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  1. Article: Role of socio-economic research in developing, delivering and scaling new crop varieties: the case of staple crop biofortification.

    Birol, Ekin / Bouis, Howarth E

    Frontiers in plant science

    2023  Volume 14, Page(s) 1099496

    Abstract: ... development, delivery and scaling - the program was designed to be interdisciplinary, with plant breeding R&D ...

    Abstract The CGIAR biofortification program, HarvestPlus, was founded with the aim of improving the quality of diets through micronutrient-dense varieties of staple food crops. Implemented in four phases - discovery, development, delivery and scaling - the program was designed to be interdisciplinary, with plant breeding R&D supported by nutrition and socio-economic research. This paper explains the need, use and usefulness of socio-economic research in each phase of the program.
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1099496
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  2. Article ; Online: Role of socio-economic research in developing, delivering and scaling new crop varieties

    Birol, Ekin / Bouis, Howarth E. / Bouis, Howarth

    Frontiers in Plant Science 14: 1099496

    The case of staple crop biofortification

    2023  

    Abstract: ... development, delivery and scaling – the program was designed to be interdisciplinary, with plant breeding R&D ... for initial biofortification R&D and implementation in each subsequent phase, as well as encouraged ... biofortification in their crop R&D, policies, and programs. Socio-economics research helped guide plant breeding ...

    Abstract The CGIAR biofortification program, HarvestPlus, was founded with the aim of improving the quality of diets through micronutrient-dense varieties of staple food crops. Implemented in four phases – discovery, development, delivery and scaling – the program was designed to be interdisciplinary, with plant breeding R&D supported by nutrition and socio-economic research. This paper explains the need, use and usefulness of socio-economic research in each phase of the program. Ex ante and ex post benefit-cost analyses facilitated fundraising for initial biofortification R&D and implementation in each subsequent phase, as well as encouraged other public, private, and civil society and non-governmental organizations to take on and mainstream biofortification in their crop R&D, policies, and programs. Socio-economics research helped guide plant breeding by identifying priority micronutrient- crop- geography combinations for maximum impact. Health impacts of biofortification could be projected both by using empirical results obtained through randomized controlled bioefficacy trials conducted by nutritionists, and through farmer-adoption models estimating impact at scale. Farmer and consumer surveys and monitoring systems provided the underlying information for estimating farmer adoption models and helped understand input/output markets, farmer and consumer preferences, and additional opportunities and challenges –all of which informed crop breeding and delivery activities, while building the knowledge base for catalyzing the scaling of biofortification.

    PR

    IFPRI3; ISI; HarvestPlus; 2 Promoting Healthy Diets and Nutrition for all

    DGO; A4NH; HarvestPlus

    CGIAR Research Program on Agriculture for Nutrition and Health (A4NH)
    Keywords WORLD ; biofortification ; nutrition ; plant breeding ; research ; staple foods ; trace elements ; socio-economic research
    Subject code 360
    Language English
    Publisher Frontiers Media S.A.
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Article ; Online: Will Food Be Affordable to Filipinos by 2030? Alternative Expenditure Policies toward Ending Hunger by 2030

    Briones, Roehlano M. / Bouis, Howarth E. / Angeles-Agdeppa, Imelda / Espineli, Isabel B. / Maniego, Ma. Lynell V.

    2023  

    Abstract: ... in general services such as R&D and infrastructure, as the preferred strategy to achieving affordable diets. ...

    Abstract The current inflationary period has placed the spotlight on hunger and food insecurity, as the current Philippine Development Plan has strongly emphasized the attainment of food affordability for all Filipinos. This study offers a scenario analysis using computable general equilibrium modeling of household purchasing power and affordability of a diet with sufficient energy, protein, and Vitamin A. Scenarios posited are as follows: Reference scenario, which projects forward from recent past trends; the Subsidy scenario, based on producer support; and Productivity, which is a long-term government investment focusing on general services. The scenario analysis finds the following: Under current economic trends, most Filipino households will be able to afford adequate levels of energy and protein by 2030, but not Vitamin A. The Reference scenario is also associated with higher relative consumer and producer prices, as well as far greater levels of output. Despite attenuation of sharp changes in the consumer price of Rice & corn, changes in energy/nutrient intakes under the Subsidy scenario are just equal to those of the Reference scenario. The Productivity scenario entails significantly faster increases in energy, protein, and Vitamin A intake compared with the previous scenarios. The Productivity scenario also leads to smaller changes in price and greater changes in quantity compared with the other scenarios. Implications for policy may be summarized as follows: a) Maintaining overall growth in the range of 5 - 6 percent per year is key to improving diet quality and thereby an affordable energy- and protein-sufficient diet; b) The slightly favorable impact of rice subsidies on the price of rice and on energy/nutrient intake of households may not be worth the added risk of fiscal instability; c) The scenario analysis tend to justify investing in general services such as R&D and infrastructure, as the preferred strategy to achieving affordable diets.
    Keywords ddc:330 ; computable general equilibrium ; food security ; scenario analysis ; agricultural subsidy ; producer support ; general services support
    Subject code 338
    Language English
    Publisher Quezon City: Philippine Institute for Development Studies (PIDS)
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Multiplying the efficiency and impact of biofortification through metabolic engineering

