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Article ; Conference proceedings: Digital Single-Operator Pancreatoscopy Guided Laser Lithotripsy of Symptomatic Pancreatic Ductal Stones: A Single Centre Care Experience

Chavan, R. / Solanki, R. / Patel, M. / Gandhi, C. / Rajput, S.

2024 Volume 56, Issue S 02

Event/congress	ESGE Days 2024, Berlin, Germany, 2024-04-25
Language	English
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0044-1783071
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Conference proceedings: Spiralling Small Bowel with Power Spiral Enteroscopy: Not Business as Usual

Chavan, R. / Gandhi, C. / Bachkaniwala, V. / Rajput, S.

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765104
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Distinct context- and content-dependent population codes in superior colliculus during sensation and action.

Ayar, Eve C / Heusser, Michelle R / Bourrelly, Clara / Gandhi, Neeraj J

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 40, Page(s) e2303523120

Abstract: Sensorimotor transformation is the process of first sensing an object in the environment and then producing a movement in response to that stimulus. For visually guided saccades, neurons in the superior colliculus (SC) emit a burst of spikes to register ... ...

Abstract	Sensorimotor transformation is the process of first sensing an object in the environment and then producing a movement in response to that stimulus. For visually guided saccades, neurons in the superior colliculus (SC) emit a burst of spikes to register the appearance of stimulus, and many of the same neurons discharge another burst to initiate the eye movement. We investigated whether the neural signatures of sensation and action in SC depend on context. Spiking activity along the dorsoventral axis was recorded with a laminar probe as Rhesus monkeys generated saccades to the same stimulus location in tasks that require either executive control to delay saccade onset until permission is granted or the production of an immediate response to a target whose onset is predictable. Using dimensionality reduction and discriminability methods, we show that the subspaces occupied during the visual and motor epochs were both distinct within each task and differentiable across tasks. Single-unit analyses, in contrast, show that the movement-related activity of SC neurons was not different between tasks. These results demonstrate that statistical features in neural activity of simultaneously recorded ensembles provide more insight than single neurons. They also indicate that cognitive processes associated with task requirements are multiplexed in SC population activity during both sensation and action and that downstream structures could use this activity to extract context. Additionally, the entire manifolds associated with sensory and motor responses, respectively, may be larger than the subspaces explored within a certain set of experiments.
MeSH term(s)	Animals ; Superior Colliculi ; Eye Movements ; Neurons ; Body Fluids ; Macaca mulatta ; Sensation
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2303523120
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Conference proceedings: Efficacy and Safety of Digital Single-Operator Cholangioscopy Guided Laser Lithotripsy for Impacted Retained Cystic duct stones – A Single Tertiary Care Centre Experience

Chavan, R. / Gandhi, C. / Bachkaniwala, V. / Rajput, S.

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765232
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Endoscopic ultrasound-guided drainage of perforated gallbladder in patients with hilar cholangiocarcinoma postbiliary uncovered self-expandable metal stent placement.

Chavan, Radhika / Gandhi, Chaiti / Rajput, Sanjay

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2023 Volume 35, Issue 7, Page(s) e144–e145

Language	English
Publishing date	2023-09-11
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.14668
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3854: Show issues

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Article ; Online: Ventral hernia repair using bioresorbable poly-4-hydroxybutyrate mesh in clean and contaminated surgical fields: a systematic review and meta-analysis.

Ahmed, A / Gandhi, S / Ganam, S / Diab, A-R F / Mhaskar, R / Sujka, J / DuCoin, C / Docimo, S

Hernia : the journal of hernias and abdominal wall surgery

2024 Volume 28, Issue 2, Page(s) 575–584

Abstract: Purpose: Use of biologic or synthetic mesh in hernia repair shifts is based on evolving evidence. Poly-4-hydroxybutyrate (P4HB) biosynthetic mesh is a potential alternative to biologic and synthetic mesh in ventral hernia repair (VHR). This meta- ... ...

