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Article ; Online: Prospective, Multi-center, Single-Arm Study of the Auryon Laser System for Treatment of Below-the-Knee Arteries in Patients With Chronic Limb-Threatening Ischemia: 30-Day Results of the Auryon BTK.

Shammas, Nicolas W / Yates, Timothy / Sastry, Ashwani / Ricotta, Joseph / Beasley, Robert / Swee, Warren / Torey, James T / Shammas, Gail A / Jones-Miller, Sue / Corbet, Michele

The American journal of cardiology

2024 Volume 219, Page(s) 1–8

Abstract: The 355 nm Auryon laser (AngioDynamics, Inc., Latham, New York) has been shown to be effective and safe in treating various morphology lesions in the femoropopliteal arteries. There are limited data on the Auryon laser in treating below-the-knee (BTK) ... ...

Abstract	The 355 nm Auryon laser (AngioDynamics, Inc., Latham, New York) has been shown to be effective and safe in treating various morphology lesions in the femoropopliteal arteries. There are limited data on the Auryon laser in treating below-the-knee (BTK) arteries in patients with chronic limb-threatening ischemia. We present the 30-day efficacy and safety findings from the ongoing Auryon BTK study. Patients with chronic limb-threatening ischemia were prospectively enrolled in the Auryon BTK study between March 2022 and February 2023 in 4 US centers after obtaining written informed consent. The primary safety end point included major adverse limb events + postoperative death at 30 days, defined as a composite of all-cause death, major amputation, and target vessel revascularization. Demographic, procedural, angiographic, and outcome data were collected. A total of 60 patients (61 lesions) were treated. The mean age was 74.6 ± 10.3 years, with 65.0% men, 58.3% with diabetes, 43.3% Rutherford Becker (RB) IV, and 56.7% RB V. Of the 61 lesions, 59% had severe calcification, 31.1% were chronic total occlusions, and 90.2% were de novo disease. The baseline diameter stenosis was 80.2 ± 16.4%, after laser 57.4 ± 21.7%, and after final treatment 24.0 ± 23.1% (p <0.0050). The primary performance end point showed a procedure success rate of 37 of 68 (63.8%). Bailout stenting occurred in 1 of 61 lesions (1.6%). The RB category was 100% RB IV or higher at baseline versus 35.3% at 30 days. At 30 days, there was no target vessel revascularization and the patency was 88.9% (Peak Systolic Velocity Ratio (PSVR) ≤2.4). In conclusion, the Auryon laser is safe and relatively effective in treating BTK lesions with minimal complications.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2024.03.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Residents' Report of COVID-19 Associated Training Disruptions, Stressors, and Opportunities During the Pandemic-The Singapore Experience.

Koh, Samuel Ji Quan / Woon, Ting Hui / Fong, Warren / Kwan, Yu Heng / Lim, Swee Han / Lee, Jodie Ling Horng / Tan, Hak Koon

Journal of graduate medical education

2023 Volume 15, Issue 4, Page(s) 494–499

Abstract: Background: The COVID-19 pandemic has disrupted residency training. Several studies have been performed to investigate the impact of the pandemic on residency training in Accreditation Council for Graduate Medical Education-International (ACGME-I)- ... ...

