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Article ; Online: Central nervous system outcomes of COVID-19.

Doyle, Margaret F

Translational research : the journal of laboratory and clinical medicine

2021 Volume 241, Page(s) 41–51

Abstract: The worldwide pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected an estimated 200 million people with over 4 million deaths. Although COVID-19, the disease caused by the SARS-CoV-2 virus, is primarily a ... ...

Abstract	The worldwide pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected an estimated 200 million people with over 4 million deaths. Although COVID-19, the disease caused by the SARS-CoV-2 virus, is primarily a respiratory disease, an increasing number of neurologic symptoms have been reported. Some of these symptoms, such as loss of smell or taste, are mild and non-life threatening, while others, such as stroke or seizure, are more critical. Many of these symptoms remain long after the acute illness has passed, a phenomenon known as "long COVID" or postacute sequelae of SARS-CoV-2 infection (PASC). Neurological symptoms can be difficult to study due to the complexity of the central and peripheral nervous system. These neurologic symptoms can be difficult to identify and quantitate. This narrative review will describe approaches for assessing neurologic manifestations of COVID-19, with examples of the data they provide, as well as some directions for future research to aid in understanding the pathophysiology of COVID-19-related neurological implications.
MeSH term(s)	COVID-19/complications ; COVID-19/virology ; Central Nervous System/physiopathology ; Humans ; SARS-CoV-2/isolation & purification ; Post-Acute COVID-19 Syndrome
Language	English
Publishing date	2021-09-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2246684-8
ISSN	1878-1810 ; 1532-6543 ; 1931-5244
ISSN (online)	1878-1810 ; 1532-6543
ISSN	1931-5244
DOI	10.1016/j.trsl.2021.09.002
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Article ; Online: Correction for: Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants.

Fang, Yuan / Doyle, Margaret F / Chen, Jiachen / Mez, Jesse / Satizabal, Claudia L / Alosco, Michael L / Qiu, Wei Qiao / Lunetta, Kathryn L / Murabito, Joanne M

Aging

2023 Volume 15, Issue 15, Page(s) 7855–7856

Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204988
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Article ; Online: Investigating peripheral blood monocyte and T-cell subsets as non-invasive biomarkers for asymptomatic hepatic steatosis: results from the Multi-Ethnic Study of Atherosclerosis.

Niedecker, Rhys W / Delaney, Joseph A / Doyle, Margaret F / Sparks, Andrew D / Sitlani, Colleen M / Buzkova, Petra / Zeb, Irfan / Tracy, Russell P / Psaty, Bruce M / Budoff, Matthew J / Olson, Nels C

Frontiers in immunology

2024 Volume 15, Page(s) 1243526

Abstract: Background: Circulating immune cells have gained interest as biomarkers of hepatic steatosis. Data on the relationships between immune cell subsets and early-stage steatosis in population-based cohorts are limited.: Methods: This study included 1,944 ...

Abstract	Background: Circulating immune cells have gained interest as biomarkers of hepatic steatosis. Data on the relationships between immune cell subsets and early-stage steatosis in population-based cohorts are limited. Methods: This study included 1,944 asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis (MESA) with immune cell phenotyping and computed tomography measures of liver fat. Participants with heavy alcohol use were excluded. A liver-to-spleen ratio Hounsfield units (HU) <1.0 and liver attenuation <40 HU were used to diagnose liver fat presence and >30% liver fat content, respectively. Logistic regression estimated cross-sectional associations of immune cell subsets with liver fat parameters adjusted for risk factors. We hypothesized that higher proportions of non-classical monocytes, Th1, Th17, and memory CD4 Results: None of the hypothesized cells were associated with presence of liver fat. Higher memory CD4 Conclusions: Higher circulating memory CD4
MeSH term(s)	Humans ; Monocytes ; Cross-Sectional Studies ; Fatty Liver/diagnosis ; T-Lymphocyte Subsets ; Biomarkers ; Atherosclerosis
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1243526
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Article ; Online: Viral hepatitis testing and treatment in community pharmacies: a systematic review and meta-analysis.

Hayes, Mark J / Beavon, Emma / Traeger, Michael W / Dillon, John F / Radley, Andrew / Nielsen, Suzanne / Byrne, Christopher J / Richmond, Jacqui / Higgs, Peter / Hellard, Margaret E / Doyle, Joseph S

EClinicalMedicine

2024 Volume 69, Page(s) 102489

Abstract: Background: The World Health Organization seeks to eliminate viral hepatitis as a public health threat by 2030. This review and meta-analysis aims to evaluate the effectiveness of programs for hepatitis B and C testing and treatment in community ... ...

