidative stress, possibly as a result of systemic and localized inflammatory responses. This article provides an overview of endothelial dysfunction in hypertension and focuses on the purported role of oxidative stress and inflammation as the catalysts for this process.
    MeSH term(s) Animals ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Humans ; Hypertension/etiology ; Hypertension/immunology ; Inflammation/complications ; Oxidative Stress ; Rats ; Stem Cells/physiology
    Language English
    Publishing date 2008-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2007.1998
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  7. Article: Arterial disease and venous thromboembolism: a modern paradigm?

    Goon, Patrick K Y / Lip, Gregory Y H

    Thrombosis and haemostasis

    2006  Volume 96, Issue 2, Page(s) 111–112

    MeSH term(s) Humans ; Risk Factors ; Thromboembolism/diagnosis ; Thromboembolism/pathology ; Thrombosis/diagnosis ; Thrombosis/pathology ; Vascular Diseases/diagnosis ; Vascular Diseases/pathology ; Venous Thrombosis/diagnosis ; Venous Thrombosis/pathology
    Language English
    Publishing date 2006-08
    Publishing country Germany
    Document type Comment ; Editorial
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
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  8. Article: Proteomics, metabolomics and circulating endothelial progenitor cells in acute coronary syndromes.

    Goon, Patrick K Y / Lip, Gregory Y H

    Journal of thrombosis and thrombolysis

    2006  Volume 22, Issue 2, Page(s) 155–156

    MeSH term(s) Angina, Unstable/diagnosis ; Angina, Unstable/metabolism ; Biomarkers/analysis ; Endothelial Cells/cytology ; Endothelial Cells/physiology ; Humans ; Myocardial Infarction/diagnosis ; Myocardial Infarction/metabolism ; Proteomics ; Stem Cells
    Chemical Substances Biomarkers
    Language English
    Publishing date 2006-10
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 1230645-9
    ISSN 0929-5305
    ISSN 0929-5305
    DOI 10.1007/s11239-006-8983-x
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  9. Article ; Online: DIEP flap rescue by venesection of the superficial epigastric vein.

    Stasch, Tilman / Goon, Patrick K Y / Haywood, Richard M / Sassoon, Elaine M

    Annals of plastic surgery

    2009  Volume 62, Issue 4, Page(s) 372–373

    Abstract: Microsurgical breast reconstruction with the deep inferior epigastric perforator flap is a technically challenging procedure, where flap survival depends on sufficient arterial input and venous outflow. Rarely, these flaps can become congested because of ...

    Abstract Microsurgical breast reconstruction with the deep inferior epigastric perforator flap is a technically challenging procedure, where flap survival depends on sufficient arterial input and venous outflow. Rarely, these flaps can become congested because of insufficient venous pathways and dominance of the superficial venous system. We describe a simple technique to allow the rescue of congested flaps by intermittent venesection of the superficial inferior epigastric vein. This relieves the venous congestion in the immediate postoperative period, allowing the flap to develop venous drainage through alternate channels.
    MeSH term(s) Female ; Graft Survival ; Humans ; Mammaplasty ; Microsurgery ; Surgical Flaps/blood supply ; Veins/surgery ; Venous Insufficiency/surgery
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423835-7
    ISSN 1536-3708 ; 0148-7043
    ISSN (online) 1536-3708
    ISSN 0148-7043
    DOI 10.1097/SAP.0b013e318184aab5
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  10. Article: The endothelium, inflammation, and coagulation in sepsis.

    Boos, Christopher J / Goon, Patrick K Y / Lip, Gregory Y H

    Clinical pharmacology and therapeutics

    2006  Volume 79, Issue 1, Page(s) 20–22

    MeSH term(s) Animals ; Antithrombins/pharmacology ; Blood Coagulation/physiology ; Endothelium/pathology ; Humans ; Inflammation/pathology ; Sepsis/blood ; Sepsis/pathology ; Thrombosis/pathology
    Chemical Substances Antithrombins
    Language English
    Publishing date 2006-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1016/j.clpt.2005.10.004
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