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Article ; Online: Aging with multiple sclerosis: Clinical characterization of an elderly population, a cross-sectional study.

Michelis, Daniele / Brunetti, Nicole / Solaro, Claudio / Mancardi, Giovanni Luigi / Uccelli, Antonio / Inglese, Matilde / Laroni, Alice

Multiple sclerosis and related disorders

2022 Volume 69, Page(s) 104464

MeSH term(s)	Humans ; Aged ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/epidemiology ; Cross-Sectional Studies ; Aging
Language	English
Publishing date	2022-12-09
Publishing country	Netherlands
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2022.104464
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Article ; Online: Surgical treatment in Takayasu's arteritis with patch reconstruction of the left anterior descending coronary artery.

Barbato, Luciano / Grasso, Maria Antonietta / Inglese, Luigi / Spagnolo, Salvatore

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2018 Volume 53, Issue 5, Page(s) 1097

MeSH term(s)	Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Humans ; Reconstructive Surgical Procedures/methods ; Takayasu Arteritis/diagnostic imaging ; Takayasu Arteritis/surgery
Language	English
Publishing date	2018-01-08
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezx454
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Zs.A 2303: Show issues

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Article ; Online: Multisocieties position paper: Microbiological surveillance on flexible endoscopes.

Casini, Beatrice / Pan, Angelo / Guarini, Alessandra / Rivara, Cinzia / Zullo, Angelo / Monica, Fabio / Cimbro, Monica / Casarano, Salvatore / Inglese, Agostino / Vaghi, Adriano / Schiffino, Luigi / Capezzuto, Erminio / Da Massa Carrara, Paola / Pasquale, Luigi

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2021 Volume 53, Issue 9, Page(s) 1105–1111

Abstract: Transmission with endoscopes, particularly duodenoscope, of potential lethal infections prompted different scientific societies to deliver recommendations aimed reducing this risk. Some International societies extended recommendations on microbial ... ...

Abstract	Transmission with endoscopes, particularly duodenoscope, of potential lethal infections prompted different scientific societies to deliver recommendations aimed reducing this risk. Some International societies extended recommendations on microbial surveillance to all the endoscopes and devices used in the reprocessing procedure. Considering the relevance of the topic, 8 Italian scientific societies of physicians, nurses and technical operators prepared a concerted document taking into account Institutional advisories and facilities in Italy. The rules for a correct microbial surveillance on endoscopes were detailed in term of what, how and when to perform the procedure, also suggesting behaviors in case of contamination.
MeSH term(s)	Cross Infection/prevention & control ; Cross Infection/transmission ; Endoscopes, Gastrointestinal/adverse effects ; Endoscopes, Gastrointestinal/microbiology ; Equipment Contamination/prevention & control ; Humans ; Safety Management/standards
Language	English
Publishing date	2021-07-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2021.06.016
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Zs.A 1134: Show issues

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Article ; Online: Position Sense Deficits at the Lower Limbs in Early Multiple Sclerosis: Clinical and Neural Correlates.

Iandolo, Riccardo / Bommarito, Giulia / Falcitano, Laura / Schiavi, Simona / Piaggio, Niccolò / Mancardi, Giovanni Luigi / Casadio, Maura / Inglese, Matilde

Neurorehabilitation and neural repair

2020 Volume 34, Issue 3, Page(s) 260–270

Abstract: Background/ ... ...

Abstract	Background/Objective
MeSH term(s)	Adult ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/physiopathology ; Corpus Callosum/diagnostic imaging ; Corpus Callosum/pathology ; Diffusion Tensor Imaging ; Female ; Humans ; Lower Extremity/physiopathology ; Magnetic Resonance Imaging ; Male ; Multiple Sclerosis, Relapsing-Remitting/complications ; Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging ; Multiple Sclerosis, Relapsing-Remitting/pathology ; Multiple Sclerosis, Relapsing-Remitting/physiopathology ; Neuronal Plasticity/physiology ; Postural Balance/physiology ; Proprioception/physiology ; Prospective Studies ; Psychomotor Performance/physiology ; Sensation Disorders/etiology ; Sensation Disorders/physiopathology
Language	English
Publishing date	2020-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491637-x
ISSN	1552-6844 ; 1545-9683 ; 0888-4390
ISSN (online)	1552-6844
ISSN	1545-9683 ; 0888-4390
DOI	10.1177/1545968320902126
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Zs.B 3096: Show issues

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Article ; Online: Obesity and Dysmetabolic Factors among Deceased COVID-19 Adults under 65 Years of Age in Italy: A Retrospective Case-Control Study.

