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Article ; Online: From ABCD to E for endothelin in resistant hypertension.

Abraham, George R / Davenport, Anthony P

2023 Volume 186, Issue 2, Page(s) 240–242

Abstract: The potent vasoconstrictor peptide endothelin-1 has long been recognized as a physiological regulator of vascular tone. However, pharmacological blockade of the endothelin-1 pathway has few proven indications thus far. A recent clinical trial for ... ...

Abstract	The potent vasoconstrictor peptide endothelin-1 has long been recognized as a physiological regulator of vascular tone. However, pharmacological blockade of the endothelin-1 pathway has few proven indications thus far. A recent clinical trial for resistant hypertension published in The Lancet may yet herald a new era for endothelin receptor antagonists into the clinical mainstream.
MeSH term(s)	Humans ; Endothelin-1/physiology ; Hypertension/drug therapy ; Hypertension/metabolism ; Endothelins/physiology ; Endothelin Receptor Antagonists/therapeutic use
Chemical Substances	Endothelin-1 ; Endothelins ; Endothelin Receptor Antagonists
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.12.014
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Fluorescent Enzymatic Sensor Based Glucose Oxidase Modified Bovine Serum Albumin-Gold nanoclusters for Detection of Glucose.

Abraham, Merin K / Madanan, Anju S / Varghese, Susan / R S, Lekshmi / Shkhair, Ali Ibrahim / N S, Vijila / George, Sony

ChemPlusChem

2024 , Page(s) e202300601

Abstract: An enzymatic fluorescent probe is developed for the selective detection of glucose. In this work, a Bovine Serum Albumin stabilized gold nanocluster (BSA-AuNCs) was synthesized by microwave assisted method, and it is modified with glucose oxidase, ... ...

Abstract	An enzymatic fluorescent probe is developed for the selective detection of glucose. In this work, a Bovine Serum Albumin stabilized gold nanocluster (BSA-AuNCs) was synthesized by microwave assisted method, and it is modified with glucose oxidase, thereby a fluorescent enzymatic sensor (BSA-AuNCs@GoX) was designed for the sensitive detection of glucose with a limit of detection of 0.03 mM. The red fluorescence exhibited by the probe is quenched by the production of H
Language	English
Publishing date	2024-01-19
Publishing country	Germany
Document type	Journal Article
ISSN	2192-6506
ISSN (online)	2192-6506
DOI	10.1002/cplu.202300601
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Article ; Online: High-Value Epilepsy Care in the United States: Predictors of Increased Costs and Complications from the National Inpatient Sample Database 2016-2019.

Singh, Rohin / Zamanian, Cameron / Bcharah, George / Stonnington, Henry / George, Derek D / Bhandarkar, Archis R / Shahrestani, Shane / Brown, Nolan / Abraham, Mickey E / Mammis, Antonios / Bydon, Mohamad / Gonda, David

World neurosurgery

2024

Abstract: Background: For patients with medically refractory epilepsy, newer minimally invasive techniques such as laser interstitial thermal therapy (LITT) have been developed in recent years. This study aims to characterize trends in the utilization of surgical ...