Abstract	Purpose: Use of biologic or synthetic mesh in hernia repair shifts is based on evolving evidence. Poly-4-hydroxybutyrate (P4HB) biosynthetic mesh is a potential alternative to biologic and synthetic mesh in ventral hernia repair (VHR). This meta-analysis assesses the efficacy of P4HB mesh in clean and contaminated surgical settings. Methods: Two authors searched literature on PubMed, reviewing titles and abstracts of all articles to determine inclusion eligibility. Post-operative data were compared via transformation method to convert the proportion of patients with the outcome of interest into a suitable quantity for random-effects synthesis using STATA software. Results: Initial search yielded 287 citations. Six studies were included and categorized on whether hernia repairs were conducted in clean (CDC class I) or contaminated cases (CDC class II-IV). The pooled proportion of surgical site infection (SSI), surgical site occurrence (SSO), hernia recurrence, total surgical complications, and reoperation were calculated in 391 clean and 81 contaminated cases. For clean vs. contaminated cases, the following pooled proportions were noted: SSI (2% (CI 0-7%) vs 9% (CI 0-025) (p = 0.03), SSO: 14% (CI 5-25%) vs 35% (CI 22-50%) (p = 0.006), hernia recurrence (8% (CI 1-19%) vs 4% (CI 0-12%) (p = 0.769); surgical complications (17% (CI 6-32%) vs 50% (CI 27-72%) (p = 0.009). Reoperation data were available in 298 clean cases across four studies: 5% (CI 0-15%). Conclusions: P4HB biosynthetic mesh may be more effective than previously thought, particularly in clean wounds. P4HB may also be superior to biologic mesh when compared to clinical trial data. Further research is necessary for more direct comparison.
MeSH term(s)	Humans ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Treatment Outcome ; Surgical Mesh/adverse effects ; Absorbable Implants ; Surgical Wound Infection/surgery ; Hernia, Ventral/surgery ; Hernia, Ventral/complications ; Hydroxybutyrates ; Biological Products ; Recurrence ; Retrospective Studies
Chemical Substances	Hydroxybutyrates ; Biological Products
Language	English
Publishing date	2024-02-12
Publishing country	France
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-023-02951-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5390: Show issues

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Article: Evaluation of the Effects of Topical Fluoride Varnish and Fluoride Releasing Adhesive on Shear Bond Strength of Orthodontic Brackets: An

Chauhan, Charu / Mangla, Rajat / Gandhi, Geetanjali / Bhatnagar, Deepankar / Singh, Kanika / Baijal, Rheia

International journal of clinical pediatric dentistry

2023 Volume 16, Issue 1, Page(s) 37–41

Abstract: ... successfully used for bonding brackets.: How to cite this article: Chauhan C, Mangla R, Gandhi G, ...

Abstract	Aim: The aim of this study was to evaluate the Materials and methods: A total of 60 extracted premolars were bonded to 0.022, stainless steel brackets and equally divided into three groups ( Results: There were no significant differences between the SBSs ( Conclusion: The orthodontic adhesives used in our study, with or without the application of topical fluoride varnish, did not have a significant effect on the bond strengths of brackets. Clinical significance: Adhesives evaluated in this study can be successfully used for bonding brackets. How to cite this article: Chauhan C, Mangla R, Gandhi G,
Language	English
Publishing date	2023-02-16
Publishing country	India
Document type	Journal Article
ISSN	0974-7052
ISSN	0974-7052
DOI	10.5005/jp-journals-10005-2501
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Article ; Online: Efficient management of new patient referrals to a breast service: the safe introduction of an advanced nurse practitioner-led telephone breast pain service.

Ellis, K S / Robinson, C E / Foster, R / Fatayer, H / Gandhi, A

Annals of the Royal College of Surgeons of England

2023 Volume 106, Issue 4, Page(s) 359–363

Abstract: Introduction: There has been an almost 100% increase in referrals to breast cancer diagnostic clinics in the past decade. Breaching of the two-week cancer referral target is now commonplace, potentially delaying diagnoses of breast malignancy in many ... ...

Abstract	Introduction: There has been an almost 100% increase in referrals to breast cancer diagnostic clinics in the past decade. Breaching of the two-week cancer referral target is now commonplace, potentially delaying diagnoses of breast malignancy in many women. Almost one in five of these referrals are women with mastalgia, not a symptom linked to breast cancer. The objective of the study was the safe introduction of an advanced nurse practitioner-led telephone service for women with mastalgia to improve the service for women and create capacity for those with "red flag" breast symptoms. Methods: Referrals to clinic were triaged, women with mastalgia only were directed to a telephone-based assessment clinic and symptoms evaluated using a multidisciplinary created proforma. Results: Within 23 months, 1,427 women were assessed in the breast pain telephone assessment clinic: 863 (61%) were aged over 40 and 564 (39%) aged under 40. A total of 1,238 underwent telephone assessment. Reassurance and discharge only was needed for 365 (26%). The aetiology of pain was identified as musculoskeletal in 1,104/1,238 (89%) of patients, with only 39/1,238 (3.2%) identified as having true breast pain. Additional symptoms were mentioned by 264 women (18%) during the consultation; all immediately redirected back to a diagnostic clinic. Mammography was undertaken in 609 women (43%). Seven women (0.6%) were diagnosed with a breast malignancy. Patient survey indicated that 93% of patients were satisfied with the care received and 97% said they would recommend the service to a family member or friend. Conclusions: Although face-to-face assessments for breast pain remain the standard practice in many breast units, data indicating the safety of a telephone assessment clinic, along with high levels of patient satisfaction, question whether services can be delivered differently.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Aged ; Male ; Mastodynia/diagnosis ; Mastodynia/etiology ; Mastodynia/therapy ; Breast Neoplasms/complications ; Breast Neoplasms/diagnosis ; Referral and Consultation ; Telephone ; Nurse Practitioners
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2023.0056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Uk I Zs.234: Show issues