Kondili, Loreta A / Quaranta, Maria Giovanna / Viganò, Mauro / Tata, Xhimi / D'Angelo, Franca / Lo Noce, Cinzia / Palmieri, Luigi / Onder, Graziano / D'Amico, Federico / Inglese, Elvira / Puoti, Massimo / Aghemo, Alessio / Tosti, Maria Elena

Viruses

2022 Volume 14, Issue 9

Abstract: Background: Italy has witnessed high levels of COVID-19 deaths, mainly at the elderly age. We assessed the comorbidity and the biochemical profiles of consecutive patients ≤65 years of age to identify a potential risk profile for death.: Methods: We ... ...

Abstract	Background: Italy has witnessed high levels of COVID-19 deaths, mainly at the elderly age. We assessed the comorbidity and the biochemical profiles of consecutive patients ≤65 years of age to identify a potential risk profile for death. Methods: We retrospectively analyzed clinical data from consecutive hospitalized-for-COVID-19 patients ≤65 years, who were died (593 patients) or discharged (912 patients) during February-December 2020. Multivariate logistic regression identified the mortality risk factors. Results: Overweight (adjusted odds ratio (adjOR) 5.53, 95% CI 2.07-14.76), obesity (adjOR 8.58, CI 3.30-22.29), dyslipidemia (adjOR 10.02, 95% CI 1.06-94.22), heart disease (adjOR 17.68, 95% CI 3.80-82.18), cancer (adjOR 13.28, 95% CI 4.25-41.51) and male sex (adjOR 5.24, 95% CI 2.30-11.94) were associated with death risk in the youngest population. In the older population (46-65 years of age), the overweight and obesity were also associated with the death risk, however at a lower extent: the adjORs varyied from 1.49 to 2.36 for overweight patients and from 3.00 to 4.07 for obese patients. Diabetes was independently associated with death only in these older patients. Conclusion: Overweight, obesity and dyslipidemia had a pivotal role in increasing young individuals' death risk. Their presence should be carefully evaluated for prevention and/or prompt management of SARS-CoV2 infection in such high-risk patients to avoid the worst outcomes.
MeSH term(s)	Adult ; Age Factors ; Aged ; COVID-19/epidemiology ; Case-Control Studies ; Dyslipidemias/epidemiology ; Humans ; Italy/epidemiology ; Male ; Obesity/complications ; Obesity/epidemiology ; Overweight/complications ; Overweight/epidemiology ; RNA, Viral ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14091981
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Article: Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment?

Colizzi, Marco / Ciceri, Marco Luigi / Di Gennaro, Gianfranco / Morari, Beatrice / Inglese, Alessandra / Gandolfi, Marialuisa / Smania, Nicola / Zoccante, Leonardo

Brain sciences

2020 Volume 10, Issue 9

Abstract: Motor abnormalities have been suggested to play a role in most neuropsychiatric disorders, as a potential generic neurodevelopmental vulnerability. However, they still represent a neglected area, with a paucity of empirical studies, especially in ... ...

Abstract	Motor abnormalities have been suggested to play a role in most neuropsychiatric disorders, as a potential generic neurodevelopmental vulnerability. However, they still represent a neglected area, with a paucity of empirical studies, especially in pediatric populations. This case-control study aimed to comprehensively assess motor functioning in children with atypical neurodevelopment and investigate whether any socio-demographic or clinical characteristics would concur with motor difficulties to distinguish children with neurodevelopmental disorders (NDD) from healthy controls. Socio-demographic (age and gender) and clinical (intelligence quotient, gait, movement, and coordination) data were collected on 114 children aged 5-15 (83 with NDD, 31 healthy controls). Male children were at significantly higher risk for NDD (OR: 13.023,
Language	English
Publishing date	2020-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci10090601
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Article ; Online: Antibody response elicited by the SARS-CoV-2 vaccine booster in patients with multiple sclerosis: Who gains from it?