    Van Der Straeten, Dominique / Bhullar, Navreet K. / De Steur, Hans / Gruissem, Wilhelm / Bouis, Howarth E. / Bouis, Howarth

    Nature Communications 11: 5203

    2020  

    Abstract: Ending all forms of hunger by 2030, as set forward in the UN-Sustainable Development Goal 2 (UN-SDG2), is a daunting but essential task, given the limited timeline ahead and the negative global health and socio-economic impact of hunger. Malnutrition or ... ...

    Abstract Ending all forms of hunger by 2030, as set forward in the UN-Sustainable Development Goal 2 (UN-SDG2), is a daunting but essential task, given the limited timeline ahead and the negative global health and socio-economic impact of hunger. Malnutrition or hidden hunger due to micronutrient deficiencies affects about one third of the world population and severely jeopardizes economic development. Staple crop biofortification through gene stacking, using a rational combination of conventional breeding and metabolic engineering strategies, should enable a leap forward within the coming decade. A number of specific actions and policy interventions are proposed to reach this goal.

    PR

    IFPRI3; DCA; CRP4; HarvestPlus; 2 Promoting Healthy Diets and Nutrition for all; ISI

    HarvestPlus; A4NH

    CGIAR Research Programs on Agriculture for Nutrition and Health (A4NH)
    Keywords WORLD ; biofortification ; metabolism ; Goal 2 Zero hunger ; Sustainable Development Goals ; malnutrition ; hunger ; trace elements ; trace elements deficiencies ; plant breeding
    Subject code 360
    Language English
    Publisher Springer
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: CD73 Promotes Age-Dependent Accretion of Atherosclerosis.

    Sutton, Nadia R / Bouïs, Diane / Mann, Kris M / Rashid, Imran M / McCubbrey, Alexandra L / Hyman, Matt C / Goldstein, Daniel R / Mei, Annie / Pinsky, David J

    Arteriosclerosis, thrombosis, and vascular biology

    2019  Volume 40, Issue 1, Page(s) 61–71

    Abstract: Objective: CD73 is an ectonucleotidase which catalyzes the conversion of AMP (adenosine monophosphate) to adenosine. Adenosine has been shown to be anti-inflammatory and vasorelaxant. The impact of ectonucleotidases on age-dependent atherosclerosis ... ...

    Abstract Objective: CD73 is an ectonucleotidase which catalyzes the conversion of AMP (adenosine monophosphate) to adenosine. Adenosine has been shown to be anti-inflammatory and vasorelaxant. The impact of ectonucleotidases on age-dependent atherosclerosis remains unclear. Our aim was to investigate the role of CD73 in age-dependent accumulation of atherosclerosis. Approach and results: Mice doubly deficient in CD73 and ApoE (apolipoprotein E; (
    Conclusions: At early time points, CD73 exerts a subtle antiatherosclerotic influence, but with age, the pattern reverses, and the presence of CD73 promoted suppression of lipid catabolism.
    MeSH term(s) 5'-Nucleotidase/biosynthesis ; 5'-Nucleotidase/genetics ; Animals ; Aorta, Thoracic/metabolism ; Aorta, Thoracic/pathology ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Female ; Flow Cytometry ; Gene Expression Regulation, Developmental ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phenotype ; RNA/genetics
    Chemical Substances RNA (63231-63-0) ; 5'-Nucleotidase (EC 3.1.3.5)
    Language English
    Publishing date 2019-10-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.119.313002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: CD4 T cell autophagy is integral to memory maintenance.

    Murera, Diane / Arbogast, Florent / Arnold, Johan / Bouis, Delphine / Muller, Sylviane / Gros, Frédéric

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 5951

    Abstract: Studies of mice deficient for autophagy in T cells since thymic development, concluded that autophagy is integral to mature T cell homeostasis. Basal survival and functional impairments in vivo, limited the use of these models to delineate the role of ... ...

