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  1. Book: Practical handbook of thoracic anesthesia

    Hartigan, Philip M. / Mentzer, Steven J.

    2012  

    Author's details Philip M. Hartigan ; Steven J. Mentzer ed
    Language English
    Size XVIII, 636 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017118868
    ISBN 978-0-387-88492-9 ; 0-387-88492-0 ; 9780387884936 ; 0387884939
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2012 A 633 order for loan Magazin

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  2. Article: The puzzling mechanism of compensatory lung growth.

    Mentzer, Steven J

    Stem cell investigation

    2018  Volume 5, Page(s) 8

    Language English
    Publishing date 2018-03-31
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2884645-X
    ISSN 2313-0792 ; 2306-9759
    ISSN (online) 2313-0792
    ISSN 2306-9759
    DOI 10.21037/sci.2018.03.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to Bush

    Ackermann, Maximilian / Mentzer, Steven J / Jonigk, Danny D

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 2, Page(s) 229–230

    MeSH term(s) Humans ; COVID-19 ; Microcirculation ; SARS-CoV-2 ; Bronchi
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202201-0122LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19.

    Mentzer, Steven J / Ackermann, Maximilian / Jonigk, Danny

    Cold Spring Harbor perspectives in medicine

    2022  Volume 12, Issue 10

    Abstract: COVID-19 has been associated with a range of illness severity-from minimal symptoms to life-threatening multisystem organ failure. The severe forms of COVID-19 appear to be associated with an angiocentric or vascular phase of the disease. In studying ... ...

    Abstract COVID-19 has been associated with a range of illness severity-from minimal symptoms to life-threatening multisystem organ failure. The severe forms of COVID-19 appear to be associated with an angiocentric or vascular phase of the disease. In studying autopsy patients succumbing to COVID-19, we found alveolar capillary microthrombi were 9 times more common in COVID-19 than in comparable patients with influenza. Corrosion casting of the COVID-19 microcirculation has revealed microvascular distortion, enhanced bronchial circulation, and striking increases in intussusceptive angiogenesis. In patients with severe COVID-19, endothelial cells commonly demonstrate significant ultrastructural injury. High-resolution imaging suggests that microcirculation perturbations are linked to ischemic changes in microanatomic compartments of the lung (secondary lobules). NanoString profiling of these regions has confirmed a transcriptional signature compatible with microischemia. We conclude that irreversible tissue ischemia provides an explanation for the cystic and fibrotic changes associated with long-haul COVID-19 symptoms.
    MeSH term(s) COVID-19/complications ; COVID-19/pathology ; COVID-19/physiopathology ; Corrosion Casting ; Endothelial Cells/pathology ; Endothelial Cells/ultrastructure ; Humans ; Ischemia/complications ; Microcirculation ; Neovascularization, Pathologic/complications
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a041157
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  5. Article ; Online: Vascularization of the adult mouse lung grafted onto the chick chorioallantoic membrane.

    Chamoto, Kenji / Gibney, Barry C / Wagner, Willi L / Ackermann, Maximilian / Khalil, Hassan A / Mentzer, Steven J

    Microvascular research

    2023  Volume 151, Page(s) 104596

    Abstract: In the later stages of angiogenesis, the vascular sprout transitions into a functional vessel by fusing with a target vessel. Although this process appears to routinely occur in embryonic tissue, the biologic rules for sprout fusion and lumenization in ... ...

    Abstract In the later stages of angiogenesis, the vascular sprout transitions into a functional vessel by fusing with a target vessel. Although this process appears to routinely occur in embryonic tissue, the biologic rules for sprout fusion and lumenization in adult regenerating tissue are unknown. To investigate this process, we grafted portions of the regenerating post-pneumonectomy lung onto the chick chorioallantoic membrane (CAM). Grafts from all 4 lobes of the post-pneumonectomy right lung demonstrated peri-graft angiogenesis as reflected by fluorescent plasma markers; however, fluorescent microsphere perfusion primarily occurred in the lobe of the lung that is the dominant site of post-pneumonectomy angiogenesis-namely, the cardiac lobe. Vascularization of the cardiac lobe grafts was confirmed by active tissue growth (p < .05). Functional vascular connections between the cardiac lobe and the CAM vascular network were demonstrated by confocal fluorescence microscopy as well as corrosion casting and scanning electron microscopy (SEM). Bulk transcriptional profiling of the cardiac lobe demonstrated the enhanced expression of many genes relative to alveolar epithelial cell (CD11b
    MeSH term(s) Mice ; Animals ; Chorioallantoic Membrane/blood supply ; Neovascularization, Physiologic ; Chickens ; Neovascularization, Pathologic ; Lung
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2023.104596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Facilitated Transport across Glycocalyceal Barriers in the Chick Chorioallantoic Membrane.

    Dayal, Anuhya / Pan, Jennifer M / Kwan, Stacey P / Ackermann, Maximilian / Khalil, Hassan A / Mentzer, Steven J

    Polymers

    2023  Volume 16, Issue 1

    Abstract: Targeted drug delivery to visceral organs offers the possibility of not only limiting the required dose, but also minimizing drug toxicity; however, there is no reliable method for delivering drugs to the surface of visceral organs. Here, we used six ... ...

