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  1. Article: Takayuki Asahara, M.D., PH.D. Interview by Vicki P. Glaser.

    Asahara, Takayuki

    Journal of hematotherapy & stem cell research

    2002  Volume 11, Issue 4, Page(s) 579–582

    MeSH term(s) Antigens, CD/analysis ; Antigens, CD34/analysis ; Bone Marrow Cells/cytology ; Cell Count ; Hematopoietic Stem Cells/cytology ; Humans
    Chemical Substances Antigens, CD ; Antigens, CD34
    Language English
    Publishing date 2002-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1494547-2
    ISSN 1525-8165
    ISSN 1525-8165
    DOI 10.1089/15258160260194721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3616: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: MicroRNA-140 is not involved in sepsis-induced muscle atrophy.

    Shin, Jaehoon / Miyaki, Shigeru / Asahara, Hiroshi / Akimoto, Takayuki

    American journal of physiology. Cell physiology

    2023  Volume 325, Issue 2, Page(s) C509–C518

    Abstract: Sepsis is a life-threatening inflammatory response to infection, often accompanied by skeletal muscle atrophy. A previous study demonstrated that the administration of microRNA-140 (miR-140) attenuated lipopolysaccharide (LPS)-induced muscle atrophy, ... ...

    Abstract Sepsis is a life-threatening inflammatory response to infection, often accompanied by skeletal muscle atrophy. A previous study demonstrated that the administration of microRNA-140 (miR-140) attenuated lipopolysaccharide (LPS)-induced muscle atrophy, whereas miR-140 knockdown with siRNA promoted atrophy. Therefore, we investigated whether miR-140 is involved in LPS-induced muscle atrophy using a genetic model,
    MeSH term(s) Animals ; Mice ; Lipopolysaccharides ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Muscle, Skeletal/metabolism ; Muscular Atrophy/metabolism ; Sepsis/complications ; Sepsis/genetics ; Sepsis/metabolism
    Chemical Substances Lipopolysaccharides ; MicroRNAs ; MIRN140 microRNA, mouse
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00157.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: CD34 positive cells as endothelial progenitor cells in biology and medicine.

    Hassanpour, Mehdi / Salybekov, Amankeldi A / Kobayashi, Shuzo / Asahara, Takayuki

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1128134

    Abstract: CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. Therefore, regenerative therapy using ... ...

    Abstract CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. Therefore, regenerative therapy using CD34
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1128134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Therapeutic application of regeneration-associated cells: a novel source of regenerative medicine.

    Salybekov, Amankeldi A / Hassanpour, Mehdi / Kobayashi, Shuzo / Asahara, Takayuki

    Stem cell research & therapy

    2023  Volume 14, Issue 1, Page(s) 191

    Abstract: Chronic diseases with comorbidities or associated risk factors may impair the function of regenerative cells and the regenerative microenvironment. Following this consideration, the vasculogenic conditioning culture (VCC) method was developed to boost ... ...

    Abstract Chronic diseases with comorbidities or associated risk factors may impair the function of regenerative cells and the regenerative microenvironment. Following this consideration, the vasculogenic conditioning culture (VCC) method was developed to boost the regenerative microenvironment to achieve regeneration-associated cells (RACs), which contain vasculogenic endothelial progenitor cells (EPCs) and anti-inflammatory/anti-immunity cells. Preclinical and clinical studies demonstrate that RAC transplantation is a safe and convenient cell population for promoting ischemic tissue recovery based on its strong vasculogenicity and functionality. The outputs of the scientific reports reviewed in the present study shed light on the fact that RAC transplantation is efficient in curing various diseases. Here, we compactly highlight the universal features of RACs and the latest progress in their translation toward clinics.
    MeSH term(s) Regenerative Medicine/methods ; Endothelial Progenitor Cells ; Stem Cell Transplantation ; Cell Differentiation
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-023-03428-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characterization of Endothelial Progenitor Cell: Past, Present, and Future.