    Abstract Studies of mice deficient for autophagy in T cells since thymic development, concluded that autophagy is integral to mature T cell homeostasis. Basal survival and functional impairments in vivo, limited the use of these models to delineate the role of autophagy during the immune response. We generated Atg5
    MeSH term(s) Animals ; Antibodies/immunology ; Antigens/immunology ; Autophagy/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation/immunology ; Cell Survival/immunology ; Homeostasis/immunology ; Immunologic Memory/immunology ; Mice ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/immunology ; Mitochondria/immunology
    Chemical Substances Antibodies ; Antigens ; Microtubule-Associated Proteins
    Language English
    Publishing date 2018-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-23993-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Scaling up in agriculture, rural development, and nutrition

    Bouis, Howdy / Islam, Yassir;

    Delivering nutrients widely through biofortification: building on orange sweet potato ; 2020 Vision Focus Brief; 19(11)

    2012  

    Abstract: Washington, D.C.; 2020 Vision Focus; IFPRI-1; 2020; Non-PR ... 2 pages ...

    Abstract Washington, D.C.; 2020 Vision Focus; IFPRI-1; 2020; Non-PR

    2 pages
    Keywords UGANDA; MOZAMBIQUE; AFRICA; AFRICA SOUTH OF SAHARA; SOUTHERN AFRICA; Scaling up; Agriculture; Rural development; Nutrition; Biofortification; Sweet potato; Vitamin A;
    Language English
    Publisher International Food Policy Research Institute (IFPRI);
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Biofortification

    Bouis, Howarth E. / Islam, Yassir;

    In Reshaping agriculture for nutrition and health. Ed. Shenggen Fan and Rajul Pandya-Lorch. Chapter 10. Pp. 83-92

    Leveraging Agriculture to Reduce Hidden Hunger ; 2020 Conference Book

    2012  

    Abstract: Washington, D.C.; Book chapter; IFPRI-1; GRP-4; 2020 ... DGO; PR ...

    Abstract Washington, D.C.; Book chapter; IFPRI-1; GRP-4; 2020

    DGO; PR
    Keywords Food supply; Nutrition policy; Agriculture; Public health; Nutrition; health
    Language English
    Publisher InterInternational Food Policy Research Institute (IFPRI);
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Biofortification ; Leveraging agriculture to reduce hidden hunger ; 2020 Conference Brief ; 19

    Bouis, Howarth E. / Islam, Yassir

    2011  

    Abstract: Washington, D.C. ... Experts estimate that 2 billion people, mostly in poorer countries, suffer ...

    Abstract Washington, D.C.

    Experts estimate that 2 billion people, mostly in poorer countries, suffer from micronutrient malnutrition, also known as hidden hunger. This is caused by a lack of critical micronutrients such as vitamin A, zinc, and iron in the diet. Hidden hunger impairs the mental and physical development of children and adolescents and can result in lower IQ, stunting, and blindness; women and children are especially vulnerable. Hidden hunger also reduces the productivity of adult men and women due to increased risk of illness and reduced work capacity.

    Brief

    IFPRI-1; 2020; HarvestPlus

    Non-PR

    4 pages
    Keywords Agriculture; Hunger; Biofortification
    Language English
    Publisher International Food Policy Research Institute (IFPRI)
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Positive and negative selection shape the human naive B cell repertoire.

    Chen, Jeff W / Schickel, Jean-Nicolas / Tsakiris, Nikolaos / Sng, Joel / Arbogast, Florent / Bouis, Delphine / Parisi, Daniele / Gera, Ruchi / Boeckers, Joshua M / Delmotte, Fabien R / Veselits, Margaret / Schuetz, Catharina / Jacobsen, Eva-Maria / Posovszky, Carsten / Schulz, Ansgar S / Schwarz, Klaus / Clark, Marcus R / Menard, Laurence / Meffre, Eric

    The Journal of clinical investigation

    2021  Volume 132, Issue 2

    Abstract: Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection remains elusive. Using 2 humanized mouse models, we demonstrate that there was strong skewing of the ... ...

    Abstract Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection remains elusive. Using 2 humanized mouse models, we demonstrate that there was strong skewing of the expressed immunoglobulin repertoire upon transit into the peripheral naive B cell pool. This positive selection of expanded naive B cells in humanized mice resembled that observed in healthy human donors and was independent of autologous thymic tissue. In contrast, negative selection of autoreactive B cells required thymus-derived Tregs and MHC class II-restricted self-antigen presentation by B cells. Indeed, both defective MHC class II expression on B cells of patients with rare bare lymphocyte syndrome and prevention of self-antigen presentation via HLA-DM inhibition in humanized mice resulted in the production of autoreactive naive B cells. These latter observations suggest that Tregs repressed autoreactive naive B cells continuously produced by the bone marrow. Thus, a model emerged, in which both positive and negative selection shaped the human naive B cell repertoire and that each process was mediated by fundamentally different molecular and cellular mechanisms.
    MeSH term(s) Animals ; Antigen Presentation ; B-Lymphocytes/immunology ; Female ; Histocompatibility Antigens Class II/immunology ; Humans ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Severe Combined Immunodeficiency/immunology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Histocompatibility Antigens Class II
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI150985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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