Abstract	Background: The World Health Organization seeks to eliminate viral hepatitis as a public health threat by 2030. This review and meta-analysis aims to evaluate the effectiveness of programs for hepatitis B and C testing and treatment in community pharmacies. Methods: Medline, Embase, Cochrane CENTRAL, and Global Health were searched from database inception until 12 November 2023. Comparative and single arm intervention studies were eligible for inclusion if they assessed delivery of any of the following interventions for hepatitis B or C in pharmacies: (1) pre-testing risk assessment, (2) testing, (3) pre-treatment assessment or (4) treatment. Primary outcomes were proportions testing positive and reaching each stage in the cascade. Random effects meta-analysis was used to estimate pooled proportions stratified by recruitment strategy and setting where possible; other results were synthesised narratively. This study was pre-registered (PROSPERO: CRD42022324218). Findings: Twenty-seven studies (4 comparative, 23 single arm) were included, of which 26 reported hepatitis C outcomes and four reported hepatitis B outcomes. History of injecting drug use was the most identified risk factor from pre-testing risk assessments. The pooled proportion hepatitis C antibody positive from of 19 studies testing 5096 participants was 16.6% (95% CI 11.0%-23.0%; heterogeneity Interpretation: These findings add pharmacies to the growing evidence supporting community-based testing and treatment for hepatitis C. Few comparative studies and high degrees of statistical heterogeneity were important limitations. Hepatitis B care in pharmacies presents an opportunity for future research. Funding: None.
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2024.102489
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Article: Aging-Related Immune Cell Phenotypes and Mortality in the Framingham Heart Study.

Ragab, Ahmed A Y / Doyle, Margaret F / Chen, Jiachen / Fang, Yuan / Lunetta, Kathryn L / Murabito, Joanne M

Research square

2023

Abstract: Background: The global increase in human life expectancy is evident. The total number of individuals aged 60 or above is anticipated to reach 2 billion by 2050. Aging, an inherently complex process, manifests prominently in the changes observed in the ... ...

Abstract	Background: The global increase in human life expectancy is evident. The total number of individuals aged 60 or above is anticipated to reach 2 billion by 2050. Aging, an inherently complex process, manifests prominently in the changes observed in the immune system. A notable marker of immune system aging is the presence of Aging-Related Immune Cell Phenotypes (ARIPs). Despite their significance, the connections between various ARIPs and mortality have not been thoroughly investigated. We prospectively investigated 16 different ARIPs using flow cytometry, namely, CD4/CD8 ratio, Granzyme B + CD8/Granyzme B + CD4, T Results: Among 996 participants (mean age 62 years, range 40 to 88 years, 52% female), the survival rate was 65% during 19 years of follow-up. For the model adjusting for age, sex, and cytomegalovirus (CMV) serostatus, higher CD4/CD8 and Tc17/CD8 + Treg ratios were significantly associated with lower all-cause mortality (HR:0.86 [0.76-0.96], 0.84 [0.74-0.94], respectively) and higher CD8 regulatory cell levels (CD8 + CD25 + FoxP3+) were associated with higher all-cause mortality (HR = 1.17, [1.03-1.32]). Higher IL-6 levels were associated with higher all-cause, cardiovascular, and non-cardiovascular mortality (HR = 1.43 [1.26-1.62], 1.70 [1.31-2.21], and 1.36 [1.18-1.57], respectively).
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3773986/v1
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Article ; Online: Evolutionary diversity of proton and water channels on the oxidizing side of photosystem II and their relevance to function.

Hussein, Rana / Ibrahim, Mohamed / Bhowmick, Asmit / Simon, Philipp S / Bogacz, Isabel / Doyle, Margaret D / Dobbek, Holger / Zouni, Athina / Messinger, Johannes / Yachandra, Vittal K / Kern, Jan F / Yano, Junko

Photosynthesis research

2023 Volume 158, Issue 2, Page(s) 91–107

Abstract: One of the reasons for the high efficiency and selectivity of biological catalysts arise from their ability to control the pathways of substrates and products using protein channels, and by modulating the transport in the channels using the interaction ... ...

Abstract	One of the reasons for the high efficiency and selectivity of biological catalysts arise from their ability to control the pathways of substrates and products using protein channels, and by modulating the transport in the channels using the interaction with the protein residues and the water/hydrogen-bonding network. This process is clearly demonstrated in Photosystem II (PS II), where its light-driven water oxidation reaction catalyzed by the Mn
MeSH term(s)	Protons ; Photosystem II Protein Complex/metabolism ; Water/metabolism ; Cryoelectron Microscopy ; Oxidation-Reduction
Chemical Substances	Protons ; Photosystem II Protein Complex ; Water (059QF0KO0R)
Language	English
Publishing date	2023-06-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1475688-2
ISSN	1573-5079 ; 0166-8595
ISSN (online)	1573-5079
ISSN	0166-8595
DOI	10.1007/s11120-023-01018-w
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Article ; Online: Water Networks in Photosystem II Using Crystalline Molecular Dynamics Simulations and Room-Temperature XFEL Serial Crystallography.

Doyle, Margaret D / Bhowmick, Asmit / Wych, David C / Lassalle, Louise / Simon, Philipp S / Holton, James / Sauter, Nicholas K / Yachandra, Vittal K / Kern, Jan F / Yano, Junko / Wall, Michael E

Journal of the American Chemical Society

2023 Volume 145, Issue 27, Page(s) 14621–14635

Abstract: Structural dynamics of water and its hydrogen-bonding networks play an important role in enzyme function via the transport of protons, ions, and substrates. To gain insights into these mechanisms in the water oxidation reaction in Photosystem II (PS II), ...