Abstract	Background: The COVID-19 pandemic has disrupted residency training. Several studies have been performed to investigate the impact of the pandemic on residency training in Accreditation Council for Graduate Medical Education-International (ACGME-I)-accredited institutions. However, these were either limited to certain specialties or failed to consider possible opportunities from the pandemic. Objective: To determine the stressors on residents as well as the opportunities that arose from the COVID-19 pandemic across multiple specialities in Singapore. Methods: A cross-sectional survey among SingHealth residents was conducted between July and September 2020. The survey assessed the balance between service and training during hospital postings, the pandemic's influence on examination and teaching, the psychological impact of the pandemic, the level of burnout, and the effect on morale of residents during the pandemic. Results: The response rate was 27.1% (253 of 934). Out of the 253 residents, 136 (53.8%) felt stressed during the pandemic. Concerns about family's health and safety pertaining to potential COVID-19 infection, progression in training, and completion of examinations were the top 3 stressors. One-hundred and three residents (40.7%) had their training disrupted either by being placed in an interim posting not part of their residency requirements or being deployed to care for patients with COVID-19. Although administrative support and information for virtual teaching were sufficient, only 108 (42.7%) agreed it had the same value as face-to-face sessions. Despite the challenges, 179 (70.8%) thought that experiencing this crisis provided more meaning in their career. Conclusions: The COVID-19 pandemic has brought about challenges and learning opportunities for residents.
MeSH term(s)	Humans ; COVID-19 ; Cross-Sectional Studies ; Internship and Residency ; Pandemics ; Singapore
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2578612-X
ISSN	1949-8357 ; 1949-8357
ISSN (online)	1949-8357
ISSN	1949-8357
DOI	10.4300/JGME-D-22-00569.1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Newborn screening for abnormal haemoglobins in Jamaica: Practical issues in an island programme.

Serjeant, Graham R / Serjeant, Beryl E / Mason, Karlene P / Gibson, Felicea / Gardner, Ruth-Ann / Warren, Lansford / Hambleton, Ian R / Thein, Swee L / Happich, Margit / Kulozik, Andreas E

Journal of medical screening

2022 Volume 29, Issue 4, Page(s) 219–223

Abstract: Objective: To report the diagnostic challenges of newborn screening for abnormal haemoglobins.: Setting: Cord blood samples from 13 hospitals in southwest Jamaica taken in 2008-2019.: Methods: Blood spots, collected from the umbilical cord, were ... ...

Abstract	Objective: To report the diagnostic challenges of newborn screening for abnormal haemoglobins. Setting: Cord blood samples from 13 hospitals in southwest Jamaica taken in 2008-2019. Methods: Blood spots, collected from the umbilical cord, were analysed by high pressure liquid chromatography (HPLC) to reveal phenotypes for HbSS and HbCC, but genotype confirmation may require parental studies or gene sequencing. Such cases that were successfully traced were analysed in this follow-up study. Results: HPLC screening of 121,306 samples detected HbAS in 11,846 (9.8%), HbAC in 4508 (3.7%) and other electrophoretic abnormalities in 1090 babies. Among 101 previously unconfirmed cases, 34/90 (38%) with HPLC evidence of a HbSS phenotype had other genotypes, and 7/11 (64%) with a HbCC phenotype had other genotypes. Syndromes from the interaction of β thalassaemia occurred in 112 babies (85 with HbS, 27 with HbC) and of genes for hereditary persistence of fetal haemoglobin (HPFH) in 18 (12 with HbS, 6 with HbC). Variants other than HbS and HbC occurred in 270 babies, 16 in combination with either HbS or HbC, and 254 as traits. Most variants are benign even when inherited with HbS, although HbO Arab, HbD Punjab, or Hb Lepore Washington, which occurred in 6 cases, may cause sickle cell disease. Conclusions: Genes for β thalassaemia and HPFH are common in western Jamaica and when associated with HbS may present diagnostic challenges in newborns, as HbF and HbA
MeSH term(s)	Anemia, Sickle Cell/diagnosis ; DNA ; Follow-Up Studies ; Hemoglobin, Sickle/genetics ; Hemoglobins, Abnormal/genetics ; Humans ; Infant, Newborn ; Jamaica ; Neonatal Screening/methods ; beta-Thalassemia
Chemical Substances	Hemoglobin, Sickle ; Hemoglobins, Abnormal ; DNA (9007-49-2)
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1235253-6
ISSN	1475-5793 ; 0969-1413
ISSN (online)	1475-5793
ISSN	0969-1413
DOI	10.1177/09691413221111209
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Article ; Online: Assessment of medical professionalism using the Professionalism Mini-Evaluation Exercise (P-MEX)