    Salybekov, Amankeldi A / Kobayashi, Shuzo / Asahara, Takayuki

    International journal of molecular sciences

    2022  Volume 23, Issue 14

    Abstract: Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several ... ...

    Abstract Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The challenges and issues surrounding the use of EPCs and the current paradigm being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed. It has been observed that controversies have emerged regarding the isolation techniques and classification and origin of EPCs. This manuscript attempts to highlight the concept of EPCs in a sequential manner, from the initial discovery to the present (origin, sources of EPCs, isolation, and identification techniques). Human and murine EPC marker diversity is also discussed. Additionally, this manuscript is aimed at summarizing our current and future prospects regarding the crosstalk of EPCs with the biology of hematopoietic cells and culture techniques in the context of regeneration-associated cells (RACs).
    MeSH term(s) Animals ; Biomarkers ; Endothelial Progenitor Cells ; Humans ; Mice ; Regenerative Medicine/methods
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-07-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23147697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CD34 positive cells as endothelial progenitor cells in biology and medicine

    Mehdi Hassanpour / Amankeldi A. Salybekov / Shuzo Kobayashi / Takayuki Asahara

    Frontiers in Cell and Developmental Biology, Vol

    2023  Volume 11

    Abstract: CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. Therefore, regenerative therapy using CD34+ cells ... ...

    Abstract CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. Therefore, regenerative therapy using CD34+ cells has attracted interest for application in patients with various vascular, ischemic, and inflammatory diseases. CD34+ cells have recently been reported to improve therapeutic angiogenesis in a variety of diseases. Mechanistically, CD34+ cells are involved in both direct incorporation into the expanding vasculature and paracrine activity through angiogenesis, anti-inflammatory, immunomodulatory, and anti-apoptosis/fibrosis roles, which support the developing microvasculature. Preclinical, pilot, and clinical trials have well documented a track record of safety, practicality, and validity of CD34+ cell therapy in various diseases. However, the clinical application of CD34+ cell therapy has triggered scientific debates and controversies in last decade. This review covers all preexisting scientific literature and prepares an overview of the comprehensive biology of CD34+ cells as well as the preclinical/clinical details of CD34+ cell therapy for regenerative medicine.
    Keywords CD34 positive cells ; endothelial progenitor cells ; vasculogenesis ; exosome ; regenerative medicine ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Characterization of Endothelial Progenitor Cell

    Amankeldi A. Salybekov / Shuzo Kobayashi / Takayuki Asahara

    International Journal of Molecular Sciences, Vol 23, Iss 14, p

    Past, Present, and Future

    2022  Volume 7697

    Abstract: Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several ... ...

    Abstract Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The challenges and issues surrounding the use of EPCs and the current paradigm being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed. It has been observed that controversies have emerged regarding the isolation techniques and classification and origin of EPCs. This manuscript attempts to highlight the concept of EPCs in a sequential manner, from the initial discovery to the present (origin, sources of EPCs, isolation, and identification techniques). Human and murine EPC marker diversity is also discussed. Additionally, this manuscript is aimed at summarizing our current and future prospects regarding the crosstalk of EPCs with the biology of hematopoietic cells and culture techniques in the context of regeneration-associated cells (RACs).
    Keywords endothelial progenitor cells ; endothelial colony-forming cells ; hemogenic angioblasts ; regeneration-associated cells ; resident endothelial progenitor cells ; extracellular vesicles ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Overview of Basic Mechanisms of Notch Signaling in Development and Disease.

    McIntyre, Brendan / Asahara, Takayuki / Alev, Cantas

    Advances in experimental medicine and biology

    2020  Volume 1227, Page(s) 9–27

    Abstract: Notch signaling is an evolutionarily conserved pathway associated with the development and differentiation of all metazoans. It is needed for proper germ layer formation and segmentation of the embryo and controls the timing and duration of ... ...