Abstract	Structural dynamics of water and its hydrogen-bonding networks play an important role in enzyme function via the transport of protons, ions, and substrates. To gain insights into these mechanisms in the water oxidation reaction in Photosystem II (PS II), we have performed crystalline molecular dynamics (MD) simulations of the dark-stable S
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c01412
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Article ; Online: Nursing in the spotlight: Talk about nurses and the nursing profession on Twitter during the early COVID-19 pandemic.

Miller, Wendy R / Malloy, Caeli / Mravec, Michelle / Sposato, Margaret F / Groves, Doyle

Nursing outlook

2022 Volume 70, Issue 4, Page(s) 580–589

Abstract: Background: Nurses comprise the largest portion of healthcare workers and are integral to the COVID-19 response. Twitter has become a popular platform for the public, including nurses, to engage in pandemic-related discourse.: Purpose: We sought to ... ...

Abstract	Background: Nurses comprise the largest portion of healthcare workers and are integral to the COVID-19 response. Twitter has become a popular platform for the public, including nurses, to engage in pandemic-related discourse. Purpose: We sought to analyze the representation of the nursing profession and characterize nurses' experiences during the pandemic from tweets published in April 2020. Methods: We analyzed tweets using natural language processing, Word Adjacency Graph (WAG) Modeling, and thematic analysis. Authors independently reviewed 10% of raw tweets in each WAG-generated topic, qualitatively analyzed tweets, and identified emerging themes. Findings: Six themes emerged: Support and Recognition of Nurses, Military Metaphors, Superhuman/Spiritual Metaphors, Advocacy, Personal Experiences with Nurses, and Social/Political Commentary. Public perception of nurses was positive, but nurses conveyed harsh realities of their work. Discussion: Findings highlight discrepancies in nursing experiences and public perceptions of nursing. Further research should accurately identify and convey the complexities of the nursing profession.
MeSH term(s)	COVID-19/epidemiology ; Humans ; Natural Language Processing ; Pandemics ; Social Media
Language	English
Publishing date	2022-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	300568-9
ISSN	1528-3968 ; 0029-6554
ISSN (online)	1528-3968
ISSN	0029-6554
DOI	10.1016/j.outlook.2022.02.009
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Article ; Online: Immune cell subpopulations as risk factors for atrial fibrillation: The Cardiovascular Health Study and Multi-Ethnic Study of Atherosclerosis.

Floyd, James S / Sitlani, Colleen M / Doyle, Margaret F / Feinstein, Matthew J / Olson, Nels C / Heckbert, Susan R / Huber, Sally A / Tracy, Russell P / Psaty, Bruce M / Delaney, Joseph A C

Heart rhythm

2022 Volume 20, Issue 2, Page(s) 315–317

MeSH term(s)	Humans ; United States/epidemiology ; Atrial Fibrillation ; Risk Factors ; Atherosclerosis ; Heart ; Incidence
Language	English
Publishing date	2022-10-18
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2022.10.012
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Article ; Online: Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants.

Fang, Yuan / Doyle, Margaret F / Chen, Jiachen / Mez, Jesse / Satizabal, Claudia L / Alosco, Michael L / Qiu, Wei Qiao / Lunetta, Kathryn L / Murabito, Joanne M

Aging

2023 Volume 15, Issue 10, Page(s) 3939–3966

Abstract: Understanding the composition of circulating immune cells with aging and the underlying biologic mechanisms driving aging may provide molecular targets to slow the aging process and reduce age-related disease. Utilizing cryopreserved cells from 996 ... ...

Abstract	Understanding the composition of circulating immune cells with aging and the underlying biologic mechanisms driving aging may provide molecular targets to slow the aging process and reduce age-related disease. Utilizing cryopreserved cells from 996 Framingham Heart Study (FHS) Offspring Cohort participants aged 40 and older (mean 62 years, 48% female), we report on 116 immune cell phenotypes including monocytes, T-, B-, and NK cells and their subtypes, across age groups, sex, cytomegalovirus (CMV) exposure groups, smoking and other cardiovascular risk factors. The major cellular differences with CMV exposure were higher Granzyme B+ cells, effector cells, and effector-memory re-expressing CD45RA (TEMRA) cells for both CD4+ and CD8+. Older age was associated with lower CD3+ T cells, lower naïve cells and naïve/memory ratios for CD4+ and CD8+. We identified many immune cell differences by sex, with males showing lower naïve cells and higher effector and effector memory cells. Current smokers showed lower pro-inflammatory CD8 cells, higher CD8 regulatory type cells and altered B cell subsets. No significant associations were seen with BMI and other cardiovascular risk factors. Our cross-sectional observations of immune cell phenotypes provide a reference to further the understanding of the complexity of immune cells in blood, an easily accessible tissue.
MeSH term(s)	Male ; Humans ; Female ; Cytomegalovirus ; Cytomegalovirus Infections ; Cross-Sectional Studies ; CD8-Positive T-Lymphocytes ; Phenotype ; Longitudinal Studies ; Smoking ; CD4-Positive T-Lymphocytes
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204686
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