Warren Fong / Yu Heng Kwan / Sungwon Yoon / Jie Kie Phang / Julian Thumboo / Swee Cheng Ng

The Asia Pacific Scholar, Vol 6, Iss 1, Pp 114-

A survey of faculty perception of relevance, feasibility and comprehensiveness

2021 Volume 118

Abstract: Introduction: This study aimed to examine the perception of faculty on the relevance, feasibility and comprehensiveness of the Professionalism Mini Evaluation Exercise (P-MEX) in the assessment of medical professionalism in residency programmes in an ... ...

Abstract	Introduction: This study aimed to examine the perception of faculty on the relevance, feasibility and comprehensiveness of the Professionalism Mini Evaluation Exercise (P-MEX) in the assessment of medical professionalism in residency programmes in an Asian postgraduate training centre. Methods: Cross-sectional survey data was collected from faculty in 33 residency programmes. Items were deemed to be relevant to assessment of medical professionalism when at least 80% of the faculty gave a rating of ≥8 on a 0-10 numerical rating scale (0 representing not relevant, 10 representing very relevant). Feedback regarding the feasibility and comprehensiveness of the P-MEX assessment was also collected from the faculty through open-ended questions. Results: In total, 555 faculty from 33 residency programmes participated in the survey. Of the 21 items in the P-MEX, 17 items were deemed to be relevant. For the remaining four items ‘maintained appropriate appearance’, ‘extended his/herself to meet patient needs’, ‘solicited feedback’, and ‘advocated on behalf of a patient’, the percentage of faculty who gave a rating of ≥8 was 78%, 75%, 74%, and 69% respectively. Of the 333 respondents to the open-ended question on feasibility, 34% (n=113) felt that there were too many questions in the P-MEX. Faculty also reported that assessments about ‘collegiality’ and ‘communication with empathy’ were missing in the current P-MEX. Conclusion: The P-MEX is relevant and feasible for assessment of medical professionalism. There may be a need for greater emphasis on the assessment of collegiality and empathetic communication in the P-MEX.
Keywords	professionalism ; singapore ; survey ; assessment ; Education (General) ; L7-991 ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	National University of Singapore
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of medical professionalism

Warren Fong / Yu Heng Kwan / Sungwon Yoon / Jie Kie Phang / Julian Thumboo / Ying Ying Leung / Swee Cheng Ng

BMC Medical Education, Vol 20, Iss 1, Pp 1-

preliminary results of a qualitative study

2020 Volume 12

Abstract: Abstract Background The importance of medical professionalism has been well documented in the literature. Cultural background affects the constituents of professionalism. However, few studies have explored the domains of medical professionalism in an ... ...

Abstract	Abstract Background The importance of medical professionalism has been well documented in the literature. Cultural background affects the constituents of professionalism. However, few studies have explored the domains of medical professionalism in an Asian context. We aim to describe the views and experiences of both patients and faculty on medical professionalism in an urban Asian city state. Methods Data for this qualitative study were collected through focus group discussions (FGDs) with patients and in-depth interviews (IDIs) with faculty members. The IDIs and FGDs were audio-recorded and transcribed verbatim. Thematic analysis was conducted by two independent coders using a priori framework derived from Professionalism Mini Evaluation Exercise (P-MEX). Sociodemographic data of faculty members and patients were obtained through brief questionnaires. Results A total of 31 patients (58.1% male, all had visited healthcare facilities within the past year) and 26 faculty members (42.3% male, 38.5% from medical disciplines, median years as faculty is 11) participated in this study. The results supported the four domains of medical professionalism - Doctor-patient relationship skills, Reflective skills, Time management and Inter-professional relationship skills. Two new sub-domains which emerged from data were (1) communicated effectively with patient and (2) demonstrated collegiality. Conclusions The domains of professionalism in Singapore were similar to previous studies. This study allows a better understanding of medical professionalism to enhance the assessment and ultimately, the teaching of medical professionalism in an urban multi-ethnic Asian city.
Keywords	Professionalism ; Singapore ; Qualitative ; Assessment ; Special aspects of education ; LC8-6691 ; Medicine ; R
Subject code	001
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of medical professionalism using the Professionalism Mini Evaluation Exercise (P-MEX) in a multi-ethnic society