Abstract	Background: For patients with medically refractory epilepsy, newer minimally invasive techniques such as laser interstitial thermal therapy (LITT) have been developed in recent years. This study aims to characterize trends in the utilization of surgical resection versus LITT to treat medically refractory epilepsy, characterize complications, and understand the cost of this innovative technique to the public. Methods: The National Inpatient Sample database was queried from 2016 to 2019 for all patients admitted with a diagnosis of medically refractory epilepsy. Patient demographics, hospital length of stay, complications, and costs were tabulated for all patients who underwent LITT or surgical resection within these cohorts. Results: A total of 6019 patients were included, 223 underwent LITT procedures, while 5796 underwent resection. Significant predictors of increased patient charges for both cohorts included diabetes (odds ratio: 1.7, confidence interval [CI]: 1.44-2.19), infection (odds ratio: 5.12, CI 2.73-9.58), and hemorrhage (odds ratio: 2.95, CI 2.04-4.12). Procedures performed at nonteaching hospitals had 1.54 greater odds (CI 1.02-2.33) of resulting in a complication compared to teaching hospitals. Insurance status did significantly differ (P = 0.001) between those receiving LITT (23.3% Medicare; 25.6% Medicaid; 44.4% private insurance; 6.7 Other) and those undergoing resection (35.3% Medicare; 22.5% Medicaid; 34.7% private Insurance; 7.5% other). When adjusting for patient demographics, LITT patients had shorter length of stay (2.3 vs. 8.9 days, P < 0.001), lower complication rate (1.9% vs. 3.1%, P = 0.385), and lower mean hospital ($139,412.79 vs. $233,120.99, P < 0.001) and patient ($55,394.34 vs. $37,756.66, P < 0.001) costs. Conclusions: The present study highlights LITT's advantages through its association with lower costs and shorter length of stay. The present study also highlights the associated predictors of LITT versus resection, such as that most LITT cases happen at academic centers for patients with private insurance. As the adoption of LITT continues, more data will become available to further understand these issues.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.03.061
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Article ; Online: L-Methionine and D-Methionine Capped Fluorescent Silicon Quantum Dots Based Probes for Turn on Sensing of Glutathione - A Comparative Study.

Varghese, Susan / Aiswarya, G R / Madanan, Anju S / Abraham, Merin K / Shkhair, Ali Ibrahim / Indongo, Geneva / Rajeevan, Greeshma / Arathy, B K / George, Sony

Journal of fluorescence

2024

Abstract: Oral Squamous Cell Carcinoma (OSCC), a prevalent type of oral cancer originates in squamous cells that develop due to tobacco use, excess alcohol consumption, human papillomavirus infection, chronic irritation and weakened immune system. When detected ... ...

Abstract	Oral Squamous Cell Carcinoma (OSCC), a prevalent type of oral cancer originates in squamous cells that develop due to tobacco use, excess alcohol consumption, human papillomavirus infection, chronic irritation and weakened immune system. When detected early, survival rates of OSCC can be increased to more than 85%. Hence its early detection is crucial for appropriate management. Oxidative stress has a vital role in pathogenesis of various cancers including OSCC. Early detection of OSCC can be done by exploring serum Glutathione (GSH); an oxidative stress biomarker. Herein, we have developed two Silicon quantum dots (SiQDs); (L-methionine capped Silicon quantum dots (LSiQDs) and D-methionine capped Silicon quantum dots (DSiQDs)) and their fluorescence was quenched with Cu
Language	English
Publishing date	2024-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2016892-5
ISSN	1573-4994 ; 1053-0509
ISSN (online)	1573-4994
ISSN	1053-0509
DOI	10.1007/s10895-024-03592-1
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Article ; Online: Heat and mass transfer modeling of an artisan coffee roasting process: A comparative study

Uren, Kenneth R. / Vosloo, Johandri / van der Merwe, Abraham F. / van Schoor, George

Drying Technology. 2023 July 31, v. 41, no. 10 p.1697-1713

2023

Abstract: In order to achieve effective coffee roasting control, there is a need for coffee roasting process models that can solve in real-time. This paper contributes by evaluating the roasting process model performance for different roasting time periods and ... ...

Abstract	In order to achieve effective coffee roasting control, there is a need for coffee roasting process models that can solve in real-time. This paper contributes by evaluating the roasting process model performance for different roasting time periods and bean moisture contents. The method firstly involved selecting roasting profile models from literature on the basis of their computational efficiency and simplified geometry definition of the coffee bean structure. Three models were considered constituting different bean temperature and moisture content sub-models. Next the modeled results were compared with experimental results obtained from an instrumented commercial artisan roaster. It was found that all three models could sufficiently predict the roast profile from the modeled bean temperature and moisture content. However, all three consistently overestimated the moisture content during roasting. For longer roasting times, the final moisture content prediction was closer to the experimental value.
Keywords	beans ; coffee beans ; comparative study ; geometry ; heat ; mass transfer ; model validation ; prediction ; technology ; temperature ; water content ; Roast profile ; degree of roast ; bean temperature ; moisture content
Language	English
Dates of publication	2023-0731
Size	p. 1697-1713.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2049461-0
ISSN	1532-2300 ; 0737-3937
ISSN (online)	1532-2300
ISSN	0737-3937
DOI	10.1080/07373937.2023.2175851
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Spectrum of malignant scalp tumours and its impact on management-a tertiary care cancer centre experience.