    Abstract Targeted drug delivery to visceral organs offers the possibility of not only limiting the required dose, but also minimizing drug toxicity; however, there is no reliable method for delivering drugs to the surface of visceral organs. Here, we used six color tracers and the chick chorioallantoic membrane (CAM) model to investigate the use of the heteropolysaccharide pectin to facilitate tracer diffusion across the glycocalyceal charge barrier. The color tracers included brilliant blue, Congo red, crystal violet, indocyanine green, methylene blue, and methyl green. The direct application of the tracers to the CAM surface or embedding tracers into linear-chain nanocellulose fiber films resulted in no significant diffusion into the CAM. In contrast, when the tracers were actively loaded into branched-chain pectin films, there was significant detectable diffusion of the tracers into the CAM. The facilitated diffusion was observed in the three cationic tracers but was limited in the three anionic tracers. Diffusion appeared to be dependent on ionic charge, but independent of tracer size or molecular mass. We conclude that dye-loaded pectin films facilitated the diffusion of color tracers across the glycocalyceal charge barrier and may provide a therapeutic path for drug delivery to the surface of visceral organs.
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16010004
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  7. Article ; Online: Stochastic simulations of self-organized elastogenesis in the developing lung.

    Fan, Xiru / Valenzuela, Cristian / Zhao, Weijing / Chen, Zi / Wang, Dong / Mentzer, Steven J

    PLoS computational biology

    2023  Volume 19, Issue 6, Page(s) e1011219

    Abstract: In the normal lung, the dominant cable is an elastic "line element" composed of elastin fibers bound to a protein scaffold. The cable line element maintains alveolar geometry by balancing surface forces within the alveolus and changes in lung volume with ...

    Abstract In the normal lung, the dominant cable is an elastic "line element" composed of elastin fibers bound to a protein scaffold. The cable line element maintains alveolar geometry by balancing surface forces within the alveolus and changes in lung volume with exercise. Recent work in the postnatal rat lung has suggested that the process of cable development is self-organized in the extracellular matrix. Early in postnatal development, a blanket of tropoelastin (TE) spheres appear in the primitive lung. Within 7 to 10 days, the TE spheres are incorporated into a distributed protein scaffold creating the mature cable line element. To study the process of extracellular assembly, we used cellular automata (CA) simulations. CA simulations demonstrated that the intermediate step of tropoelastin self-aggregation into TE spheres enhanced the efficiency of cable formation more than 5-fold. Similarly, the rate of tropoelastin production had a direct impact on the efficiency of scaffold binding. The binding affinity of the tropoelastin to the protein scaffold, potentially reflecting heritable traits, also had a significant impact on cable development. In contrast, the spatial distribution of TE monomer production, increased Brownian motion and variations in scaffold geometry did not significantly impact simulations of cable development. We conclude that CA simulations are useful in exploring the impact of concentration, geometry, and movement on the fundamental process of elastogenesis.
    MeSH term(s) Animals ; Rats ; Tropoelastin/metabolism ; Lung/metabolism ; Extracellular Matrix/metabolism
    Chemical Substances Tropoelastin
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011219
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  8. Article ; Online: Visualization of SARS-CoV-2 in the Lung. Reply.

    Ackermann, Maximilian / Mentzer, Steven J / Jonigk, Danny

    The New England journal of medicine

    2020  Volume 383, Issue 27, Page(s) 2689–2690

    MeSH term(s) COVID-19 ; Humans ; Lung/diagnostic imaging ; SARS-CoV-2
    Language English
    Publishing date 2020-12-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2030450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Topography of pleural epithelial structure enabled by en face isolation and machine learning.

    Liu, Betty S / Valenzuela, Cristian D / Mentzer, Katherine L / Wagner, Willi L / Khalil, Hassan A / Chen, Zi / Ackermann, Maximilian / Mentzer, Steven J

    Journal of cellular physiology

    2022  Volume 238, Issue 1, Page(s) 274–284

    Abstract: Pleural epithelial adaptations to mechanical stress are relevant to both normal lung function and parenchymal lung diseases. Assessing regional differences in mechanical stress, however, has been complicated by the nonlinear stress-strain properties of ... ...

    Abstract Pleural epithelial adaptations to mechanical stress are relevant to both normal lung function and parenchymal lung diseases. Assessing regional differences in mechanical stress, however, has been complicated by the nonlinear stress-strain properties of the lung and the large displacements with ventilation. Moreover, there is no reliable method of isolating pleural epithelium for structural studies. To define the topographic variation in pleural structure, we developed a method of en face harvest of murine pleural epithelium. Silver-stain was used to highlight cell borders and facilitate imaging with light microscopy. Machine learning and watershed segmentation were used to define the cell area and cell perimeter of the isolated pleural epithelial cells. In the deflated lung at residual volume, the pleural epithelial cells were significantly larger in the apex (624 ± 247 μm
    MeSH term(s) Animals ; Mice ; Lung/anatomy & histology ; Machine Learning ; Pleura/anatomy & histology ; Respiration ; Thorax ; Epithelial Cells/cytology
    Language English
    Publishing date 2022-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.30927
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  10. Article ; Online: Geometric and network organization of visceral organ epithelium.

    Liu, Betty S / Sutlive, Joseph / Wagner, Willi L / Khalil, Hassan A / Chen, Zi / Ackermann, Maximilian / Mentzer, Steven J

    Frontiers in network physiology

    2023  Volume 3, Page(s) 1144186

    Abstract: Mammalian epithelia form a continuous sheet of cells that line the surface of visceral organs. To analyze the epithelial organization of the heart, lung, liver and bowel, epithelial cells were ... ...

    Abstract Mammalian epithelia form a continuous sheet of cells that line the surface of visceral organs. To analyze the epithelial organization of the heart, lung, liver and bowel, epithelial cells were labeled
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2674-0109
    ISSN (online) 2674-0109
    DOI 10.3389/fnetp.2023.1144186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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