Warren Fong / Yu Heng Kwan / Sungwon Yoon / Jie Kie Phang / Julian Thumboo / Ying Ying Leung / Swee Cheng Ng

BMC Medical Education, Vol 20, Iss 1, Pp 1-

a Delphi study

2020 Volume 9

Abstract: Abstract Background The importance of medical professionalism and its assessment has been well documented in the literature. However, there is currently no culturally-adapted tool to assess medical professionalism in Singapore. This study sets out to ... ...

Abstract	Abstract Background The importance of medical professionalism and its assessment has been well documented in the literature. However, there is currently no culturally-adapted tool to assess medical professionalism in Singapore. This study sets out to find consensus on relevance of the items from the Professionalism Mini Evaluation Exercise (P-MEX) for assessing medical professionalism in Singapore. Methods A two-round Delphi survey was completed by an expert panel consisting of program directors, associate designated institutional officials, and designated institutional official (n = 15) from residency programs in Singapore. Round 1 comprised of 23 items from the P-MEX rated on a 5-point scale (1 = Definitely include, 2 = Possibly include, 3 = Neutral, 4 = Possibly exclude, 5 = Definitely exclude). In round 2, the experts received feedback from the previous round, and were asked to re-rate the items which did not achieve consensus in the previous round. The threshold for consensus in the study was defined as 70% or greater agreement among experts. Results Completed questionnaires for both rounds were received from all 15 experts. In round 1, 18 items (78%) achieved consensus to be included. In round 2, 1 (4%) item achieved consensus to be included. However, none of the remaining items achieved consensus to be removed, and they exhibited stability in responses. A list of 19 items covering four domains of medical professionalism (Doctor-patient relationship skills, Reflective skills, Time management and Inter-professional relationship skills) was obtained during the two-rounds of Delphi survey. Conclusions Nineteen items in the P-MEX had garnered consensus and is suitable for assessing medical professionalism in Singapore. The findings of this study can provide guidance for faculty and institutions who want to assess medical professionalism of their medical trainees.
Keywords	Professionalism ; Singapore ; Delphi ; Assessment ; Special aspects of education ; LC8-6691 ; Medicine ; R
Subject code	005
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of medical professionalism: preliminary results of a qualitative study.

Fong, Warren / Kwan, Yu Heng / Yoon, Sungwon / Phang, Jie Kie / Thumboo, Julian / Leung, Ying Ying / Ng, Swee Cheng

BMC medical education

2020 Volume 20, Issue 1, Page(s) 27

Abstract: Background: The importance of medical professionalism has been well documented in the literature. Cultural background affects the constituents of professionalism. However, few studies have explored the domains of medical professionalism in an Asian ... ...