Varghese, Bipin T / Nadarajan, Abinaya R / Thomas, Shaji / Iype, Elizabeth Mathew / George, Nebu Abraham / K M, Jagathnath Krishna / Lal, Sahya S / Somanathan, Thara

World journal of surgical oncology

2023 Volume 21, Issue 1, Page(s) 330

Abstract: Background: Tumours on the scalp are diverse and often exhibit site- and histology-specific characteristics. Reconstructing the scalp after oncological resection has always been challenging because of its unique anatomy.: Methodology: A retrospective ...

Abstract	Background: Tumours on the scalp are diverse and often exhibit site- and histology-specific characteristics. Reconstructing the scalp after oncological resection has always been challenging because of its unique anatomy. Methodology: A retrospective review of patients with malignant scalp tumour operated on at a single institution over 10 years was performed. Data were collected and analysed regarding the scalp tumour profile, treatment, and the outcome of these procedures. Results: Of the 66 patients in our study, 33 (50%) had SCC. In addition to this, 21% were sarcomas, 17% were appendageal carcinomas, 11% were BCCs, and 1% was neuroendocrine carcinoma. Cortical erosion was observed in 6 patients in the CT imaging, all with SCC histology. Among the eight patients with pathological nodal involvement, three had angiosarcoma, three had SCC, one had appendageal carcinoma, and one had neuroendocrine carcinoma. The mean surgical defect size was 67.4 cm Conclusion: Scalp tumours are heterogeneous in their clinical profiles. Often, its tumour biology and microscopic extent are underestimated. High suspicion, histological diagnosis, and clear surgical margins are all requirements in successfully treating scalp tumours. In order to minimize morbidity and restore an aesthetic and functional outcome, it is critical to use the simplest scalp reconstruction whenever possible.
MeSH term(s)	Humans ; Scalp/surgery ; Tertiary Healthcare ; Surgical Flaps ; Sarcoma/pathology ; Soft Tissue Neoplasms/pathology ; Carcinoma, Neuroendocrine/pathology ; Retrospective Studies ; Skin Neoplasms/surgery ; Skin Neoplasms/pathology
Language	English
Publishing date	2023-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-023-03200-9
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Article: The psychological impact of quarantine due to COVID-19: A systematic review of risk, protective factors and interventions using socio-ecological model framework.

Rajkumar, Eslavath / Rajan, Anugraha Merin / Daniel, Monica / Lakshmi, R / John, Romate / George, Allen Joshua / Abraham, John / Varghese, Jee

Heliyon

2022 Volume 8, Issue 6, Page(s) e09765

Abstract: Background: Though quarantine is a pertinent control measure for the spread of COVID-19, it is equally important to consider its negative impacts, as it causes severe psychological, emotional, and financial problems not only for those who are ... ...