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Article: Protein S Deficiency: A Case Report.

Gandhi, Shirley M / Patel, Pruthvi / Conner, James R

Cureus

2023 Volume 15, Issue 10, Page(s) e46864

Abstract: ... fibrinogen, and protein C levels but protein S levels were reduced to 24%. This case displays the intricate ...

Abstract	Protein S is a glycoprotein created by the body that aids in the prevention of a hypercoagulable state. Protein S-deficient patients are placed on anticoagulant regimens, as there is no current definitive cure. Failure to bring balance to the hematological system in these patients will lead to complications such as widespread clot formation and pulmonary embolisms. Here, we present a 74-year-old female who was admitted to the ICU after collapsing. She presented with respiratory failure, urinary tract infection (UTI), and pneumonia. Magnetic resonance imaging (MRI) scans depicted a thrombus in the distal right transverse sinus and sigmoid sinus. Her hematologic workup showed normal levels of homocysteine, fibrinogen, and protein C levels but protein S levels were reduced to 24%. This case displays the intricate presentation of a rare hematological disease as well as the importance of routine follow-up to maintain patient health.
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46864
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Article ; Online: C9orf72-associated dipeptide protein repeats form A11-positive oligomers in amyotrophic lateral sclerosis and frontotemporal dementia.

Bhatt, Nemil / Puangmalai, Nicha / Sengupta, Urmi / Jerez, Cynthia / Kidd, Madison / Gandhi, Shailee / Kayed, Rakez

The Journal of biological chemistry

2024 Volume 300, Issue 2, Page(s) 105628

Abstract: Hexanucleotide repeat expansion in C9orf72 is one of the most common causes of amyotrophic lateral sclerosis and frontotemporal dementia. The hexanucleotide expansion, formed by GGGGCC (G4C2) repeats, leads to the production of five dipeptide protein ... ...

Abstract	Hexanucleotide repeat expansion in C9orf72 is one of the most common causes of amyotrophic lateral sclerosis and frontotemporal dementia. The hexanucleotide expansion, formed by GGGGCC (G4C2) repeats, leads to the production of five dipeptide protein repeats (DPRs) via repeat-associated non-AUG translation. Among the five dipeptide repeats, Gly-Arg, Pro-Arg, and Gly-Ala form neuronal inclusions that contain aggregates of the peptides. Several studies have attempted to model DPR-associated toxicity using various repeat lengths, which suggests a unique conformation that is cytotoxic and is independent of the repeat length. However, the structural characteristics of DPR aggregates have yet to be determined. Increasing evidence suggests that soluble species, such as oligomers, are the main cause of toxicity in proteinopathies, such as Alzheimer's and Parkinson's disease. To investigate the ability of DPRs to aggregate and form toxic oligomers, we adopted a reductionist approach using small dipeptide repeats of 3, 6, and 12. This study shows that DPRs, particularly glycine-arginine and proline-arginine, form oligomers that exhibit distinct dye-binding properties and morphologies. Importantly, we also identified toxic DPR oligomers in amyotrophic lateral sclerosis and frontotemporal dementia postmortem brains that are morphologically similar to those generated recombinantly. This study demonstrates that, similar to soluble oligomers formed by various amyloid proteins, DPR oligomers are toxic, independent of their repeat length.
MeSH term(s)	Humans ; Frontotemporal Dementia/genetics ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; C9orf72 Protein/genetics ; C9orf72 Protein/metabolism ; DNA Repeat Expansion ; Dipeptides/chemistry ; Arginine ; Amyloidogenic Proteins ; Glycine
Chemical Substances	C9orf72 Protein ; Dipeptides ; Arginine (94ZLA3W45F) ; Amyloidogenic Proteins ; Glycine (TE7660XO1C) ; C9orf72 protein, human
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2024.105628
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