Abstract	Background: The importance of medical professionalism has been well documented in the literature. Cultural background affects the constituents of professionalism. However, few studies have explored the domains of medical professionalism in an Asian context. We aim to describe the views and experiences of both patients and faculty on medical professionalism in an urban Asian city state. Methods: Data for this qualitative study were collected through focus group discussions (FGDs) with patients and in-depth interviews (IDIs) with faculty members. The IDIs and FGDs were audio-recorded and transcribed verbatim. Thematic analysis was conducted by two independent coders using a priori framework derived from Professionalism Mini Evaluation Exercise (P-MEX). Sociodemographic data of faculty members and patients were obtained through brief questionnaires. Results: A total of 31 patients (58.1% male, all had visited healthcare facilities within the past year) and 26 faculty members (42.3% male, 38.5% from medical disciplines, median years as faculty is 11) participated in this study. The results supported the four domains of medical professionalism - Doctor-patient relationship skills, Reflective skills, Time management and Inter-professional relationship skills. Two new sub-domains which emerged from data were (1) communicated effectively with patient and (2) demonstrated collegiality. Conclusions: The domains of professionalism in Singapore were similar to previous studies. This study allows a better understanding of medical professionalism to enhance the assessment and ultimately, the teaching of medical professionalism in an urban multi-ethnic Asian city.
MeSH term(s)	Adult ; Aged ; Attitude of Health Personnel ; Attitude to Health ; Communication ; Faculty, Medical ; Female ; Focus Groups ; Humans ; Interprofessional Relations ; Male ; Middle Aged ; Physician-Patient Relations ; Professional Competence ; Professionalism ; Qualitative Research ; Singapore ; Surveys and Questionnaires ; Time Management
Language	English
Publishing date	2020-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-020-1943-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessment of medical professionalism using the Professionalism Mini Evaluation Exercise (P-MEX) in a multi-ethnic society: a Delphi study.

Fong, Warren / Kwan, Yu Heng / Yoon, Sungwon / Phang, Jie Kie / Thumboo, Julian / Leung, Ying Ying / Ng, Swee Cheng

BMC medical education

2020 Volume 20, Issue 1, Page(s) 225

Abstract: Background: The importance of medical professionalism and its assessment has been well documented in the literature. However, there is currently no culturally-adapted tool to assess medical professionalism in Singapore. This study sets out to find ... ...

Abstract	Background: The importance of medical professionalism and its assessment has been well documented in the literature. However, there is currently no culturally-adapted tool to assess medical professionalism in Singapore. This study sets out to find consensus on relevance of the items from the Professionalism Mini Evaluation Exercise (P-MEX) for assessing medical professionalism in Singapore. Methods: A two-round Delphi survey was completed by an expert panel consisting of program directors, associate designated institutional officials, and designated institutional official (n = 15) from residency programs in Singapore. Round 1 comprised of 23 items from the P-MEX rated on a 5-point scale (1 = Definitely include, 2 = Possibly include, 3 = Neutral, 4 = Possibly exclude, 5 = Definitely exclude). In round 2, the experts received feedback from the previous round, and were asked to re-rate the items which did not achieve consensus in the previous round. The threshold for consensus in the study was defined as 70% or greater agreement among experts. Results: Completed questionnaires for both rounds were received from all 15 experts. In round 1, 18 items (78%) achieved consensus to be included. In round 2, 1 (4%) item achieved consensus to be included. However, none of the remaining items achieved consensus to be removed, and they exhibited stability in responses. A list of 19 items covering four domains of medical professionalism (Doctor-patient relationship skills, Reflective skills, Time management and Inter-professional relationship skills) was obtained during the two-rounds of Delphi survey. Conclusions: Nineteen items in the P-MEX had garnered consensus and is suitable for assessing medical professionalism in Singapore. The findings of this study can provide guidance for faculty and institutions who want to assess medical professionalism of their medical trainees.
MeSH term(s)	Adult ; Aged ; Delphi Technique ; Ethnic Groups ; Female ; Humans ; Interprofessional Relations ; Male ; Middle Aged ; Physician-Patient Relations ; Professional Competence ; Professionalism ; Singapore
Language	English
Publishing date	2020-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-020-02147-9
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Article ; Online: Lavender essential oil induces oxidative stress which modifies the bacterial membrane permeability of carbapenemase producing Klebsiella pneumoniae.