    Abstract Notch signaling is an evolutionarily conserved pathway associated with the development and differentiation of all metazoans. It is needed for proper germ layer formation and segmentation of the embryo and controls the timing and duration of differentiation events in a dynamic manner. Perturbations of Notch signaling result in blockades of developmental cascades, developmental anomalies, and cancers. An in-depth understanding of Notch signaling is thus required to comprehend the basis of development and cancer, and can be further exploited to understand and direct the outcomes of targeted cellular differentiation into desired cell types and complex tissues from pluripotent or adult stem and progenitor cells. In this chapter, we briefly summarize the molecular, evolutionary, and developmental basis of Notch signaling. We will focus on understanding the basics of Notch signaling and its signaling control mechanisms, its developmental outcomes and perturbations leading to developmental defects, as well as have a brief look at mutations of the Notch signaling pathway causing human hereditary disorders or cancers.
    MeSH term(s) Animals ; Cell Differentiation ; Embryonic Development ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Signal Transduction/genetics ; Stem Cells/cytology ; Stem Cells/metabolism
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2020-02-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-36422-9_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Latest Advances in Endothelial Progenitor Cell-Derived Extracellular Vesicles Translation to the Clinic.

    Salybekov, Amankeldi A / Kunikeyev, Aidyn D / Kobayashi, Shuzo / Asahara, Takayuki

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 734562

    Abstract: Almost all nucleated cells secrete extracellular vesicles (EVs) that are heterogeneous spheroid patterned or round shape particles ranging from 30 to 200 nm in size. Recent preclinical and clinical studies have shown that endothelial progenitor cell- ... ...

    Abstract Almost all nucleated cells secrete extracellular vesicles (EVs) that are heterogeneous spheroid patterned or round shape particles ranging from 30 to 200 nm in size. Recent preclinical and clinical studies have shown that endothelial progenitor cell-derived EVs (EPC-EVs) have a beneficial therapeutic effect in various diseases, including cardiovascular diseases and kidney, and lung disorders. Moreover, some animal studies have shown that EPC-EVs selectively accumulate at the injury site with a specific mechanism of binding along with angiogenic and restorative effects that are superior to those of their ancestors. This review article highlights current advances in the biogenesis, delivery route, and long-term storage methods of EPC-EVs and their favorable effects such as anti-inflammatory, angiogenic, and tissue protection in various diseases. Finally, we review the possibility of therapeutic application of EPC-EVs in the clinic.
    Language English
    Publishing date 2021-10-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.734562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Inflammation in myocardial infarction: roles of mesenchymal stem cells and their secretome.

    Shao, Lianbo / Shen, Ying / Ren, Chuanlu / Kobayashi, Shuzo / Asahara, Takayuki / Yang, Junjie

    Cell death discovery

    2022  Volume 8, Issue 1, Page(s) 452

    Abstract: Inflammation plays crucial roles in the regulation of pathophysiological processes involved in injury, repair and remodeling of the infarcted heart; hence, it has become a promising target to improve the prognosis of myocardial infarction (MI). ... ...

    Abstract Inflammation plays crucial roles in the regulation of pathophysiological processes involved in injury, repair and remodeling of the infarcted heart; hence, it has become a promising target to improve the prognosis of myocardial infarction (MI). Mesenchymal stem cells (MSCs) serve as an effective and innovative treatment option for cardiac repair owing to their paracrine effects and immunomodulatory functions. In fact, transplanted MSCs have been shown to accumulate at injury sites of heart, exerting multiple effects including immunomodulation, regulating macrophages polarization, modulating the activation of T cells, NK cells and dendritic cells and alleviating pyroptosis of non-immune cells. Many studies also proved that preconditioning of MSCs can enhance their inflammation-regulatory effects. In this review, we provide an overview on the current understanding of the mechanisms on MSCs and their secretome regulating inflammation and immune cells after myocardial infarction and shed light on the applications of MSCs in the treatment of cardiac infarction.
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-022-01235-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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