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  1. Article ; Online: Serial placental growth factor-based testing in pre-eclampsia.

    Cerdeira, Ana Sofia / Karumanchi, S Ananth

    Lancet (London, England)

    2024  Volume 403, Issue 10427, Page(s) 588–589

    MeSH term(s) Pregnancy ; Female ; Humans ; Pre-Eclampsia/diagnosis ; Placenta Growth Factor ; Placenta
    Chemical Substances Placenta Growth Factor (144589-93-5)
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02578-3
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  2. Article ; Online: Translation of mechanistic advances in preeclampsia to the clinic: Long and winding road.

    Thadhani, Ravi / Cerdeira, Ana Sofia / Karumanchi, S Ananth

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2024  Volume 38, Issue 3, Page(s) e23441

    Abstract: As one of the leading causes of premature birth and maternal and infant mortality worldwide, preeclampsia remains a major unmet public health challenge. Preeclampsia and related hypertensive disorders of pregnancy are estimated to cause >75 000 maternal ... ...

    Abstract As one of the leading causes of premature birth and maternal and infant mortality worldwide, preeclampsia remains a major unmet public health challenge. Preeclampsia and related hypertensive disorders of pregnancy are estimated to cause >75 000 maternal and 500 000 infant deaths globally each year. Because of rising rates of risk factors such as obesity, in vitro fertilization and advanced maternal age, the incidence of preeclampsia is going up with rates ranging from 5% to 10% of all pregnancies worldwide. A major discovery in the field was the realization that the clinical phenotypes related to preeclampsia, such as hypertension, proteinuria, and other adverse maternal/fetal events, are due to excess circulating soluble fms-like tyrosine kinase-1 (sFlt-1, also referred to as sVEGFR-1). sFlt-1 is an endogenous anti-angiogenic protein that is made by the placenta and acts by neutralizing the pro-angiogenic proteins vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). During the last decade, this work has spawned a new era of molecular diagnostics for early detection of this condition. Antagonizing sFlt-1 either by reducing production or blocking its actions has shown salutary effects in animal models. Further, in early-stage human studies, the therapeutic removal of sFlt-1 from maternal circulation has shown promise in delaying disease progression and improving outcomes. Recently, the FDA approved the first molecular test for preterm preeclampsia (sFlt-1/PlGF ratio) for clinical use in the United States. Measuring serum sFlt-1/PlGF ratio in the acute hospital setting may aid short-term management, particularly regarding step-up or step-down of care, decision to transfer to settings better equipped to manage both the mother and the preterm neonate, appropriate timing of administration of steroids and magnesium sulfate, and in expectant management decisions. The test itself has the potential to save lives. Furthermore, the availability of a molecular test that correlates with adverse outcomes has set the stage for interventional clinical trials testing treatments for this disorder. In this review, we will discuss the role of circulating sFlt-1 and related factors in the pathogenesis of preeclampsia and specifically how this discovery is leading to concrete advances in the care of women with preeclampsia.
    MeSH term(s) Animals ; Infant ; Infant, Newborn ; Pregnancy ; Female ; Humans ; Pre-Eclampsia ; Vascular Endothelial Growth Factor A ; Placenta Growth Factor ; Hypertension ; Angiogenic Proteins
    Chemical Substances Vascular Endothelial Growth Factor A ; Placenta Growth Factor (144589-93-5) ; Angiogenic Proteins
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202301808R
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  3. Article ; Online: Novel therapeutic and diagnostic approaches for preeclampsia.

    Vatish, Manu / Powys, Veronica R / Cerdeira, Ana Sofia

    Current opinion in nephrology and hypertension

    2023  Volume 32, Issue 2, Page(s) 124–133

    Abstract: Purpose of review: This review will summarize recent findings relating to the diagnostic approach to preeclampsia and current avenues of research aimed at modifying the underlying disease process.: Recent findings: Growing international consensus ... ...