Yang, Shun-Kai / Yusoff, Khatijah / Thomas, Warren / Akseer, Riaz / Alhosani, Maryam Sultan / Abushelaibi, Aisha / Lim, Swee-Hua-Erin / Lai, Kok-Song

Scientific reports

2020 Volume 10, Issue 1, Page(s) 819

Abstract: Misuse of antibiotics in the clinical and agricultural sectors has caused the emergence of multidrug-resistant (MDR) Klebsiella pneumoniae which contributes a threat to human health. In this study, we assessed the feasibility of lavender essential oil ( ... ...

Abstract	Misuse of antibiotics in the clinical and agricultural sectors has caused the emergence of multidrug-resistant (MDR) Klebsiella pneumoniae which contributes a threat to human health. In this study, we assessed the feasibility of lavender essential oil (LVO) as an antimicrobial agent in combinatory therapy with meropenem in suppressing the growth of carbapenemase-producing K. pneumoniae (KPC-KP). Synergistic interactions between LVO and meropenem were detected, which significantly reduce the inhibitory concentration of both LVO and meropenem by 15 and 4-fold respectively. Comparative proteomic profiling identified a disruption in the bacterial membrane via oxidative stress that was indicated by loss of membrane and cytoplasmic proteins and the upregulation of oxidative regulators. As a proof of concept, zeta potential measurements showed a change in cell surface charge while outer membrane permeability measurement indicated an increase in membrane permeability following exposure to LVO. This was indicative of a disrupted outer membrane. Ethidium bromide influx/efflux assays demonstrated no significant efflux pump inhibition by LVO, and scanning electron microscopy revealed irregularities on the cell surface after exposure to LVO. Oxidative stress was also detected with increased level of ROS and lipid peroxidation in LVO-treated cells. In conclusion, our data suggest that LVO induced oxidative stress in K. pneumoniae which oxidizes the outer membrane, enabling the influx of generated ROS, LVO and meropenem into the bacterial cells, causing damage to the cells and eventually death.
MeSH term(s)	Anti-Bacterial Agents ; Bacterial Proteins/metabolism ; Cell Membrane Permeability/drug effects ; Drug Resistance, Bacterial ; Drug Synergism ; Feasibility Studies ; Klebsiella pneumoniae/cytology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/growth & development ; Klebsiella pneumoniae/metabolism ; Meropenem/pharmacology ; Microbial Sensitivity Tests ; Oils, Volatile/pharmacology ; Oxidative Stress/drug effects ; Plant Oils/pharmacology ; Reactive Oxygen Species/metabolism ; beta-Lactamases/metabolism
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; Oils, Volatile ; Plant Oils ; Reactive Oxygen Species ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6) ; Meropenem (FV9J3JU8B1) ; lavender oil (ZBP1YXW0H8)
Language	English
Publishing date	2020-01-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-55601-0
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Article ; Online: Endovascular management of thoracic dissections.

Swee, Warren / Dake, Michael D

Circulation

2008 Volume 117, Issue 11, Page(s) 1460–1473

MeSH term(s)	Aneurysm, Dissecting/classification ; Aneurysm, Dissecting/complications ; Aneurysm, Dissecting/surgery ; Angioplasty/methods ; Aortic Aneurysm, Thoracic/classification ; Aortic Aneurysm, Thoracic/complications ; Aortic Aneurysm, Thoracic/surgery ; Aortic Rupture/etiology ; Aortic Rupture/prevention & control ; Follow-Up Studies ; Humans ; Ischemia/etiology ; Ischemia/prevention & control ; Meta-Analysis as Topic ; Minimally Invasive Surgical Procedures/methods ; Multicenter Studies as Topic/statistics & numerical data ; Paraplegia/etiology ; Paraplegia/prevention & control ; Postoperative Complications/etiology ; Randomized Controlled Trials as Topic/statistics & numerical data ; Registries ; Spinal Cord/blood supply ; Stents ; Treatment Outcome ; Tunica Intima/pathology ; Tunica Intima/surgery
Language	English
Publishing date	2008-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.107.690966
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