Abstract	Background: Though quarantine is a pertinent control measure for the spread of COVID-19, it is equally important to consider its negative impacts, as it causes severe psychological, emotional, and financial problems not only for those who are quarantined but also for many others who are directly or indirectly connected to those who are quarantined. There appears to be a need to synthesise the available literature evidence on the psychological impact of quarantine experience, especially the multilevel risk factors that make individuals vulnerable to psychological impact and the protective factors to deal with the negative effects of quarantine. Objective: This systematic review attempted to identify the various psychological impacts associated with the experience of quarantine, the risk and protective factors and list out various psycho-social interventions that can minimise the risks and facilitate the protective factors associated with the experience of quarantine. Methods: A systematic search adhering to the PRISMA guidelines was performed in four databases PubMed, Scopus, PsycNet, Web of Science and 10518 articles related to COVID-19 and quarantine were obtained. After screening processes and quality assessment using standard checklist 74 articles that fulfilled the eligibility criteria were chosen for the final review. Findings: Individuals subjected to quarantine had anxiety, depression, post-traumatic stress symptoms, sleep problems, and somatic difficulties. Some of the key risk factors during quarantine are young age, female gender, low money, fear of infection, poor sleep quality, reduced physical activity, increased sedentary behaviours, and a lack of social support. Financial difficulties and stigma remained risk factors even after the quarantine period had ended. Key protective factors were coping skills, home based exercise, leisure, recreational activities, maintaining relationships using social media and availability of mental health services. The findings also highlight the necessity for tele mental health interventions to address the psychological effects of quarantine. Conclusion: Multilevel interventions are required to minimise the impact of risk factors and enhance protective factors.
Language	English
Publishing date	2022-06-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e09765
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Article: Impact of COVID-19 on Disease Progression and Postoperative Complications in Patients with Head and Neck Cancer.

Nadarajan, Abinaya R / George, Nebu Abraham / Thomas, Shaji / Varghese, Bipin T / Iype, Elizabeth Mathew / K M, Jagathnath Krishna

Indian journal of surgical oncology

2023 , Page(s) 1–5

Abstract: The COVID-19 pandemic has created a remarkable challenge for the healthcare system. The delayed presentation, diagnosis, and treatment of head and neck cancer during the COVID-19 pandemic is expected to adversely affect outcomes. COVIDSurg collaborative ... ...

Abstract	The COVID-19 pandemic has created a remarkable challenge for the healthcare system. The delayed presentation, diagnosis, and treatment of head and neck cancer during the COVID-19 pandemic is expected to adversely affect outcomes. COVIDSurg collaborative group in 2020 concluded surgery ≥ 4 weeks after a positive COVID-19 swab result was associated with a lower risk of postoperative mortality. The aim of this study is to assess the disease progression due to COVID-19 infection in patients with head and neck cancer planned for surgery and to analyze the postoperative complications in head and neck cancer patients who underwent surgery after COVID-19 infection. This is an ambispective observational study and included patients with head and neck cancer who recovered from COVID-19 infection and underwent surgery from June 2020 to May 2022. There were a total of 1849 patients with head and neck cancer operated in the mentioned study period during COVID-19 pandemic. One hundred fifty-nine patients had documented COVID-19 infection. One hundred two patients had oral cavity carcinoma (64%), and 38 patients had thyroid carcinoma (23.8%). Early disease was noted in 49 patients (30.8%) and locally advanced disease in 108 patients (67.9%). Mean duration of delay in surgery was 4 weeks. Disease progression was noted in 27 patients (17%) out of which 15 patients were inoperable. Thirty-seven out of 159 patients (23%) had postoperative complications, and it included 2 mortality. There was increased trend noted in pulmonary complications and hemorrhage when compared to pre-COVID-19 era. Due to COVID-19 pandemic, delayed elective head and neck cancer surgery has resulted in higher rates of inoperability. COVID-19 has been associated with increased postoperative pulmonary complications and hemorrhage.
Language	English
Publishing date	2023-06-08
Publishing country	India
Document type	Journal Article
ZDB-ID	2568289-1
ISSN	0976-6952 ; 0975-7651
ISSN (online)	0976-6952
ISSN	0975-7651
DOI	10.1007/s13193-023-01779-9
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Article ; Online: Nuclear lamina strain states revealed by intermolecular force biosensor.

Danielsson, Brooke E / George Abraham, Bobin / Mäntylä, Elina / Cabe, Jolene I / Mayer, Carl R / Rekonen, Anna / Ek, Frans / Conway, Daniel E / Ihalainen, Teemu O

Nature communications

2023 Volume 14, Issue 1, Page(s) 3867

Abstract: Nuclear lamins have been considered an important structural element of the nucleus. The nuclear lamina is thought both to shield DNA from excessive mechanical forces and to transmit mechanical forces onto the DNA. However, to date there is not yet a ... ...