Schiavetti, Irene / Inglese, Matilde / Frau, Jessica / Signoriello, Elisabetta / Caleri, Francesca / Stromillo, Maria Laura / Ferrò, Maria Teresa / Rilla, Maria Teresa / Gandoglia, Ilaria / Gazzola, Paola / Brichetto, Giampaolo / Pasquali, Livia / Grimaldi, Luigi / Ulivelli, Monica / Marinelli, Fabiana / Cordera, Susanna / Clerico, Marinella / Conte, Antonella / Salvetti, Marco /

Battaglia, Mario Alberto / Franciotta, Diego / Uccelli, Antonio / Sormani, Maria Pia

European journal of neurology

2023 Volume 30, Issue 8, Page(s) 2357–2364

Abstract: Background and purpose: Although two doses of COVID-19 vaccine elicited a protective humoral response in most persons with multiple sclerosis (pwMS), a significant group of them treated with immunosuppressive disease-modifying therapies (DMTs) showed ... ...

Abstract	Background and purpose: Although two doses of COVID-19 vaccine elicited a protective humoral response in most persons with multiple sclerosis (pwMS), a significant group of them treated with immunosuppressive disease-modifying therapies (DMTs) showed less efficient responses. Methods: This prospective multicenter observational study evaluates differences in immune response after a third vaccine dose in pwMS. Results: Four hundred seventy-three pwMS were analyzed. Compared to untreated patients, there was a 50-fold decrease (95% confidence interval [CI] = 14.3-100.0, p < 0.001) in serum SARS-CoV-2 antibody levels in those on rituximab, a 20-fold decrease (95% CI = 8.3-50.0, p < 0.001) in those on ocrelizumab, and a 2.3-fold decrease (95% CI = 1.2-4.6, p = 0.015) in those on fingolimod. As compared to the antibody levels after the second vaccine dose, patients on the anti-CD20 drugs rituximab and ocrelizumab showed a 2.3-fold lower gain (95% CI = 1.4-3.8, p = 0.001), whereas those on fingolimod showed a 1.7-fold higher gain (95% CI = 1.1-2.7, p = 0.012), compared to patients treated with other DMTs. Conclusions: All pwMS increased their serum SARS-CoV-2 antibody levels after the third vaccine dose. The mean antibody values of patients treated with ocrelizumab/rituximab remained well below the empirical "protective threshold" for risk of infection identified in the CovaXiMS study (>659 binding antibody units/mL), whereas for patients treated with fingolimod this value was significantly closer to the cutoff.
MeSH term(s)	Humans ; COVID-19 Vaccines ; Antibody Formation ; Fingolimod Hydrochloride ; Multiple Sclerosis/drug therapy ; Prospective Studies ; Rituximab/therapeutic use ; COVID-19/prevention & control ; SARS-CoV-2 ; Antibodies, Viral ; Vaccination
Chemical Substances	COVID-19 Vaccines ; Fingolimod Hydrochloride (G926EC510T) ; Rituximab (4F4X42SYQ6) ; Antibodies, Viral
Language	English
Publishing date	2023-05-28
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.15830
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Impact of Natural Killer (NK) Cells on Immune Reconstitution, and Their Potential as a Biomarker of Disease Activity, in Alemtuzumab-Treated Patients with Relapsing Remitting Multiple Sclerosis: An Observational Study.

Palmeri, Serena / Ponzano, Marta / Ivaldi, Federico / Signori, Alessio / Lapucci, Caterina / Casella, Valentina / Ferrò, Maria Teresa / Vigo, Tiziana / Inglese, Matilde / Mancardi, Giovanni Luigi / Uccelli, Antonio / Laroni, Alice

CNS drugs

2021 Volume 36, Issue 1, Page(s) 83–96

Abstract: Background: Defining immune mechanisms leading to multiple sclerosis (MS) is difficult, due to the great inter-individual difference in immune system responses. The anti-CD52 antibody alemtuzumab transiently abolishes differences in immune parameters ... ...