    Abstract Purpose of review: This review will summarize recent findings relating to the diagnostic approach to preeclampsia and current avenues of research aimed at modifying the underlying disease process.
    Recent findings: Growing international consensus supports a broad preeclampsia definition that incorporates maternal end-organ and uteroplacental dysfunction. Recent evidence demonstrates that this definition better identifies women and babies at risk of adverse outcomes compared to the traditional definition of hypertension and proteinuria. Multiple studies have demonstrated the usefulness and cost-effectiveness of angiogenic biomarkers such as soluble fms-like tyrosine kinase-1 and placental growth factor as a clinical adjunct to diagnose and predict severity of preeclampsia associated outcomes. Current novel therapeutic approaches to preeclampsia target pathogenic pathways (e.g. antiangiogenesis) or downstream effects such as oxidative stress and nitric oxide. Recent findings relating to these promising candidates are discussed. Multicenter clinical trials are needed to evaluate their effectiveness and ability to improve fetal and maternal outcomes.
    Summary: We provide an updated framework of the current approaches to define and diagnose preeclampsia. Disease modifying therapies (in particular, targeting the angiogenic pathway) are being developed for the first time and promise to revolutionize the way we manage preeclampsia.
    MeSH term(s) Female ; Humans ; Pregnancy ; Biomarkers/metabolism ; Multicenter Studies as Topic ; Placenta Growth Factor ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/therapy ; Vascular Endothelial Growth Factor Receptor-1/metabolism
    Chemical Substances Biomarkers ; Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000870
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  4. Article ; Online: Is Prolonging Gestation in Preeclampsia For Better or Worse in Preventing Cardiovascular Disease?

    Cerdeira, Ana Sofia / Rana, Sarosh / Karumanchi, S Ananth

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 78, Issue 5, Page(s) 1395–1397

    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Female ; Humans ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/prevention & control ; Pregnancy ; Risk Factors
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.121.18013
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  5. Article ; Online: The diagnostic value of angiogenic and antiangiogenic factors in differential diagnosis of preeclampsia.

    Cerdeira, Ana Sofia / James, Tim / Vatish, Manu

    American journal of obstetrics and gynecology

    2021  Volume 226, Issue 1, Page(s) 156

    MeSH term(s) Diagnosis, Differential ; Female ; Humans ; Placenta Growth Factor ; Pre-Eclampsia/diagnosis ; Pregnancy ; Vascular Endothelial Growth Factor Receptor-1
    Chemical Substances Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2021.08.048
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  6. Article ; Online: Taming preeclampsia at its source.

    Cerdeira, Ana Sofia / Vatish, Manu

    Nature biotechnology

    2018  Volume 36, Issue 12, Page(s) 1151–1152

    Language English
    Publishing date 2018-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/nbt.4311
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  7. Article ; Online: Predicting the Future Is Not Difficult.

    Cerdeira, Ana Sofia / Thadhani, Ravi I

    Hypertension (Dallas, Tex. : 1979)

    2018  Volume 73, Issue 1, Page(s) 47–48

    MeSH term(s) Cardiovascular Diseases ; Female ; Forecasting ; Humans ; Hypertension, Pregnancy-Induced ; Pregnancy ; Risk Factors
    Language English
    Publishing date 2018-12-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.118.11931
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  8. Article ; Online: The value of MRI in management of uterine fibroids in pregnancy.

    Cerdeira, Ana Sofia / Tome, Mariana / Lim, Lee

    European journal of obstetrics, gynecology, and reproductive biology

    2020  Volume 256, Page(s) 522–523

    MeSH term(s) Female ; Humans ; Leiomyoma/diagnostic imaging ; Magnetic Resonance Imaging ; Pregnancy ; Uterine Neoplasms/diagnostic imaging
    Language English
    Publishing date 2020-11-10
    Publishing country Ireland
    Document type Letter
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2020.11.018
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  9. Article ; Online: Retroperitoneal leiomyomatosis: a benign outcome of power morcellation with potentially serious consequences.

    Cerdeira, Ana Sofia / Ismail, Lamiese / Moore, Niall / George, Bruce / Majd, Hooman Soleymani

    Lancet (London, England)

    2022  Volume 399, Issue 10324, Page(s) 554

    MeSH term(s) Female ; Humans ; Hysterectomy/methods ; Laparoscopy/methods ; Leiomyomatosis/diagnosis ; Leiomyomatosis/surgery ; Magnetic Resonance Imaging/methods ; Middle Aged ; Morcellation/methods ; Myoma/diagnosis ; Myoma/surgery ; Retroperitoneal Neoplasms/diagnosis ; Retroperitoneal Neoplasms/surgery ; Treatment Outcome ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/surgery
    Language English
    Publishing date 2022-02-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00005-8
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  10. Article ; Online: One Step Closer to a Cure for Preeclampsia?: Boosting the Natural Affinity of VEGF (Vascular Endothelial Growth Factor) to sFlt (Soluble fms-Like Tyrosine Kinase)-1.

    Cerdeira, Ana Sofia / Vatish, Manu / Lecarpentier, Edouard

    Hypertension (Dallas, Tex. : 1979)

    2020  Volume 76, Issue 4, Page(s) 1081–1083

    MeSH term(s) Adsorption ; Female ; Humans ; Placenta Growth Factor ; Pre-Eclampsia ; Pregnancy ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-1 ; Vascular Endothelial Growth Factors
    Chemical Substances Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.120.15112
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