Abstract	Nuclear lamins have been considered an important structural element of the nucleus. The nuclear lamina is thought both to shield DNA from excessive mechanical forces and to transmit mechanical forces onto the DNA. However, to date there is not yet a technical approach to directly measure mechanical forces on nuclear lamins at the protein level. To overcome this limitation, we developed a nanobody-based intermolecular tension FRET biosensor capable of measuring the mechanical strain of lamin filaments. Using this sensor, we were able to show that the nuclear lamina is subjected to significant force. These forces are dependent on nuclear volume, actomyosin contractility, functional LINC complex, chromatin condensation state, cell cycle, and EMT. Interestingly, large forces were also present on nucleoplasmic lamins, indicating that these lamins may also have an important mechanical role in the nucleus. Overall, we demonstrate that the nanobody-based approach allows construction of biosensors for complex protein structures for mechanobiology studies.
MeSH term(s)	Nuclear Lamina ; Cell Nucleus ; Lamins ; Nuclear Envelope ; Chromatin
Chemical Substances	Lamins ; Chromatin
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39563-6
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Article ; Online: Longitudinal assessment of HCV core antigen kinetics to monitor therapeutic response in the age of DAAs.

Ponnuvel, Suresh / Prakash, Arul / Steve, Runal John / Doss, George Priya / Goel, Ashish / Zachariah, Uday George / Eapen, Chundamannil Eapen / Rebekah, Grace / Kannangai, Rajesh / Fletcher, Gnanadurai John / Abraham, Priya

PloS one

2023 Volume 18, Issue 2, Page(s) e0282013

Abstract: ... at baseline, ETR and SVR, except RVR in both groups (r>0.6; p<0.0001). Furthermore, HCV genotypes, treatment ...

Abstract	Background: In the economy of therapeutic monitoring, an affordable viral marker is essential in the era of direct-acting antivirals (DAAs). We elucidated the kinetics of HCVcAg to delineate its precise role in monitoring therapeutic response. Methods: In this longitudinal study, 3208 patients were tested for HCV RNA. A total of 423 patients were started on DAAs. Treatment response and kinetics of HCVcAg/RNA were assessed in treatment-naïve (n = 383) and previously treated (n = 40) patients with follow-up for 2 years. Results: After the initiation of DAAs, the rate of relapse was significantly higher in the previously treated group than naive group [12.5% (5/40) Vs 2% (7/383), p<0.0001]. The response rate at RVR was significantly higher with HCVcAg than RNA in both groups (p<0.02). The kinetics of HCVcAg and RNA were significantly different at ETR and SVR12 in the naïve (p<0.04), but similar at all therapeutic points in the previously treated group. The correlation between HCVcAg and RNA was good at baseline, ETR and SVR, except RVR in both groups (r>0.6; p<0.0001). Furthermore, HCV genotypes, treatment regimen, CTP (<7/≥7) and MELD (<15/≥15) did not influence the therapeutic response and the viral replication kinetics (p>0.05). Conclusions: It is the first longitudinal study from India shows that the response rate and kinetics of HCVcAg are comparable to HCV RNA for an extended duration, except at RVR, irrespective of the HCV genotypes, treatment regimen, and liver disease severity. Hence, HCVcAg can be considered as a pragmatic marker to monitor therapeutic response and predict relapse in the era of DAAs.
MeSH term(s)	Humans ; Antiviral Agents/therapeutic use ; Longitudinal Studies ; RNA, Viral/genetics ; Hepacivirus/genetics ; Hepatitis C Antigens ; Hepatitis C, Chronic/drug therapy ; Recurrence ; Genotype
Chemical Substances	Antiviral Agents ; RNA, Viral ; Hepatitis C Antigens
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0282013
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