Abstract	Background: Defining immune mechanisms leading to multiple sclerosis (MS) is difficult, due to the great inter-individual difference in immune system responses. The anti-CD52 antibody alemtuzumab transiently abolishes differences in immune parameters among individuals, allowing analysis of subsequent immune cell repopulation patterns, and their possible role in MS. Objective: To evaluate the correlation between innate and adaptive immune cell subsets and disease activity in MS in the context of treatment with alemtuzumab. Methods: A two-center observational cohort of patients treated with alemtuzumab underwent immune profiling of T, B, and natural killer (NK) cells, biomarker, clinical and radiological follow-up. Results: After treatment, the percentage of NK and B cells increased; NK, T- and B-cell populations underwent a profound rearrangement. Within the effector T-cell compartment, treatment led to a transient decrease, followed by an increase, of T-helper 1 cells, and to a transient decrease of T-helper 17 cells. Within the T-regulatory compartment, naïve T-regulatory cells increased. Within the B-cell compartment, memory B cells and mature B cells decreased, whereas transitional B cells increased. Within the NK cell compartment, CD56 Conclusions: The results of this study provide novel evidence that NK cells influence reconstitution of adaptive immune cells upon alemtuzumab and that patients with a successful response to alemtuzumab have an early immune reconstitution dominated by NK cells.
MeSH term(s)	Adult ; Alemtuzumab/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; Biomarkers/blood ; Female ; Humans ; Italy ; Killer Cells, Natural/immunology ; Longitudinal Studies ; Male ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/immunology
Chemical Substances	Antineoplastic Agents, Immunological ; Biomarkers ; Alemtuzumab (3A189DH42V)
Language	English
Publishing date	2021-12-11
Publishing country	New Zealand
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1203800-3
ISSN	1179-1934 ; 1172-7047
ISSN (online)	1179-1934
ISSN	1172-7047
DOI	10.1007/s40263-021-00875-0
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Zs.A 4083: Show issues

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Article: Strategie riperfusive nell'infarto miocardico acuto: cosa dicono i trial.

Inglese, Luigi / Fantoni, Cecilia

Giornale italiano di cardiologia (2006)

2010 Volume 11, Issue 10 Suppl 1, Page(s) 57S–60S

Abstract: The efficacy of reperfusion therapy, both pharmacological and mechanical, in patients with ST-elevation myocardial infarction (STEMI) is time-dependent. The relation is closer the earlier we are from symptom onset and is valid for thrombolysis within 6h ... ...

Title translation	ST-elevation myocardial infarction: reperfusion strategy based on the results from large clinical trials.
Abstract	The efficacy of reperfusion therapy, both pharmacological and mechanical, in patients with ST-elevation myocardial infarction (STEMI) is time-dependent. The relation is closer the earlier we are from symptom onset and is valid for thrombolysis within 6h and for primary angioplasty till to at least the twelfth hour. Benefits of reperfusion bring to an advantage both in terms of myocardial salvage and left ventricular systolic function and in terms of quality of life and long-term survival. Although mortality and morbidity of STEMI patients have been greatly reduced in the last 20 years, the need for guideline revision and implementation remains urgent, mostly because mortality of real-world STEMI patients keeps to be always much higher compared to what reported in big randomized controlled trials. The most important indications from big trials and guidelines regarding both pharmacological and non-pharmacological reperfusion strategy in STEMI patients are discussed.
MeSH term(s)	Angioplasty, Balloon, Coronary ; Anticoagulants/administration & dosage ; Anticoagulants/therapeutic use ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/therapeutic use ; Guidelines as Topic ; Heparin/administration & dosage ; Heparin/therapeutic use ; Humans ; Meta-Analysis as Topic ; Myocardial Infarction/drug therapy ; Myocardial Infarction/mortality ; Myocardial Infarction/therapy ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/therapeutic use ; Pyridines/administration & dosage ; Pyridines/therapeutic use ; Quality of Life ; Randomized Controlled Trials as Topic ; Thrombolytic Therapy ; Ticlopidine/administration & dosage ; Ticlopidine/analogs & derivatives ; Ticlopidine/therapeutic use ; Time Factors
Chemical Substances	Anticoagulants ; Fibrinolytic Agents ; Platelet Aggregation Inhibitors ; Pyridines ; thienopyridine ; Heparin (9005-49-6) ; clopidogrel (A74586SNO7) ; Ticlopidine (OM90ZUW7M1)
Language	Italian
Publishing date	2010-10
Publishing country	Italy
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
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Article ; Online: Carbon dioxide (CO

De Angelis, Chiara / Sardanelli, Francesco / Perego, Matteo / Alì, Marco / Casilli, Francesco / Inglese, Luigi / Mauri, Giovanni

The international journal of cardiovascular imaging

2017 Volume 33, Issue 11, Page(s) 1655–1662

Abstract: To assess feasibility, efficacy and safety of carbon dioxide ( ... ...

Abstract	To assess feasibility, efficacy and safety of carbon dioxide (CO
Language	English
Publishing date	2017-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2055311-0
ISSN	1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
ISSN (online)	1875-8312 ; 1573-0743
ISSN	1569-5794 ; 0167-9899
DOI	10.1007/s10554-017-1175-2
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